Jennifer J Schlezinger

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    J Immunol 169:6831-41. 2002
  2. pmc Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists
    Gregory J Howard
    Environmental Health Department, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:666-72. 2010
  3. pmc Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humans
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:693-8. 2010
  4. ncbi request reprint An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Toxicol Sci 98:125-36. 2007
  5. ncbi request reprint Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Massachusetts 02118, USA
    Toxicol Sci 92:433-44. 2006
  6. ncbi request reprint Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    J Immunol 173:3165-77. 2004
  7. pmc Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology study
    Brenda A Jensen
    Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Environ Health 2:16. 2003
  8. ncbi request reprint Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis
    Lenka L Allan
    Department of Environmental Health, Boston University Schools of Medicine and Public Health, Massachusetts 02118, USA
    Toxicol Sci 76:357-65. 2003
  9. pmc An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways
    Stephanie L Bissonnette
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    J Immunol 181:1728-36. 2008
  10. pmc Proximal events in 7,12-dimethylbenz[a]anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: stromal cell-B cell communication and apoptosis signaling
    Jessica E Teague
    Department of Microbiology, School of Medicine, Boston University, Boston, MA 02118, USA
    J Immunol 185:3369-78. 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    J Immunol 169:6831-41. 2002
    ..These results have implications for the nominal role of the PPARgamma in B cell development and for the use of PPARgamma agonists as immunomodulatory therapeutics...
  2. pmc Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists
    Gregory J Howard
    Environmental Health Department, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:666-72. 2010
    ..However, the TEF method assumes that individual agents are full aryl hydrocarbon receptor (AhR) agonists with parallel dose-response curves, whereas many mixtures include partial agonists...
  3. pmc Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humans
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:693-8. 2010
    ..However, assessment of the significance of human exposures is hampered by an incomplete understanding of how complex mixtures affect AhR activation/inactivation...
  4. ncbi request reprint An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Toxicol Sci 98:125-36. 2007
    ..These data support the hypothesis that pharmacologic concentrations of PPARgamma agonists induce an intrinsic apoptotic pathway that is driven in normal bone marrow B cells by multiple amplification loops...
  5. ncbi request reprint Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Massachusetts 02118, USA
    Toxicol Sci 92:433-44. 2006
    ..The results support the hypothesis that GW7845 initiates an apoptotic pathway in early B cells through the activation of a kinase cascade that includes at least p38 MAPK and JNK...
  6. ncbi request reprint Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    J Immunol 173:3165-77. 2004
    ..These data demonstrate that environmental phthalates can cooperate with an endogenous ligand, 15d-PGJ(2), to inhibit proliferation of and induce apoptosis in developing bone marrow B cells, potentially via PPARgamma activation...
  7. pmc Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology study
    Brenda A Jensen
    Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Environ Health 2:16. 2003
    ..Here, we extend these studies to evaluate the potential for two prototypic AhR agonists, 7,12-dimethylbenz [a]anthracene (DMBA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), to alter stromal cell cytokine responses...
  8. ncbi request reprint Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis
    Lenka L Allan
    Department of Environmental Health, Boston University Schools of Medicine and Public Health, Massachusetts 02118, USA
    Toxicol Sci 76:357-65. 2003
    ..g., metabolite-protein complexes, may affect the function of distant stromal cells, the effector death signal delivered by stromal cells to bone marrow B cells is mediated by cell-cell contact...
  9. pmc An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways
    Stephanie L Bissonnette
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    J Immunol 181:1728-36. 2008
    ..Thus, endogenous 15d-PGJ(2)-mediated enhancement of environmental chemical-induced apoptosis represents activation of an overlapping but distinct signaling pathway...
  10. pmc Proximal events in 7,12-dimethylbenz[a]anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: stromal cell-B cell communication and apoptosis signaling
    Jessica E Teague
    Department of Microbiology, School of Medicine, Boston University, Boston, MA 02118, USA
    J Immunol 185:3369-78. 2010
    ..Indeed, we provide evidence that metabolite transfer from bone marrow stromal cells occurs through membrane exchange, which may represent a novel communication mechanism between developing B cells and stromal cells...
  11. pmc The role of CaMKII in calcium-activated death pathways in bone marrow B cells
    Stephanie L Bissonnette
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Toxicol Sci 118:108-18. 2010
    ..Thus, we show that early B cells are susceptible to calcium-triggered cell death through a CaMKII/MAPK-dependent pathway...
  12. ncbi request reprint Environmental chemical-induced bone marrow B cell apoptosis: death receptor-independent activation of a caspase-3 to caspase-8 pathway
    Heui Young Ryu
    Boston University School of Public Health, Dept of Environmental Health, MA 02118, USA
    Mol Pharmacol 68:1087-96. 2005
    ..These results suggest a complex death receptor-independent B cell apoptosis pathway in which caspase-8 is activated downstream of caspase-3...
  13. pmc Organotins are potent activators of PPARĪ³ and adipocyte differentiation in bone marrow multipotent mesenchymal stromal cells
    Susan C Yanik
    Department of Environmental Health, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Toxicol Sci 122:476-88. 2011
    ..Activation of multiple nuclear receptor pathways by organotins may have significant implications for bone physiology...
  14. ncbi request reprint Environmental chemical-induced pro/pre-B cell apoptosis: analysis of c-Myc, p27Kip1, and p21WAF1 reveals a death pathway distinct from clonal deletion
    Heui Young Ryu
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    J Immunol 170:4897-904. 2003
    ....
  15. ncbi request reprint CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression
    Lenka L Allan
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    Biochem Biophys Res Commun 342:227-35. 2006
    ..These studies show for the first time the metabolic requirements for PAH-mediated suppression of human B cell growth...
  16. ncbi request reprint Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo
    Yasushi Takai
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 144:69-74. 2003
    ....
  17. ncbi request reprint A role for the aryl hydrocarbon receptor in mammary gland tumorigenesis
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    Biol Chem 387:1175-87. 2006
    ..The theme that malignant cells reveal the functions for which the AhR has been evolutionarily conserved is presented throughout this discussion...