Sayon Roy

Summary

Affiliation: Boston University
Country: USA

Publications

  1. doi request reprint New insights into hyperglycemia-induced molecular changes in microvascular cells
    S Roy
    Departments of Medicine and Ophthalmology, Boston University School of Medicine, MA 02118, USA
    J Dent Res 89:116-27. 2010
  2. doi request reprint Vascular basement membrane thickening in diabetic retinopathy
    Sayon Roy
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Eye Res 35:1045-56. 2010
  3. ncbi request reprint Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats
    Sayon Roy
    Department of Ophthalmology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Diabetes 52:1229-34. 2003
  4. ncbi request reprint Vascular complications and gene therapy
    Sayon Roy
    Department of Ophthlamology, Boston University School of Medicine, Boston, MA 02118, USA
    Expert Opin Biol Ther 3:71-83. 2003
  5. pmc A long-term siRNA strategy regulates fibronectin overexpression and improves vascular lesions in retinas of diabetic rats
    Sumon Roy
    Department of Medicine and Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Vis 17:3166-74. 2011
  6. ncbi request reprint High glucose alters connexin 43 expression and gap junction intercellular communication activity in retinal pericytes
    An Fei Li
    Department of Ophthalmology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Invest Ophthalmol Vis Sci 44:5376-82. 2003
  7. pmc FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats
    Yugal Behl
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts, USA
    Diabetes 58:917-25. 2009
  8. ncbi request reprint Effect of excess synthesis of extracellular matrix components by trabecular meshwork cells: possible consequence on aqueous outflow
    Nobuhiro Tane
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Exp Eye Res 84:832-42. 2007
  9. doi request reprint High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells
    An Fei Li
    Department of Ophthalmology, University School of Medicine, Boston, Massachusetts 02118, USA
    Invest Ophthalmol Vis Sci 50:1400-7. 2009
  10. doi request reprint Tight glycemic control regulates fibronectin expression and basement membrane thickening in retinal and glomerular capillaries of diabetic rats
    Saira Cherian
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Invest Ophthalmol Vis Sci 50:943-9. 2009

Collaborators

Detail Information

Publications25

  1. doi request reprint New insights into hyperglycemia-induced molecular changes in microvascular cells
    S Roy
    Departments of Medicine and Ophthalmology, Boston University School of Medicine, MA 02118, USA
    J Dent Res 89:116-27. 2010
    ..The majority of the changes described relate to retinal microangiopathy, since ultrastructural, structural, and biochemical alterations have been well-characterized in this tissue...
  2. doi request reprint Vascular basement membrane thickening in diabetic retinopathy
    Sayon Roy
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Eye Res 35:1045-56. 2010
    ....
  3. ncbi request reprint Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats
    Sayon Roy
    Department of Ophthalmology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Diabetes 52:1229-34. 2003
    ..The antisense fibronectin oligos may provide a useful approach for reducing vascular lesions in diabetic retinopathy. The thickened vascular BM may be a potential therapeutic target for preventing retinal lesions in diabetic retinopathy...
  4. ncbi request reprint Vascular complications and gene therapy
    Sayon Roy
    Department of Ophthlamology, Boston University School of Medicine, Boston, MA 02118, USA
    Expert Opin Biol Ther 3:71-83. 2003
    ..Gene therapy is becoming a reality and, more importantly, it appears to be safe and does not require supplementary immuno-suppressing drugs. Gene therapy seems to have begun delivering on its promises...
  5. pmc A long-term siRNA strategy regulates fibronectin overexpression and improves vascular lesions in retinas of diabetic rats
    Sumon Roy
    Department of Medicine and Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Vis 17:3166-74. 2011
    ..We investigated the efficacy of a small interference RNA (siRNA) strategy in mediating the long-term downregulatory effect of fibronectin (FN) overexpression in vivo...
  6. ncbi request reprint High glucose alters connexin 43 expression and gap junction intercellular communication activity in retinal pericytes
    An Fei Li
    Department of Ophthalmology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Invest Ophthalmol Vis Sci 44:5376-82. 2003
    ..To investigate the role of the gap junction protein, connexin-43 (Cx43) in the maintenance of retinal vascular homeostasis in diabetic retinopathy...
  7. pmc FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats
    Yugal Behl
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts, USA
    Diabetes 58:917-25. 2009
    ..To investigate early events leading to microvascular cell loss in diabetic retinopathy...
  8. ncbi request reprint Effect of excess synthesis of extracellular matrix components by trabecular meshwork cells: possible consequence on aqueous outflow
    Nobuhiro Tane
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Exp Eye Res 84:832-42. 2007
    ..These findings suggest that increased LM and Col deposition in the outflow pathway may cause resistance to aqueous outflow and contribute to the development of primary open angle glaucoma (POAG)...
  9. doi request reprint High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells
    An Fei Li
    Department of Ophthalmology, University School of Medicine, Boston, Massachusetts 02118, USA
    Invest Ophthalmol Vis Sci 50:1400-7. 2009
    ..This study aims to determine whether high glucose-induced inhibition of connexin 43 (Cx43) expression and reduced gap junction intercellular communication (GJIC) promote microvascular endothelial cell loss...
  10. doi request reprint Tight glycemic control regulates fibronectin expression and basement membrane thickening in retinal and glomerular capillaries of diabetic rats
    Saira Cherian
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Invest Ophthalmol Vis Sci 50:943-9. 2009
    ....
  11. ncbi request reprint Effect of combined antisense oligonucleotides against high-glucose- and diabetes-induced overexpression of extracellular matrix components and increased vascular permeability
    Toshiyuki Oshitari
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Diabetes 55:86-92. 2006
    ..The findings suggest that abnormal synthesis of ECM components may contribute to vascular leakage in the diabetic retina...
  12. doi request reprint High glucose-induced altered basement membrane composition and structure increases trans-endothelial permeability: implications for diabetic retinopathy
    Argyrios Chronopoulos
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Eye Res 36:747-53. 2011
    ..The following study was designed to investigate early biosynthetic and ultrastructural changes that alter functional properties of the basement membrane (BM) and affect vascular permeability in diabetic retinopathy...
  13. pmc Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy
    Yugal Behl
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    Am J Pathol 172:1411-8. 2008
    ....
  14. pmc Downregulation of mitochondrial connexin 43 by high glucose triggers mitochondrial shape change and cytochrome C release in retinal endothelial cells
    Kyle Trudeau
    Department of Medicine and Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA
    Invest Ophthalmol Vis Sci 53:6675-81. 2012
    ....
  15. pmc High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes
    Kyle Trudeau
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Invest Ophthalmol Vis Sci 52:8657-64. 2011
    ..In this study, the effects of HG on mitochondrial morphology, membrane potential, and metabolic changes and whether they could contribute to HG-induced apoptosis in retinal pericytes were investigated...
  16. pmc Fenofibric acid reduces fibronectin and collagen type IV overexpression in human retinal pigment epithelial cells grown in conditions mimicking the diabetic milieu: functional implications in retinal permeability
    Kyle Trudeau
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Invest Ophthalmol Vis Sci 52:6348-54. 2011
    ..To determine whether fenofibric acid (FA) reduces high glucose (HG)-induced basement membrane component overexpression and hyperpermeability in human retinal pigment epithelial (RPE) cells...
  17. doi request reprint Aging increases retinal vascular lesions characteristic of early diabetic retinopathy
    Sumon Roy
    Departments of Medicine and Ophthalmology, Boston University School of Medicine, MA, USA
    Biogerontology 11:447-55. 2010
    ..The breakdown of normal vascular architecture with aging appears to have resemblance with the anatomical and histological lesions associated with diabetic retinopathy...
  18. ncbi request reprint Fibronectin overexpression inhibits trabecular meshwork cell monolayer permeability
    An Fei Li
    Department of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Vis 10:750-7. 2004
    ..To study whether excess synthesis of an extracellular matrix (ECM) component, fibronectin (FN), underlying the monolayer of human trabecular meshwork (HTM) cells, influences permeability...
  19. pmc High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function
    Argyrios Chronopoulos
    Departments of Medicine and Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 59:3159-66. 2010
    ..In this study we determined whether altered expression and activity of lysyl oxidase (LOX), a cross-linking enzyme, may compromise vascular basement membrane functional integrity under high-glucose (HG) conditions...
  20. ncbi request reprint SiRNA strategy against overexpression of extracellular matrix in diabetic retinopathy
    Toshiyuki Oshitari
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Exp Eye Res 81:32-7. 2005
    ..SiRNA may be a useful tool in preventing excess vascular permeability, a characteristic feature of early diabetic retinopathy...
  21. pmc High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy
    Kyle Trudeau
    Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston 02118, USA
    Am J Pathol 177:447-55. 2010
    ....
  22. pmc High glucose-induced downregulation of connexin 30.2 promotes retinal vascular lesions: implications for diabetic retinopathy
    Julia Manasson
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Invest Ophthalmol Vis Sci 54:2361-6. 2013
    ..2 (Cx30.2) and influences gap junction intercellular communication (GJIC) in retinal endothelial cells and promotes vascular lesions characteristic of diabetic retinopathy (DR)...
  23. ncbi request reprint Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells
    Tsuyoshi Sato
    Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Diabetes 51:1565-71. 2002
    ..These results indicate that high glucose concentrations inhibited GJIC activity by reducing Cx43 synthesis in RME cells. Impaired intercellular communication may contribute to breakdown of homeostatic balance in diabetic microangiopathy...
  24. ncbi request reprint Diabetes: a potential enhancer of retinal injury in rat retinas
    Toshiyuki Oshitari
    Departments of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Neurosci Lett 390:25-30. 2005
    ..Thus, it is likely that Bax dependent pathways may be activated in injured neuronal cells of the diabetic retinas...
  25. ncbi request reprint Effect of high glucose on fibronectin expression and cell proliferation in trabecular meshwork cells
    Tsuyoshi Sato
    Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Invest Ophthalmol Vis Sci 43:170-5. 2002
    ....

Research Grants8

  1. BASEMENT MEMBRANE THICKENING IN DIABETIC RETINOPATHY
    Sayon Roy; Fiscal Year: 2002
    ..A successful study would provide the critical information that inhibition of excess synthesis of basement membranes prevents background diabetic retinopathy. ..
  2. Thickening of basement membrane in diabetic retinopathy
    Sayon Roy; Fiscal Year: 2007
    ..Findings from this project will establish or exclude a pathogenetic link between a discrete biosynthetic abnormality and the development of structural and functional lesions of diabetic retinopathy. ..
  3. Thickening of basement membrane in diabetic retinopathy
    Sayon Roy; Fiscal Year: 2007
    ..Findings from this project will establish or exclude a pathogenetic link between a discrete biosynthetic abnormality and the development of structural and functional lesions of diabetic retinopathy. ..
  4. Role of intercellular communication in pathogenesis of diabetic retinopathy
    Sayon Roy; Fiscal Year: 2010
    ....