Valentina Sabino

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Pharmacological characterization of the 20% alcohol intermittent access model in Sardinian alcohol-preferring rats: a model of binge-like drinking
    Valentina Sabino
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA
    Alcohol Clin Exp Res 37:635-43. 2013
  2. pmc mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats
    Valentina Sabino
    Laboratory of Addictive Disorders LAD, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA
    Behav Brain Res 247:9-16. 2013
  3. pmc Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 36:1207-18. 2011
  4. pmc Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist
    Valentina Sabino
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Psychopharmacology (Berl) 205:327-35. 2009
  5. pmc The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropsychopharmacology 34:1482-93. 2009
  6. pmc Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 67:831-9. 2010
  7. pmc Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala
    Angelo Blasio
    Laboratory of Addictive Disorders, Department of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA
    Neuropsychopharmacology 38:2498-507. 2013
  8. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
  9. ncbi request reprint Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 189:175-86. 2006
  10. pmc CRF mediates the anxiogenic and anti-rewarding, but not the anorectic effects of PACAP
    Riccardo Dore
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics and Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA
    Neuropsychopharmacology 38:2160-9. 2013

Collaborators

Detail Information

Publications25

  1. pmc Pharmacological characterization of the 20% alcohol intermittent access model in Sardinian alcohol-preferring rats: a model of binge-like drinking
    Valentina Sabino
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA
    Alcohol Clin Exp Res 37:635-43. 2013
    ....
  2. pmc mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats
    Valentina Sabino
    Laboratory of Addictive Disorders LAD, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA
    Behav Brain Res 247:9-16. 2013
    ..The effects of ketamine, but not memantine, are mediated by mTOR. The results support the therapeutic potential of uncompetitive NMDA receptor antagonists, especially memantine, in alcohol addiction...
  3. pmc Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 36:1207-18. 2011
    ..These results suggest a key facilitatory role for σ-receptors in the reinforcing effects of alcohol and identify a potential mechanism that contributes to binge-like and excessive drinking...
  4. pmc Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist
    Valentina Sabino
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Psychopharmacology (Berl) 205:327-35. 2009
    ..Sigma receptors have been implicated in appetitive effects of psychostimulants and in high levels of ethanol intake. This study tested the hypothesis that the sigma-1 receptor subtype (Sig-1R) may modulate ethanol intake...
  5. pmc The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropsychopharmacology 34:1482-93. 2009
    ....
  6. pmc Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 67:831-9. 2010
    ..Ethanol augments CeA GABA release in ethanol-naive rats and mice...
  7. pmc Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala
    Angelo Blasio
    Laboratory of Addictive Disorders, Department of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA
    Neuropsychopharmacology 38:2498-507. 2013
    ..These findings help elucidate the link between compulsive eating and anxiety, and it will be valuable to develop better pharmacological treatments for eating disorders and obesity...
  8. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
    ....
  9. ncbi request reprint Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 189:175-86. 2006
    ..The role of positive vs negative ethanol reinforcement in ethanol intake of Sardinian alcohol-preferring (sP) rats is unclear...
  10. pmc CRF mediates the anxiogenic and anti-rewarding, but not the anorectic effects of PACAP
    Riccardo Dore
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics and Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA
    Neuropsychopharmacology 38:2160-9. 2013
    ..In addition, we identified the mechanism by which PACAP exerts its anxiogenic and pro-depressant effects, via the recruitment of the central CRF system and independently from HPA axis activation. ..
  11. pmc CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food
    Attilio Iemolo
    Laboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA
    Neuropsychopharmacology 38:2456-66. 2013
    ..These results provide functional evidence that the CRF-CRF1 receptor system in CeA and BlA has a differential role in mediating maladaptive behaviors resulting from palatable diet cycling...
  12. doi request reprint Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats
    Attilio Iemolo
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Behav Pharmacol 23:593-602. 2012
    ....
  13. pmc Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1066-76. 2008
    ..The results suggest that intermittent access to highly preferred food, as practiced by many restrained eaters, may progressively decrease the acceptability of less palatable foods, and may promote relapse to more rewarding alternatives...
  14. pmc Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA or
    J Physiol 583:487-504. 2007
    ..Because central CRF(2) stimulation retains full anorectic efficacy at higher doses in the DIO model, manipulating this neuropeptidergic system might yield new therapeutic approaches for diet-induced obesity...
  15. ncbi request reprint Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:524-35. 2008
    ..Such rats show changes in ingestive, metabolic, endocrine, and anxiety-related measures, which resemble features of binge eating disorders or obesity...
  16. ncbi request reprint 14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 192:537-46. 2007
    ..14-methoxymetopon is a centrally acting, selective micro opioid receptor agonist with greater systemic antinociceptive potency than morphine and a putatively improved therapeutic index...
  17. pmc The uncompetitive NMDA receptor antagonists ketamine and memantine preferentially increase the choice for a small, immediate reward in low-impulsive rats
    Pietro Cottone
    Department of Pharmacology, Laboratory of Addictive Disorders, Boston University School of Medicine, 72 E Concord St, R 618, Boston, MA 02118, USA
    Psychopharmacology (Berl) 226:127-38. 2013
    ..While the effects of N-methyl-D-aspartic acid (NMDA) receptor antagonists on impulsive action have been extensively characterized, there are very few and conflicting reports on the effects of this class of drugs on impulsive choice...
  18. pmc Sigma-1 receptor knockout mice display a depressive-like phenotype
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 198:472-6. 2009
    ..The results further suggest that Sig-1Rs inversely modulate depressive-like behavior...
  19. pmc Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses
    Sarah L Parylak
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Physiol Behav 107:231-42. 2012
    ..The results suggest that CB(1)-dependent positive reinforcement rather than CRF(1)-dependent negative reinforcement mechanisms predominantly maintain excessive intake in this limited access model of sweet-fat diet binges...
  20. pmc Antagonism of sigma-1 receptors blocks compulsive-like eating
    Pietro Cottone
    Laboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA
    Neuropsychopharmacology 37:2593-604. 2012
    ..These findings suggest that the Sig-1R system may contribute to the neurobiological adaptations driving compulsive-like eating, opening new avenues of investigation towards pharmacologically treating binge eating disorder...
  21. pmc Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders CNAD, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Psychoneuroendocrinology 34:38-49. 2009
    ..The present diet cycling procedure may model consummatory, anxiety-related, and metabolic effects of qualitative dieting in humans...
  22. doi request reprint A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT₂A/C and 5-HT₁A receptor agonists
    Angelo Blasio
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 72 E Concord St, R 618, Boston, MA 02118, USA
    Psychopharmacology (Berl) 219:377-86. 2012
    ..These factors represent energy-homeostasis limitations, which may confound the interpretation of results and limit the applicability of these models...
  23. pmc Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake
    Vez Repunte-Canonigo
    Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1339:1-10. 2010
    ..Altogether, the data implicate K-ras-regulated pathways in the regulation of excessive alcohol drinking after a history of dependence...
  24. ncbi request reprint FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1069-81. 2007
    ..5 mg/kg) female rats (n=48) in the elevated plus-maze. Thus, benzodiazepine receptor inverse agonists preferentially lessen the maintenance of feeding in female rats, effects opposite to those of palatable food...
  25. ncbi request reprint Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation
    Glenn R Valdez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 28:865-72. 2004
    ....