Research Topics
Genomes and Genes | Sudha SeshadriSummaryAffiliation: Boston University School of Medicine Country: USA Publications
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Publications
The lifetime risk of stroke: estimates from the Framingham StudySudha Seshadri
Department of Neurology, School of Medicine, Boston University, Boston, MA 02118 2526, USA
Stroke 37:345-50. 2006..The lifetime risk (LTR) of stroke has not been reported for the United States population; such data would assist public education and health planning...
Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham studyJose R Romero
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Stroke 40:1590-6. 2009..The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear...- Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study)Angela L Jefferson
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Am J Cardiol 108:1346-51. 2011..In conclusion, although these observational cross-sectional data cannot establish causality, they suggest a nonlinear association between LVEF and measures of accelerated cognitive aging... - Homocysteine and cognitive performance in the Framingham offspring study: age is importantMerrill F Elias
The Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA, USA
Am J Epidemiol 162:644-53. 2005..Early preventive interventions may be important, because the inverse association between tHcy and cognitive performance is observed beyond middle age... - Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring StudyJose R Romero
Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
J Stroke Cerebrovasc Dis 17:412-7. 2008..We sought to relate circulating biomarkers of extracellular matrix turnover to site-specific measures of carotid artery atherosclerosis on duplex ultrasound... - Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart StudyThomas M van Himbergen
Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Arch Neurol 69:594-600. 2012.... - Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohortRenke Maas
Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
Stroke 40:2715-9. 2009..We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT... - Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring StudyStephanie Debette
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Stroke 41:600-6. 2010..We simultaneously assessed the relation of white matter hyperintensities and BI with incident stroke, mild cognitive impairment, dementia, and mortality in a middle-aged community-based cohort... - Parental occurrence of stroke and risk of stroke in their children: the Framingham studySudha Seshadri
Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
Circulation 121:1304-12. 2010..Data relating parental history of stroke to stroke risk in offspring remain surprisingly inconsistent, largely because of heterogeneity of study design and the absence of verified, as opposed to historical, data on parental stroke status... - Association of matrix metalloproteinases with MRI indices of brain ischemia and agingJose Rafael Romero
Department of Neurology, School of Medicine at Boston University, Boston, MA 02118 2526, United States
Neurobiol Aging 31:2128-35. 2010..04). Neither biomarker was associated with SCI. Our findings are preliminary but if confirmed in further studies, suggest a pathophysiological role for the MMP/TIMP pathway in processes of brain ischemia and aging... - Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring StudySudha Seshadri
Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
Arch Neurol 65:642-9. 2008..Elevated plasma total homocysteine (tHcy) levels have been associated with increased risk of dementia and stroke, but it is uncertain whether the mediating mechanisms are predominantly cellular, vascular, or both... - Visceral fat is associated with lower brain volume in healthy middle-aged adultsStephanie Debette
Department of Neurology, Boston University School of Medicine, MA, USA
Ann Neurol 68:136-44. 2010.... - Cardiac index is associated with brain aging: the Framingham Heart StudyAngela L Jefferson
Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, 72 E Concord St, B 7800, Boston, MA 02118, USA
Circulation 122:690-7. 2010..We hypothesized that cardiac function, as measured by cardiac index, would be associated with preclinical brain magnetic resonance imaging (MRI) and neuropsychological markers of ischemia and Alzheimer disease in the community... - Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring StudyZaldy S Tan
Veterans Administration Boston HealthcareSystem, Boston, MA, USA
Diabetes Care 34:1766-70. 2011..We aimed to comprehensively relate all of the components of metabolic dysregulation to cognitive function and brain magnetic resonance imaging (MRI) in middle-aged adults... - Inflammatory markers and neuropsychological functioning: the Framingham Heart StudyAngela L Jefferson
Boston University School of Medicine, Boston, MA 02118, USA
Neuroepidemiology 37:21-30. 2011..We hypothesized that inflammatory markers are cross-sectionally and longitudinally associated with neuropsychological indicators of early ischemia and Alzheimer's disease... - The Framingham Brain Donation Program: neuropathology along the cognitive continuumRhoda Au
Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Curr Alzheimer Res 9:673-86. 2012..We observed that an aggregate ischemic injury score was significantly higher in persons with a CDR score of 0.5 than in normal controls... 
Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart StudyJane A Driver
Geriatric Research Education and Clinical Center and Boston VA Medical Center, Boston, MA 02130, USA
BMJ 344:e1442. 2012..To relate cancer since entry into the Framingham Heart Study with the risk of incident Alzheimer's disease and to estimate the risk of incident cancer among participants with and without Alzheimer's disease...- Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2Sudha Seshadri
Department of Neurology, Boston University School of Medicine, MA, USA
Alzheimers Dement 7:35-52. 2011..Improved accuracy in the clinical diagnosis of AD is anticipated with the addition of molecular and structural biomarkers in the next generation of epidemiological studies... - Prevalence and correlates of silent cerebral infarcts in the Framingham offspring studyRohit R Das
Department of Neurology, Boston University, Boston, MA 02118, USA
Stroke 39:2929-35. 2008..8% and 17.7% depending on age, ethnicity, presence of comorbidities, and imaging techniques. We document the prevalence and risk factors associated with SCI at midlife in the community-based Framingham sample... - The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring CohortCoreyann Poly
Department of Neurology, Boston University School of Medicine, MA, 02118 2526, USA
Am J Clin Nutr 94:1584-91. 2011..Brain atrophy and white-matter hyperintensity (WMH) are also associated with impaired cognitive function and AD... - Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspringMerrill F Elias
Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Mass, USA
Hypertension 49:439-45. 2007.... - Thyroid function and the risk of Alzheimer disease: the Framingham StudyZaldy S Tan
Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, 110 Francis St, LMOB 1A, Boston, MA 02215, USA
Arch Intern Med 168:1514-20. 2008..Clinical hypothyroidism and hyperthyroidism are recognized causes of reversible dementia, but previous studies relating thyrotropin levels to cognitive performance in clinically euthyroid persons have yielded inconsistent results... - Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart StudyPhilip A Wolf
Boston University School of Medicine, Boston, MA 02118 2526, USA
Curr Alzheimer Res 4:111-6. 2007..We hypothesized that mid-life obesity may modulate the impact of conventional cardiovascular risk factors (CVRF) on cognitive impairment. We tested this hypothesis in the community-based Framingham Offspring Study sample... - Gender differences in stroke incidence and poststroke disability in the Framingham heart studyRodica E Petrea
Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
Stroke 40:1032-7. 2009..Stroke is emerging as a major public health problem for women, as it is for men. Controversy persists regarding gender differences in stroke incidence, severity, and poststroke disability... - Bone mineral density and the risk of Alzheimer diseaseZaldy Sy Tan
Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02215, USA
Arch Neurol 62:107-11. 2005..Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration... - Genome-wide analysis of genetic loci associated with Alzheimer diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
JAMA 303:1832-40. 2010..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)... - Dementia after stroke: the Framingham StudyCristina S Ivan
Department of Neurology, Boston University School of Medicine, Boston, Mass 02118-2526, USA
Stroke 35:1264-8. 2004..4; 95% CI: 1.5 to 3.9). CONCLUSIONS: Stroke increases a subject's risk of dementia as compared with age- and sex-matched controls. Primary and secondary prevention of stroke should significantly decrease the risk of all dementia... - Framingham stroke risk profile and lowered cognitive performanceMerrill F Elias
Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
Stroke 35:404-9. 2004.... - Profiles by sex of brain MRI and cognitive function in the framingham offspring studyMark Albert
Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
Alzheimer Dis Assoc Disord 24:190-3. 2010..To examine whether there are sex-specific associations between brain magnetic resonance imaging (MRI) measures and neuropsychologic (NP) test performance... - White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart StudyKarina Stavitsky
Department of Psychology, Boston University, Boston, MA 02118, USA
Neuroepidemiology 35:117-22. 2010..This study investigated the association of WMH and cognition in an ethnic and racial minority cohort (Omni) of the Framingham Heart Study and compared these results to the Caucasian (Offspring) cohort... - Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 yearsRaphael Carandang
Department of Neurology, School of Medicine, Boston University, Boston, Mass 02118-2526, USA
JAMA 296:2939-46. 2006..The results of this study suggest that improved control of risk factors has lowered stroke incidence but emphasize the need for continued primary prevention efforts... - Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring studyAleksandra Pikula
Boston University School of Medicine, Boston, MA, USA
Stroke 40:2959-64. 2009..The relation of plasma ADMA to subclinical vascular brain injury has not been previously studied in a middle-aged, community-based sample... - Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham StudyZaldy Sy Tan
Division on Aging, Harvard Medical School, Boston, MA, USA
Arch Intern Med 163:1053-7. 2003..97; 95% confidence interval, 0.90-1.05). CONCLUSION: In this large, population-based cohort, baseline and long-term average serum total cholesterol levels were not associated with the risk for incident AD... - Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart StudyRhoda Au
Department of Neurology, Boston University School of Medicine, Boston, Mass 02118-2526, USA
Arch Neurol 63:246-50. 2006..Further study will clarify whether large WMH volume and associated cognitive impairment lead to future risk of stroke or dementia... - Lipoprotein phospholipase A2 and cerebral microbleeds in the Framingham Heart StudyJose Rafael Romero
Department of Neurology, School of Medicine, Boston University, 715 Albany Street, B 608, Boston, MA 02118 2526, USA
Stroke 43:3091-4. 2012..We hypothesized that higher Lp-PLA2 levels would be related to higher prevalence of CMB, with possible regional specificity... - Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring StudyAleksandra Pikula
Boston University Schools of Medicine and Public Health, MA, USA
Circulation 125:2100-7. 2012.... - New norms for a new generation: cognitive performance in the framingham offspring cohortRhoda Au
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
Exp Aging Res 30:333-58. 2004..These findings suggest that continued surveillance of each generation is necessary to document the impact that unique social and economic variables have on cognitive function. Here, the authors provide updated normative data... - Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham StudySudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
Lancet Neurol 6:1106-14. 2007..Thus, the lifetime burden attributable to common neurological disease is immense... - Bivariate heritability of total and regional brain volumes: the Framingham StudyAnita L Destefano
Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA
Alzheimer Dis Assoc Disord 23:218-23. 2009..These data extend current knowledge by showing that these 2 different types of magnetic resonance imaging measures do not share underlying genetic or environmental influences... - Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structureDavid Zade
Veterans Affairs Boston Medical Center, Geriatric Research Education and Clinical Center, Boston, Massachusetts 02130, USA
J Stroke Cerebrovasc Dis 22:119-25. 2013..This study aimed to determine whether relationships between obesity, as measured by waist-to-hip ratio (WHR), and cognition and brain structure were modified by the apolipoprotein epsilon 4 allele (apoE4)... - Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart StudyMing Huei Chen
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
PLoS ONE 7:e51589. 2012..Further examination may be required to generalize this threshold to other studies... - Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathologyPatricia F Kao
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
J Neuropathol Exp Neurol 71:654-64. 2012..In subsequent stages of AD, the higher levels of TrkB and Capzb2 expression achieved may not be sufficient to prevent cognitive decline... - Homocysteine and the brain: vascular risk factor or neurotoxin?Sudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Lancet Neurol 2:11. 2003 - Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?Sudha Seshadri
Department of Neurology, Boston University School of Medicine, 715 Albany Street B 608, Boston, MA 02118, USA
J Alzheimers Dis 9:393-8. 2006.... - Risk estimations, risk factors, and genetic variants associated with Alzheimer's disease in selected publications from the Framingham Heart StudyGalit Weinstein
Department of Neurology, Boston University School of Medicine, Boston, MA 20008, USA
J Alzheimers Dis 33:S439-45. 2013..The second is a large meta-analysis GWA study of AD, in which novel loci of AD susceptibility were found. Together, these findings demonstrate the FHS multi-directional efforts in investigating dementia and AD... - The Framingham Heart Study clock drawing performance: normative data from the offspring cohortJustin A Nyborn
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Exp Aging Res 39:80-108. 2013..The objective of the current study was to provide normative data on an expanded version of previous CDT scoring protocols from a large community-based sample of middle to older adults (aged 43 to 91) from the Framingham Heart Study... - Plasma homocysteine as a risk factor for dementia and Alzheimer's diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
N Engl J Med 346:476-83. 2002..Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the onset of dementia or result from dementia-related nutritional and vitamin deficiencies... - δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changesGyungah Jun
Department of Medicine, Biomedical Genetics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
PLoS ONE 7:e43728. 2012..Our findings suggest that genetic variation in delta catenin may underlie both cortical lens opacities in mid-life and subsequent MRI and cognitive changes that presage the development of AD... - Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE ConsortiumStephanie Debette
Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
Stroke 41:210-7. 2010..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium... - Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander?Zaldy S Tan
Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Division of Aging in the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston, MA 02120, USA
Alzheimers Res Ther 2:6. 2010.... - Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levelsStephanie Debette
Department of Neurology, Boston University School of Medicine, B602, 72 East Concord St, Boston, MA 02118, USA
Circ Res 109:554-63. 2011..Vascular endothelial growth factor (VEGF) affects angiogenesis, atherosclerosis, and cancer. Although the heritability of circulating VEGF levels is high, little is known about its genetic underpinnings... - Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham StudyAbimbola Akomolafe
Department of Medicine, Morehouse School of Medicine, Atlanta, GA, USA
Arch Neurol 63:1551-5. 2006..28-17.72; P = .02). CONCLUSION: Diabetes mellitus did not increase the risk of incident AD in the Framingham cohort overall; however, DM may be a risk factor for AD in the absence of other known major AD risk factors... - Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham StudyKathryn L Lunetta
The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S13. 2007..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span... - Association of alcohol consumption with brain volume in the Framingham studyCarol Ann Paul
Neuroscience Program, Wellesley College, 106 Central St, Wellesley, MA 02418, USA
Arch Neurol 65:1363-7. 2008..There is evidence that drinking large amounts of alcohol is related to brain atrophy. It is uncertain what the effects of low to moderate consumption might be... - Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomesMartin G Larson
The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S5. 2007..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes... - Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart StudyRamachandran S Vasan
Framingham Heart Study, 5 Thurber St, Framingham, MA 01702, USA
JAMA 287:1003-10. 2002..The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown... - Visual association pathology in preclinical Alzheimer diseaseAnn C McKee
Department of Neurology and Pathology, Boston University School of Medicine, Bedford Veterans Administration Medical Center, MA 01730, USA
J Neuropathol Exp Neurol 65:621-30. 2006..Dense AD pathology in area 19 is present in some cognitively intact subjects with preclinical AD. The unique metabolic, connectional, and vascular features of this region may confer enhanced vulnerability to neurodegeneration... - Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study Ramachandran S Vasan
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
Circulation 105:48-53. 2002..It is unclear whether time-averaged past BP measures incrementally improve CVD risk assessment... - Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham StudySudha Seshadri
The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S15. 2007..We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample... - The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reportsL Adrienne Cupples
National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S1. 2007.... - Stroke risk profile predicts white matter hyperintensity volume: the Framingham StudyTom Jeerakathil
Division of Neurology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
Stroke 35:1857-61. 2004..CONCLUSIONS: FSRP and several cardiovascular risk factors were related to both WMHV measured continuously and to a categorical designation of large volumes of WMH. These findings provide strong evidence of a vascular basis for WMH...