N Ruderman

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome
    Neil Ruderman
    Department of Medicine, Boston University School of Medicine and Diabetes Unit, Section of Endocrinology, Boston Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Rev Drug Discov 3:340-51. 2004
  2. ncbi Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes
    N B Ruderman
    Diabetes Unit, Section of Endocrinology and Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Biochem Soc Trans 31:202-6. 2003
  3. ncbi Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity
    Neil B Ruderman
    D Phil, Diabetes Unit, Boston Medical Center, 650 Albany Street, X825, Boston, Massachusetts 02118, USA
    Endocrinology 144:5166-71. 2003
  4. ncbi Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells
    Z Dagher
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Circ Res 88:1276-82. 2001
  5. ncbi The metabolically obese, normal-weight individual revisited
    N Ruderman
    Evans Department of Medicine, Boston University Medical Center, Massachusetts 02118, USA
    Diabetes 47:699-713. 1998
  6. ncbi AMPK, the metabolic syndrome and cancer
    Zhijun Luo
    Diabetes Research Unit, Section of Endocrinology, Department of Medicine, 650 Albany Street, EBRC 820, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Pharmacol Sci 26:69-76. 2005
  7. ncbi AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells
    Jose M Cacicedo
    Diabetes and Metabolism Research Unit, Department of Medicine and Section of Endocrinology, Boston University School of Medicine, 650 Albany St, 8th Floor, Room 820, Boston, MA 02118, USA
    Biochem Biophys Res Commun 324:1204-9. 2004
  8. ncbi Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 288:E133-42. 2005
  9. ncbi AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
    Mengwei Zang
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:47898-905. 2004
  10. ncbi AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats
    Murwarid M Assifi
    Diabetes and Metabolism Unit, Boston Univ Medical Center, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 289:E794-800. 2005

Collaborators

Detail Information

Publications41

  1. ncbi AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome
    Neil Ruderman
    Department of Medicine, Boston University School of Medicine and Diabetes Unit, Section of Endocrinology, Boston Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Rev Drug Discov 3:340-51. 2004
  2. ncbi Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes
    N B Ruderman
    Diabetes Unit, Section of Endocrinology and Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Biochem Soc Trans 31:202-6. 2003
    ..v) The comparative roles of AMPK in regulating metabolism, signalling and gene expression in muscle and endothelial cells warrant further study...
  3. ncbi Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity
    Neil B Ruderman
    D Phil, Diabetes Unit, Boston Medical Center, 650 Albany Street, X825, Boston, Massachusetts 02118, USA
    Endocrinology 144:5166-71. 2003
    ..In addition, preliminary studies suggest that malonyl CoA and AMPK take part in fuel-sensing and signaling mechanisms in the hypothalamus that could regulate food intake and energy expenditure...
  4. ncbi Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells
    Z Dagher
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Circ Res 88:1276-82. 2001
    ..Finally, they suggest that AMPK is likely to be a major factor in modulating the response of the endothelium to stresses that alter its energy state...
  5. ncbi The metabolically obese, normal-weight individual revisited
    N Ruderman
    Evans Department of Medicine, Boston University Medical Center, Massachusetts 02118, USA
    Diabetes 47:699-713. 1998
    ....
  6. ncbi AMPK, the metabolic syndrome and cancer
    Zhijun Luo
    Diabetes Research Unit, Section of Endocrinology, Department of Medicine, 650 Albany Street, EBRC 820, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Pharmacol Sci 26:69-76. 2005
    ..In addition, other studies indicate that mammalian homolog of target of rapamycin (mTOR), which has been implicated in the pathogenesis of insulin resistance and many types of cancer, is inhibited by AMPK...
  7. ncbi AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells
    Jose M Cacicedo
    Diabetes and Metabolism Research Unit, Department of Medicine and Section of Endocrinology, Boston University School of Medicine, 650 Albany St, 8th Floor, Room 820, Boston, MA 02118, USA
    Biochem Biophys Res Commun 324:1204-9. 2004
    ....
  8. ncbi Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 288:E133-42. 2005
    ..They also suggest that, with high muscle glycogen, the availability of free carnitine may limit fat oxidation during exercise, due to its increased use for acetylcarnitine formation...
  9. ncbi AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
    Mengwei Zang
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:47898-905. 2004
    ..Metformin lowers hepatic lipid content by activating AMPK, thereby mediating beneficial effects in hyperglycemia and insulin resistance...
  10. ncbi AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats
    Murwarid M Assifi
    Diabetes and Metabolism Unit, Boston Univ Medical Center, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 289:E794-800. 2005
    ..They also suggest that the changes in these enzymes, and later occurring increases in enzymes regulating fatty acid and glycerolipid synthesis, could be coordinated by AMPK...
  11. ncbi Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats
    Edward W Kraegen
    Garvan Institute of Medical Research, Sydney NSW 2010 Australia
    Am J Physiol Endocrinol Metab 290:E471-9. 2006
    ..In contrast, it was not associated with increased whole tissue LCA-CoA content in any tissue or triglyceride in muscle, although both are observed at later times...
  12. ncbi Why might thiazolidinediones increase exercise capacity in patients with type 2 diabetes?
    Nathan K Lebrasseur
    Diabetes Care 28:2975-7. 2005
  13. ncbi Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists
    Andrea R Nawrocki
    Department of Cell Biology, Division of Endocrinology, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 281:2654-60. 2006
    ..In summary, adiponectin is an important contributor to PPARgamma-mediated improvements in glucose tolerance through mechanisms that involve the activation of the AMPK pathway...
  14. ncbi Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle
    Jeanette E Kuhl
    Dept of Molecular Medicine and Surgery, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 290:E1296-303. 2006
    ..These changes persist after the increases in AMPK activity and whole body insulin sensitivity and fatty acid oxidation, typically caused by an acute bout of exercise in healthy individuals, have dissipated...
  15. ncbi Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues
    Nathan K Lebrasseur
    Diabetes and Metabolism Research Unit, Boston University School of Medicine, 650 Albany St, X 820, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 291:E175-81. 2006
    ..They suggest that this effect is associated with a change in cellular energy state and that it is not dependent on PPARgamma-mediated gene transcription...
  16. ncbi Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A
    Neil B Ruderman
    Division of Endocrinology, Boston University Medical Center, Boston, MA 02118, USA
    Obesity (Silver Spring) 14:25S-33S. 2006
    ..The possibility is also raised that pharmacological agents and other factors that activate AMPK and/or decrease malonyl CoA could be therapeutic targets...
  17. ncbi AMPK regulation of the growth of cultured human keratinocytes
    Asish K Saha
    Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Biochem Biophys Res Commun 349:519-24. 2006
    ..They also suggest that AMPK activators, such as AICAR and troglitazone, inhibit keratinocyte growth and that the inhibition of cell growth by 1,25-dihydroxyvitamin D3 is AMPK-independent...
  18. ncbi Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome
    Neil B Ruderman
    Section of Endocrinology, Diabetes Unit, Boston Medical Center, 650 Albany St, X 820, Boston, MA 02118, USA
    Diabetes 55:S48-54. 2006
    ....
  19. pmc AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance
    Marie Soleil Gauthier
    Diabetes and Metabolism Unit, Department of Medicine Section of Endocrinology, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Biol Chem 283:16514-24. 2008
    ..Finally, this AMPK activation appears to restrain the energy depletion and oxidative stress caused by lipolysis...
  20. ncbi AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms
    Xiaoqin Xiang
    Diabetes Research Unit, Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem Biophys Res Commun 321:161-7. 2004
    ..The results suggest that AMPK is a potential target for the treatment of prostate cancer...
  21. ncbi Metabolic and hormonal interactions between muscle and adipose tissue
    Eva Tomas
    Department of Medicine, Physiology and Biophysics, Diabetes Unit, Boston University Medical Center, Boston, MA, USA
    Proc Nutr Soc 63:381-5. 2004
    ..Thus, hormonal communications exist between the adipocyte and muscle that could enable them to talk to each other. The physiological relevance of this cross talk clearly warrants further study...
  22. ncbi AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise
    Meghan Kelly
    Diabetes Unit, Section of Endocrinology, Boston Medical Center and Departments of Medicine and Physiology, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem Biophys Res Commun 320:449-54. 2004
    ..They also suggest that a genetic lack of IL-6 is associated with a decrease in AMPK activity...
  23. ncbi Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus
    Eleazar Shafrir
    Department of Biochemistry and Diabetes Research Unit, Hadassah University Hospital, Jerusalem 91120, Israel
    Diabetes Metab Res Rev 18:217-23. 2002
    ..In keeping with this it shows a low rate of glucose transport and a failure of insulin to suppress hepatic glucose production during a hyperinsulinemic-euglycemic clamp...
  24. ncbi Exercise and insulin signaling: a historical perspective
    Eva Tomas
    Diabetes Unit, Section of Endocrinology, Boston Medical Center and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Appl Physiol 93:765-72. 2002
    ..In addition, we will discuss briefly some of the avenues that research in this area is likely to follow...
  25. ncbi AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats
    Miguel A Iglesias
    Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Diabetes 51:2886-94. 2002
    ..Independent of this, the results suggest that pharmacological activation of AMPK may have potential in treating insulin-resistant states and type 2 diabetes...
  26. ncbi Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    Samar I Itani
    Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Diabetes 51:2005-11. 2002
    ..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains to be established...
  27. pmc Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
    Eva Tomas
    Diabetes Unit, Section of Endocrinology, Boston Medical Center and Departments of Medicine and Physiology, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 99:16309-13. 2002
    ..Thus, gACRP30 most likely exerts its actions on muscle fatty acid oxidation by inactivating ACC via activation of AMPK and perhaps other signal transduction proteins...
  28. ncbi Hyperglycemia and insulin resistance: possible mechanisms
    Eva Tomas
    Diabetes and Metabolism Research Unit, Department of Medicine, and Section of Endocrinology, Boston University School of Medicine, Massachusetts 02118, USA
    Ann N Y Acad Sci 967:43-51. 2002
    ..Whether AMPK activation can reverse or prevent insulin resistance in all of these cells remains to be determined...
  29. ncbi Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation
    Peter N Bavenholm
    Division of Medicine, Departments of Emergency and Cardiovascular Medicine, Karolinska Hospital and Institute, S 17176 Stockholm, Sweden
    J Clin Endocrinol Metab 88:82-7. 2003
    ..Whether the unexpectedly high levels of malonyl CoA in muscle, together with the diminished suppression of plasma free fatty acid, explains the insulin resistance of the diabetic patients during the clamp remains to be determined...
  30. ncbi Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
    Haejoe Park
    Diabetes Unit, Section of Endocrinology and Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Biol Chem 277:32571-7. 2002
    ..They also suggest that in each of them, it acts to increase fatty acid oxidation and decrease its esterification...
  31. ncbi Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase
    Samar I Itani
    Diabetes and Metabolism Unit and Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Diabetes 52:1635-40. 2003
    ....
  32. ncbi Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats
    Gabriela Suchankova
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Biochem Biophys Res Commun 326:851-8. 2005
    ....
  33. ncbi Malonyl-CoA and AMP-activated protein kinase: an expanding partnership
    Asish K Saha
    Diabetes Research Unit, Section of Endocrinology and Departments of Medicine and Physiology, Boston University Medical Center, Boston, MA 02118, USA
    Mol Cell Biochem 253:65-70. 2003
    ..This review will describe the current literature on the regulation of malonyl CoA/AMPK mechanism and its physiological function...
  34. ncbi Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo
    Asish K Saha
    Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Biochem Biophys Res Commun 314:580-5. 2004
    ..They also suggest that this activation of AMPK may be mediated by a change in cellular energy state. Whether these effects of pioglitazone contribute to its insulin-sensitizing and other actions in vivo remains to be determined...
  35. ncbi Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle
    Yenshou Lin
    Diabetes and Metabolism Unit and Department of Physiology, Boston University Medical Center, Boston, Massachusettes 02118, USA
    Am J Physiol Endocrinol Metab 283:E318-25. 2002
    ..The significance of the observed alterations to GSK-3 and PP1 alpha distribution remain to be determined...
  36. pmc Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers
    Naomi M Hamburg
    Section of Cardiology, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 27:2650-6. 2007
    ..Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance...
  37. ncbi Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes
    Erik Joly
    Molecular Nutrition Unit and the Montreal Diabetes Research Center, Centre de Recherche du CHUM, Pavillon de Sève, Y 4603, 1560 Sherbrooke Est, and the Department of Nutrition and Biochemistry, Universite de Montreal, Montreal PQ, Canada, H3T 1C5
    FEBS Lett 579:6581-6. 2005
    ....
  38. ncbi Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes
    Thomas A Miller
    Molecular Stress Response Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem Biophys Res Commun 336:309-15. 2005
    ..These results support a model for palmitate-induced apoptosis, activation of SAPKs, and protein oxidative stress in myocytes that involves cytosolic accumulation of saturated fatty acids...
  39. ncbi Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide
    Jose M Cacicedo
    Diabetes and Metabolism Research Unit, Department of Medicine and Section of Endocrinology, Boston University School of Medicine, 650 Albany St, 8th Floor, Room 820, Boston, MA 02118, USA
    Diabetes 54:1838-45. 2005
    ..The precise interactions between these molecules in causing apoptosis and the importance of oxidant stress as a contributory factor remain to be determined...
  40. ncbi Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways
    Tsu Shuen Tsao
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Biol Chem 278:50810-7. 2003
    ..Thus, trimeric and HMW/hexameric Acrp30 activate different signal transduction pathways, and Acrp30 represents a novel example of the control of ligand signaling via changes in its oligomerization state...
  41. ncbi Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity
    Sandeep Gupta
    Diabetes and Metabolism Unit, Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Physiol Cell Physiol 282:C560-6. 2002
    ..These data suggest that hyperglycemia induces an increase in endothelial superoxide that inhibits the stimulatory effect of NO on vascular Na+-K+-ATPase activity...