D L Rosene

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Hippocampal formation lesions produce memory impairment in the rhesus monkey
    L L Beason-Held
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Massachusetts 02118, USA
    Hippocampus 9:562-74. 1999
  2. ncbi request reprint Prenatal protein malnutrition in rats alters the c-Fos response of neurons in the anterior cingulate and medial prefrontal region to behavioral stress
    Douglas L Rosene
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Nutr Neurosci 7:281-9. 2004
  3. ncbi request reprint Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys
    Yu Ming Chang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Cereb Cortex 15:409-18. 2005
  4. pmc Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey
    Michael P Bowley
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 518:3046-64. 2010
  5. ncbi request reprint Effect of prenatal protein malnutrition on numbers of neurons in the principal cell layers of the adult rat hippocampal formation
    James P Lister
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Hippocampus 15:393-403. 2005
  6. pmc An MRI study of age-related white and gray matter volume changes in the rhesus monkey
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, United States
    Neurobiol Aging 29:1563-75. 2008
  7. doi request reprint Neuron numbers in the hypothalamus of the normal aging rhesus monkey: stability across the adult lifespan and between the sexes
    D E Roberts
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02127, USA
    J Comp Neurol 520:1181-97. 2012
  8. ncbi request reprint Organization of direct hippocampal efferent projections to the cerebral cortex of the rhesus monkey: projections from CA1, prosubiculum, and subiculum to the temporal lobe
    G J Blatt
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Massachusetts 02118, USA
    J Comp Neurol 392:92-114. 1998
  9. pmc Methods of MRI-based structural imaging in the aging monkey
    N Makris
    Harvard Medical School Departments of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Methods 50:166-77. 2010
  10. ncbi request reprint Effects of prenatal protein malnutrition and acute postnatal stress on granule cell genesis in the fascia dentata of neonatal and juvenile rats
    Raymond S King
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA
    Brain Res Dev Brain Res 150:9-15. 2004

Research Grants

Detail Information

Publications48

  1. ncbi request reprint Hippocampal formation lesions produce memory impairment in the rhesus monkey
    L L Beason-Held
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Massachusetts 02118, USA
    Hippocampus 9:562-74. 1999
    ..This finding illustrates the importance of the HF in the acquisition and retention of new information...
  2. ncbi request reprint Prenatal protein malnutrition in rats alters the c-Fos response of neurons in the anterior cingulate and medial prefrontal region to behavioral stress
    Douglas L Rosene
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Nutr Neurosci 7:281-9. 2004
    ..These results suggest that neurons in anterior cingulate and medial prefrontal regions respond excessively to restraint stress in prenatally malnourished rats...
  3. ncbi request reprint Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys
    Yu Ming Chang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Cereb Cortex 15:409-18. 2005
    ..These data indicate that an increase in AP firing rate may be responsible, in part, for age-related PFC dysfunction...
  4. pmc Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey
    Michael P Bowley
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 518:3046-64. 2010
    ..These results further demonstrate the important role myelinated nerve fiber degeneration plays in the pathogenesis of age-related cognitive decline...
  5. ncbi request reprint Effect of prenatal protein malnutrition on numbers of neurons in the principal cell layers of the adult rat hippocampal formation
    James P Lister
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Hippocampus 15:393-403. 2005
    ....
  6. pmc An MRI study of age-related white and gray matter volume changes in the rhesus monkey
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, United States
    Neurobiol Aging 29:1563-75. 2008
    ..We found that none of the cognitive measures were related to ROI volume changes in our sample size of monkeys...
  7. doi request reprint Neuron numbers in the hypothalamus of the normal aging rhesus monkey: stability across the adult lifespan and between the sexes
    D E Roberts
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02127, USA
    J Comp Neurol 520:1181-97. 2012
    ..These results demonstrate that hypothalamic neuron loss cannot account for age-related deficits in hypothalamic function and provides further evidence of the absence of neurodegeneration and cell death in the normal aging rhesus monkey...
  8. ncbi request reprint Organization of direct hippocampal efferent projections to the cerebral cortex of the rhesus monkey: projections from CA1, prosubiculum, and subiculum to the temporal lobe
    G J Blatt
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Massachusetts 02118, USA
    J Comp Neurol 392:92-114. 1998
    ..Thus, in the monkey, CA1 is not a single uniform entity and may have a unique role as a source of direct hippocampal projections to the cerebral cortex...
  9. pmc Methods of MRI-based structural imaging in the aging monkey
    N Makris
    Harvard Medical School Departments of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Methods 50:166-77. 2010
    ....
  10. ncbi request reprint Effects of prenatal protein malnutrition and acute postnatal stress on granule cell genesis in the fascia dentata of neonatal and juvenile rats
    Raymond S King
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA
    Brain Res Dev Brain Res 150:9-15. 2004
    ..Thus, the pattern of neurogenesis in the fascia dentata and its response to stress has been fundamentally altered by prenatal protein deprivation...
  11. ncbi request reprint Hypertension-induced changes in monoamine receptors in the prefrontal cortex of rhesus monkeys
    T L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W 701, Boston, MA 02118, USA
    Neuroscience 120:177-89. 2003
    ..While the mechanisms by which untreated hypertension alters DA and NE receptors is not known, the use of this non-human primate model should provide the means to uncover neurobiological changes that occur with untreated hypertension...
  12. ncbi request reprint A non-human primate test of abstraction and set shifting: an automated adaptation of the Wisconsin Card Sorting Test
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W 701 Boston, MA 02118, USA
    J Neurosci Methods 146:165-73. 2005
    ....
  13. ncbi request reprint Light and electron microscopic immunohistochemical detection of bromodeoxyuridine-labeled cells in the brain: different fixation and processing protocols
    Laura B Ngwenya
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    J Histochem Cytochem 53:821-32. 2005
    ..Additionally, we developed a protocol to visualize BrdU-labeled cells in the electron microscope with adequate preservation of fine structure in both rat and monkey brain...
  14. ncbi request reprint Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA
    Behav Brain Res 160:208-21. 2005
    ..Further analysis revealed a significant relationship between monoamine receptor binding and cognitive performance on three tasks: delayed non-matching to sample, delayed recognition span test and the conceptual set-shifting task...
  15. ncbi request reprint Executive system dysfunction occurs as early as middle-age in the rhesus monkey
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W 701, Boston, MA 02118, USA
    Neurobiol Aging 27:1484-93. 2006
    ....
  16. ncbi request reprint Asymmetry of neuron numbers in the hippocampal formation of prenatally malnourished and normally nourished rats: a stereological investigation
    James P Lister
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Hippocampus 16:946-58. 2006
    ..Our findings agree with previous reports of left dominant asymmetries in the rat brain and suggest that this may result from differences in total numbers of neurons...
  17. ncbi request reprint Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: a stereological experiment
    Elizabeth R Whitney
    Department of Anatomy and Neurobiology, L 1004, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Neurosci Methods 168:42-7. 2008
    ..Regardless of the exact cause, these observations suggest that Nissl staining may not be a reliable marker for PCs and that CB is an excellent alternative marker...
  18. ncbi request reprint An ultrastructural characterization of the newly generated cells in the adult monkey dentate gyrus
    Laura B Ngwenya
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Hippocampus 18:210-20. 2008
    ..The results demonstrate that immature neurons, immature astrocytes, and oligodendrocyte progenitor cells can be reliably distinguished by ultrastructural features, without immunohistochemical processing...
  19. pmc Generating a model of the three-dimensional spatial distribution of neurons using density maps
    Luis Cruz
    Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA
    Neuroimage 40:1105-15. 2008
    ....
  20. doi request reprint Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k
    Elizabeth R Whitney
    Department of Anatomy and Neurobiology, L 1004, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Cerebellum 7:406-16. 2008
    ..These data demonstrate that a reduction in cerebellar PCs was not a consistent feature of these autistic brains and that it occurred without discernible correlation between their density and the clinical features or severity of autism...
  21. pmc Density of cerebellar basket and stellate cells in autism: evidence for a late developmental loss of Purkinje cells
    Elizabeth R Whitney
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02218 2526, USA
    J Neurosci Res 87:2245-54. 2009
    ..2008) suggests that PCs were generated, migrated to their proper location in the PC layer, and subsequently died in the autistic cases that showed a reduction in PCs...
  22. doi request reprint Effects on executive function following damage to the prefrontal cortex in the rhesus monkey (Macaca mulatta)
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W 701, Boston, MA 02118, USA
    Behav Neurosci 123:231-41. 2009
    ..Rhesus monkeys with lesions of the dorsolateral PFC were impaired in abstraction, establishing a response pattern to a specific category and maintaining and shifting that response pattern on the category set-shifting task...
  23. doi request reprint Assessment of motor function of the hand in aged rhesus monkeys
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Somatosens Mot Res 27:121-30. 2010
    ..However, the magnitude and extent of impairment in the current study does differ from previous findings and is likely due to methodological differences in the degree of task complexity...
  24. ncbi request reprint Maturational sequence of newly generated neurons in the dentate gyrus of the young adult rhesus monkey
    Laura B Ngwenya
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 498:204-16. 2006
    ....
  25. ncbi request reprint In aging, is it gray or white?
    Alan Peters
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 462:139-43. 2003
  26. ncbi request reprint Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey
    Jennifer I Luebke
    Center for Behavioral Development, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 460:573-84. 2003
    ..Nevertheless, these changes in dendritic morphology, input resistance, and inhibitory signaling properties may be part of a constellation of subtle functional changes contributing to age-associated cognitive impairment...
  27. ncbi request reprint Impairment in abstraction and set shifting in aged rhesus monkeys
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W 701, Boston, MA 02118, USA
    Neurobiol Aging 24:125-34. 2003
    ..The pattern of performance displayed by the aged monkeys suggests an age-related decline in prefrontal cortex (PFC) functioning...
  28. ncbi request reprint Melatonin promotes sleep in three species of diurnal nonhuman primates
    Irina V Zhdanova
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Physiol Behav 75:523-9. 2002
    ....
  29. ncbi request reprint GABAA receptor-mediated neurotransmission in the dentate gyrus of the rhesus monkey: comparison with the rat
    Susan O'Brien
    Center for Behavioral Development, Boston University School of Medicine, 85 E Newton Street, Boston, MA 02118, USA
    Synapse 49:287-9. 2003
  30. ncbi request reprint Parcellation of cortical afferents to three distinct sectors in the parahippocampal gyrus of the rhesus monkey: an anatomical and neurophysiological study
    Gene J Blatt
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 466:161-79. 2003
    ....
  31. ncbi request reprint Impairment of executive function induced by hypertension in the rhesus monkey (Macaca mulatta)
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Massachusetts 02118, USA
    Behav Neurosci 116:387-96. 2002
    ..Although the neural basis of this impairment is unclear, evidence from studies with humans and monkeys suggests that the prefrontal cortex may be the locus for this effect of hypertension...
  32. ncbi request reprint A statistically based density map method for identification and quantification of regional differences in microcolumnarity in the monkey brain
    Luis Cruz
    Department of Physics, Center for Polymer Studies, Boston University, 590 Commonwealth Ave, Boston, MA 02215, USA
    J Neurosci Methods 141:321-32. 2005
    ....
  33. pmc Age-related reduction in microcolumnar structure in area 46 of the rhesus monkey correlates with behavioral decline
    Luis Cruz
    Center for Polymer Studies and Department of Physics, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:15846-51. 2004
    ..Therefore, quantitative measurement of microcolumnar structure may provide a sensitive morphological method to assay microcolumnar function in aging and other conditions...
  34. ncbi request reprint Serum amyloid A is present in the capillaries and microinfarcts of hypertensive monkey brain: an immunohistochemical study
    E Bartolak-Suki
    Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA
    Amyloid 7:111-7. 2000
    ..These findings suggest that high blood pressure in the brain can result in either local production of A-apoSAA in the capillaries and within microinfarcts or uptake of A-apoSAA from the blood..
  35. ncbi request reprint Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex
    J I Luebke
    Center for Behavioral Development, Department of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA
    Neuroscience 125:277-88. 2004
    ..The observed change in excitatory-inhibitory synaptic balance likely leads to significantly altered signaling properties of layer 2/3 pyramidal cells in the PFC with age...
  36. doi request reprint Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta
    I V Zhdanova
    Laboratory of Sleep and Circadian Physiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany St R 913, Boston, MA 02118 2394, USA
    J Biol Rhythms 26:149-59. 2011
    ....
  37. ncbi request reprint Motor projections to the basis pontis in rhesus monkey
    Jeremy D Schmahmann
    Department of Neurology VBK 915, Massachusetts General Hospital and Harvard Medical School, Fruit Street, Boston, Massachusetts 02114, USA
    J Comp Neurol 478:248-68. 2004
    ....
  38. ncbi request reprint Increased density of hippocampal kainate receptors but normal density of NMDA and AMPA receptors in a rat model of prenatal protein malnutrition
    Todd A Fiacco
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 456:350-60. 2003
    ....
  39. pmc Automated identification of neurons and their locations
    A Inglis
    Center for Polymer Studies, Department of Physics, Boston University, Boston, MA 02215, USA
    J Microsc 230:339-52. 2008
    ....
  40. ncbi request reprint Age-related molecular reorganization at the node of Ranvier
    Jason D Hinman
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 495:351-62. 2006
    ..Thus, age-dependent myelin alterations affect axonal protein localization and may be detrimental to maintenance of axonal conduction...
  41. pmc A rhesus monkey reference label atlas for template driven segmentation
    Jonathan J Wisco
    Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    J Med Primatol 37:250-60. 2008
    ..To analyze these legacy data for regional volume changes, we have created a reference label atlas for the Template Driven Segmentation (TDS) algorithm...
  42. ncbi request reprint Birthdates and number of neurons in the serotonergic raphe nuclei in the rat with prenatal protein malnutrition
    R S King
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 80 E, Concord Street, Boston, MA 02118, USA
    Nutr Neurosci 5:391-7. 2002
    ....
  43. ncbi request reprint Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey
    James A Duce
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Glia 56:106-17. 2008
    ..In conclusion, the overall changes described in this study could provide an explanation for aging changes in white matter that might be initiated or enhanced by an altered expression of life span associated genes such as Klotho...
  44. ncbi request reprint Ataxia after pontine stroke: insights from pontocerebellar fibers in monkey
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Ann Neurol 55:585-9. 2004
    ....
  45. ncbi request reprint MRI-guided focused ultrasound surgery in the brain: tests in a primate model
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Magn Reson Med 49:1188-91. 2003
    ..The capabilities demonstrated in this study will be of benefit for clinical ultrasound therapies in the brain...
  46. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007
    ..To our knowledge this is the first investigation reporting such alterations in the aging monkey...
  47. ncbi request reprint Sex, age, and training modulate spatial memory in the rhesus monkey (Macaca mulatta)
    AGNES LACREUSE
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, 30322 USA
    Behav Neurosci 119:118-26. 2005
    ..The results confirm a male advantage in spatial working memory at a young age and confirm a greater decline with age in males than in females. It is important to note that prior training completely reverses the deficits of young females...
  48. pmc Beta-secretase activity increases with aging in human, monkey, and mouse brain
    Hiroaki Fukumoto
    Department of Neurology, Alzheimer Disease Research Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    Am J Pathol 164:719-25. 2004
    ..These data suggest that an age-related increase of BACE activity contributes to the increased production and accumulation of brain A beta, and potentially predisposes to Alzheimer's disease in humans...

Research Grants3

  1. NEURAL SUBSTRATES OF COGNITIVE DECLINE IN AGING MONKEYS
    DOUGLAS ROSENE; Fiscal Year: 2007
    ..Finally, the core will also provide statistical support for all of the Cores and Projects and will maintain the Archival Program Database of Program Project Data. ..