J D Safer

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi Thyroid hormone action on skin: diverging effects of topical versus intraperitoneal administration
    Joshua D Safer
    Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Thyroid 13:159-65. 2003
  2. ncbi Role for inner ring deiodination preventing transcutaneous passage of thyroxine
    Ferruccio Santini
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:2825-30. 2003
  3. ncbi AMPK regulation of the growth of cultured human keratinocytes
    Asish K Saha
    Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Biochem Biophys Res Commun 349:519-24. 2006
  4. pmc Thyroid hormone and wound healing
    Joshua D Safer
    Section of Endocrinology, Boston University School of Medicine, Room M 1016, 715 Albany Street, Boston, MA 02118, USA
    J Thyroid Res 2013:124538. 2013
  5. doi A simple curriculum content change increased medical student comfort with transgender medicine
    Joshua D Safer
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachussetts 02118, USA
    Endocr Pract 19:633-7. 2013
  6. doi Thyroid hormone action on skin
    Joshua D Safer
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Curr Opin Endocrinol Diabetes Obes 19:388-93. 2012
  7. ncbi A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma
    J D Safer
    Section of Endocrinology, Metabolism, and Diabetes, Boston University School of Medicine, Massachusetts 02118, USA
    Thyroid 11:281-91. 2001
  8. ncbi Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats
    J D Safer
    Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Thyroid 11:717-24. 2001
  9. ncbi The thyroid hormone receptor-beta gene mutation R383H is associated with isolated central resistance to thyroid hormone
    J D Safer
    Thyroid Unit, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 84:3099-109. 1999
  10. ncbi A role for thyroid hormone in wound healing through keratin gene expression
    Joshua D Safer
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 715 Albany Street, Room M 1022, Boston, Massachusetts 02118, USA
    Endocrinology 145:2357-61. 2004

Collaborators

Detail Information

Publications16

  1. ncbi Thyroid hormone action on skin: diverging effects of topical versus intraperitoneal administration
    Joshua D Safer
    Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Thyroid 13:159-65. 2003
    ..Insight into the interplay among the competing factors will be important in understanding thyroid hormone regulation of skin physiology...
  2. ncbi Role for inner ring deiodination preventing transcutaneous passage of thyroxine
    Ferruccio Santini
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:2825-30. 2003
    ..In conclusion, our study indicates that normal human skin serves as a substantial, but incomplete, barrier to T(4) passage. D3 plays an important role in augmenting T(4) blockade by inactivating T(4) to rT(3)...
  3. ncbi AMPK regulation of the growth of cultured human keratinocytes
    Asish K Saha
    Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Biochem Biophys Res Commun 349:519-24. 2006
    ..They also suggest that AMPK activators, such as AICAR and troglitazone, inhibit keratinocyte growth and that the inhibition of cell growth by 1,25-dihydroxyvitamin D3 is AMPK-independent...
  4. pmc Thyroid hormone and wound healing
    Joshua D Safer
    Section of Endocrinology, Boston University School of Medicine, Room M 1016, 715 Albany Street, Boston, MA 02118, USA
    J Thyroid Res 2013:124538. 2013
    ..The paper is intended to provide a context for recent findings of direct thyroid hormone action on cutaneous cells in vitro and in vivo which may portend the use of thyroid hormone to promote wound healing...
  5. doi A simple curriculum content change increased medical student comfort with transgender medicine
    Joshua D Safer
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachussetts 02118, USA
    Endocr Pract 19:633-7. 2013
    ..Our objective was to demonstrate that a simple content change in a medical school curriculum would increase students' willingness to care for transgender patients...
  6. doi Thyroid hormone action on skin
    Joshua D Safer
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Curr Opin Endocrinol Diabetes Obes 19:388-93. 2012
    ..To review the current understanding regarding thyroid hormone action on skin. To provide a historical context for the recent findings...
  7. ncbi A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma
    J D Safer
    Section of Endocrinology, Metabolism, and Diabetes, Boston University School of Medicine, Massachusetts 02118, USA
    Thyroid 11:281-91. 2001
    ..As such, it raises the question of whether RTH predisposes to pituitary hyperplasia and adenoma development...
  8. ncbi Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats
    J D Safer
    Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Thyroid 11:717-24. 2001
    ..01). Thus, topically applied thyroid hormone has dramatic effects on both skin and hair growth. These observations offer a new strategy for developing thyroid hormone and its analogues for treating disorders of skin and hair growth...
  9. ncbi The thyroid hormone receptor-beta gene mutation R383H is associated with isolated central resistance to thyroid hormone
    J D Safer
    Thyroid Unit, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 84:3099-109. 1999
    ..Our clinical evaluation presented here represents the most thorough documentation to date of the central thyroid hormone resistance phenotype in an individual with an identified TR-beta mutation...
  10. ncbi A role for thyroid hormone in wound healing through keratin gene expression
    Joshua D Safer
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 715 Albany Street, Room M 1022, Boston, Massachusetts 02118, USA
    Endocrinology 145:2357-61. 2004
    ..Thus, for hypothyroid patients undergoing surgery that cannot be delayed until euthyroidism is achieved, our data support T(3) treatment for the perioperative period...
  11. ncbi Topical thyroid hormone accelerates wound healing in mice
    Joshua D Safer
    Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Room M 1016, Boston, Massachusetts 02118, USA
    Endocrinology 146:4425-30. 2005
    ..The data support our previous hypothesis that T3 is necessary for optimal wound healing. Now, we further suggest that topical thyroid hormone may be an inexpensive agent to hasten healing of certain wounds...
  12. ncbi A topical parathyroid hormone/parathyroid hormone-related peptide receptor antagonist stimulates hair growth in mice
    Joshua D Safer
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 715 Albany Street, Room M 1016, Boston, MA 02118, USA
    Endocrinology 148:1167-70. 2007
    ..Our study is the first to report the hair-stimulating effect of a PTH/PTHrP receptor antagonist topically applied to skin in vivo. Thus, we introduce a novel paradigm to develop topical PTH analogs for treating disorders of hair growth...
  13. doi A thyroid hormone deiodinase inhibitor can decrease cutaneous cell proliferation in vitro
    Joshua D Safer
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Thyroid 19:181-5. 2009
    ..Although IOP is known to inhibit T(4) to T(3) conversion, the inhibition of cutaneous cell proliferation by IOP might conceivably result from other properties of IOP...
  14. ncbi Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone
    J D Safer
    Thyroid Unit, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 273:30175-82. 1998
    ..Our data also suggest that solution T3 binding by RTH mutants may not accurately reflect physiologically relevant T3 binding by TR when bound to DNA...
  15. ncbi Diagnostic confusion attributable to spurious elevation of both total thyroid hormone and thyroid hormone uptake measurements in the setting of autoantibodies: case report and review of related literature
    Sara M Pietras
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    Endocr Pract 14:738-42. 2008
    ....
  16. doi Male sex, African American race or ethnicity, and triiodothyronine levels at diagnosis predict weight gain after antithyroid medication and radioiodine therapy for hyperthyroidism
    Miguel A Ariza
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
    Endocr Pract 16:609-16. 2010
    ..To determine whether racial or ethnic differences affect weight gain after treatment of hyperthyroidism and to reassess established risk factors such as sex, age, and cause of hyperthyroidism...