Sudha Seshadri

Summary

Affiliation: Boston University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The lifetime risk of stroke: estimates from the Framingham Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, MA 02118 2526, USA
    Stroke 37:345-50. 2006
  2. pmc Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study
    Jose R Romero
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 40:1590-6. 2009
  3. pmc Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study)
    Angela L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 108:1346-51. 2011
  4. pmc Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study
    Jose R Romero
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    J Stroke Cerebrovasc Dis 17:412-7. 2008
  5. ncbi request reprint Homocysteine and cognitive performance in the Framingham offspring study: age is important
    Merrill F Elias
    The Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA, USA
    Am J Epidemiol 162:644-53. 2005
  6. pmc Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study
    Galit Weinstein
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts2The Framingham Heart Study, Boston, Massachusetts
    JAMA Neurol 71:55-61. 2014
  7. pmc Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study
    Thomas M van Himbergen
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arch Neurol 69:594-600. 2012
  8. pmc Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 41:600-6. 2010
  9. pmc Parental occurrence of stroke and risk of stroke in their children: the Framingham study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
    Circulation 121:1304-12. 2010
  10. pmc Association of matrix metalloproteinases with MRI indices of brain ischemia and aging
    Jose Rafael Romero
    Department of Neurology, School of Medicine at Boston University, Boston, MA 02118 2526, United States
    Neurobiol Aging 31:2128-35. 2010

Detail Information

Publications69

  1. ncbi request reprint The lifetime risk of stroke: estimates from the Framingham Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, MA 02118 2526, USA
    Stroke 37:345-50. 2006
    ..The lifetime risk (LTR) of stroke has not been reported for the United States population; such data would assist public education and health planning...
  2. pmc Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study
    Jose R Romero
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 40:1590-6. 2009
    ..The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear...
  3. pmc Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study)
    Angela L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 108:1346-51. 2011
    ..In conclusion, although these observational cross-sectional data cannot establish causality, they suggest a nonlinear association between LVEF and measures of accelerated cognitive aging...
  4. pmc Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study
    Jose R Romero
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    J Stroke Cerebrovasc Dis 17:412-7. 2008
    ..We sought to relate circulating biomarkers of extracellular matrix turnover to site-specific measures of carotid artery atherosclerosis on duplex ultrasound...
  5. ncbi request reprint Homocysteine and cognitive performance in the Framingham offspring study: age is important
    Merrill F Elias
    The Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA, USA
    Am J Epidemiol 162:644-53. 2005
    ..Early preventive interventions may be important, because the inverse association between tHcy and cognitive performance is observed beyond middle age...
  6. pmc Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study
    Galit Weinstein
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts2The Framingham Heart Study, Boston, Massachusetts
    JAMA Neurol 71:55-61. 2014
    ..Some prior studies showed lower circulating BDNF in persons with Alzheimer disease (AD) compared with control participants; however, it remains uncertain whether reduced levels precede dementia onset...
  7. pmc Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study
    Thomas M van Himbergen
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arch Neurol 69:594-600. 2012
    ....
  8. pmc Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 41:600-6. 2010
    ..We simultaneously assessed the relation of white matter hyperintensities and BI with incident stroke, mild cognitive impairment, dementia, and mortality in a middle-aged community-based cohort...
  9. pmc Parental occurrence of stroke and risk of stroke in their children: the Framingham study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
    Circulation 121:1304-12. 2010
    ..Data relating parental history of stroke to stroke risk in offspring remain surprisingly inconsistent, largely because of heterogeneity of study design and the absence of verified, as opposed to historical, data on parental stroke status...
  10. pmc Association of matrix metalloproteinases with MRI indices of brain ischemia and aging
    Jose Rafael Romero
    Department of Neurology, School of Medicine at Boston University, Boston, MA 02118 2526, United States
    Neurobiol Aging 31:2128-35. 2010
    ..04). Neither biomarker was associated with SCI. Our findings are preliminary but if confirmed in further studies, suggest a pathophysiological role for the MMP/TIMP pathway in processes of brain ischemia and aging...
  11. pmc Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort
    Renke Maas
    Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Stroke 40:2715-9. 2009
    ..We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT...
  12. pmc Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    Arch Neurol 65:642-9. 2008
    ..Elevated plasma total homocysteine (tHcy) levels have been associated with increased risk of dementia and stroke, but it is uncertain whether the mediating mechanisms are predominantly cellular, vascular, or both...
  13. pmc Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study
    Zaldy S Tan
    Veterans Administration Boston HealthcareSystem, Boston, MA, USA
    Diabetes Care 34:1766-70. 2011
    ..We aimed to comprehensively relate all of the components of metabolic dysregulation to cognitive function and brain magnetic resonance imaging (MRI) in middle-aged adults...
  14. pmc Visceral fat is associated with lower brain volume in healthy middle-aged adults
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, MA, USA
    Ann Neurol 68:136-44. 2010
    ....
  15. pmc Cardiac index is associated with brain aging: the Framingham Heart Study
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, 72 E Concord St, B 7800, Boston, MA 02118, USA
    Circulation 122:690-7. 2010
    ..We hypothesized that cardiac function, as measured by cardiac index, would be associated with preclinical brain magnetic resonance imaging (MRI) and neuropsychological markers of ischemia and Alzheimer disease in the community...
  16. pmc Inflammatory markers and neuropsychological functioning: the Framingham Heart Study
    Angela L Jefferson
    Boston University School of Medicine, Boston, MA 02118, USA
    Neuroepidemiology 37:21-30. 2011
    ..We hypothesized that inflammatory markers are cross-sectionally and longitudinally associated with neuropsychological indicators of early ischemia and Alzheimer's disease...
  17. pmc Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure
    David Zade
    Veterans Affairs Boston Medical Center, Geriatric Research Education and Clinical Center, Boston, Massachusetts 02130, USA
    J Stroke Cerebrovasc Dis 22:119-25. 2013
    ..This study aimed to determine whether relationships between obesity, as measured by waist-to-hip ratio (WHR), and cognition and brain structure were modified by the apolipoprotein epsilon 4 allele (apoE4)...
  18. pmc The Framingham Brain Donation Program: neuropathology along the cognitive continuum
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Curr Alzheimer Res 9:673-86. 2012
    ..We observed that an aggregate ischemic injury score was significantly higher in persons with a CDR score of 0.5 than in normal controls...
  19. pmc Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study
    Jane A Driver
    Geriatric Research Education and Clinical Center and Boston VA Medical Center, Boston, MA 02130, USA
    BMJ 344:e1442. 2012
    ..To relate cancer since entry into the Framingham Heart Study with the risk of incident Alzheimer's disease and to estimate the risk of incident cancer among participants with and without Alzheimer's disease...
  20. pmc Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study
    Rohit R Das
    Department of Neurology, Boston University, Boston, MA 02118, USA
    Stroke 39:2929-35. 2008
    ..8% and 17.7% depending on age, ethnicity, presence of comorbidities, and imaging techniques. We document the prevalence and risk factors associated with SCI at midlife in the community-based Framingham sample...
  21. pmc Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA, USA
    Alzheimers Dement 7:35-52. 2011
    ..Improved accuracy in the clinical diagnosis of AD is anticipated with the addition of molecular and structural biomarkers in the next generation of epidemiological studies...
  22. pmc Relations of arterial stiffness and endothelial function to brain aging in the community
    Connie W Tsao
    From the Department of Medicine C W T, Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston Departments of Neurology S S, A S B, A J W, R A, J J H, P A W, Medicine N M H, J A V, D L, E J B, R S V, and Biostatistics A S B, J J H, M G L, School of Public Health, School of Medicine and the Department of Mathematics M G L, Boston University, MA Department of Neurology C D, Center for Neuroscience and Division of Biostatistics, Department of Public Health Sciences, School of Medicine, University of California, Davis National Heart Lung and Blood Institute D L, NHLBI s Framingham Heart Study C W T, S S, A S B, R A, D L, M G L, E J B, P A W, R S V
    Neurology 81:984-91. 2013
    ..To determine the association of arterial stiffness and pressure pulsatility, which can damage small vessels in the brain, with vascular and Alzheimer-type brain aging...
  23. pmc Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study
    Ming Huei Chen
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS ONE 7:e51589. 2012
    ..Further examination may be required to generalize this threshold to other studies...
  24. pmc Association of parental stroke with brain injury and cognitive measures in offspring: the Framingham Heart Study
    Galit Weinstein
    Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 44:812-5. 2013
    ..This study examines whether parental stroke is also associated with increased vascular brain injury and poorer cognitive performance among offspring free of clinical stroke...
  25. pmc The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort
    Coreyann Poly
    Department of Neurology, Boston University School of Medicine, MA, 02118 2526, USA
    Am J Clin Nutr 94:1584-91. 2011
    ..Brain atrophy and white-matter hyperintensity (WMH) are also associated with impaired cognitive function and AD...
  26. pmc Thyroid function and the risk of Alzheimer disease: the Framingham Study
    Zaldy S Tan
    Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, 110 Francis St, LMOB 1A, Boston, MA 02215, USA
    Arch Intern Med 168:1514-20. 2008
    ..Clinical hypothyroidism and hyperthyroidism are recognized causes of reversible dementia, but previous studies relating thyrotropin levels to cognitive performance in clinically euthyroid persons have yielded inconsistent results...
  27. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  28. pmc Gender differences in stroke incidence and poststroke disability in the Framingham heart study
    Rodica E Petrea
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Stroke 40:1032-7. 2009
    ..Stroke is emerging as a major public health problem for women, as it is for men. Controversy persists regarding gender differences in stroke incidence, severity, and poststroke disability...
  29. ncbi request reprint Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study
    Philip A Wolf
    Boston University School of Medicine, Boston, MA 02118 2526, USA
    Curr Alzheimer Res 4:111-6. 2007
    ..We hypothesized that mid-life obesity may modulate the impact of conventional cardiovascular risk factors (CVRF) on cognitive impairment. We tested this hypothesis in the community-based Framingham Offspring Study sample...
  30. ncbi request reprint Bone mineral density and the risk of Alzheimer disease
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02215, USA
    Arch Neurol 62:107-11. 2005
    ..Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration...
  31. ncbi request reprint Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspring
    Merrill F Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Mass, USA
    Hypertension 49:439-45. 2007
    ....
  32. pmc Qualitative neuropsychological measures: normative data on executive functioning tests from the Framingham offspring study
    Lisa D Hankee
    a Boston University School of Medicine, Boston, Massachusetts, USA
    Exp Aging Res 39:515-35. 2013
    ....
  33. ncbi request reprint Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Arch Neurol 63:246-50. 2006
    ..To examine the relationship between white matter hyperintensity (WMH) volume on magnetic resonance images and cognitive tests in a large, population-based sample...
  34. ncbi request reprint Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Boston, MA, USA
    Arch Intern Med 163:1053-7. 2003
    ..We examined the impact of baseline and lifetime plasma total cholesterol levels averaged across many years on the risk for AD in a large, population-based cohort...
  35. pmc The Framingham Heart Study clock drawing performance: normative data from the offspring cohort
    Justin A Nyborn
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Exp Aging Res 39:80-108. 2013
    ..The objective of the current study was to provide normative data on an expanded version of previous CDT scoring protocols from a large community-based sample of middle to older adults (aged 43 to 91) from the Framingham Heart Study...
  36. ncbi request reprint Dementia after stroke: the Framingham Study
    Cristina S Ivan
    Department of Neurology, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Stroke 35:1264-8. 2004
    ..Previous case-control studies were hospital-based. We used a nested case-control design to prospectively evaluate these risk factors in the community-based Framingham Study cohort...
  37. ncbi request reprint Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years
    Raphael Carandang
    Department of Neurology, School of Medicine, Boston University, Boston, Mass 02118 2526, USA
    JAMA 296:2939-46. 2006
    ..Prior estimates of long-term trends in the incidence and severity of stroke have varied; trends in lifetime risk have not been reported...
  38. ncbi request reprint Framingham stroke risk profile and lowered cognitive performance
    Merrill F Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Stroke 35:404-9. 2004
    ....
  39. pmc White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart Study
    Karina Stavitsky
    Department of Psychology, Boston University, Boston, MA 02118, USA
    Neuroepidemiology 35:117-22. 2010
    ..This study investigated the association of WMH and cognition in an ethnic and racial minority cohort (Omni) of the Framingham Heart Study and compared these results to the Caucasian (Offspring) cohort...
  40. pmc Profiles by sex of brain MRI and cognitive function in the framingham offspring study
    Mark Albert
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Alzheimer Dis Assoc Disord 24:190-3. 2010
    ..To examine whether there are sex-specific associations between brain magnetic resonance imaging (MRI) measures and neuropsychologic (NP) test performance...
  41. pmc Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study
    Galit Weinstein
    From the Department of Neurology, Boston University School of Medicine, Boston, MA G W, A S B, R A, P A W, S S The Framingham Heart Study, Boston, MA G W, A S B, R A, P A W, S S Department of Biostatistics, Boston University School of Public Health, Boston, MA A S B and the Department of Neurology, University of California at Davis, Sacramento, CA C D
    Stroke 44:2787-94. 2013
    ..Exposure to vascular risk factors has a gradual deleterious effect on brain MRI and cognitive measures. We explored whether a pattern of these measures exists that predicts stroke and Alzheimer disease (AD) risk...
  42. pmc Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study
    Aleksandra Pikula
    Boston University School of Medicine, Boston, MA, USA
    Stroke 40:2959-64. 2009
    ..The relation of plasma ADMA to subclinical vascular brain injury has not been previously studied in a middle-aged, community-based sample...
  43. pmc Transient global amnesia and neurological events: the framingham heart study
    Jose Rafael Romero
    Department of Neurology, Boston University Medical Center Boston MA, USA Framingham Heart Study, The National Heart, Lung, and Blood Institute Framingham, MA, USA
    Front Neurol 4:47. 2013
    ..However, our study is limited by small sample size and power, and larger studies are required to exclude an association...
  44. pmc Lipoprotein phospholipase A2 and cerebral microbleeds in the Framingham Heart Study
    Jose Rafael Romero
    Department of Neurology, School of Medicine, Boston University, 715 Albany Street, B 608, Boston, MA 02118 2526, USA
    Stroke 43:3091-4. 2012
    ..We hypothesized that higher Lp-PLA2 levels would be related to higher prevalence of CMB, with possible regional specificity...
  45. pmc Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study
    Aleksandra Pikula
    Boston University Schools of Medicine and Public Health, MA, USA
    Circulation 125:2100-7. 2012
    ....
  46. ncbi request reprint Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Lancet Neurol 6:1106-14. 2007
    ..Thus, the lifetime burden attributable to common neurological disease is immense...
  47. ncbi request reprint New norms for a new generation: cognitive performance in the framingham offspring cohort
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Exp Aging Res 30:333-58. 2004
    ..These findings suggest that continued surveillance of each generation is necessary to document the impact that unique social and economic variables have on cognitive function. Here, the authors provide updated normative data...
  48. pmc Bivariate heritability of total and regional brain volumes: the Framingham Study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 23:218-23. 2009
    ..These data extend current knowledge by showing that these 2 different types of magnetic resonance imaging measures do not share underlying genetic or environmental influences...
  49. pmc Parental longevity is associated with cognition and brain ageing in middle-aged offspring
    Joanne M Murabito
    Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Age Ageing 43:358-63. 2014
    ..offspring of long-lived individuals have lower risk for dementia. We examined the relation between parental longevity and cognition and subclinical markers of brain ageing in community-dwelling adult offspring...
  50. pmc Midlife cardiovascular risk impacts executive function: framingham offspring study
    Arvind Nishtala
    Framingham Heart Study, Department of Neurology, Boston University School of Medicine Framingham Heart Study, Department of Biostatistics, Boston University School of Public Health, Boston, MA
    Alzheimer Dis Assoc Disord 28:16-22. 2014
    ..Novel error scores and traditional indices of executive function (EF) were related to cardiovascular risk factors measured 10 to 15 years earlier...
  51. pmc Risk estimations, risk factors, and genetic variants associated with Alzheimer's disease in selected publications from the Framingham Heart Study
    Galit Weinstein
    Department of Neurology, Boston University School of Medicine, Boston, MA 20008, USA
    J Alzheimers Dis 33:S439-45. 2013
    ..The second is a large meta-analysis GWA study of AD, in which novel loci of AD susceptibility were found. Together, these findings demonstrate the FHS multi-directional efforts in investigating dementia and AD...
  52. pmc Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology
    Patricia F Kao
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Neuropathol Exp Neurol 71:654-64. 2012
    ..In subsequent stages of AD, the higher levels of TrkB and Capzb2 expression achieved may not be sufficient to prevent cognitive decline...
  53. ncbi request reprint Homocysteine and the brain: vascular risk factor or neurotoxin?
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Lancet Neurol 2:11. 2003
  54. ncbi request reprint Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, 715 Albany Street B 608, Boston, MA 02118, USA
    J Alzheimers Dis 9:393-8. 2006
    ....
  55. ncbi request reprint Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
    ..Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the onset of dementia or result from dementia-related nutritional and vitamin deficiencies...
  56. pmc δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes
    Gyungah Jun
    Department of Medicine, Biomedical Genetics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e43728. 2012
    ..Our findings suggest that genetic variation in delta catenin may underlie both cortical lens opacities in mid-life and subsequent MRI and cognitive changes that presage the development of AD...
  57. pmc Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
    Stroke 41:210-7. 2010
    ..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium...
  58. pmc Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander?
    Zaldy S Tan
    Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Division of Aging in the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston, MA 02120, USA
    Alzheimers Res Ther 2:6. 2010
    ....
  59. pmc Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, B602, 72 East Concord St, Boston, MA 02118, USA
    Circ Res 109:554-63. 2011
    ..Vascular endothelial growth factor (VEGF) affects angiogenesis, atherosclerosis, and cancer. Although the heritability of circulating VEGF levels is high, little is known about its genetic underpinnings...
  60. ncbi request reprint Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study
    Abimbola Akomolafe
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA, USA
    Arch Neurol 63:1551-5. 2006
    ..Diabetes mellitus (DM) could increase the risk of Alzheimer disease (AD) through several biologically plausible pathways, but the relationship between DM and the development of AD remains uncertain...
  61. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  62. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
    ..We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample...
  63. ncbi request reprint Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, 5 Thurber St, Framingham, MA 01702, USA
    JAMA 287:1003-10. 2002
    ..The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown...
  64. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
    ..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...
  65. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  66. pmc Association of alcohol consumption with brain volume in the Framingham study
    Carol Ann Paul
    Neuroscience Program, Wellesley College, 106 Central St, Wellesley, MA 02418, USA
    Arch Neurol 65:1363-7. 2008
    ..There is evidence that drinking large amounts of alcohol is related to brain atrophy. It is uncertain what the effects of low to moderate consumption might be...
  67. ncbi request reprint Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 105:48-53. 2002
    ..It is unclear whether time-averaged past BP measures incrementally improve CVD risk assessment...
  68. ncbi request reprint Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study
    Tom Jeerakathil
    Division of Neurology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
    Stroke 35:1857-61. 2004
    ..We examined the relationship between Framingham Stroke Risk Profile (FSRP) and WMHV measured quantitatively in a stroke and dementia-free subset of the Framingham Offspring Cohort...
  69. ncbi request reprint Visual association pathology in preclinical Alzheimer disease
    Ann C McKee
    Department of Neurology and Pathology, Boston University School of Medicine, Bedford Veterans Administration Medical Center, MA 01730, USA
    J Neuropathol Exp Neurol 65:621-30. 2006
    ..Dense AD pathology in area 19 is present in some cognitively intact subjects with preclinical AD. The unique metabolic, connectional, and vascular features of this region may confer enhanced vulnerability to neurodegeneration...