Edward A Ruiz-Narváez

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Use of alternative promoters may hide genetic effects on phenotypic traits
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
    J Hum Genet 58:47-50. 2013
  2. pmc Validation of a small set of ancestral informative markers for control of population admixture in African Americans
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, Massachusetts 02215, USA
    Am J Epidemiol 173:587-92. 2011
  3. pmc Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, Department of Epidemiology, School of Public Health, 1010 Commonwealth Avenue, Boston MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 19:1320-7. 2010
  4. pmc MHC region and risk of systemic lupus erythematosus in African American women
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Hum Genet 130:807-15. 2011
  5. pmc What is a functional locus? Understanding the genetic basis of complex phenotypic traits
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Med Hypotheses 76:638-42. 2011
  6. pmc Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Breast Cancer Res Treat 123:525-30. 2010
  7. pmc Genetic susceptibility loci for subtypes of breast cancer in an African American population
    Julie R Palmer
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 22:127-34. 2013
  8. pmc African ancestry and genetic risk for uterine leiomyomata
    Lauren A Wise
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th Floor, Boston, MA 02215, USA
    Am J Epidemiol 176:1159-68. 2012
  9. ncbi request reprint Ala12 variant of the peroxisome proliferator-activated receptor-gamma gene (PPARG) is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction
    Edward A Ruiz-Narváez
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:1238-42. 2007
  10. ncbi request reprint APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica
    Edward A Ruiz-Narváez
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Lipid Res 46:2605-13. 2005

Detail Information

Publications19

  1. pmc Use of alternative promoters may hide genetic effects on phenotypic traits
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
    J Hum Genet 58:47-50. 2013
    ..As a consequence, genetic variation because of those observed polymorphisms will be reduced. The present report suggests new paths of research to elucidate the genetic basis of human complex traits...
  2. pmc Validation of a small set of ancestral informative markers for control of population admixture in African Americans
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, Massachusetts 02215, USA
    Am J Epidemiol 173:587-92. 2011
    ..0001). A set of 200 AIMs gave an almost perfect correlation with the entire set (r = 0.98; P < 0.0001). These results show that a small number of AIMs are sufficiently precise to estimate European admixture in African Americans...
  3. pmc Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, Department of Epidemiology, School of Public Health, 1010 Commonwealth Avenue, Boston MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 19:1320-7. 2010
    ..Because linkage disequilibrium blocks are smaller in populations of African ancestry, fine-mapping in African ancestry samples might be an effective approach to narrowing the position of the causal variant(s) in the TOX3/LOC643714 locus...
  4. pmc MHC region and risk of systemic lupus erythematosus in African American women
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Hum Genet 130:807-15. 2011
    ..In summary, we found four independent signals in the MHC region associated with risk of SLE in African American women...
  5. pmc What is a functional locus? Understanding the genetic basis of complex phenotypic traits
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Med Hypotheses 76:638-42. 2011
    ..The hypothesis makes predictions that can be tested, offering potential paths of research to elucidate the genetic basis of complex human traits...
  6. pmc Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Breast Cancer Res Treat 123:525-30. 2010
    ..We successfully used the shorter range of LD in our AA sample to refine the localization of the putative causal variant...
  7. pmc Genetic susceptibility loci for subtypes of breast cancer in an African American population
    Julie R Palmer
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 22:127-34. 2013
    ..Few GWAS hits have replicated in African ancestry populations...
  8. pmc African ancestry and genetic risk for uterine leiomyomata
    Lauren A Wise
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th Floor, Boston, MA 02215, USA
    Am J Epidemiol 176:1159-68. 2012
    ....
  9. ncbi request reprint Ala12 variant of the peroxisome proliferator-activated receptor-gamma gene (PPARG) is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction
    Edward A Ruiz-Narváez
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:1238-42. 2007
    ..The Ala12 allele of the peroxisome proliferator-activated receptor-gamma gene (PPARG) decreases the lipolysis of triacylglycerols in adipose tissue, which results in the accumulation of fatty acids in adipocytes...
  10. ncbi request reprint APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica
    Edward A Ruiz-Narváez
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Lipid Res 46:2605-13. 2005
    ..In summary, this study supports the hypothesis that haplotypes in the APOC3 gene but not in the APOA5 gene increase susceptibility to MI...
  11. pmc Fine-mapping of the 6q25 locus identifies a novel SNP associated with breast cancer risk in African-American women
    Edward A Ruiz-Narváez
    Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
    Carcinogenesis 34:287-91. 2013
    ..We replicated the rs2046210 association, after accounting for the haplotype background that included rs2046211 in African-American women, and we report the presence of a novel signal that is tagged by rs2046211...
  12. pmc General and abdominal obesity and risk of death among black women
    Deborah A Boggs
    Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
    N Engl J Med 365:901-8. 2011
    ..The limited data available on blacks indicate that the risk of death is increased only at very high levels of BMI (≥35.0)...
  13. doi request reprint West African and Amerindian ancestry and risk of myocardial infarction and metabolic syndrome in the Central Valley population of Costa Rica
    Edward A Ruiz-Narváez
    Slone Epidemiology Center, Boston University, Boston, MA, USA
    Hum Genet 127:629-38. 2010
    ..20 (1.01, 1.42). These results show that the high variability of admixture proportions in the Central Valley population offers a unique opportunity to uncover the genetic basis of ethnic differences on the risk of disease...
  14. pmc Genome-wide association study of age at menarche in African-American women
    Ellen W Demerath
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    Hum Mol Genet 22:3329-46. 2013
    ..The findings provide the first evidence of cross-ethnic generalization of menarche loci identified to date, and suggest a number of novel biological links to menarche timing in AA women. ..
  15. pmc Cross-sectional study of conjugated linoleic acid in adipose tissue and risk of diabetes
    Nelsy Castro-Webb
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 96:175-81. 2012
    ..Some experimental studies on conjugated linoleic acid (CLA) and insulin regulation suggested that CLA could be associated with risk of diabetes, but epidemiologic studies are lacking...
  16. pmc Coffee, tea, and alcohol intake in relation to risk of type 2 diabetes in African American women
    Deborah A Boggs
    Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
    Am J Clin Nutr 92:960-6. 2010
    ..Numerous studies have reported inverse associations of coffee, tea, and alcohol intake with risk of type 2 diabetes, but none has reported results separately among African American women...
  17. doi request reprint Evolutionary rate heterogeneity of Alu repeats upstream of the APOA5 gene: do they regulate APOA5 expression?
    Edward A Ruiz-Narváez
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Hum Genet 53:247-53. 2008
    ..Some Alu sequences may have functional relevance on the regulation of the APOA5-gene expression...
  18. ncbi request reprint Transmission disequilibrium test (TDT) for case-control studies
    Edward A Ruiz-Narváez
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Hum Genet 12:105-14. 2004
    ..In sum, this study describes a novel procedure that can be used to identify the transmission of disease susceptibility markers in population-based studies...
  19. pmc Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction
    Edward A Ruiz-Narváez
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 87:1932-8. 2008
    ..Genetic variation in the insulin response element of the APOC3 promoter is associated with an increased risk of MI...