THOMAS SEYFRIED

Summary

Affiliation: Boston College
Country: USA

Publications

  1. pmc On the origin of cancer metastasis
    Thomas N Seyfried
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Crit Rev Oncog 18:43-73. 2013
  2. doi request reprint Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?
    Thomas N Seyfried
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Epilepsy Res 100:310-26. 2012
  3. pmc Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report
    Giulio Zuccoli
    Radiology Department, Arcispedale Santa Maria Nuova, Reggio E, 42100, Italy
    Nutr Metab (Lond) 7:33. 2010
  4. pmc Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain
    Purna Mukherjee
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Mol Cancer 7:37. 2008
  5. pmc Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans
    Lisa B Mahoney
    Biology Department, Boston College, Chestnut Hill, MA, USA
    Lipids Health Dis 5:13. 2006
  6. pmc Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis
    Melanie A McNally
    Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    J Negat Results Biomed 6:8. 2007
  7. pmc Perspectives on the mesenchymal origin of metastatic cancer
    Leanne C Huysentruyt
    Department of Medicine, Hematology and Oncology, University of California, San Francisco, San Francisco, CA, USA
    Cancer Metastasis Rev 29:695-707. 2010
  8. pmc Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors
    Michael A Kiebish
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    BMC Cancer 5:102. 2005
  9. ncbi request reprint Perspectives on brain tumor formation involving macrophages, glia, and neural stem cells
    T N Seyfried
    Department of Biology, Boston College, Chestnut Hill, MA 02167 3811, USA
    Perspect Biol Med 44:263-82. 2001
  10. doi request reprint Brain lipid analysis in mice with Rett syndrome
    Thomas N Seyfried
    Department of Biology, Boston College, Boston, MA 02467, USA
    Neurochem Res 34:1057-65. 2009

Research Grants

Collaborators

  • Purna Mukherjee
  • Leanne C Huysentruyt
  • Michael A Kiebish
  • Allan J Yates
  • Min-Cheol Lee
  • S C Heinrichs
  • Melanie A McNally
  • Gregory L Holmes
  • Lisa B Mahoney
  • Xianlin Han
  • Jeffrey H Chuang
  • Julie L Kasperzyk
  • Christine A Denny
  • ALESSANDRA D'AZZO
  • M T Todorova
  • Eric C Hauser
  • Giulio Zuccoli
  • Jeremy Marsh
  • Nicholas T Seyfried
  • Justin M Prien
  • Rena C Baek
  • Frances M Platt
  • Laura E Abate
  • J L Kasperzyk
  • Elizabeth L Venit
  • Amanda E Greene
  • F M Platt
  • Michael G Drage
  • M K Ranes
  • A E Greene
  • M El-Abbadi
  • Norina Marcello
  • Anna Pisanello
  • Franco Servadei
  • Salvatore Vaccaro
  • David J Ashline
  • Vernon N Reinhold
  • James A Atwood
  • Ron Orlando
  • Anthony J Lapadula
  • Qiangwei Xia
  • Basil S Pawlyk
  • Michael A Sandberg
  • Joseph Alroy
  • C Y Kim
  • J G Mantis
  • M Le
  • Kristen N Gorham
  • Roderick T Bronson
  • J Alroy
  • A D'AZZO
  • Blythe D Shepard
  • Mohga M El-Abbadi
  • Mariana T Todorova
  • R McGowan
  • M G Manfredi
  • M El Abbadi
  • C Orosz
  • C E Garey
  • H J Flavin
  • K M Allen
  • M L Rise
  • A L Schwarzman

Detail Information

Publications40

  1. pmc On the origin of cancer metastasis
    Thomas N Seyfried
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Crit Rev Oncog 18:43-73. 2013
    ..The view of metastasis as a macrophage metabolic disease can provide novel insight for therapeutic management...
  2. doi request reprint Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?
    Thomas N Seyfried
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Epilepsy Res 100:310-26. 2012
    ..Hence, the RKD can be an effective non-toxic therapeutic option to the current standard of care for inhibiting the growth and invasive properties of malignant brain cancer...
  3. pmc Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report
    Giulio Zuccoli
    Radiology Department, Arcispedale Santa Maria Nuova, Reggio E, 42100, Italy
    Nutr Metab (Lond) 7:33. 2010
    ..Following incomplete surgical resection, the patient was diagnosed with glioblastoma multiforme expressing hypermethylation of the MGMT gene promoter...
  4. pmc Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain
    Purna Mukherjee
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Mol Cancer 7:37. 2008
    ..Activated AMPK acts as either an inducer or suppressor of apoptosis depending on the severity of energy stress and the presence or absence of certain functional tumor suppressor genes...
  5. pmc Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans
    Lisa B Mahoney
    Biology Department, Boston College, Chestnut Hill, MA, USA
    Lipids Health Dis 5:13. 2006
    ..It is also unclear how these biomarker changes in calorically restricted mice relate to those observed previously in calorically restricted humans...
  6. pmc Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis
    Melanie A McNally
    Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    J Negat Results Biomed 6:8. 2007
    ....
  7. pmc Perspectives on the mesenchymal origin of metastatic cancer
    Leanne C Huysentruyt
    Department of Medicine, Hematology and Oncology, University of California, San Francisco, San Francisco, CA, USA
    Cancer Metastasis Rev 29:695-707. 2010
    ..Such cells would naturally embody the capacity to express the multiple behaviors of metastatic cells. The view of metastasis as a myeloid/macrophage disease will impact future cancer research and anti-metastatic therapies...
  8. pmc Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors
    Michael A Kiebish
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    BMC Cancer 5:102. 2005
    ..Two hypervariable regions of mononucleotide repeats occur in the mouse mitochondrial genome, i.e., the origin of replication of the light strand (OL) and the Arg tRNA...
  9. ncbi request reprint Perspectives on brain tumor formation involving macrophages, glia, and neural stem cells
    T N Seyfried
    Department of Biology, Boston College, Chestnut Hill, MA 02167 3811, USA
    Perspect Biol Med 44:263-82. 2001
    ..Also discussed are implications of these concepts for the diagnosis and therapy of human brain tumors...
  10. doi request reprint Brain lipid analysis in mice with Rett syndrome
    Thomas N Seyfried
    Department of Biology, Boston College, Boston, MA 02467, USA
    Neurochem Res 34:1057-65. 2009
    ..1Bird) or the Mecp2 (308/y) RS mice...
  11. pmc Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet
    Jeremy Marsh
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Nutr Metab (Lond) 5:33. 2008
    ..The goal here was to determine if low doses of 2-DG could act synergistically with the KD-R to better manage growth of the CT-2A malignant mouse astrocytoma...
  12. doi request reprint Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets
    Thomas N Seyfried
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Epilepsia 49:114-6. 2008
    ..The CRKD is effective in managing brain tumor growth in animal models and in patients, and appears to act through antiangiogenic, anti-inflammatory, and proapoptotic mechanisms...
  13. pmc Cancer as a metabolic disease
    Thomas N Seyfried
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Nutr Metab (Lond) 7:7. 2010
    ..A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention...
  14. pmc Role of glucose and ketone bodies in the metabolic control of experimental brain cancer
    T N Seyfried
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Br J Cancer 89:1375-82. 2003
    ..Our results in a mouse astrocytoma suggest that malignant brain tumours are potentially manageable with dietary therapies that reduce glucose and elevate ketone bodies...
  15. doi request reprint Metabolic management of brain cancer
    Thomas N Seyfried
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Biochim Biophys Acta 1807:577-94. 2011
    ..Issues of implementation and use protocols are presented for the metabolic management of brain cancer...
  16. ncbi request reprint Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose
    A E Greene
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02167, USA
    Epilepsia 42:1371-8. 2001
    ..CONCLUSIONS: We propose that CR may reduce seizure susceptibility in EL mice by reducing brain glycolytic energy. Our preclinical findings suggest that CR may be an effective antiseizure dietary therapy for human seizure disorders...
  17. pmc Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model
    P Mukherjee
    Biology Department, Boston College, Chestnut Hill, Massachusetts, MA 02467, USA
    Br J Cancer 86:1615-21. 2002
    ..Our data suggest that moderate dietary restriction may be an effective antiangiogenic therapy for recurrent malignant brain cancers...
  18. pmc N -butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours
    M K Ranes
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Br J Cancer 84:1107-14. 2001
    ..We conclude that N B-DNJ may inhibit tumour growth through an effect on ganglioside biosynthesis and may be useful as a new chemotherapy for brain tumours...
  19. ncbi request reprint Ceruloplasmin gene defect associated with epilepsy in EL mice
    C E Garey
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02167
    Nat Genet 6:426-31. 1994
    ..The findings are relevant to the basic mechanisms of epilepsy and to theories of genetic recombination and gene mapping...
  20. pmc Genetic analysis of nucleotide triphosphatase activity in the mouse brain
    K M Allen
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02167
    Genetics 137:257-65. 1994
    ..Although an association was observed previously between Ca(2+)-ATPase activity and susceptibility to audiogenic seizures (AGS), no significant association was observed for the expression of Ntp and AGS susceptibility...
  21. ncbi request reprint Experimental models of multifactorial epilepsies: the EL mouse and mice susceptible to audiogenic seizures
    T N Seyfried
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02035, USA
    Adv Neurol 79:279-90. 1999
    ..The genetic dissection of convulsive behavior in EL and AGS susceptible mice could help identify candidate genes for human multifactorial epilepsies...
  22. ncbi request reprint Genetic and environmental interactions determine seizure susceptibility in epileptic EL mice
    M T Todorova
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Genes Brain Behav 5:518-27. 2006
    ....
  23. ncbi request reprint Enhanced aspartate release related to epilepsy in (EL) mice
    H J Flavin
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02167 3811
    J Neurochem 63:592-5. 1994
    ..6, respectively) or GABA (23.5 +/- 0.7, 19.5 +/- 3.2, and 21.8 +/- 3.2, respectively). Thus, enhanced aspartate release precedes the onset of EL seizures and may be related to the cause rather than to the effects of seizure activity...
  24. pmc Ganglioside composition and histology of a spontaneous metastatic brain tumour in the VM mouse
    M El Abbadi
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Br J Cancer 85:285-92. 2001
    ..This tumour will be a useful natural model for evaluating the role of gangliosides and other glycolipids in tumour cell invasion and metastasis...
  25. ncbi request reprint Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice
    J L Kasperzyk
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Lipid Res 46:744-51. 2005
    ....
  26. ncbi request reprint Gene-linked shift in ganglioside distribution influences growth and vascularity in a mouse astrocytoma
    Laura E Abate
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA
    J Neurochem 98:1973-84. 2006
    ..These data suggest that gene-linked changes in ganglioside composition influence the growth and angiogenic properties of the CT-2A astrocytoma...
  27. ncbi request reprint N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis
    Julie L Kasperzyk
    Department of Biology, Boston College, Chestnut Hill, Massachussetts, USA
    J Neurochem 89:645-53. 2004
    ..These findings suggest that substrate reduction therapy using NB-DGJ may be an effective early intervention for GM1 gangliosidosis and possibly other GSL lysosomal storage diseases...
  28. ncbi request reprint Oxygenation prevents sudden death in seizure-prone mice
    Elizabeth L Venit
    Boston College Biology Department, Chestnut Hill, Massachusetts 02167, USA
    Epilepsia 45:993-6. 2004
    ....
  29. ncbi request reprint Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors
    Purna Mukherjee
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Clin Cancer Res 10:5622-9. 2004
    ..In this study, we evaluated the effects of moderate (40%) DR on the orthotopic growth of mouse and human brain tumors that differ in cell origin, angiogenicity, host environment, and biochemical composition...
  30. ncbi request reprint Perspectives on the metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies
    Amanda E Greene
    Boston College Biology Department, Chestnut Hill, Massachusetts, USA
    J Neurochem 86:529-37. 2003
    ..A better understanding of the compensatory genetic and neurochemical networks of brain energy metabolism may produce novel antiepileptic therapies that are more effective and biologically friendly than those currently available...
  31. ncbi request reprint Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice
    Christine A Denny
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Neurosci Res 83:1028-38. 2006
    ..We suggest that the CR delays disease progression in SD and possibly in other ganglioside storage diseases through anti-inflammatory mechanisms...
  32. ncbi request reprint Behavioral seizure correlates in animal models of epilepsy: a road map for assay selection, data interpretation, and the search for causal mechanisms
    Stephen C Heinrichs
    Department of Psychology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Epilepsy Behav 8:5-38. 2006
    ....
  33. doi request reprint Metastatic cancer cells with macrophage properties: evidence from a new murine tumor model
    Leanne C Huysentruyt
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Int J Cancer 123:73-84. 2008
    ..The new VM tumor model will be useful for defining the biological processes of cancer metastasis and for evaluating potential therapies for tumor management...
  34. pmc Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria
    Michael A Kiebish
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Neurochem 106:299-312. 2008
    ..NS and Syn mitochondrial lipidomic heterogeneity could influence energy metabolism, which may contribute to metabolic compartmentation of the brain...
  35. pmc Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: a membrane proteomics approach
    Nicholas T Seyfried
    Complex Carbohydrate Research Center, University of Georgia, 330 Riverbend Road, Athens, GA 30602, USA
    Cancer Lett 263:243-52. 2008
    ..Moreover, the CT-2A cells also express a series of interferon-induced signature proteins that may be specific to this tumor. These data highlight the utility of LC-MS/MS for the identification of brain tumor membrane biomarkers...
  36. ncbi request reprint Hippocampal neurons and glia in epileptic EL mice
    Michael G Drage
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    J Neurocytol 31:681-92. 2002
    ..The EL mouse can be a useful model for evaluating neuron-glia interactions related to idiopathic epilepsy...
  37. ncbi request reprint Neurochemical, morphological, and neurophysiological abnormalities in retinas of Sandhoff and GM1 gangliosidosis mice
    Christine A Denny
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Neurochem 101:1294-302. 2007
    ..Our findings present a model system for assessing retinal pathobiology and therapies for the gangliosidoses...
  38. ncbi request reprint Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice
    Eric C Hauser
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA
    Biochem Genet 42:241-57. 2004
    ..These results suggest that the reduced brain beta-gal activity alone cannot account for the elevation of total brain gangliosides and GM1 in the D2 mice...
  39. pmc Differentiating N-linked glycan structural isomers in metastatic and nonmetastatic tumor cells using sequential mass spectrometry
    Justin M Prien
    Division of Molecular, Cellular, and Biomedical Sciences, The Glycomics Center, Durham, NH 03824, USA
    Glycobiology 18:353-66. 2008
    ....
  40. doi request reprint N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice
    Rena C Baek
    Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Neurochem Int 52:1125-33. 2008
    ..Our results show that NB-DGJ is effective in reducing total brain ganglioside and GM2 content at early neonatal ages...

Research Grants11

  1. GLYCOSPHINGOLIPIDS IN MURINE NEURODEGENERATIVE DISEASES
    THOMAS SEYFRIED; Fiscal Year: 2007
    ..The proposed studies will provide essential information on combinatorial therapies for the ganglioside storage diseases and will have translational benefit to the clinic. ..
  2. Glycosphingolipid Effects on Brain Tumor Angiogenesis
    THOMAS SEYFRIED; Fiscal Year: 2006
    ..The proposed research will better define the relationship between gangliosides and tumor angiogenesis and can lead to new experimental strategies for managing brain tumors. ..
  3. GLYCOSPHINGOLIPIDS IN MURINE NEURODEGENERATIVE DISEASES
    THOMAS SEYFRIED; Fiscal Year: 2004
    ..Since there are no effective treatments for human ganglioside storages disease, the proposed research could offer a novel therapy for the early intervention of these neurodegenerative disorders. ..
  4. GLYCOSPHINGOLIPIDS IN MURINE NEURODEGENERATIVE DISEASES
    THOMAS SEYFRIED; Fiscal Year: 2009
    ..The proposed studies will provide essential information on combinatorial therapies for the ganglioside storage diseases and will have translational benefit to the clinic. ..