Research Topics
Genomes and Genes
Species | S SeshadriSummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Association of parental stroke with brain injury and cognitive measures in offspring: the Framingham Heart StudyGalit Weinstein
Boston University School of Medicine, Boston, MA 02118, USA
Stroke 44:812-5. 2013..This study examines whether parental stroke is also associated with increased vascular brain injury and poorer cognitive performance among offspring free of clinical stroke...
Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in TaiwanYi Chen Hsieh
School of Public Health, Taipei Medical University, Taipei, Taiwan
J Biomed Sci 19:1. 2012..The purpose of this study was to investigate the association between these two SNPs and ischemic stroke risk, as well as prognostic outcomes in a Taiwanese sample...- Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring StudyAleksandra Pikula
Boston University Schools of Medicine and Public Health, MA, USA
Circulation 125:2100-7. 2012.... - The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reportsL Adrienne Cupples
National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S1. 2007.... - Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomesMartin G Larson
The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S5. 2007..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes... - Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham StudyKathryn L Lunetta
The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S13. 2007..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span... - Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander?Zaldy S Tan
Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Division of Aging in the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston, MA 02120, USA
Alzheimers Res Ther 2:6. 2010.... - Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham StudySudha Seshadri
The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S15. 2007..We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample... 
Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?Sudha Seshadri
Department of Neurology, Boston University School of Medicine, 715 Albany Street B 608, Boston, MA 02118, USA
J Alzheimers Dis 9:393-8. 2006....- Methodology for measuring cerebrovascular disease burdenSudha Seshadri
Department of Neurology, School of Medicine, Boston University, Boston, USA
Int Rev Psychiatry 18:409-22. 2006..There are several studies using these techniques to study 'normal' aging populations, and the techniques used in the most widely known of these studies are briefly highlighted in this review... - Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring StudySudha Seshadri
Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
Arch Neurol 65:642-9. 2008..Elevated plasma total homocysteine (tHcy) levels have been associated with increased risk of dementia and stroke, but it is uncertain whether the mediating mechanisms are predominantly cellular, vascular, or both... - Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham StudySudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
Lancet Neurol 6:1106-14. 2007..Thus, the lifetime burden attributable to common neurological disease is immense... - Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2Sudha Seshadri
Department of Neurology, Boston University School of Medicine, MA, USA
Alzheimers Dement 7:35-52. 2011..Improved accuracy in the clinical diagnosis of AD is anticipated with the addition of molecular and structural biomarkers in the next generation of epidemiological studies... - Parental occurrence of stroke and risk of stroke in their children: the Framingham studySudha Seshadri
Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
Circulation 121:1304-12. 2010..Data relating parental history of stroke to stroke risk in offspring remain surprisingly inconsistent, largely because of heterogeneity of study design and the absence of verified, as opposed to historical, data on parental stroke status... - Midlife vascular risk factor exposure accelerates structural brain aging and cognitive declineS Debette
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Neurology 77:461-8. 2011..Our aim was to test the association of vascular risk factor exposure in midlife with progression of MRI markers of brain aging and measures of cognitive decline... - Association of parental dementia with cognitive and brain MRI measures in middle-aged adultsS Debette
Department of Neurology, Boston University School of Medicine, B602, 72 East Concord Street, Boston, MA 02118, USA
Neurology 73:2071-8. 2009..We related prospectively verified parental dementia to brain MRI and cognitive testing in the offspring, within a 2-generational community-based cohort... - Elevated midlife blood pressure increases stroke risk in elderly persons: the Framingham StudyS Seshadri
National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA, USA
Arch Intern Med 161:2343-50. 2001..CONCLUSIONS: Antecedent BP contributes to the future risk of ischemic stroke. Optimal prevention of late-life stroke will likely require control of midlife BP... - Depressive symptoms and risk of dementia: the Framingham Heart StudyJ S Saczynski
Department of Medicine and Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA, USA
Neurology 75:35-41. 2010..We examined the association between depressive symptoms and incident dementia over a 17-year follow-up period... - Inflammatory markers and the risk of Alzheimer disease: the Framingham StudyZ S Tan
Department of Medicine, Institute for Aging Research, Hebrew Senior Life, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02131, USA
Neurology 68:1902-8. 2007..To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) cytokines are associated with the risk of incident Alzheimer disease (AD)... - Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changesDavid Zade
Department of Veterans Affairs Boston Medical Center, Geriatric Research Education and Clinical Center, Framingham, Massachusetts, USA
J Stroke Cerebrovasc Dis 19:261-8. 2010.... - Inflammatory biomarkers are associated with total brain volume: the Framingham Heart StudyA L Jefferson
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Neurology 68:1032-8. 2007..We hypothesized that inflammatory biomarkers would be associated with neuroimaging markers of ischemia (i.e., white matter hyperintensities [WMH]) and AD (i.e., total brain volume [TCB])... - Computing estimates of incidence, including lifetime risk: Alzheimer's disease in the Framingham Study. The Practical Incidence Estimators (PIE) macroA Beiser
Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Stat Med 19:1495-522. 2000..We illustrate the use of the PIE macro using Alzheimer's Disease incidence data collected in the Framingham Study... - The lifetime risk of stroke: estimates from the Framingham StudySudha Seshadri
Department of Neurology, School of Medicine, Boston University, Boston, MA 02118 2526, USA
Stroke 37:345-50. 2006..The lifetime risk (LTR) of stroke has not been reported for the United States population; such data would assist public education and health planning... - Framingham stroke risk profile and lowered cognitive performanceMerrill F Elias
Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
Stroke 35:404-9. 2004.... - Bone mineral density and verbal memory impairment: Third National Health and Nutrition Examination SurveyY Zhang
Boston University Arthritis Center, Boston University School of Medicine, Boston, MA 02115, USA
Am J Epidemiol 154:795-802. 2001..001). These results suggest that bone mineral density in the elderly is associated with verbal memory impairment. The mechanisms underlying this relation are not understood, but cumulative exposure to estrogen may play a role... - Plasma homocysteine as a risk factor for dementia and Alzheimer's diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
N Engl J Med 346:476-83. 2002..Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the onset of dementia or result from dementia-related nutritional and vitamin deficiencies... - Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring StudyS Seshadri
Department of Neurology, School of Medicine, Boston University, MA 02118-2526, USA
Neurology 63:1591-9. 2004..CONCLUSIONS: The Framingham Stroke Risk Profile may identify subjects with smaller brains and poorer cognitive function among stroke- and dementia-free subjects, reinforcing the importance of managing stroke risk factors... - Bivariate heritability of total and regional brain volumes: the Framingham StudyAnita L Destefano
Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA
Alzheimer Dis Assoc Disord 23:218-23. 2009..These data extend current knowledge by showing that these 2 different types of magnetic resonance imaging measures do not share underlying genetic or environmental influences... - Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring StudyStephanie Debette
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Stroke 41:600-6. 2010..We simultaneously assessed the relation of white matter hyperintensities and BI with incident stroke, mild cognitive impairment, dementia, and mortality in a middle-aged community-based cohort... - Cardiac index is associated with brain aging: the Framingham Heart StudyAngela L Jefferson
Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, 72 E Concord St, B 7800, Boston, MA 02118, USA
Circulation 122:690-7. 2010..We hypothesized that cardiac function, as measured by cardiac index, would be associated with preclinical brain magnetic resonance imaging (MRI) and neuropsychological markers of ischemia and Alzheimer disease in the community... - Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham StudyZaldy Sy Tan
Division on Aging, Harvard Medical School, Boston, MA, USA
Arch Intern Med 163:1053-7. 2003..97; 95% confidence interval, 0.90-1.05). CONCLUSION: In this large, population-based cohort, baseline and long-term average serum total cholesterol levels were not associated with the risk for incident AD... - Visceral fat is associated with lower brain volume in healthy middle-aged adultsStephanie Debette
Department of Neurology, Boston University School of Medicine, MA, USA
Ann Neurol 68:136-44. 2010.... - Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham studyJose R Romero
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Stroke 40:1590-6. 2009..The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear... - Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart StudyPhilip A Wolf
Boston University School of Medicine, Boston, MA 02118 2526, USA
Curr Alzheimer Res 4:111-6. 2007..We hypothesized that mid-life obesity may modulate the impact of conventional cardiovascular risk factors (CVRF) on cognitive impairment. We tested this hypothesis in the community-based Framingham Offspring Study sample... - Visual association pathology in preclinical Alzheimer diseaseAnn C McKee
Department of Neurology and Pathology, Boston University School of Medicine, Bedford Veterans Administration Medical Center, MA 01730, USA
J Neuropathol Exp Neurol 65:621-30. 2006..Dense AD pathology in area 19 is present in some cognitively intact subjects with preclinical AD. The unique metabolic, connectional, and vascular features of this region may confer enhanced vulnerability to neurodegeneration... - Prevalence and correlates of silent cerebral infarcts in the Framingham offspring studyRohit R Das
Department of Neurology, Boston University, Boston, MA 02118, USA
Stroke 39:2929-35. 2008..8% and 17.7% depending on age, ethnicity, presence of comorbidities, and imaging techniques. We document the prevalence and risk factors associated with SCI at midlife in the community-based Framingham sample... - New norms for a new generation: cognitive performance in the framingham offspring cohortRhoda Au
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
Exp Aging Res 30:333-58. 2004..These findings suggest that continued surveillance of each generation is necessary to document the impact that unique social and economic variables have on cognitive function. Here, the authors provide updated normative data... - Thyroid function and the risk of Alzheimer disease: the Framingham StudyZaldy S Tan
Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, 110 Francis St, LMOB 1A, Boston, MA 02215, USA
Arch Intern Med 168:1514-20. 2008..Clinical hypothyroidism and hyperthyroidism are recognized causes of reversible dementia, but previous studies relating thyrotropin levels to cognitive performance in clinically euthyroid persons have yielded inconsistent results... - Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 yearsRaphael Carandang
Department of Neurology, School of Medicine, Boston University, Boston, Mass 02118-2526, USA
JAMA 296:2939-46. 2006..The results of this study suggest that improved control of risk factors has lowered stroke incidence but emphasize the need for continued primary prevention efforts... - Profiles by sex of brain MRI and cognitive function in the framingham offspring studyMark Albert
Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
Alzheimer Dis Assoc Disord 24:190-3. 2010..To examine whether there are sex-specific associations between brain magnetic resonance imaging (MRI) measures and neuropsychologic (NP) test performance... - White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart StudyKarina Stavitsky
Department of Psychology, Boston University, Boston, MA 02118, USA
Neuroepidemiology 35:117-22. 2010..This study investigated the association of WMH and cognition in an ethnic and racial minority cohort (Omni) of the Framingham Heart Study and compared these results to the Caucasian (Offspring) cohort... - Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspringMerrill F Elias
Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Mass, USA
Hypertension 49:439-45. 2007.... - Homocysteine and cognitive performance in the Framingham offspring study: age is importantMerrill F Elias
The Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA, USA
Am J Epidemiol 162:644-53. 2005..Early preventive interventions may be important, because the inverse association between tHcy and cognitive performance is observed beyond middle age... - Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE ConsortiumStephanie Debette
Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
Stroke 41:210-7. 2010..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium... - Gender differences in stroke incidence and poststroke disability in the Framingham heart studyRodica E Petrea
Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
Stroke 40:1032-7. 2009..Stroke is emerging as a major public health problem for women, as it is for men. Controversy persists regarding gender differences in stroke incidence, severity, and poststroke disability... - Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohortRenke Maas
Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
Stroke 40:2715-9. 2009..We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT... - Postmenopausal estrogen replacement therapy and the risk of Alzheimer diseaseS Seshadri
Framingham Heart Study and Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Arch Neurol 58:435-40. 2001..CONCLUSION: The use of ERT in women after the onset of menopause was not associated with a reduced risk of developing AD... - Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring StudyJose R Romero
Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
J Stroke Cerebrovasc Dis 17:412-7. 2008..We sought to relate circulating biomarkers of extracellular matrix turnover to site-specific measures of carotid artery atherosclerosis on duplex ultrasound... - Bone mineral density and the risk of Alzheimer diseaseZaldy Sy Tan
Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02215, USA
Arch Neurol 62:107-11. 2005..Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration... - Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart StudyRhoda Au
Department of Neurology, Boston University School of Medicine, Boston, Mass 02118-2526, USA
Arch Neurol 63:246-50. 2006..Further study will clarify whether large WMH volume and associated cognitive impairment lead to future risk of stroke or dementia... - Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring studyAleksandra Pikula
Boston University School of Medicine, Boston, MA, USA
Stroke 40:2959-64. 2009..The relation of plasma ADMA to subclinical vascular brain injury has not been previously studied in a middle-aged, community-based sample... - Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart StudyRamachandran S Vasan
Framingham Heart Study, 5 Thurber St, Framingham, MA 01702, USA
JAMA 287:1003-10. 2002..The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown... - Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain agingWolfgang Lieb
Framingham Heart Study, Framingham, Massachusetts, USA
JAMA 302:2565-72. 2009..The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the hippocampus, promotes beta-amyloid clearance, and improves memory function in animal models of aging and Alzheimer disease (AD)... - Homocysteine and the brain: vascular risk factor or neurotoxin?Sudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Lancet Neurol 2:11. 2003 - Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study Ramachandran S Vasan
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
Circulation 105:48-53. 2002..It is unclear whether time-averaged past BP measures incrementally improve CVD risk assessment... - Genome-wide analysis of genetic loci associated with Alzheimer diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
JAMA 303:1832-40. 2010..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)... - Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levelsStephanie Debette
Department of Neurology, Boston University School of Medicine, B602, 72 East Concord St, Boston, MA 02118, USA
Circ Res 109:554-63. 2011..Vascular endothelial growth factor (VEGF) affects angiogenesis, atherosclerosis, and cancer. Although the heritability of circulating VEGF levels is high, little is known about its genetic underpinnings... - Dementia after stroke: the Framingham StudyCristina S Ivan
Department of Neurology, Boston University School of Medicine, Boston, Mass 02118-2526, USA
Stroke 35:1264-8. 2004..4; 95% CI: 1.5 to 3.9). CONCLUSIONS: Stroke increases a subject's risk of dementia as compared with age- and sex-matched controls. Primary and secondary prevention of stroke should significantly decrease the risk of all dementia... - Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham StudyAbimbola Akomolafe
Department of Medicine, Morehouse School of Medicine, Atlanta, GA, USA
Arch Neurol 63:1551-5. 2006..28-17.72; P = .02). CONCLUSION: Diabetes mellitus did not increase the risk of incident AD in the Framingham cohort overall; however, DM may be a risk factor for AD in the absence of other known major AD risk factors... - Association of alcohol consumption with brain volume in the Framingham studyCarol Ann Paul
Neuroscience Program, Wellesley College, 106 Central St, Wellesley, MA 02418, USA
Arch Neurol 65:1363-7. 2008..There is evidence that drinking large amounts of alcohol is related to brain atrophy. It is uncertain what the effects of low to moderate consumption might be...
Research Grants
- Collaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesSudha Seshadri; Fiscal Year: 2009..We believe our analyses will identify new genes and pathways underlying the risk of Alzheimer's disease, and this in turn may improve our understanding of the disease guiding us to new preventive strategies and treatments. ..
- Neurotrophic Factors: Genetic Variation and Serum Levels in Brain AgingSudha Seshadri; Fiscal Year: 2009....
- Collaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesSudha Seshadri; Fiscal Year: 2010..We believe our analyses will identify new genes and pathways underlying the risk of Alzheimer's disease, and this in turn may improve our understanding of the disease guiding us to new preventive strategies and treatments. ..
- Neurotrophic Factors: Genetic Variation and Serum Levels in Brain AgingSudha Seshadri; Fiscal Year: 2010....