Rahul Ray

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Effect of dietary vitamin D and calcium on the growth of androgen-insensitive human prostate tumor in a murine model
    Rahul Ray
    Department of Medicine, Boston University School of Medicine, 85 East Newton Street, M 1002, Boston, MA 02118, USA
    Anticancer Res 32:727-31. 2012
  2. pmc 1α,25-Dihydroxyvitamin D3-3β-bromoacetate, a potential cancer therapeutic agent: synthesis and molecular mechanism of action
    Rahul Ray
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Bioorg Med Chem Lett 21:2537-40. 2011
  3. ncbi request reprint Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells
    Narasimha Swamy
    Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Clin Cancer Res 10:8018-27. 2004
  4. ncbi request reprint 1alpha,25-Dihydroxyvitamin D3-3beta-(2)-bromoacetate, an affinity labeling derivative of 1alpha,25-dihydroxyvitamin D3 displays strong antiproliferative and cytotoxic behavior in prostate cancer cells
    Narasimha Swamy
    Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    J Cell Biochem 89:909-16. 2003
  5. pmc Covalent labeling of nuclear vitamin D receptor with affinity labeling reagents containing a cross-linking probe at three different positions of the parent ligand: structural and biochemical implications
    Taner Kaya
    Boston University, Boston, MA 02215, USA
    Bioorg Chem 37:57-63. 2009
  6. ncbi request reprint Photodynamic cell-kill analysis of breast tumor cells with a tamoxifen-pyropheophorbide conjugate
    Ana Fernandez Gacio
    Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 99:665-70. 2006
  7. ncbi request reprint Nuclear estrogen receptor targeted photodynamic therapy: selective uptake and killing of MCF-7 breast cancer cells by a C17alpha-alkynylestradiol-porphyrin conjugate
    Narasimha Swamy
    Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 99:966-77. 2006
  8. pmc A vitamin D receptor-alkylating derivative of 1α,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth
    James R Lambert
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Cancer Prev Res (Phila) 3:1596-607. 2010
  9. ncbi request reprint Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution
    James F Head
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochemistry 41:9015-20. 2002
  10. doi request reprint Internalization of a C17α-alkynylestradiol-porphyrin conjugate into estrogen receptor positive MCF-7 breast cancer cells
    Sara Sadler
    Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA
    Bioorg Med Chem Lett 21:4638-41. 2011

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Effect of dietary vitamin D and calcium on the growth of androgen-insensitive human prostate tumor in a murine model
    Rahul Ray
    Department of Medicine, Boston University School of Medicine, 85 East Newton Street, M 1002, Boston, MA 02118, USA
    Anticancer Res 32:727-31. 2012
    ..Our results suggest an important role of dietary vitamin D as a preventive agent in androgen-insensitive PC...
  2. pmc 1α,25-Dihydroxyvitamin D3-3β-bromoacetate, a potential cancer therapeutic agent: synthesis and molecular mechanism of action
    Rahul Ray
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Bioorg Med Chem Lett 21:2537-40. 2011
    ..We also report that mechanism of action of 1,25(OH)(2)D(3)-3-BE may involve reduction of its catabolism, as evidenced by the reduced and delayed expression of 1α,25-dihydroxyvitamin D(3)-24-hydroxylase (CYP24) gene in cellular assays...
  3. ncbi request reprint Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells
    Narasimha Swamy
    Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Clin Cancer Res 10:8018-27. 2004
    ..Collectively, these results strongly suggested that 25-OH-D(3)-3-BE has a strong potential as a therapeutic agent for androgen-sensitive and androgen-refractory prostate cancer...
  4. ncbi request reprint 1alpha,25-Dihydroxyvitamin D3-3beta-(2)-bromoacetate, an affinity labeling derivative of 1alpha,25-dihydroxyvitamin D3 displays strong antiproliferative and cytotoxic behavior in prostate cancer cells
    Narasimha Swamy
    Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    J Cell Biochem 89:909-16. 2003
    ..Therefore, these results raise the possibility that 1,25(OH)(2)D(3)-3-BE or similar VDR-cross linking analogs of 1,25(OH)(2)D(3) might be considered for further development as potential candidates for prostate cancer...
  5. pmc Covalent labeling of nuclear vitamin D receptor with affinity labeling reagents containing a cross-linking probe at three different positions of the parent ligand: structural and biochemical implications
    Taner Kaya
    Boston University, Boston, MA 02215, USA
    Bioorg Chem 37:57-63. 2009
    ..Therefore, we conclude that the beta-hairpin region (modified by 1,25(OH)(2)D(3)-3-BE) is most important for growth inhibition by 1,25(OH)(2)D(3), while helices 3 and 6 are less important for such activity...
  6. ncbi request reprint Photodynamic cell-kill analysis of breast tumor cells with a tamoxifen-pyropheophorbide conjugate
    Ana Fernandez Gacio
    Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 99:665-70. 2006
    ..Therefore, it is a potential candidate for ER-targeted photodynamic therapy of cancers (PDT) of tissues and organs that respond to estrogens/antiestrogens...
  7. ncbi request reprint Nuclear estrogen receptor targeted photodynamic therapy: selective uptake and killing of MCF-7 breast cancer cells by a C17alpha-alkynylestradiol-porphyrin conjugate
    Narasimha Swamy
    Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 99:966-77. 2006
    ....
  8. pmc A vitamin D receptor-alkylating derivative of 1α,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth
    James R Lambert
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Cancer Prev Res (Phila) 3:1596-607. 2010
    ....
  9. ncbi request reprint Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution
    James F Head
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochemistry 41:9015-20. 2002
    ..The larger "footprint" of DBP on actin also leads to an overlap with the actin-binding site of gelsolin domain I...
  10. doi request reprint Internalization of a C17α-alkynylestradiol-porphyrin conjugate into estrogen receptor positive MCF-7 breast cancer cells
    Sara Sadler
    Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA
    Bioorg Med Chem Lett 21:4638-41. 2011
    ..This study is a direct demonstration of our hypothesis about ER-mediated internalization of estrogen-porphyrin conjugates...
  11. ncbi request reprint Anti-growth effect of 1,25-dihydroxyvitamin D3-3-bromoacetate alone or in combination with 5-amino-imidazole-4-carboxamide-1-beta-4-ribofuranoside in pancreatic cancer cells
    Kelly S Persons
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Anticancer Res 30:1875-80. 2010
    ..In conclusion, 1,25(OH)(2)D(3)-3-BE displays a strong therapeutic potential, alone and in combination with AICAR, in pancreatic cancer...
  12. ncbi request reprint Biochemical and preliminary crystallographic characterization of the vitamin D sterol- and actin-binding by human vitamin D-binding protein
    Narasimha Swamy
    Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arch Biochem Biophys 402:14-23. 2002
    ....
  13. pmc Cross-talk among structural domains of human DBP upon binding 25-hydroxyvitamin D
    Arjun Ray
    Bioorganic Chemistry and Structural Biology, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Biochem Biophys Res Commun 365:746-50. 2008
    ..These results provide a direct evidence of cross-talk among the structural domains of DBP...
  14. pmc Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and tumor growth in mice
    Oliver Kisker
    Division of Surgical Research, Children s Hospital, Boston, MA 02115, USA
    Neoplasia 5:32-40. 2003
    ..Taken together, these data suggest that DBP-maf is an antiangiogenic molecule that can act directly on endothelium as well as stimulate macrophages to attack both the endothelial and tumor cell compartment of a growing malignancy...
  15. pmc Fatty acid-binding site environments of serum vitamin D-binding protein and albumin are different
    Narasimha Swamy
    Bioorganic Chemistry and Structural Biology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Bioorg Chem 36:165-8. 2008
    ....
  16. ncbi request reprint An estradiol-porphyrin conjugate selectively localizes into estrogen receptor-positive breast cancer cells
    Narasimha Swamy
    Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA
    Bioorg Med Chem 10:3237-43. 2002
    ..Therefore, ER-binding conjugates of estradiol and porphyrins could potentially be used for ER-targeted photodynamic therapy of hormone-sensitive cancers of breast, ovary, gonads etc...
  17. ncbi request reprint Affinity labeling of the nuclear vitamin D receptor with nonsteroidal alkylating agents
    Ana Fernandez-Gacio
    Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Bioorg Med Chem Lett 13:213-6. 2003
    ..Synthesis of an affinity alkylating non steroidal mimic of 1alpha,25-dihydroxyvitamin D(3) and its radiolabeled counterpart is presented. We also report the affinity labeling of the VDR-ligand binding domain (VDR-LBD) with this analogue...
  18. ncbi request reprint The C(19) position of 25-hydroxyvitamin D(3) faces outward in the vitamin D sterol-binding pocket of vitamin D-binding protein
    James K Addo
    Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Bioorg Med Chem Lett 12:279-81. 2002
    ....
  19. ncbi request reprint Mechanistic and pharmacodynamic studies of a 25-hydroxyvitamin D3 derivative in prostate cancer cells
    James R Lambert
    Department of Pathology, University of Colorado Health Science Center, Aurora, CO, USA
    Biochem Biophys Res Commun 361:189-95. 2007
    ..Furthermore, we carried out cellular uptake and serum stability studies of 25-OH-D(3)-3-BE to demonstrate potential therapeutic applicability of 25-OH-D(3)-3-BE in hormone-sensitive and hormone-insensitive prostate cancer...