Research Topics
| DAVID SELDINSummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Amyloidotic cardiomyopathy: multidisciplinary approach to diagnosis and treatmentDavid C Seldin
Amyloidosis Treatment and Research Program, Department of Medicine, Boston University School of Medicine, Boston Medical Center, K5, 72 East Concord Street, Boston, MA 02118, USA
Heart Fail Clin 7:385-93. 2011..Growing numbers of treatment options exist for these diseases, and timely diagnosis and institution of therapy is essential for preservation of cardiac function...
Gene targeting of CK2 catalytic subunitsDavid C Seldin
Department of Medicine, Boston University School of Medicine and Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
Mol Cell Biochem 316:141-7. 2008....- Successful treatment of AL amyloidosis with high-dose melphalan and autologous stem cell transplantation in patients over age 65David C Seldin
Section of Hematology Oncology, Boston University Medical Center, 650 Albany St, Boston, MA 02118, USA
Blood 108:3945-7. 2006.... - The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic developmentDavid Y Lou
Boston University Medical Center, 650 Albany Street, Boston, MA 02118, USA
Mol Cell Biol 28:131-9. 2008..Defects in the formation of the heart lead to hydrops fetalis and are likely the cause of embryonic lethality. Thus, CK2alpha appears to play an essential and uncompensated role in mammalian development... 
CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signalingDiane H Song
Department of Medicine, Boston University Medical Center, Boston University, Boston, Massachusetts 02118, USA
J Biol Chem 278:24018-25. 2003..Thus, CK2 is a positive regulator of Wnt signaling through phosphorylation of beta-catenin at Thr393, leading to proteasome resistance and increased protein and co-transcriptional activity...- Short and long-term outcome of treatment with high-dose melphalan and stem cell transplantation for multiple myeloma-associated AL amyloidosisSaulius Girnius
Amyloid Treatment and Research Program, Boston University School of Medicine, Boston, MA 02118, USA
Ann Hematol 89:579-84. 2010..Hematologic relapses occurred in 60% of patients at a median of 1 year after HDM/SCT. In conclusion, HDM/SCT can prolong overall survival in patients with MM/AL who are eligible to receive it... - High-dose intravenous melphalan with autologous stem cell transplantation in AL amyloidosis-associated end-stage renal diseaseLiam F Casserly
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Kidney Int 63:1051-7. 2003..This treatment should be considered for patients with AL amyloidosis-associated ESRD... - Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesisPadmalatha Channavajhala
Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, MA 02118, USA
Oncogene 21:5280-8. 2002..Thus, CK2 is a critical regulator of c-myc protein stability and of the proliferation of these T cell lymphomas... - A role for CK2alpha/beta in Xenopus early embryonic developmentIsabel Dominguez
Hematology Oncology Section, Department of Medicine, Boston University Medical School, Boston, MA, USA
Mol Cell Biochem 274:125-31. 2005..Our results demonstrate that CK2 is required for dorsal axis formation and is for normal upregulation of Wnt signaling genes and targets. Thus, CK2 is a regulator of endogenous axis formation in vertebrates... - Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lensRichard I Near
Department of Medicine, Boston Medical Center, Boston, MA 2118, USA
Mol Vis 15:685-99. 2009..Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. We sought to establish the effects of the loss of AND-34 expression in a mammalian organism... - CK2 as a positive regulator of Wnt signalling and tumourigenesisDavid C Seldin
Section of Hematology Oncology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
Mol Cell Biochem 274:63-7. 2005..Inhibitors of GSK3 under development for treatment of diabetes could promote tumours, while CK2 inhibitors should be useful agents for treatment of cancer... - Association of acquired von Willebrand syndrome with AL amyloidosisCynthia A Kos
Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
Am J Hematol 82:363-7. 2007..AVWS should be considered in AL amyloidosis patients with hemorrhagic diatheses and normal clotting factor levels... - Heterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic kappa1 immunoglobulin light chainsLawreen H Connors
Alan and Sandra Gerry Amyloid Research Laboratory in the Amyloid Treatment and Research Program, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Biochemistry 46:14259-71. 2007..This study demonstrated the extensive heterogeneity in primary structure, post-translational modifications, and germline gene usage that occurred in nine amyloidogenic kappa1 LC proteins... - AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequencesKip Bodi
Amyloid Treatment and Research Program, Alan and Sandra Gerry Amyloid Research Laboratory, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Amyloid 16:1-8. 2009..The likelihood that each sequence has evolved through somatic hypermutation can be predicted using an automated binomial or multinomial distribution model. AL-Base is available to the scientific community for research purposes... - Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosisLawreen H Connors
Amyloid Treatment and Research Program, Boston University School of Medicine, Boston, MA 02118, USA
Am Heart J 158:607-14. 2009..9%. This retrospective study describes TTR V122I-associated cardiac amyloid disease (ATTR) in a major amyloid referral clinic population... - Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid depositionAndreia Biolo
Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Circ Heart Fail 1:249-57. 2008.... - The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chainElena S Klimtchuk
Gerry Amyloid Research Laboratory, Amyloid Treatment and Research Center, Department of Medicine, Boston University School of Medicine, 72 East Concord Street, Boston, Massachusetts 02118, United States
Biochemistry 49:9848-57. 2010..The kinetic barrier for this aggregation is regulated by the stability of the V(L) region. This represents a paradigm shift in AL fibrillogenesis and suggests C(L) region as a potential therapeutic target... - Soft tissue, joint, and bone manifestations of AL amyloidosis: clinical presentation, molecular features, and survivalTatiana Prokaeva
Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
Arthritis Rheum 56:3858-68. 2007.... - High-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: an 8-year studyMartha Skinner
Boston University School of Medicine, Boston, Massachusetts 02118, USA
Ann Intern Med 140:85-93. 2004..AL amyloidosis is a fatal disease resulting from tissue deposition of amyloid fibrils derived from monoclonal immunoglobulin light chains. Treatment with oral chemotherapy is minimally effective... - T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birthMaria I Ramirez
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
Dev Biol 256:61-72. 2003.... - Persistent pleural effusions in primary systemic amyloidosis: etiology and prognosisJohn L Berk
Amyloid Treatment and Research Program, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Chest 124:969-77. 2003..We hypothesized that disruption of pleural function by amyloid deposits underlies persistent pleural effusions (PPEs) in patients with AL disease... - Tolerability and efficacy of thalidomide for the treatment of patients with light chain-associated (AL) amyloidosisDavid C Seldin
Boston University Medical Center, Boston Medical Center, MA, USA
Clin Lymphoma 3:241-6. 2003..No complete hematologic responses were seen, but 25% of patients had a significant reduction in Bence-Jones proteinuria. Thus, while thalidomide has activity in AL amyloidosis, it also has significant toxicity in this patient population... - Protein kinase CK2 is required for dorsal axis formation in Xenopus embryosIsabel Dominguez
Section of Hematology Oncology Department of Medicine, Boston University School of Medicine, Boston MA 02118, USA
Dev Biol 274:110-24. 2004..Taken together, these studies demonstrate that CK2 is a bona fide member of the Wnt pathway and has a critical role in the establishment of the dorsal embryonic axis... - Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantationDavid C Seldin
Amyloid Treatment and Research Program, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Blood 104:1888-93. 2004..Thus, treatment of AL amyloidosis patients with HDM/SCT produces measurable and sustained improvements in quality of life, particularly in those patients who achieve hematologic CR... - Incidence and outcome of acute renal failure complicating autologous stem cell transplantation for AL amyloidosisAmit Fadia
The Renal Section, Stem Cell Transplant Program of the Hematology/Oncology Section, and Amyloid Treatment and Research Program, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
Kidney Int 63:1868-73. 2003..9 years. CONCLUSION: ARF is a frequent but often reversible complication of HDM/SCT for AL amyloidosis. Specific clinical and treatment-related factors are associated with the development of this complication... - Kidney dysfunction during lenalidomide treatment for AL amyloidosisRichard Specter
Renal Section, Boston University School of Medicine, Boston, MA, USA
Nephrol Dial Transplant 26:881-6. 2011..The objective of this study is to characterize alterations in kidney function among patients with AL amyloidosis undergoing treatment with lenalidomide... - Mouse mammary tumor virus c-rel transgenic mice develop mammary tumorsRaphaelle Romieu-Mourez
Department of Biochemistry, Boston University Medical School, Boston, Massachusetts 02118, USA
Mol Cell Biol 23:5738-54. 2003..These results indicate for the first time that dysregulated expression of c-Rel, as observed in breast cancers, is capable of contributing to mammary tumorigenesis... - An overview of high-dose melphalan and stem cell transplantation in the treatment of AL amyloidosisVaishali Sanchorawala
Section of Hematology Oncology in the Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Amyloid 14:261-9. 2007..This review outlines an overview of high-dose intravenous melphalan and stem cell transplantation in the treatment of AL amyloidosis. An algorithm of our recommendations for the treatment of AL amyloidosis is also outlined... - Threonine 393 of beta-catenin regulates interaction with AxinHao Wu
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Cell Biochem 108:52-63. 2009..In addition, the increased recruitment of GSK3beta to the destruction complex in the presence of activated beta-catenin mutants could be a feedback mechanism to suppress overactive Wnt signaling... - Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesisMarganit Farago
Molecular Medicine Program, Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
Cancer Res 65:5792-801. 2005..Thus, antagonism of GSK3beta activity is oncogenic in the mammary epithelium; mutation or pharmacologic down-regulation of GSK3beta could promote mammary tumors... - Cardiac transplantation followed by dose-intensive melphalan and autologous stem-cell transplantation for light chain amyloidosis and heart failureBimalangshu R Dey
Massachusetts General Hospital, Boston, MA, USA
Transplantation 90:905-11. 2010..Autologous stem-cell transplantation (ASCT) has become a common therapy for AL amyloidosis, but there is an exceedingly high treatment-related mortality in patients with heart failure... - Low-dose continuous oral melphalan for the treatment of primary systemic (AL) amyloidosisVaishali Sanchorawala
Department of Medicine, Section of Hematology Oncology, Boston Medical Center, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA
Br J Haematol 117:886-9. 2002..This regimen appeared to be effective in inducing haematological responses in patients who received total doses of melphalan > 300 mg... - Spontaneous rupture of the liver in a patient with systemic AL amyloidosis undergoing treatment with high-dose melphalan and autologous stem cell transplantation: a case report with literature reviewMartin Tam
Graduate Medical Sciences Division, Boston University School of Medicine, Boston, Massachusetts, USA
Amyloid 16:103-7. 2009..A literature review of spontaneous liver rupture in patients with amyloidosis is presented... - RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary glandElizabeth G Demicco
Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
Mol Cell Biol 25:10136-47. 2005..Inhibition of RelB in breast cancer cells repressed cyclin D1 and c-Myc levels and growth in soft agar. These results implicate RelB/p52 complexes in mammary gland development and carcinogenesis... - Hepatic response after high-dose melphalan and stem cell transplantation in patients with AL amyloidosis associated liver diseaseSaulius Girnius
Department of Medicine, Boston University School of Medicine, Boston University School of Public Health, Boston, MA, USA
Haematologica 94:1029-32. 2009..In conclusion, hepatic disease improves in almost 2/3 patients treated with high-dose intravenous melphalan and autologous stem cell transplantation who have a complete or partial hematologic response to treatment... - Protein kinase CK2 promotes aberrant activation of nuclear factor-kappaB, transformed phenotype, and survival of breast cancer cellsRaphaelle Romieu-Mourez
Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118 2394, USA
Cancer Res 62:6770-8. 2002.... - Direct identification of PTEN phosphorylation sitesSusan J Miller
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
FEBS Lett 528:145-53. 2002.... - Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cellsSean F Eddy
Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
Cancer Res 65:11375-83. 2005..Thus, CK2 induces functional IKK-i/IKKepsilon, which is an important mediator of the activation of NF-kappaB that plays a critical role in the pathogenesis of breast cancer... - Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantationVaishali Sanchorawala
Stem Cell Transplantation Program of the Section of Hematology Oncology, Boston University School of Medicine, Boston, MA 02118, USA
Blood 110:3561-3. 2007..001). In conclusion, HDM/SCT leads to durable remissions and prolonged survival, particularly for those patients who achieve a hematologic CR... - Lenalidomide and dexamethasone in the treatment of AL amyloidosis: results of a phase 2 trialVaishali Sanchorawala
Department of Medicine, F 302, 732 Harrison Ave, Boston University Medical Center, MA 02118, USA
Blood 109:492-6. 2007..Findings from this trial indicate that lenalidomide can be effective in treating AL amyloidosis... - Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cellsMohd Shahid
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Wellman Center for Photomedicine, Boston, Mass 02114, USA
Hypertension 56:705-12. 2010.... - Dynamic expression of a LEF-EGFP Wnt reporter in mouse development and cancerNicolas Currier
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
Genesis 48:183-94. 2010..Thus, this transgenic line is useful for ex vivo and in vitro studies of Wnt signaling in development and cancer... - Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathwayJianru Shi
Cardiac Muscle Research Laboratory, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:4188-93. 2010.... - Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotypeKarine Belguise
Departments of Biochemistry, Boston University School of Public Health, Boston, Massachusetts, USA
Cancer Res 67:11742-50. 2007..Thus, activation of c-Rel and CK2 and downstream targets AhR and Slug by DMBA induces EMT; EGCG can inhibit this signaling... - Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumorsNicolas Currier
Boston University School of Medicine, Department of Medicine, Boston, MA, USA
Toxicol Pathol 33:726-37. 2005..These data suggest that environmental carcinogens can produce long-lasting alterations in growth and anti-apoptotic pathways, leading to mammary tumorigenesis... - Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrilsRuiyi Ren
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 285:37672-82. 2010..These findings highlight the importance of the variable and constant LC regions in GAG interaction and suggest potential therapeutic targets for treatment... - Xth International Symposium on Amyloid and Amyloidosis April 18-22, 2004 (selected highlights) Tours, Loire Valley, FranceJean D Sipe
Emerita, Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
Amyloid 11:268-72. 2004 - Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosisHarun Akar
Amyloid Treatment and Research Program at Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA
Amyloid 12:210-5. 2005..After a histologic tissue diagnosis of amyloidosis, determining the type as AL amyloidosis relies on a panel of hematologic tests to determine light chain clonality and the exclusion other forms of amyloidosis... - The A2B adenosine receptor protects against inflammation and excessive vascular adhesionDan Yang
Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Clin Invest 116:1913-23. 2006..Hence, we identify the A2BAR as a new critical regulator of inflammation and vascular adhesion primarily via signals from hematopoietic cells to the vasculature, focusing attention on the receptor as a therapeutic target... - A role for the aryl hydrocarbon receptor in mammary gland tumorigenesisJennifer J Schlezinger
Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
Biol Chem 387:1175-87. 2006..The theme that malignant cells reveal the functions for which the AhR has been evolutionarily conserved is presented throughout this discussion... - Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissueFrancesca Lavatelli
Amyloid Treatment and Research Program, Boston, Massachusetts, USA
Mol Cell Proteomics 7:1570-83. 2008.... - Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHLVipul C Chitalia
Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Nat Cell Biol 10:1208-16. 2008..The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1... - AL amyloidosis, a curable disease?David C Seldin
Amyloid 9:203-6. 2002 - Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumorsKeiko Miyoshi
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
Oncogene 21:5548-56. 2002.... - Adapting to AL amyloidosisDavid C Seldin
Haematologica 91:1591-5. 2006 - Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumorsAndrea Rosner
Center for Comparative Medicine, University of California, Davis 95616, USA
Am J Pathol 161:1087-97. 2002.... - Diagnosis and treatment of Al amyloidosisDavid C Seldin
Amyloidosis Treatment and Research Center, Boston University School of Medicine, MA, USA
Clin Adv Hematol Oncol 1:154-5. 2003
Research Grants
- Multistep Lymphomagenesis/Tumorigenesis in Transgenic Mice: Protein Kinase Ck2DAVID SELDIN; Fiscal Year: 2009..Since CK2 is upregulated in all human tumors that have been studied, CK2 may be a suitable target for cancer treatment. Understanding basic CK2 biology and signaling is a necessary prelude to developing novel therapeutics against it. ..
- Multistep Lymphomagenesis/Tumorigenesis in Transgenic Mice: Protein Kinase Ck2DAVID SELDIN; Fiscal Year: 2007..Since CK2 is upregulated in all human tumors that have been studied, CK2 may be a suitable target for cancer treatment. Understanding basic CK2 biology and signaling is a necessary prelude to developing novel therapeutics against it. ..
- MULTISTEP LYMPHOMAGENESISDAVID SELDIN; Fiscal Year: 2004..abstract_text> ..
- MULTISTEP LYMPHOMAGENESIS IN TRANSGENIC MICEDAVID SELDIN; Fiscal Year: 1999....
- Multistep Lymphomagenesis/Tumorigenesis in Transgenic Mice: Protein Kinase Ck2David C Seldin; Fiscal Year: 2010..Since CK2 is upregulated in all human tumors that have been studied, CK2 may be a suitable target for cancer treatment. Understanding basic CK2 biology and signaling is a necessary prelude to developing novel therapeutics against it. ..