Daniel Remick

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model
    Dominic R Beal
    Boston Univ School of Medicine, 670 Albany St, Rm 405, Boston, MA 02118
    Am J Physiol Lung Cell Mol Physiol 305:L866-77. 2013
  2. pmc Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study
    Louis J Vaickus
    Boston University School of Medicine, Department of Pathology and Laboratory Medicine, Boston, MA, USA
    Respir Res 11:160. 2010
  3. pmc Reducing LPS content in cockroach allergens increases pulmonary cytokine production without increasing inflammation: a randomized laboratory study
    Sudha Natarajan
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 670 Albany Street, 720 Harisson Avenue, Boston, MA 02118, USA
    BMC Pulm Med 11:12. 2011
  4. pmc Pathophysiology of sepsis
    Daniel G Remick
    Boston University School of Medicine, Boston, MA, USA
    Am J Pathol 170:1435-44. 2007
  5. ncbi request reprint Mechanisms of oxidant regulation of monocyte chemotactic protein 1 production in human whole blood and isolated mononuclear cells
    Liyu Xing
    Department of Pathology, University of Michigan, Medical School Ann Arbor, Ann Arbor, MI, USA
    Shock 28:178-85. 2007
  6. pmc The pathogenesis of sepsis
    Deborah J Stearns-Kurosawa
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Massachusetts 02218, USA
    Annu Rev Pathol 6:19-48. 2011
  7. pmc The ELISA Standard Save: calculation of sample concentrations in assays with a failed standard curve
    Sudha Natarajan
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, United States
    J Immunol Methods 336:242-5. 2008
  8. ncbi request reprint Selective macrophage suppression during sepsis
    Ekram Ellaban
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Cell Immunol 231:103-11. 2004
  9. ncbi request reprint Acute pancreatitis: models, markers, and mediators
    Jill Granger
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    Shock 24:45-51. 2005
  10. pmc Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis
    Marcin F Osuchowski
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA
    Crit Care Med 37:1567-73. 2009

Research Grants

  1. Regulation of IL-8 Gene Expression
    Daniel Remick; Fiscal Year: 2003
  2. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 2004
  3. Regulation of IL-8 Gene Expression
    Daniel Remick; Fiscal Year: 2004
  4. Regulation of Ongoing Inflammation
    Daniel Remick; Fiscal Year: 2006
  5. Regulation of Ongoing Inflammation
    Daniel Remick; Fiscal Year: 2007
  6. Endotoxin, allergens and pollutants in asthma
    Daniel Remick; Fiscal Year: 2007
  7. Regulation of Ongoing Inflammation
    Daniel Remick; Fiscal Year: 2006
  8. Endotoxin, allergens and pollutants in asthma
    Daniel Remick; Fiscal Year: 2006
  9. Immunopathology of Sepsis
    Daniel Remick; Fiscal Year: 2007
  10. Regulation of Ongoing Inflammation
    Daniel Remick; Fiscal Year: 2009

Collaborators

  • Sudha Natarajan
  • G L Su
  • Jean A Nemzek
  • Jiyoun Kim
  • Lars Steinstraesser
  • Marcus Lehnhardt
  • Shinichiro Kurosawa
  • Jill Granger
  • Huan Yang
  • Peter Ward
  • Robert Gyurko
  • R M Strieter
  • Liyu Xing
  • Marcin F Osuchowski
  • Javed Siddiqui
  • Hongyan Xiao
  • Kyros Ipaktchi
  • Dominic R Beal
  • Stewart C Wang
  • Evan L Chiswick
  • Deborah J Stearns-Kurosawa
  • Louis J Vaickus
  • Devin L Horton
  • Shyam Biswal
  • Kathy Welch
  • Aladdein Mattar
  • Mark R Hemmila
  • Andreas D Niederbichler
  • Laszlo M Hoesel
  • Saman Arbabi
  • Asit K De
  • Philip O Scumpia
  • Tarek El-Sawy
  • Lyle L Moldawer
  • Shannon Copeland
  • Ekram Ellaban
  • Paul R Knight
  • Xiaokun Zeng
  • Ming Hui Fan
  • David M Stepien
  • Elizabeth Duffy
  • Brian Japp
  • Catherine Valentine
  • Elizabeth Schuller
  • Florin L Craciun
  • Jacqueline Bouchard
  • Corneliu Sima
  • Judith Connett
  • Kathleen Welch
  • James Teener
  • Sabrina Vollmannshauser
  • Steve E Calvano
  • Michael J Clare-Salzler
  • Priscilla F McAuliffe
  • Ricardo Ungaro
  • Kerri A O'Malley
  • John A Belperio
  • Carol L Miller-Graziano
  • Robert L Fairchild
  • Natasa Rajicic
  • Stephen F Lowry
  • Takefumi Uchida
  • David Schoenfeld
  • Tadashi Matsumoto
  • Krzysztof Laudanski
  • Philip A Efron
  • Ronald G Tompkins
  • Richard Kovics
  • Arun Sreekumar
  • Van Jackson
  • Bharathi Laxman
  • Gerry Bolgos
  • Arul Chinnaiyan
  • Xian Wang
  • Jing Dai
  • Richard D Klein
  • Andrew C Merry

Detail Information

Publications51

  1. pmc Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model
    Dominic R Beal
    Boston Univ School of Medicine, 670 Albany St, Rm 405, Boston, MA 02118
    Am J Physiol Lung Cell Mol Physiol 305:L866-77. 2013
    ..These data demonstrate that transfer of naïve macrophages will reduce some aspects of asthma-like pulmonary inflammation in response to CRA...
  2. pmc Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study
    Louis J Vaickus
    Boston University School of Medicine, Department of Pathology and Laboratory Medicine, Boston, MA, USA
    Respir Res 11:160. 2010
    ..In this study we endeavored to induce oral tolerance to cockroach allergen (CRA: a complex mixture of insect components) in order to ameliorate asthma-like, allergic pulmonary inflammation...
  3. pmc Reducing LPS content in cockroach allergens increases pulmonary cytokine production without increasing inflammation: a randomized laboratory study
    Sudha Natarajan
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 670 Albany Street, 720 Harisson Avenue, Boston, MA 02118, USA
    BMC Pulm Med 11:12. 2011
    ....
  4. pmc Pathophysiology of sepsis
    Daniel G Remick
    Boston University School of Medicine, Boston, MA, USA
    Am J Pathol 170:1435-44. 2007
    ..This review will briefly discuss many of the important alterations that account for the pathophysiology of sepsis...
  5. ncbi request reprint Mechanisms of oxidant regulation of monocyte chemotactic protein 1 production in human whole blood and isolated mononuclear cells
    Liyu Xing
    Department of Pathology, University of Michigan, Medical School Ann Arbor, Ann Arbor, MI, USA
    Shock 28:178-85. 2007
    ..These results provide evidence that in whole blood and PBMCs, DMSO regulates MCP-1 gene expression by decreasing the induction of MCP-1 mRNA...
  6. pmc The pathogenesis of sepsis
    Deborah J Stearns-Kurosawa
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Massachusetts 02218, USA
    Annu Rev Pathol 6:19-48. 2011
    ..Biomarkers may be used to help diagnose patients with sepsis, and they may also help to identify patients who would benefit from immunomodulatory therapies...
  7. pmc The ELISA Standard Save: calculation of sample concentrations in assays with a failed standard curve
    Sudha Natarajan
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, United States
    J Immunol Methods 336:242-5. 2008
    ..98-0.99 and slopes ranging from 0.97-1.10. In this manner, data for these samples are preserved, saving the investigator the time and money involved in repeating experiments...
  8. ncbi request reprint Selective macrophage suppression during sepsis
    Ekram Ellaban
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Cell Immunol 231:103-11. 2004
    ..Our results indicate that macrophages are not immunoparalyzed during sepsis and may still be induced to secrete some inflammatory mediators...
  9. ncbi request reprint Acute pancreatitis: models, markers, and mediators
    Jill Granger
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    Shock 24:45-51. 2005
    ..Understanding the models, documenting the markers, and deciphering the mediators have the potential to improve treatment of acute pancreatitis...
  10. pmc Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis
    Marcin F Osuchowski
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA
    Crit Care Med 37:1567-73. 2009
    ..This study examined the effectiveness of prospective stratification to identify and target high-dose glucocorticoid therapy for subjects developing lethal sepsis...
  11. doi request reprint Detection and quantification of cytokines and other biomarkers
    Evan L Chiswick
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA
    Methods Mol Biol 844:15-30. 2012
    ..Finally, the concept of a multiplex ELISA is discussed with considerations given to cost and additional time required for development...
  12. pmc Noninvasive model of sciatic nerve conduction in healthy and septic mice: reliability and normative data
    Marcin F Osuchowski
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Muscle Nerve 40:610-6. 2009
    ..This study provides a new tool for the assessment of peripheral nerve/muscle function in mouse neuromuscular disease models that require repeated, long-term, and minimally invasive monitoring...
  13. ncbi request reprint Chronic sepsis mortality characterized by an individualized inflammatory response
    Marcin F Osuchowski
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 179:623-30. 2007
    ..The pattern of late prelethal responses suggest that the systemic inflammatory response syndrome to compensatory anti-inflammatory response syndrome transition paradigm fails to follow a simple linear pattern...
  14. ncbi request reprint Evaluation of endotoxin models for the study of sepsis
    Daniel G Remick
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    Shock 24:7-11. 2005
    ..Compounds that have been shown to be effective at reducing mortality in endotoxin models should be re-evaluated in more clinically relevant models of sepsis...
  15. ncbi request reprint Cytokine therapeutics for the treatment of sepsis: why has nothing worked?
    Daniel G Remick
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 6476, USA
    Curr Pharm Des 9:75-82. 2003
    ..As patients move through different phases of the septic response, there may be intervals when it is appropriate to inhibit multiple cytokines while at other times it may be appropriate to augment the immune response...
  16. ncbi request reprint Sequential ELISA to profile multiple cytokines from small volumes
    Marcin F Osuchowski
    Department of Pathology, University of Michigan, 1301 Catherine Road, Ann Arbor, Michigan 48109, USA
    J Immunol Methods 302:172-81. 2005
    ..Given the simplistic validation procedure, the proposed sequential ELISA protocol has a wide potential for further modifications to include other inflammation-related targets...
  17. ncbi request reprint The repetitive use of samples to measure multiple cytokines: the sequential ELISA
    Marcin F Osuchowski
    Department of Pathology, University of Michigan, Ann Arbor, 48109, USA
    Methods 38:304-11. 2006
    ..Additionally, any laboratory that currently runs traditional ELISAs has all the necessary equipment and reagents to perform the sequential ELISA...
  18. ncbi request reprint Albumin depletion of human plasma also removes low abundance proteins including the cytokines
    Jill Granger
    Department of Pathology, University of Michigan, 2210 Medical Science I Building, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Proteomics 5:4713-8. 2005
    ..These data demonstrate that there may be a non-specific loss of cytokines following albumin depletion, which may confound subsequent proteomic analysis...
  19. pmc Burn wounds infected with Pseudomonas aeruginosa triggers weight loss in rats
    Lars Steinstraesser
    Dept of Surgery, University of Michigan, Ann Arbor, MI 48109 0666, USA
    BMC Surg 5:19. 2005
    ..The aim of this study was to shed light on the impact of acute burn injury with or without infection on cytokine profiles...
  20. ncbi request reprint Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality
    Marcin F Osuchowski
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 177:1967-74. 2006
    ..This multifaceted response questions the use of a simple proinflammatory cytokine measurement for classifying the inflammatory status during sepsis...
  21. pmc Mechanisms of mortality in early and late sepsis
    Hongyan Xiao
    Department of Pathology, University of Michigan, 2210 Medical Science I Building, 1301 Catherine Road, Ann Arbor, MI 48109 0602, USA
    Infect Immun 74:5227-35. 2006
    ..Determining the inflammatory status of individual patients may help guide appropriate, targeted therapy...
  22. ncbi request reprint Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injury
    Kyros Ipaktchi
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 177:8065-71. 2006
    ..Attenuating local inflammatory signaling appears effective in reducing SIRS and subsequent systemic complications after burn injury...
  23. pmc Untreated type 1 diabetes increases sepsis-induced mortality without inducing a prelethal cytokine response
    Marcin F Osuchowski
    Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Shock 34:369-76. 2010
    ..These data demonstrate that untreated type I diabetes mellitus severely exacerbates sepsis mortality without inducing a prelethal release of systemic proinflammatory or anti-inflammatory cytokines...
  24. pmc Chronic pulmonary LPS tolerance induces selective immunosuppression while maintaining the neutrophilic response
    Sudha Natarajan
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Shock 33:162-9. 2010
    ..This unrestricted neutrophil recruitment may represent a mechanism by which individuals may be protected from pulmonary bacterial infection and pneumonia...
  25. ncbi request reprint Promoter elements responsible for antioxidant regulation of MCP-1 gene expression
    Liyu Xing
    Department of Pathology University of Michigan, Medical School, Ann Arbor, Michigan 48109, USA
    Antioxid Redox Signal 9:1979-89. 2007
    ..In conclusion, DMSO inhibits MCP-1 gene expression through both NF-kappaB binding sites located far upstream of the 5'-flanking region of the MCP-1 promoter...
  26. ncbi request reprint Hypothermia and sepsis
    Daniel G Remick
    Department of Pathology, University of Michigan, M2210 Medical Science I, Ann Arbor, Michigan 48109 060, USA
    Front Biosci 11:1006-13. 2006
    ..Understanding the mechanisms of why the host response to infection is impaired by pre-existing hypothermia will both improve our basic understanding of disease as well as identify potential targets for modulation...
  27. ncbi request reprint Neutrophils as firemen, production of anti-inflammatory mediators by neutrophils in a mixed cell environment
    Liyu Xing
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Cell Immunol 231:126-32. 2004
    ..The neutrophils may be compared to firemen who bring the resources necessary to put out the flame of acute inflammation...
  28. ncbi request reprint Inflammatory status in sepsis alters efficacy of interleukin-18 binding protein therapy
    Daniel G Remick
    Department of Pathology, University of Michigan, Ann Arbor, 48109 0602, USA
    Crit Care Med 31:2096-101. 2003
    ..Interleukin-18 has been demonstrated to be an important component of the innate immune response to bacterial infections...
  29. ncbi request reprint Relative cytokine and cytokine inhibitor production by mononuclear cells and neutrophils
    Liyu Xing
    Department of Pathology, University of Michigan Medical School, Medical Science Building 1, 1301 Catherine Road, Ann Arbor, MI 48105, USA
    Shock 20:10-6. 2003
    ..8% and 15.4% of those of PBMCs, respectively. These data show that a highly purified population of PMNs makes a relatively minor to nonexistent contribution to the production of proinflammatory cytokines...
  30. ncbi request reprint Improved sensitivity of colorimetric compared to chemiluminescence ELISAs for cytokine assays
    Javed Siddiqui
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    J Immunoassay Immunochem 24:273-83. 2003
    ..5 pg/ML which was better than any of the CMIL substrates. Our data demonstrate the COL assays have the same or better sensitivity than CMIL and are significantly less expensive...
  31. ncbi request reprint Mechanisms of dimethyl sulfoxide augmentation of IL-1 beta production
    Liyu Xing
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    J Immunol 174:6195-202. 2005
    ..These data indicate that DMSO directly increases LPS-stimulated IL-1beta protein production through the mechanisms of augmenting promoter activity and increasing mRNA levels...
  32. pmc Acute pulmonary lipopolysaccharide tolerance decreases TNF-alpha without reducing neutrophil recruitment
    Sudha Natarajan
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 181:8402-8. 2008
    ..This response may be a mechanism to limit tissue damage by reducing TNF-alpha levels, while still maintaining the antimicrobial capacity of the lung...
  33. ncbi request reprint Effects of platelet inhibitors on propyl gallate-induced platelet aggregation, protein tyrosine phosphorylation, and platelet factor 3 activation
    Hongyan Xiao
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Blood Coagul Fibrinolysis 15:199-206. 2004
    ..PG is unique in its ability to stimulate platelet aggregation and coagulation simultaneously, and platelet inhibitors in this study affect only platelet aggregation but not platelet coagulation...
  34. ncbi request reprint Humane endpoints in shock research
    Jean A Nemzek
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Shock 21:17-25. 2004
    ..Equipped with the basic principles of humane endpoints, investigators can make informed decisions that meet current standards of animal care while still achieving the scientific goals of their research studies...
  35. pmc Delayed addition of glucocorticoids selectively suppresses cytokine production in stimulated human whole blood
    Devin L Horton
    University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Vaccine Immunol 17:979-85. 2010
    ..Our results show that cytokines which typically increase in concentration between 6 and 24 h after stimulation were significantly suppressed by the addition of DEX 6 h after stimulation...
  36. ncbi request reprint Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days
    Daniel G Remick
    Department of Pathology, University of Michigan, Ann Arbor 48109 0602, USA
    Shock 17:463-7. 2002
    ..This measurement may be determined quickly so that therapy may be targeted only to those individuals at significant risk of dying and initiated within sufficient time to be effective...
  37. ncbi request reprint An essential role for lipopolysaccharide-binding protein in pulmonary innate immune responses
    Ming Hui Fan
    Department of General Surgery, University of Michigan, Ann Arbor 48109, USA
    Shock 18:248-54. 2002
    ..Together, our findings suggest that LBP is essential in local pulmonary innate immune responses against bacteria...
  38. ncbi request reprint What's new in Shock, July 2008?
    Daniel G Remick
    Boston University School of Medicine, Boston, Massachusetts, USA
    Shock 30:1-2. 2008
  39. ncbi request reprint Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice
    Grace L Su
    Medical Service, Department of Veterans Affairs Medical Center and the Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Hepatology 41:187-95. 2005
    ..This suggests a novel role for LBP in modulating acetaminophen-induced liver injury. Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/O270-9139/suppmat/index.html)...
  40. ncbi request reprint What's new in Shock, May 2008?
    Daniel G Remick
    Boston University School of Medicine, Boston, Massachusetts, USA
    Shock 29:541-2. 2008
  41. ncbi request reprint Correction of perioperative hypothermia decreases experimental sepsis mortality by modulating the inflammatory response
    Hongyan Xiao
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Crit Care Med 33:161-7. 2005
    ..The objective of this study was to investigate if the correction of perioperative hypothermia improves sepsis survival...
  42. ncbi request reprint Topical p38MAPK inhibition reduces dermal inflammation and epithelial apoptosis in burn wounds
    Kyros Ipaktchi
    Department of Surgery, Burn Center, University of Michigan Medical School, Ann Arbor, MI 48109 0033, USA
    Shock 26:201-9. 2006
    ..Blunting early excessive inflammatory signaling may be an efficient strategy to improve patient outcomes after burn injury...
  43. pmc Role of interleukin-6 in mortality from and physiologic response to sepsis
    Daniel G Remick
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    Infect Immun 73:2751-7. 2005
    ..These data demonstrate that IL-6 serves as a marker of disease severity in sepsis and does modulate some physiologic responses, but complete lack of IL-6 does not does not alter mortality due to sepsis...
  44. ncbi request reprint Tumor necrosis factor inhibitors for the treatment of asthma
    Jiyoun Kim
    Department of Surgery, University of Michigan School of Medicine, 2120 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0344, USA
    Curr Allergy Asthma Rep 7:151-6. 2007
    ..In this review, we address the multipotential role of TNF-alpha in asthma and the efficacy and safety of TNF-alpha blocking agents in asthma...
  45. ncbi request reprint Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation
    Asit K De
    Department of Surgery, University of Rochester Medical Center, Rochester, NY 14627, USA
    J Immunol 175:6155-62. 2005
    ..The data indicate selective activation among Th1 subpopulations, as well as differential Th1/Th2 activation, which is consistent with a selective induction of Th1 and Th2 chemokine ligands...
  46. ncbi request reprint CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis
    Philip O Scumpia
    Department of Surgery, University of Florida, Gainesville 32610 0221, USA
    J Immunol 175:3282-6. 2005
    ..05). These data confirm that DCs are essential in the septic response and suggest that strategies to maintain DC numbers or function may improve outcome...
  47. ncbi request reprint Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes
    Xiaokun Zeng
    Institute of Vascular Medicine, Peking University Third Hospital, Beijing, People s Republic of China
    Circ Res 93:311-20. 2003
    ..Thus, activation of PPARgamma may become a therapeutic target for preventing Hcy-induced proatherogenic effects...
  48. ncbi request reprint Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection
    Tarek El-Sawy
    Department of Immunology, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circulation 112:320-31. 2005
    ..The impact of early PMN infiltration on allograft rejection compared with long-term graft survival remains poorly understood...
  49. ncbi request reprint Development of a sensitive microarray immunoassay and comparison with standard enzyme-linked immunoassay for cytokine analysis
    Paul R Knight
    Department of Anesthesiology, SUNY at Buffalo, Buffalo, New York, USA
    Shock 21:26-30. 2004
    ..These results describe the development of a sensitive, specific and cost-effective multiplexed microarray immunoassay that produces values similar to traditional ELISAs...
  50. pmc Sepsis: redox mechanisms and therapeutic opportunities
    Shyam Biswal
    Antioxid Redox Signal 9:1959-61. 2007
  51. ncbi request reprint Methods for analyzing cytokines
    Daniel G Remick
    Methods 38:235-6. 2006

Research Grants34

  1. Regulation of IL-8 Gene Expression
    Daniel Remick; Fiscal Year: 2003
    ..Successful completion of our specific aims will provide substantial insight into the regulation of chemokine gene expression and improve our understanding of basic mechanisms of disease. ..
  2. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 2004
    ..Successful completion of our studies will provide the basic knowledge about the inflammatory response in sepsis, knowledge needed to reduce the impact of sepsis. ..
  3. Regulation of IL-8 Gene Expression
    Daniel Remick; Fiscal Year: 2004
    ..Successful completion of our specific aims will provide substantial insight into the regulation of chemokine gene expression and improve our understanding of basic mechanisms of disease. ..
  4. Regulation of Ongoing Inflammation
    Daniel Remick; Fiscal Year: 2006
    ..Successful completion of each of these specific aims will help to determine both the optimal method to regulate ongoing inflammation and the precise mechanisms of how this regulation occurs. ..
  5. Regulation of Ongoing Inflammation
    Daniel Remick; Fiscal Year: 2007
    ..Successful completion of each of these specific aims will help to determine both the optimal method to regulate ongoing inflammation and the precise mechanisms of how this regulation occurs. ..
  6. Endotoxin, allergens and pollutants in asthma
    Daniel Remick; Fiscal Year: 2007
    ..We will also investigate if a new drug approved for the treatment of rheumatoid arthritis will also help prevent asthma. ..
  7. Regulation of Ongoing Inflammation
    Daniel Remick; Fiscal Year: 2006
    ..Successful completion of each of these specific aims will help to determine both the optimal method to regulate ongoing inflammation and the precise mechanisms of how this regulation occurs. ..
  8. Endotoxin, allergens and pollutants in asthma
    Daniel Remick; Fiscal Year: 2006
    ..We will also investigate if a new drug approved for the treatment of rheumatoid arthritis will also help prevent asthma. ..
  9. Immunopathology of Sepsis
    Daniel Remick; Fiscal Year: 2007
    ..Successful completion our goals will define both basic mechanisms of disease and potential targets for therapeutic intervention. ..
  10. Regulation of Ongoing Inflammation
    Daniel Remick; Fiscal Year: 2009
    ..Successful completion of each of these specific aims will help to determine both the optimal method to regulate ongoing inflammation and the precise mechanisms of how this regulation occurs. ..
  11. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 2009
    ..It is not clear why these patients die, or the best method to treat the patients. We will use an animal model to help us understand how bacteria kill patients and how to prevent this. ..
  12. Endotoxin, allergens and pollutants in asthma
    Daniel Remick; Fiscal Year: 2009
    ..We will also investigate if a new drug approved for the treatment of rheumatoid arthritis will also help prevent asthma. ..
  13. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel G Remick; Fiscal Year: 2010
    ..It is not clear why these patients die, or the best method to treat the patients. We will use an animal model to help us understand how bacteria kill patients and how to prevent this. ..
  14. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 2003
    ..Successful completion of our studies will provide the basic knowledge about the inflammatory response in sepsis, knowledge needed to reduce the impact of sepsis. ..
  15. Regulation of IL-8 Gene Expression
    Daniel Remick; Fiscal Year: 2002
    ..Successful completion of our specific aims will provide substantial insight into the regulation of chemokine gene expression and improve our understanding of basic mechanisms of disease. ..
  16. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 1990
    ..A clearer understanding of the basic events will allow the development and testing of more targeted, potentially clinically relevant therapies...
  17. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 1991
    ..A clearer understanding of the basic events will allow the development and testing of more targeted, potentially clinically relevant therapies...
  18. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 1992
    ..A clearer understanding of the basic events will allow the development and testing of more targeted, potentially clinically relevant therapies...
  19. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 1993
    ..A clearer understanding of the basic events will allow the development and testing of more targeted, potentially clinically relevant therapies...
  20. CYTOKINES AND SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 1999
    ..The results of these experiments will then be used to design combination therapies in human clinical trials. ..
  21. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 2001
    ..Successful completion of our studies will provide the basic knowledge about the inflammatory response in sepsis, knowledge needed to reduce the impact of sepsis. ..
  22. Regulation of IL-8 Gene Expression
    Daniel Remick; Fiscal Year: 2001
    ..Successful completion of our specific aims will provide substantial insight into the regulation of chemokine gene expression and improve our understanding of basic mechanisms of disease. ..
  23. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 2002
    ..Successful completion of our studies will provide the basic knowledge about the inflammatory response in sepsis, knowledge needed to reduce the impact of sepsis. ..
  24. Endotoxin, allergens and pollutants in asthma
    Daniel G Remick; Fiscal Year: 2010
    ..We will also investigate if a new drug approved for the treatment of rheumatoid arthritis will also help prevent asthma. ..