K J Rothman

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint A potential bias in safety evaluation during open-label extensions of randomized clinical trials
    Kenneth J Rothman
    Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Pharmacoepidemiol Drug Saf 13:295-8. 2004
  2. pmc Family history of later-onset breast cancer, breast healthy behavior and invasive breast cancer among postmenopausal women: a cohort study
    Robert Gramling
    Department of Family Medicine, University of Rochester, NY 14620, USA
    Breast Cancer Res 12:R82. 2010
  3. pmc Volitional determinants and age-related decline in fecundability: a general population prospective cohort study in Denmark
    Kenneth J Rothman
    Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Fertil Steril 99:1958-64. 2013
  4. pmc Apgar score and hospitalization for epilepsy in childhood: a registry-based cohort study
    Vera Ehrenstein
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    BMC Public Health 6:23. 2006
  5. pmc Association of Apgar score at five minutes with long-term neurologic disability and cognitive function in a prevalence study of Danish conscripts
    Vera Ehrenstein
    Department of Clinical Epidemiology, Aarhus University Hospital, Science Centre Skejby, Olof Palmes Alle 43 45, 8200 Aarhus N, Denmark
    BMC Pregnancy Childbirth 9:14. 2009
  6. pmc Migraine, fibromyalgia, and depression among people with IBS: a prevalence study
    J Alexander Cole
    Department of Epidemiology, Boston University School of Public Health, Boston MA, USA
    BMC Gastroenterol 6:26. 2006
  7. ncbi request reprint Interaction and evolution in epidemiology
    Kenneth J Rothman
    Department of Epidemiology, Division of Preventive Medicine, Department of Medicine, Boston University School of Medicine, USA
    Soz Praventivmed 49:105-6. 2004
  8. ncbi request reprint Causation and causal inference in epidemiology
    Kenneth J Rothman
    Boston University Medical Center, Boston, MA, USA
    Am J Public Health 95:S144-50. 2005
  9. ncbi request reprint Confounding and effect-measure modification in the evaluation of immunogenic agents
    Kenneth J Rothman
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Eur J Epidemiol 19:205-7. 2004
  10. ncbi request reprint The reporting odds ratio and its advantages over the proportional reporting ratio
    Kenneth J Rothman
    Department of Epidemiology, Boston University Medical Center, 715 Albany Street, MA 02118, USA
    Pharmacoepidemiol Drug Saf 13:519-23. 2004

Detail Information

Publications57

  1. ncbi request reprint A potential bias in safety evaluation during open-label extensions of randomized clinical trials
    Kenneth J Rothman
    Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Pharmacoepidemiol Drug Saf 13:295-8. 2004
    ..To describe a bias that can occur in the analysis of data from certain randomized trials...
  2. pmc Family history of later-onset breast cancer, breast healthy behavior and invasive breast cancer among postmenopausal women: a cohort study
    Robert Gramling
    Department of Family Medicine, University of Rochester, NY 14620, USA
    Breast Cancer Res 12:R82. 2010
    ....
  3. pmc Volitional determinants and age-related decline in fecundability: a general population prospective cohort study in Denmark
    Kenneth J Rothman
    Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Fertil Steril 99:1958-64. 2013
    ..To quantify the natural decline in fecundability by age and assess the effect of selected volitional factors...
  4. pmc Apgar score and hospitalization for epilepsy in childhood: a registry-based cohort study
    Vera Ehrenstein
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    BMC Public Health 6:23. 2006
    ..A depressed Apgar score at 5 minutes is a marker for perinatal insults, including neurologic damage. We examined the association between 5-minute Apgar score and the risk of epilepsy hospitalization in childhood...
  5. pmc Association of Apgar score at five minutes with long-term neurologic disability and cognitive function in a prevalence study of Danish conscripts
    Vera Ehrenstein
    Department of Clinical Epidemiology, Aarhus University Hospital, Science Centre Skejby, Olof Palmes Alle 43 45, 8200 Aarhus N, Denmark
    BMC Pregnancy Childbirth 9:14. 2009
    ..We aimed to examine the association of five-minute Apgar score with prevalence of neurologic disability and with cognitive function in early adulthood...
  6. pmc Migraine, fibromyalgia, and depression among people with IBS: a prevalence study
    J Alexander Cole
    Department of Epidemiology, Boston University School of Public Health, Boston MA, USA
    BMC Gastroenterol 6:26. 2006
    ..Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people with and without IBS...
  7. ncbi request reprint Interaction and evolution in epidemiology
    Kenneth J Rothman
    Department of Epidemiology, Division of Preventive Medicine, Department of Medicine, Boston University School of Medicine, USA
    Soz Praventivmed 49:105-6. 2004
  8. ncbi request reprint Causation and causal inference in epidemiology
    Kenneth J Rothman
    Boston University Medical Center, Boston, MA, USA
    Am J Public Health 95:S144-50. 2005
    ..Causal inference in epidemiology is better viewed as an exercise in measurement of an effect rather than as a criterion-guided process for deciding whether an effect is present or not...
  9. ncbi request reprint Confounding and effect-measure modification in the evaluation of immunogenic agents
    Kenneth J Rothman
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Eur J Epidemiol 19:205-7. 2004
  10. ncbi request reprint The reporting odds ratio and its advantages over the proportional reporting ratio
    Kenneth J Rothman
    Department of Epidemiology, Boston University Medical Center, 715 Albany Street, MA 02118, USA
    Pharmacoepidemiol Drug Saf 13:519-23. 2004
    ..In this paper, we review the problem with the PRR and show how the corresponding odds ratio represents an improvement over the PRR...
  11. ncbi request reprint Should cases with a 'known' cause of their disease be excluded from study? (commentary)
    K J Rothman
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 11:11-4. 2002
    ..If the exclusions from the denominator would be negligibly small or the relative number of excluded cases with 'known' causes is small, then the exclusion of just the cases with 'known' causes will introduce little bias...
  12. pmc Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial results
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S131-42. 2007
    ..The goal of restricting study populations is to make patients more homogeneous regarding potential confounding factors and treatment effects and thereby achieve less biased effect estimates...
  13. ncbi request reprint Relation between serum albumin and carotid atherosclerosis: the NHLBI Family Heart Study
    Luc Djousse
    Evans Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Mass 02118, USA
    Stroke 34:53-7. 2003
    ..Lower concentrations of albumin have been positively related to coronary disease. The aim of this project was to assess the association between serum albumin and carotid atherosclerosis...
  14. pmc An internet-based prospective study of body size and time-to-pregnancy
    Lauren A Wise
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Hum Reprod 25:253-64. 2010
    ..Recent studies have shown that both female and male obesity may delay time-to-pregnancy (TTP). Little is known about central adiposity or weight gain and fecundability in women...
  15. ncbi request reprint Perinatal risk factors for hospitalization for pneumococcal disease in childhood: a population-based cohort study
    Barbara E Mahon
    Department of Epidemiology, T3E, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA
    Pediatrics 119:e804-12. 2007
    ..The objective of this study was to examine the relation of factors that are present at birth to subsequent hospitalization for childhood pneumococcal disease...
  16. pmc A successful implementation of e-epidemiology: the Danish pregnancy planning study 'Snart-Gravid'
    Krista F Huybrechts
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Eur J Epidemiol 25:297-304. 2010
    ..The successful conduct of this pilot study suggests that the internet may be a useful tool to recruit and follow subjects in prospective cohort studies...
  17. ncbi request reprint Postterm delivery and risk for epilepsy in childhood
    Vera Ehrenstein
    Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA
    Pediatrics 119:e554-61. 2007
    ..Postterm delivery is a risk factor for perinatal complications, some of which increase risk for neurologic morbidity. We aimed to examine the association between postterm delivery and risk for epilepsy in childhood...
  18. ncbi request reprint Folate intake and the risk of neural tube defects: an estimation of dose-response
    Lynn L Moore
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Massachusetts 02118, USA
    Epidemiology 14:200-5. 2003
    ..Investigation of the relation between relative dose of supplemental folic acid or total folate intake and NTD risk is limited...
  19. ncbi request reprint Chromosomal anomalies among the offspring of women with gestational diabetes
    Lynn L Moore
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Epidemiol 155:719-24. 2002
    ..These results support the theory that some women who develop gestational diabetes may have underlying biochemical changes that induce nondisjunction and the development of chromosomal defects...
  20. ncbi request reprint Effect of serum albumin and bilirubin on the risk of myocardial infarction (the Framingham Offspring Study)
    Luc Djousse
    The Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Cardiol 91:485-8. 2003
  21. ncbi request reprint Serum albumin and risk of myocardial infarction and all-cause mortality in the Framingham Offspring Study
    Luc Djousse
    Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
    Circulation 106:2919-24. 2002
    ....
  22. ncbi request reprint No excess risk of breast cancer in mothers of boys with hypospadias
    Henrik Toft Sørensen
    Epidemiology 17:706-7. 2006
  23. ncbi request reprint Maternal asthma, preeclampsia and risk of hypospadias
    Henrik Toft Sørensen
    Epidemiology 16:806-7. 2005
  24. pmc Analytic strategies to adjust confounding using exposure propensity scores and disease risk scores: nonsteroidal antiinflammatory drugs and short-term mortality in the elderly
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Epidemiol 161:891-8. 2005
    ..26, 1.68). In this setting, analytic strategies using EPS or disease risk scores were not generally superior to "conventional" models. Various ways to use EPS and disease risk scores behaved differently with smaller study size...
  25. pmc Insights into different results from different causal contrasts in the presence of effect-measure modification
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 15:698-709. 2006
    ..In the presence of effect-measure modification, different analytic approaches produce different summary estimates...
  26. doi request reprint Epidural analgesia and risks of cesarean and operative vaginal deliveries in nulliparous and multiparous women
    Uyen Sa D T Nguyen
    Institute for Aging Research Hebrew SeniorLife, Boston, 02131, MA, USA
    Matern Child Health J 14:705-12. 2010
    ..6, 5.3) in multiparous women. Epidural anesthesia increases the risk for operative vaginal deliveries in both nulliparous and multiparous women, and increases risk for cesarean deliveries in nulliparous more so than in multiparous women...
  27. doi request reprint Loratadine during pregnancy and hypospadias
    Lars Pedersen
    Epidemiology 19:359-60. 2008
  28. pmc Consistent control of mineral and bone disorder in incident hemodialysis patients
    Mark D Danese
    Outcomes Insights, Inc, Newbury Park, California, USA
    Clin J Am Soc Nephrol 3:1423-9. 2008
    ..In 2003, the National Kidney Foundation introduced guidelines for the control of parathyroid hormone, calcium, and phosphorus in hemodialysis patients...
  29. ncbi request reprint Seasonal variation in hospitalization and case fatality of subarachnoid hemorrhage - a nationwide danish study on 9,367 patients
    Thomas Fischer
    Department of Clinical Epidemiology, Aarhus University and Aalborg Hospital, Aalborg Stengade, Denmark
    Neuroepidemiology 24:32-7. 2005
    ..The overall 30-day case fatality rate was 38% and showed less seasonal variation. We found evidence of weak seasonal variation in hospitalization for SAH and almost no seasonal variation in a 30-day case fatality rate after SAH...
  30. pmc Adjustments for unmeasured confounders in pharmacoepidemiologic database studies using external information
    TIL STURMER
    Divisions of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S158-65. 2007
    ..Nonexperimental studies of drug effects in large automated databases can provide timely assessment of real-life drug use, but are prone to confounding by variables that are not contained in these databases and thus cannot be controlled...
  31. pmc Treatment effects in the presence of unmeasured confounding: dealing with observations in the tails of the propensity score distribution--a simulation study
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 172:843-54. 2010
    ..Increasing validity based on PS trimming may be a unique advantage of PS's over conventional outcome models...
  32. doi request reprint Transfers among women intending a birth center delivery in the San Diego birth center study
    Uyen Sa D T Nguyen
    Institute forAging Research, Hebrew SeniorLife, 1200 Centre St, Boston, MA 02131 1097, USA
    J Midwifery Womens Health 54:104-10. 2009
    ..Understanding predictors of transfer may assist practitioners, patients, and policy makers in considering the appropriateness of individuals for birth center delivery or to target further education to reduce nonmedical transfers...
  33. ncbi request reprint Incidence of IBS in a cohort of people with asthma
    J Alexander Cole
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Dig Dis Sci 52:329-35. 2007
    ..0; 95% CI, 0.9-1.1.) Misclassification of IBS would have biased the rate ratio toward the null. We observed a small increase in IBS among people with asthma, and no association between oral steroids and IBS onset among asthma patients...
  34. pmc Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border
    Stacey A Missmer
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:237-41. 2006
    ..These results also call for population studies that can more directly measure individual fumonisin intakes and assess effects on the developing embryo...
  35. ncbi request reprint Prevalence of serious eosinophilia and incidence of Churg-Strauss syndrome in a cohort of asthma patients
    Jeanne E Loughlin
    Ingenix Epidemiology Division, Newton Massachusetts 02466, USA
    Ann Allergy Asthma Immunol 88:319-25. 2002
    ..Some leukotriene receptor antagonists, such as zafirlukast and montelukast, have been associated with systemic eosinophilia, with interest focused on Churg-Strauss syndrome (CSS)...
  36. ncbi request reprint Exploring the relation of alcohol consumption to risk of breast cancer
    R C Ellison
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Epidemiol 154:740-7. 2001
    ..Cohort studies with less than 10 years of follow-up gave estimates 11% higher than cohort studies with longer follow-up periods. No meaningful difference was seen by menopausal status or type of beverage consumed...
  37. pmc Performance of propensity score calibration--a simulation study
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Epidemiol 165:1110-8. 2007
    ..When surrogacy holds, PSC is a useful approach to adjust for unmeasured confounding using validation data...
  38. pmc Subgroup analyses to determine cardiovascular risk associated with nonsteroidal antiinflammatory drugs and coxibs in specific patient groups
    Daniel H Solomon
    Brigham and Women s Hospital, 1620 Tremont Street, Boston, MA 02120, USA
    Arthritis Rheum 59:1097-104. 2008
    ..There is substantial concern regarding the potential cardiovascular adverse effects of selective coxibs and nonselective NSAIDs, but many patients with arthritis experience important clinical benefits from these agents...
  39. pmc A review of the application of propensity score methods yielded increasing use, advantages in specific settings, but not substantially different estimates compared with conventional multivariable methods
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Epidemiol 59:437-47. 2006
    ..Such analyses have been proposed to address confounding by indication, but there is little empirical evidence that they achieve better control than conventional multivariate outcome modeling...
  40. ncbi request reprint Update on unethical use of placebos in randomised trials
    Karin B Michels
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Bioethics 17:188-204. 2003
    ..We suggest that the FDA's arguments defending their practice are insufficient to justify medical research that violates the Declaration of Helsinki...
  41. ncbi request reprint Seasonal variation in hospital discharge diagnosis of atrial fibrillation: a population-based study
    Lars Frost
    Department of Clinical Epidemiology, Aarhus University Hospital and Aalborg Sygehus, Denmark
    Epidemiology 13:211-5. 2002
    ..Cardiovascular events such as acute myocardial infarction and stroke vary seasonally, with a peak incidence during the winter and a trough during the summer. Few data exist on the seasonal variation of atrial fibrillation...
  42. ncbi request reprint Beyond randomized controlled trials: a critical comparison of trials with nonrandomized studies
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Hepatology 44:1075-82. 2006
    ..Observational studies cannot replace trials, nor do trials make observational studies unnecessary. Both designs are susceptible to particular bias, so neither provides perfect information...
  43. ncbi request reprint Short-term mortality of bacteraemia in elderly patients with haematological malignancies
    Mette Nørgaard
    Department of Clinical Epidemiology, Aarhus University Hospitals, Aalborg, Denmark
    Br J Haematol 132:25-31. 2006
    ..3), respectively. We found that increasing age was associated with increased mortality from bacteraemia in patients with haematological malignancies. An increased burden of comorbidity among the elderly did not explain this association...
  44. pmc Thrombosis after travel
    Kenneth J Rothman
    Epidemiology Research, RTI Health Solutions, RTI International, Research Triangle Park, North Carolina, USA
    PLoS Med 3:e300. 2006
  45. ncbi request reprint Seasonal variation in month of birth and diagnosis in children and adolescents with Hodgkin disease and non-Hodgkin lymphoma
    Vivian Langagergaard
    Department of Epidemiology and Social Medicine, University of Aarhus, Aaarhus, Denmark
    J Pediatr Hematol Oncol 25:534-8. 2003
    ....
  46. ncbi request reprint The rise and fall of epidemiology, 1950-2000 A.D. 1981
    Kenneth J Rothman
    Int J Epidemiol 36:708-10. 2007
  47. ncbi request reprint The month of birth does not affect the risk of hypospadias
    Mette Vinther Skriver
    Eur J Epidemiol 19:1135-6. 2004
  48. ncbi request reprint Mortality of cystic fibrosis patients treated with tobramycin solution for inhalation
    Kenneth J Rothman
    Ingenix, Epidemiology Division, Auburndale, MA 02466, USA
    Epidemiology 14:55-9. 2003
    ..Preliminary findings from a randomized trial indicate that patients who received TSI had about half the mortality rate of those assigned to placebo...
  49. pmc Pharmacoepidemiology and "in silico" drug evaluation: is there common ground?
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    J Clin Epidemiol 61:205-6. 2008
  50. pmc Hormone replacement therapy, family history, and breast cancer risk among postmenopausal women
    Robert Gramling
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Epidemiology 20:752-6. 2009
    ..We investigated whether the risk difference for invasive breast cancer attributable to estrogen plus progesterone replacement therapy is greater among women with a first-degree family history of the disease...
  51. pmc Variable selection for propensity score models
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Epidemiol 163:1149-56. 2006
    ..These simulation studies and other analytical results suggest that standard model-building tools designed to create good predictive models of the exposure will not always lead to optimal PS models, particularly in small studies...
  52. pmc Simple estimators of the intensity of seasonal occurrence
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Boston, MA, USA
    BMC Med Res Methodol 8:67. 2008
    ..From this fitted curve, estimates of the seasonal intensity of occurrence (i.e., peak-to-low ratio of the fitted curve) can be generated...
  53. ncbi request reprint My interview with John Snow
    Kenneth J Rothman
    Epidemiology 15:640. 2004
  54. ncbi request reprint Irritable bowel syndrome and hysterectomy: a sequence symmetry analysis
    J Alexander Cole
    Epidemiology 18:837-8. 2007
  55. ncbi request reprint Using prescription claims data for drugs available over-the-counter (OTC)
    Marianne Ulcickas Yood
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Pharmacoepidemiol Drug Saf 16:961-8. 2007
    ..The purpose of this study is to quantify the effect of misclassification of OTC use in research that uses prescription claims data as the sole source of exposure information...
  56. ncbi request reprint Commentary: Epidemiology still ascendant
    Kenneth J Rothman
    RTI Health Solutions, Research Triangle Park, NC 27709, USA
    Int J Epidemiol 36:710-1. 2007
  57. ncbi request reprint Exploring relative mortality and epoetin alfa dose among hemodialysis patients
    Brian D Bradbury
    Department of Biostatistics and Epidemiology, Amgen Inc, Thousand Oaks, CA 91320, USA
    Am J Kidney Dis 51:62-70. 2008
    ..Two recent publications reported that greater epoetin alfa (EPO) doses were associated with increased mortality rates. We assessed whether confounding-by-indication might account for these results...