S Seshadri

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Association of parental stroke with brain injury and cognitive measures in offspring: the Framingham Heart Study
    Galit Weinstein
    Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 44:812-5. 2013
  2. pmc Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan
    Yi Chen Hsieh
    School of Public Health, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 19:1. 2012
  3. pmc Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study
    Aleksandra Pikula
    Boston University Schools of Medicine and Public Health, MA, USA
    Circulation 125:2100-7. 2012
  4. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  5. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
  6. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
  7. pmc Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander?
    Zaldy S Tan
    Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Division of Aging in the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston, MA 02120, USA
    Alzheimers Res Ther 2:6. 2010
  8. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
  9. pmc Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    Arch Neurol 65:642-9. 2008
  10. pmc Parental occurrence of stroke and risk of stroke in their children: the Framingham study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
    Circulation 121:1304-12. 2010

Detail Information

Publications60

  1. pmc Association of parental stroke with brain injury and cognitive measures in offspring: the Framingham Heart Study
    Galit Weinstein
    Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 44:812-5. 2013
    ..This study examines whether parental stroke is also associated with increased vascular brain injury and poorer cognitive performance among offspring free of clinical stroke...
  2. pmc Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan
    Yi Chen Hsieh
    School of Public Health, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 19:1. 2012
    ..The purpose of this study was to investigate the association between these two SNPs and ischemic stroke risk, as well as prognostic outcomes in a Taiwanese sample...
  3. pmc Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study
    Aleksandra Pikula
    Boston University Schools of Medicine and Public Health, MA, USA
    Circulation 125:2100-7. 2012
    ....
  4. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  5. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  6. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
    ..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...
  7. pmc Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander?
    Zaldy S Tan
    Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Division of Aging in the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston, MA 02120, USA
    Alzheimers Res Ther 2:6. 2010
    ....
  8. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
    ..We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample...
  9. pmc Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    Arch Neurol 65:642-9. 2008
    ..Elevated plasma total homocysteine (tHcy) levels have been associated with increased risk of dementia and stroke, but it is uncertain whether the mediating mechanisms are predominantly cellular, vascular, or both...
  10. pmc Parental occurrence of stroke and risk of stroke in their children: the Framingham study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
    Circulation 121:1304-12. 2010
    ..Data relating parental history of stroke to stroke risk in offspring remain surprisingly inconsistent, largely because of heterogeneity of study design and the absence of verified, as opposed to historical, data on parental stroke status...
  11. ncbi request reprint Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, 715 Albany Street B 608, Boston, MA 02118, USA
    J Alzheimers Dis 9:393-8. 2006
    ....
  12. pmc Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA, USA
    Alzheimers Dement 7:35-52. 2011
    ..Improved accuracy in the clinical diagnosis of AD is anticipated with the addition of molecular and structural biomarkers in the next generation of epidemiological studies...
  13. ncbi request reprint Methodology for measuring cerebrovascular disease burden
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, USA
    Int Rev Psychiatry 18:409-22. 2006
    ..There are several studies using these techniques to study 'normal' aging populations, and the techniques used in the most widely known of these studies are briefly highlighted in this review...
  14. ncbi request reprint Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Lancet Neurol 6:1106-14. 2007
    ..Thus, the lifetime burden attributable to common neurological disease is immense...
  15. pmc Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
    S Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Neurology 77:461-8. 2011
    ..Our aim was to test the association of vascular risk factor exposure in midlife with progression of MRI markers of brain aging and measures of cognitive decline...
  16. pmc Association of parental dementia with cognitive and brain MRI measures in middle-aged adults
    S Debette
    Department of Neurology, Boston University School of Medicine, B602, 72 East Concord Street, Boston, MA 02118, USA
    Neurology 73:2071-8. 2009
    ..We related prospectively verified parental dementia to brain MRI and cognitive testing in the offspring, within a 2-generational community-based cohort...
  17. ncbi request reprint Elevated midlife blood pressure increases stroke risk in elderly persons: the Framingham Study
    S Seshadri
    National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA, USA
    Arch Intern Med 161:2343-50. 2001
    ..CONCLUSIONS: Antecedent BP contributes to the future risk of ischemic stroke. Optimal prevention of late-life stroke will likely require control of midlife BP...
  18. pmc Depressive symptoms and risk of dementia: the Framingham Heart Study
    J S Saczynski
    Department of Medicine and Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA, USA
    Neurology 75:35-41. 2010
    ..We examined the association between depressive symptoms and incident dementia over a 17-year follow-up period...
  19. ncbi request reprint Inflammatory markers and the risk of Alzheimer disease: the Framingham Study
    Z S Tan
    Department of Medicine, Institute for Aging Research, Hebrew Senior Life, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02131, USA
    Neurology 68:1902-8. 2007
    ..To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) cytokines are associated with the risk of incident Alzheimer disease (AD)...
  20. pmc Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes
    David Zade
    Department of Veterans Affairs Boston Medical Center, Geriatric Research Education and Clinical Center, Framingham, Massachusetts, USA
    J Stroke Cerebrovasc Dis 19:261-8. 2010
    ....
  21. ncbi request reprint Computing estimates of incidence, including lifetime risk: Alzheimer's disease in the Framingham Study. The Practical Incidence Estimators (PIE) macro
    A Beiser
    Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Stat Med 19:1495-522. 2000
    ..We illustrate the use of the PIE macro using Alzheimer's Disease incidence data collected in the Framingham Study...
  22. pmc Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study
    A L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 68:1032-8. 2007
    ..We hypothesized that inflammatory biomarkers would be associated with neuroimaging markers of ischemia (i.e., white matter hyperintensities [WMH]) and AD (i.e., total brain volume [TCB])...
  23. ncbi request reprint The lifetime risk of stroke: estimates from the Framingham Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, MA 02118 2526, USA
    Stroke 37:345-50. 2006
    ..The lifetime risk (LTR) of stroke has not been reported for the United States population; such data would assist public education and health planning...
  24. ncbi request reprint Framingham stroke risk profile and lowered cognitive performance
    Merrill F Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Stroke 35:404-9. 2004
    ....
  25. ncbi request reprint Bone mineral density and verbal memory impairment: Third National Health and Nutrition Examination Survey
    Y Zhang
    Boston University Arthritis Center, Boston University School of Medicine, Boston, MA 02115, USA
    Am J Epidemiol 154:795-802. 2001
    ..001). These results suggest that bone mineral density in the elderly is associated with verbal memory impairment. The mechanisms underlying this relation are not understood, but cumulative exposure to estrogen may play a role...
  26. ncbi request reprint Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
    ..Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the onset of dementia or result from dementia-related nutritional and vitamin deficiencies...
  27. ncbi request reprint Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study
    S Seshadri
    Department of Neurology, School of Medicine, Boston University, MA 02118 2526, USA
    Neurology 63:1591-9. 2004
    ..This association may result not only from clinical strokes but also from subclinical brain injury, such as a global atrophy demonstrable on quantitative brain MRI...
  28. pmc Bivariate heritability of total and regional brain volumes: the Framingham Study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 23:218-23. 2009
    ..These data extend current knowledge by showing that these 2 different types of magnetic resonance imaging measures do not share underlying genetic or environmental influences...
  29. ncbi request reprint New norms for a new generation: cognitive performance in the framingham offspring cohort
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Exp Aging Res 30:333-58. 2004
    ..These findings suggest that continued surveillance of each generation is necessary to document the impact that unique social and economic variables have on cognitive function. Here, the authors provide updated normative data...
  30. pmc Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 41:600-6. 2010
    ..We simultaneously assessed the relation of white matter hyperintensities and BI with incident stroke, mild cognitive impairment, dementia, and mortality in a middle-aged community-based cohort...
  31. pmc Cardiac index is associated with brain aging: the Framingham Heart Study
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, 72 E Concord St, B 7800, Boston, MA 02118, USA
    Circulation 122:690-7. 2010
    ..We hypothesized that cardiac function, as measured by cardiac index, would be associated with preclinical brain magnetic resonance imaging (MRI) and neuropsychological markers of ischemia and Alzheimer disease in the community...
  32. ncbi request reprint Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Boston, MA, USA
    Arch Intern Med 163:1053-7. 2003
    ..We examined the impact of baseline and lifetime plasma total cholesterol levels averaged across many years on the risk for AD in a large, population-based cohort...
  33. pmc Visceral fat is associated with lower brain volume in healthy middle-aged adults
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, MA, USA
    Ann Neurol 68:136-44. 2010
    ....
  34. pmc Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study
    Jose R Romero
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 40:1590-6. 2009
    ..The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear...
  35. ncbi request reprint Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study
    Philip A Wolf
    Boston University School of Medicine, Boston, MA 02118 2526, USA
    Curr Alzheimer Res 4:111-6. 2007
    ..We hypothesized that mid-life obesity may modulate the impact of conventional cardiovascular risk factors (CVRF) on cognitive impairment. We tested this hypothesis in the community-based Framingham Offspring Study sample...
  36. ncbi request reprint Visual association pathology in preclinical Alzheimer disease
    Ann C McKee
    Department of Neurology and Pathology, Boston University School of Medicine, Bedford Veterans Administration Medical Center, MA 01730, USA
    J Neuropathol Exp Neurol 65:621-30. 2006
    ..Dense AD pathology in area 19 is present in some cognitively intact subjects with preclinical AD. The unique metabolic, connectional, and vascular features of this region may confer enhanced vulnerability to neurodegeneration...
  37. pmc Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study
    Rohit R Das
    Department of Neurology, Boston University, Boston, MA 02118, USA
    Stroke 39:2929-35. 2008
    ..8% and 17.7% depending on age, ethnicity, presence of comorbidities, and imaging techniques. We document the prevalence and risk factors associated with SCI at midlife in the community-based Framingham sample...
  38. pmc White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart Study
    Karina Stavitsky
    Department of Psychology, Boston University, Boston, MA 02118, USA
    Neuroepidemiology 35:117-22. 2010
    ..This study investigated the association of WMH and cognition in an ethnic and racial minority cohort (Omni) of the Framingham Heart Study and compared these results to the Caucasian (Offspring) cohort...
  39. pmc Profiles by sex of brain MRI and cognitive function in the framingham offspring study
    Mark Albert
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Alzheimer Dis Assoc Disord 24:190-3. 2010
    ..To examine whether there are sex-specific associations between brain magnetic resonance imaging (MRI) measures and neuropsychologic (NP) test performance...
  40. ncbi request reprint Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years
    Raphael Carandang
    Department of Neurology, School of Medicine, Boston University, Boston, Mass 02118 2526, USA
    JAMA 296:2939-46. 2006
    ..Prior estimates of long-term trends in the incidence and severity of stroke have varied; trends in lifetime risk have not been reported...
  41. ncbi request reprint Homocysteine and cognitive performance in the Framingham offspring study: age is important
    Merrill F Elias
    The Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA, USA
    Am J Epidemiol 162:644-53. 2005
    ..Early preventive interventions may be important, because the inverse association between tHcy and cognitive performance is observed beyond middle age...
  42. pmc Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
    Stroke 41:210-7. 2010
    ..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium...
  43. ncbi request reprint Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspring
    Merrill F Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Mass, USA
    Hypertension 49:439-45. 2007
    ....
  44. pmc Gender differences in stroke incidence and poststroke disability in the Framingham heart study
    Rodica E Petrea
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Stroke 40:1032-7. 2009
    ..Stroke is emerging as a major public health problem for women, as it is for men. Controversy persists regarding gender differences in stroke incidence, severity, and poststroke disability...
  45. pmc Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort
    Renke Maas
    Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Stroke 40:2715-9. 2009
    ..We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT...
  46. pmc Thyroid function and the risk of Alzheimer disease: the Framingham Study
    Zaldy S Tan
    Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, 110 Francis St, LMOB 1A, Boston, MA 02215, USA
    Arch Intern Med 168:1514-20. 2008
    ..Clinical hypothyroidism and hyperthyroidism are recognized causes of reversible dementia, but previous studies relating thyrotropin levels to cognitive performance in clinically euthyroid persons have yielded inconsistent results...
  47. ncbi request reprint Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease
    S Seshadri
    Framingham Heart Study and Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Arch Neurol 58:435-40. 2001
    ..CONCLUSION: The use of ERT in women after the onset of menopause was not associated with a reduced risk of developing AD...
  48. pmc Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study
    Jose R Romero
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    J Stroke Cerebrovasc Dis 17:412-7. 2008
    ..We sought to relate circulating biomarkers of extracellular matrix turnover to site-specific measures of carotid artery atherosclerosis on duplex ultrasound...
  49. ncbi request reprint Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, 5 Thurber St, Framingham, MA 01702, USA
    JAMA 287:1003-10. 2002
    ..The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown...
  50. pmc Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    JAMA 302:2565-72. 2009
    ..The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the hippocampus, promotes beta-amyloid clearance, and improves memory function in animal models of aging and Alzheimer disease (AD)...
  51. ncbi request reprint Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Arch Neurol 63:246-50. 2006
    ..To examine the relationship between white matter hyperintensity (WMH) volume on magnetic resonance images and cognitive tests in a large, population-based sample...
  52. pmc Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study
    Aleksandra Pikula
    Boston University School of Medicine, Boston, MA, USA
    Stroke 40:2959-64. 2009
    ..The relation of plasma ADMA to subclinical vascular brain injury has not been previously studied in a middle-aged, community-based sample...
  53. ncbi request reprint Bone mineral density and the risk of Alzheimer disease
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02215, USA
    Arch Neurol 62:107-11. 2005
    ..Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration...
  54. ncbi request reprint Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 105:48-53. 2002
    ..It is unclear whether time-averaged past BP measures incrementally improve CVD risk assessment...
  55. ncbi request reprint Homocysteine and the brain: vascular risk factor or neurotoxin?
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Lancet Neurol 2:11. 2003
  56. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  57. pmc Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, B602, 72 East Concord St, Boston, MA 02118, USA
    Circ Res 109:554-63. 2011
    ..Vascular endothelial growth factor (VEGF) affects angiogenesis, atherosclerosis, and cancer. Although the heritability of circulating VEGF levels is high, little is known about its genetic underpinnings...
  58. ncbi request reprint Dementia after stroke: the Framingham Study
    Cristina S Ivan
    Department of Neurology, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Stroke 35:1264-8. 2004
    ..Previous case-control studies were hospital-based. We used a nested case-control design to prospectively evaluate these risk factors in the community-based Framingham Study cohort...
  59. ncbi request reprint Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study
    Abimbola Akomolafe
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA, USA
    Arch Neurol 63:1551-5. 2006
    ..Diabetes mellitus (DM) could increase the risk of Alzheimer disease (AD) through several biologically plausible pathways, but the relationship between DM and the development of AD remains uncertain...
  60. pmc Association of alcohol consumption with brain volume in the Framingham study
    Carol Ann Paul
    Neuroscience Program, Wellesley College, 106 Central St, Wellesley, MA 02418, USA
    Arch Neurol 65:1363-7. 2008
    ..There is evidence that drinking large amounts of alcohol is related to brain atrophy. It is uncertain what the effects of low to moderate consumption might be...

Research Grants4

  1. Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes
    Sudha Seshadri; Fiscal Year: 2009
    ..We believe our analyses will identify new genes and pathways underlying the risk of Alzheimer's disease, and this in turn may improve our understanding of the disease guiding us to new preventive strategies and treatments. ..
  2. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2009
    ....
  3. Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes
    Sudha Seshadri; Fiscal Year: 2010
    ..We believe our analyses will identify new genes and pathways underlying the risk of Alzheimer's disease, and this in turn may improve our understanding of the disease guiding us to new preventive strategies and treatments. ..
  4. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2010
    ....