Paola Sebastiani

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Cluster analysis of gene expression dynamics
    Marco F Ramoni
    Children s Hospital Informatics Program, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:9121-6. 2002
  2. pmc Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not so Different after all!
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health Boston, MA, USA
    Front Genet 3:26. 2012
  3. pmc Whole genome sequences of a male and female supercentenarian, ages greater than 114 years
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health Boston, MA, USA
    Front Genet 2:90. 2011
  4. pmc The genetics of extreme longevity: lessons from the new England centenarian study
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health Boston, MA, USA
    Front Genet 3:277. 2012
  5. doi request reprint Genetic signatures of exceptional longevity in humans
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Science 2010:. 2010
  6. pmc Genetic signatures of exceptional longevity in humans
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e29848. 2012
  7. pmc Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks
    Fulvia Ferrazzi
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Pavia, Italy
    BMC Bioinformatics 8:S2. 2007
  8. pmc Conditional clustering of temporal expression profiles
    Ling Wang
    Novartis Vaccines and Diagnostics, Emeryville, CA 94608, USA
    BMC Bioinformatics 9:147. 2008
  9. pmc Genome-wide association studies and the genetic dissection of complex traits
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Am J Hematol 84:504-15. 2009
  10. pmc A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston 02118 MA, USA
    BMC Genet 9:6. 2008

Research Grants

  1. Genetic Dissection of Sickle Cell Anemia Phenotypes
    Paola Sebastiani; Fiscal Year: 2006

Detail Information

Publications64

  1. pmc Cluster analysis of gene expression dynamics
    Marco F Ramoni
    Children s Hospital Informatics Program, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:9121-6. 2002
    ..A set of gene-expression time series, collected to study the response of human fibroblasts to serum, is used to identify the properties of the method...
  2. pmc Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not so Different after all!
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health Boston, MA, USA
    Front Genet 3:26. 2012
    ..In addition, we study the properties of the two approaches and describe how they can be generalized to include various models of inheritance...
  3. pmc Whole genome sequences of a male and female supercentenarian, ages greater than 114 years
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health Boston, MA, USA
    Front Genet 2:90. 2011
    ..The continued analysis of the genomes of these and other rare individuals who have survived to extremely old ages should provide insight into the processes that contribute to the maintenance of health during extreme aging...
  4. pmc The genetics of extreme longevity: lessons from the new England centenarian study
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health Boston, MA, USA
    Front Genet 3:277. 2012
    ..It appears to us that this genetic component consists of many genetic modifiers each with modest effects, but as a group they can have a strong influence...
  5. doi request reprint Genetic signatures of exceptional longevity in humans
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Science 2010:. 2010
    ..g., dementia, hypertension, and cardiovascular disease) and may help dissect this complex phenotype into subphenotypes of healthy aging...
  6. pmc Genetic signatures of exceptional longevity in humans
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e29848. 2012
    ..The correlation between 3 signatures and 3 different life spans was replicated in the combined replication sets. The different signatures may help dissect this complex phenotype into sub-phenotypes of exceptional longevity...
  7. pmc Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks
    Fulvia Ferrazzi
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Pavia, Italy
    BMC Bioinformatics 8:S2. 2007
    ..However, DBN approaches that use continuous variables, thus avoiding the information loss associated with discretization, have not yet been extensively assessed, and most of the proposed approaches have dealt with linear Gaussian models...
  8. pmc Conditional clustering of temporal expression profiles
    Ling Wang
    Novartis Vaccines and Diagnostics, Emeryville, CA 94608, USA
    BMC Bioinformatics 9:147. 2008
    ..Many microarray experiments produce temporal profiles in different biological conditions but common cluster techniques are not able to analyze the data conditional on the biological conditions...
  9. pmc Genome-wide association studies and the genetic dissection of complex traits
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Am J Hematol 84:504-15. 2009
    ..In this article, we will review the common approach to analysis of GWAS data and then discuss options to learn more from these data. We will use examples from our ongoing studies of sickle cell anemia and also GWAS in multigenic traits...
  10. pmc A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston 02118 MA, USA
    BMC Genet 9:6. 2008
    ..One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations...
  11. ncbi request reprint Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Heath, Boston, Massachusetts 02118, USA
    Am J Hematol 83:189-95. 2008
    ..By stratifying patients by age, our results also suggest that different genes might modulate the rate of decline of HbF and the final level of HbF levels in sickle cell anemia...
  12. pmc RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 4:e8210. 2009
    ..The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered...
  13. pmc Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Am J Hematol 85:29-35. 2010
    ..Additional validation, resequencing, and functional studies to understand the biology and reveal mechanisms by which candidate genes might have their effects are the future goals of this work...
  14. pmc Bayesian estimates of linkage disequilibrium
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Genet 8:36. 2007
    ..The maximum likelihood estimator of D'--a standard measure of linkage disequilibrium--is biased toward disequilibrium, and the bias is particularly evident in small samples and rare haplotypes...
  15. pmc Robust transmission/disequilibrium test for incomplete family genotypes
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Genetics 168:2329-37. 2004
    ..rTDT is applied to a database of markers of susceptibility to Crohn's disease and it shows that only 2 of the 11 markers originally associated with the phenotype do not depend on assumptions about the missing data mechanism...
  16. pmc A Bayesian dynamic model for influenza surveillance
    Paola Sebastiani
    Department of Biostatistics, Boston University, Boston, MA, USA
    Stat Med 25:1803-16; discussion 1817-25. 2006
    ..Our findings show the importance of modelling the complex dynamics of data collected for influenza surveillance, and suggest that dynamic Bayesian networks could be suitable modelling tools for developing epidemic surveillance systems...
  17. pmc Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster
    Nadia Solovieff
    Department of Biostatistics, Boston University School of Public Health, MA, USA
    Blood 115:1815-22. 2010
    ..6E-21) and in Thailand and Hong Kong subjects. Elements within the olfactory receptor gene cluster might play a regulatory role in gamma-globin gene expression...
  18. pmc Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype
    Duyen Ngo
    Center of Excellence in Sickle Cell Disease, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Blood Cells Mol Dis 51:22-6. 2013
    ..These regulatory elements, which remain to be discovered, might be specific in the Saudi and some other populations where HbF levels are especially high...
  19. pmc A prediction model for lung cancer diagnosis that integrates genomic and clinical features
    Jennifer Beane
    The Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
    Cancer Prev Res (Phila) 1:56-64. 2008
    ..These findings suggest that use of the clinicogenomic model may expedite more invasive testing and definitive therapy for smokers with lung cancer and reduce invasive diagnostic procedures for individuals without lung cancer...
  20. pmc Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway
    Vikki G Nolan
    Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Br J Haematol 133:570-8. 2006
    ..Haemolysis-driven phenotypes, such as leg ulcers, could be improved by agents that reduce sickle erythrocyte density or increase NO bioavailability...
  21. pmc Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans
    Idowu Akinsheye
    Division of Hematology Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Am J Hematol 87:217-9. 2012
    ..Thirty-eight SNPs were found. Four SNPs had significantly higher major allele frequencies in the unusually high HbF group. In silico analyses of these four polymorphisms predicted alteration in transcription factor binding sites in 3...
  22. pmc Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Nat Genet 37:435-40. 2005
    ..We validated this model in a different population by predicting the occurrence of stroke in 114 individuals with 98.2% accuracy...
  23. pmc Imputation of missing genotypes: an empirical evaluation of IMPUTE
    Zhenming Zhao
    Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston MA 02118, USA
    BMC Genet 9:85. 2008
    ....
  24. pmc Clustering by genetic ancestry using genome-wide SNP data
    Nadia Solovieff
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Genet 11:108. 2010
    ..An alternative solution is genetic matching of cases and controls that requires, however, well defined population strata for appropriate selection of cases and controls...
  25. pmc Ancestry of African Americans with sickle cell disease
    Nadia Solovieff
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Blood Cells Mol Dis 47:41-5. 2011
    ....
  26. pmc Severe sickle cell anemia is associated with increased plasma levels of TNF-R1 and VCAM-1
    Daniel A Dworkis
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Hematol 86:220-3. 2011
    ....
  27. doi request reprint Fetal hemoglobin in sickle cell anemia: a glass half full?
    Martin H Steinberg
    Center of Excellence in Sickle Cell Disease, Department of Medicine, Boston University School of Medicine, Boston, MA
    Blood 123:481-5. 2014
    ....
  28. pmc Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
    Xiaoling Zhang
    Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
    Physiol Genomics 41:1-8. 2010
    ..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
  29. pmc BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies
    Amanda E Sedgewick
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Blood Cells Mol Dis 41:255-8. 2008
    ..Taken together, the data suggest that the functional motifs responsible for modulating F-cells and HbF levels reside within a 3 kb region in the second intron of BCL11A...
  30. pmc Genetic determinants of haemolysis in sickle cell anaemia
    Jacqueline N Milton
    Biostatistics, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA
    Br J Haematol 161:270-8. 2013
    ..Perhaps by independently down-regulating expression of the HBA1/HBA2 genes, variants of the HBA1/HBA2 gene regulatory loci, tagged by rs7203560, reduce haemolysis in sickle cell anaemia...
  31. pmc A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia
    Jacqueline N Milton
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e34741. 2012
    ..15 × 10(-4)). These results confirm that the UGT1A region is the major regulator of bilirubin metabolism in African Americans with sickle cell anemia, similar to what is observed in other ethnicities...
  32. pmc Personality factors in the Long Life Family Study
    Stacy L Andersen
    New England Centenarian Study, Robinson 2400, 88 E Newton St, Boston, MA 02118, USA
    J Gerontol B Psychol Sci Soc Sci 68:739-49. 2013
    ..A linear mixed model of age and gender was implemented adjusting for other covariates...
  33. pmc Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis
    Clinton Baldwin
    Center for Human Genetics, Department of Pediatrics, Boston University School of Medicine, 715 Albany St, W408, Boston, MA 02118, USA
    Blood 106:372-5. 2005
    ..Our results may provide insight into the pathogenesis of osteonecrosis in sickle cell disease, help identify individuals who are at high risk for osteonecrosis, and thus allow earlier and more effective therapeutic intervention...
  34. pmc A network model to predict the risk of death in sickle cell disease
    Paola Sebastiani
    Boston University School of Public Health, MA 02118, USA
    Blood 110:2727-35. 2007
    ..The severity score could serve as an estimate of overall disease severity in genotype-phenotype association studies, and the model provides an additional method to study the complex pathophysiology of sickle cell disease...
  35. pmc Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span
    Stacy L Andersen
    New England Centenarian Study, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 67:395-405. 2012
    ..As the limit of human life span was effectively approached with supercentenarians, compression of morbidity was generally observed...
  36. pmc Minimal haplotype tagging
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 100:9900-5. 2003
    ..This result seems to provide further evidence that a severe bottleneck occurred during the founding of Europe and the conjectured "Out of Africa" event...
  37. pmc Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression
    Jennifer Beane
    Bioinformatics Program, Boston University, Cummington Street, Boston, MA 02215, USA
    Genome Biol 8:R201. 2007
    ..The identification of irreversible effects of tobacco smoke on airway gene expression may provide insights into the causes of this elevated risk...
  38. pmc Fetal hemoglobin in sickle cell anemia
    Idowu Akinsheye
    Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Blood 118:19-27. 2011
    ..Recent insights into HbF regulation have spurred new efforts to induce high HbF levels in sickle cell disease beyond those achievable with the current limited repertory of HbF inducers...
  39. pmc A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression
    John J Farrell
    Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Blood 117:4935-45. 2011
    ..This 3-bp deletion polymorphism is probably the most significant functional motif accounting for HMIP modulation of HbF in all 3 populations...
  40. ncbi request reprint Factors affecting automated syndromic surveillance
    Ling Wang
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Artif Intell Med 34:269-78. 2005
    ..The increased threat of bioterroristic attacks and epidemic events requires the development of accurate and timely outbreak detection systems for early identification of anomalies in public health data...
  41. pmc The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy
    Chiara Gerhardinger
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Diabetes 58:1659-67. 2009
    ..We aimed to identify candidate drug targets by investigating the molecular effects of drugs that prevent retinal capillary demise in the diabetic rat...
  42. pmc Prediction of fetal hemoglobin in sickle cell anemia using an ensemble of genetic risk prediction models
    Jacqueline N Milton
    Department of Biostatistics, Boston University School of Public Health, Boston, MA
    Circ Cardiovasc Genet 7:110-5. 2014
    ..Combining SNPs into a genetic risk score can help to explain a larger amount of the variability of HbF level, but the challenge of this approach is to select the optimal number of SNPs to be included in the genetic risk score...
  43. ncbi request reprint Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma
    Elizabeth S Klings
    The Pulmonary Center, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Physiol Genomics 21:293-8. 2005
    ..An altered EC phenotype elicited by SCD plasma may contribute to the pathogenesis of sickle vasoocclusion...
  44. ncbi request reprint Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss
    Monty Montano
    Section of Infectious Diseases, Center for HIV 1 AIDS Care and Research, School of Public Health, Boston University, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 92:2793-802. 2007
    ..Although androgen treatment increases muscle mass, the cell-intrinsic mechanisms engaged remain poorly understood...
  45. pmc A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment
    Katrina Steiling
    Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Respir Crit Care Med 187:933-42. 2013
    ..Molecular phenotyping of chronic obstructive pulmonary disease (COPD) has been impeded in part by the difficulty in obtaining lung tissue samples from individuals with impaired lung function...
  46. pmc BET bromodomain inhibition as a novel strategy for reactivation of HIV-1
    Camellia Banerjee
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Leukoc Biol 92:1147-54. 2012
    ..Thus, JQ1 may be useful in studies of potentially novel mechanisms for transcriptional control as well as in translational efforts to identify therapeutic molecules to achieve viral eradication...
  47. pmc Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer
    Bethany N Hannafon
    Department of Medicine, Boston Medical Center and Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Breast Cancer Res 13:R24. 2011
    ..Since many genetic aberrations of invasive disease are detectable in early stages, we hypothesized that miRNA expression dysregulation and the predicted changes in gene expression might also be found in early breast neoplasias...
  48. pmc Genome-wide association study of personality traits in the long life family study
    Harold T Bae
    Department of Biostatistics, Boston University School of Public Health Boston, MA, USA
    Front Genet 4:65. 2013
    ....
  49. doi request reprint Association between wind speed and the occurrence of sickle cell acute painful episodes: results of a case-crossover study
    Vikki G Nolan
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Br J Haematol 143:433-8. 2008
    ....
  50. pmc Implementing syndromic surveillance: a practical guide informed by the early experience
    Kenneth D Mandl
    Children s Hospital Informatics Program, Division of Emergency Medicine, Center for Biopreparedness, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Am Med Inform Assoc 11:141-50. 2004
    ....
  51. ncbi request reprint Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer
    Avrum Spira
    The Pulmonary Center, Boston University Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 13:361-6. 2007
    ..These findings indicate that gene expression in cytologically normal large-airway epithelial cells can serve as a lung cancer biomarker, potentially owing to a cancer-specific airway-wide response to cigarette smoke...
  52. pmc Premature expression of a muscle fibrosis axis in chronic HIV infection
    Rebecca L Kusko
    Boston University School of Medicine, 650 Albany St, EBRC 646, Boston, MA, 02118, USA
    Skelet Muscle 2:10. 2012
    ..abstract:..
  53. pmc Bayesian methods for multivariate modeling of pleiotropic SNP associations and genetic risk prediction
    Stephen W Hartley
    Department of Biostatistics, Boston University School of Public Health Boston, MA, USA
    Front Genet 3:176. 2012
    ..The proposed method is robust, computationally efficient, and provides a powerful new approach for detecting and modeling pleiotropic disease loci...
  54. doi request reprint Genetic modifiers of sickle cell disease
    Martin H Steinberg
    Division of Hematology Oncology, Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Am J Hematol 87:795-803. 2012
    ..In the future, whole genome sequencing with its promise of discovering hitherto unsuspected variants could add to our understanding of the genetic modifiers of this disease...
  55. pmc Personality traits of centenarians' offspring
    Jane L Givens
    New England Centenarian Study, Geriatrics Section, School of Medicine, Boston University and Boston Medical Center, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 57:683-5. 2009
    ..To determine whether the offspring of centenarians have personality characteristics that are distinct from the general population...
  56. pmc Early dysregulation of cell adhesion and extracellular matrix pathways in breast cancer progression
    Lyndsey A Emery
    Boston University Medical Center, 650 Albany Street, Boston, MA 02118, USA
    Am J Pathol 175:1292-302. 2009
    ..These findings could lead to novel risk stratification, prevention, and treatment approaches...
  57. pmc Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes
    Manish Bais
    Orthopaedic Research Laboratory, Boston University School of Medicine, Boston, MA, USA
    PLoS ONE 4:e5393. 2009
    ..They show that neurogenesis as well as vasculogenesis are predominant components of skeletal tissue formation and suggest common pathways are shared between post-natal stem cells and those seen in ESCs...
  58. pmc PleioGRiP: genetic risk prediction with pleiotropy
    Stephen W Hartley
    National Institutes of Health National Human Genome Research Institute, 5625 Fishers Lane, Rockville, MD 20850, USA
    Bioinformatics 29:1086-8. 2013
    ....
  59. ncbi request reprint Evidence for cross-regulated cytokine response in human peripheral blood mononuclear cells exposed to whole gonococcal bacteria in vitro
    Matthew Rarick
    Center for HIV 1 AIDS Care and Research, Section of Infectious Diseases, Boston University School of Medicine, 650 Albany Street, EBRC 640, Boston, MA 02118, USA
    Microb Pathog 40:261-70. 2006
    ....
  60. pmc Disentangling the roles of disability and morbidity in survival to exceptional old age
    Dellara F Terry
    New England Centenarian Study, Geriatrics Section of the Department of Medicine, Boston University School of Medicine and Boston Medical Center, MA 02118, USA
    Arch Intern Med 168:277-83. 2008
    ..Therefore, we hypothesize that for some centenarians, compression of disability rather than morbidity is a key feature for survival to old age...
  61. pmc Building chromosome-wide LD maps
    Maria M Abad-Grau
    Software Engineering Department, University of Granada Granada 18071, Spain
    Bioinformatics 22:1933-4. 2006
    ..BMapBuilder builds maps of pairwise linkage disequilibrium (LD) in either two or three dimensions. The optimized resolution allows for graphical display of LD for single nucleotide polymorphisms (SNPs) in a whole chromosome...
  62. ncbi request reprint HIV-1 burden influences host response to co-infection with Neisseria gonorrhoeae in vitro
    Monty Montano
    Department of Medicine, Section of Infectious Diseases, Center for HIV 1 AIDS Care and Research, Boston University School of Medicine, USA
    Int Immunol 18:125-37. 2006
    ..Further evaluation of these findings may help to better understand the role of viral burden in defining cellular contribution to host immune response upon co-infection with secondary sexually transmitted pathogens...

Research Grants1

  1. Genetic Dissection of Sickle Cell Anemia Phenotypes
    Paola Sebastiani; Fiscal Year: 2006
    ..abstract_text> ..