Katya Ravid

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc The A2b adenosine receptor modulates glucose homeostasis and obesity
    Hillary Johnston-Cox
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e40584. 2012
  2. doi request reprint Building interdisciplinary biomedical research using novel collaboratives
    Katya Ravid
    Evans Center for Interdisciplinary Biomedical Research, Boston University School of Medicine, Massachusetts, USA
    Acad Med 88:179-84. 2013
  3. pmc Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection
    Nikolaos Papadantonakis
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Blood 120:1774-81. 2012
  4. pmc The A2b adenosine receptor protects against vascular injury
    Dan Yang
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 105:792-6. 2008
  5. pmc Deregulated Aurora-B induced tetraploidy promotes tumorigenesis
    Hao G Nguyen
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    FASEB J 23:2741-8. 2009
  6. ncbi request reprint Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression
    Ying Zhang
    Department of Biochemistry, Boston University School of Medicine, 715 Albany St, K225, Boston, MA 02118
    Blood 103:3717-26. 2004
  7. pmc The A2B adenosine receptor protects against inflammation and excessive vascular adhesion
    Dan Yang
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 116:1913-23. 2006
  8. pmc Conditional overexpression of transgenes in megakaryocytes and platelets in vivo
    Hao G Nguyen
    Boston University School of Medicine, Department of Biochemistry, 715 Albany St, K225, Boston, MA 02118, USA
    Blood 106:1559-64. 2005
  9. pmc Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase
    Alexia Eliades
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 286:27630-8. 2011
  10. pmc New roles for cyclin E in megakaryocytic polyploidization
    Alexia Eliades
    Department of Medicine and Biochemistry, Evans Center for Interdisciplinary Biomedical Research, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:18909-17. 2010

Research Grants

Collaborators

Detail Information

Publications53

  1. pmc The A2b adenosine receptor modulates glucose homeostasis and obesity
    Hillary Johnston-Cox
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e40584. 2012
    ..We used a diet-induced obesity murine knockout model to investigate the role of this receptor in mediating metabolic homeostasis, and correlated our findings in obese patient samples...
  2. doi request reprint Building interdisciplinary biomedical research using novel collaboratives
    Katya Ravid
    Evans Center for Interdisciplinary Biomedical Research, Boston University School of Medicine, Massachusetts, USA
    Acad Med 88:179-84. 2013
    ..As universities seek new approaches to stimulate interdisciplinary research, the Evans Center and its ARCs are offered as a productive model for leveraging discovery...
  3. pmc Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection
    Nikolaos Papadantonakis
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Blood 120:1774-81. 2012
    ..Here, we review recent advances in the understanding of the contribution of MKs to the progression of myelofibrosis, highlighting the newly identified role of LOX...
  4. pmc The A2b adenosine receptor protects against vascular injury
    Dan Yang
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 105:792-6. 2008
    ..Thus, this study highlights the significance of the A2bAR in regulating CXCR4 expression in vivo and in protecting against vascular lesion formation...
  5. pmc Deregulated Aurora-B induced tetraploidy promotes tumorigenesis
    Hao G Nguyen
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    FASEB J 23:2741-8. 2009
    ..Thus, sustained expression of Aurora-B induces tetraploidy, which, in turn, facilitates genomic instability and tumor development in a xenograft model...
  6. ncbi request reprint Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression
    Ying Zhang
    Department of Biochemistry, Boston University School of Medicine, 715 Albany St, K225, Boston, MA 02118
    Blood 103:3717-26. 2004
    ..Future studies will examine the impact of survivin restoration on mouse megakaryocyte polyploidization...
  7. pmc The A2B adenosine receptor protects against inflammation and excessive vascular adhesion
    Dan Yang
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 116:1913-23. 2006
    ..Hence, we identify the A2BAR as a new critical regulator of inflammation and vascular adhesion primarily via signals from hematopoietic cells to the vasculature, focusing attention on the receptor as a therapeutic target...
  8. pmc Conditional overexpression of transgenes in megakaryocytes and platelets in vivo
    Hao G Nguyen
    Boston University School of Medicine, Department of Biochemistry, 715 Albany St, K225, Boston, MA 02118, USA
    Blood 106:1559-64. 2005
    ..Hence, we generated a new line, PF4-tTA-VP16, that is available for conditionally overexpressing genes of interest in the MK/platelet lineage in vivo...
  9. pmc Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase
    Alexia Eliades
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 286:27630-8. 2011
    ..Thus, our in vitro and in vivo data support a novel role for LOX in regulating MK expansion by PDGF-BB and suggest LOX as a new potential therapeutic target for myelofibrosis...
  10. pmc New roles for cyclin E in megakaryocytic polyploidization
    Alexia Eliades
    Department of Medicine and Biochemistry, Evans Center for Interdisciplinary Biomedical Research, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:18909-17. 2010
    ..These findings define a key role for cyclin E in promoting megakaryocyte entry into S phase and hence, increase in the number of cell cycling cells and in augmenting polyploidization...
  11. pmc Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells
    Nicholas Papadantonakis
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cell Cycle 7:2352-6. 2008
    ..This is the first study to document chromosomal segregation patterns during endomitosis ex vivo and to indicate their potential differential regulation in low and high ploidy cells...
  12. pmc Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice
    Donald J McCrann
    Department of Biochemistry, 15 Stoughton St, K225, Boston University School of Medicine, Boston, MA 02118, USA
    Blood 111:4092-5. 2008
    ..We conclude that elevated survivin expression does not alter MK/erythroid lineage development and that elevated survivin, alone, does not interfere with MK ploidy in vivo...
  13. pmc Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide
    Alexia Eliades
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA USA
    Cell Cycle 12:1242-50. 2013
    ..Thus, our findings defined a role for LOX-PP in reducing MK ploidy. This suggests that high-level expression of LOX in aberrantly proliferating MKs could play a part in inhibiting their polyploidization via LOX-PP...
  14. pmc Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy
    Donald J McCrann
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Blood 114:1243-9. 2009
    ..Hence, this study shows the expression of Nox isoforms in MKs and highlights a potential role of flavoproteins in promoting polyploidization in this lineage...
  15. pmc TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4
    Cynthia St Hilaire
    Department of Biochemistry, The Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Biochem Biophys Res Commun 375:292-6. 2008
    ..Nox4 upregulates the A(2B)AR, and Nox inhibitors dampen the effect of TNF-alpha. Hence, our study is the first to show that signaling associated with Nox4 is also able to upregulate the tissue protecting A(2B)AR...
  16. doi request reprint Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury
    Hongjie Chen
    Department of Biochemistry, Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Exp Hematol 37:533-8. 2009
    ..Here, we examined the contribution of the A2bAR to TNF-alpha regulation by macrophages at baseline and under vascular stress...
  17. pmc Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy
    Donald J McCrann
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Cell Cycle 8:902-8. 2009
    ..Taken together, our study is the first to show increased Nox4 levels in VSMC during aging, and to demonstrate its role in induction of polyploidy in this lineage...
  18. pmc B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells
    Cynthia St Hilaire
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 103:1962-74. 2008
    ..Our data are novel in that they show that this proliferation-inhibiting A(2B)AR is itself an inducible receptor regulated by B-Myb...
  19. ncbi request reprint Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins
    Hao G Nguyen
    Department of Biochemistry and Medicine, Cancer Center, Boston University School of Medicine, Boston, Massachusetts, USA
    J Cell Physiol 208:12-22. 2006
    ....
  20. pmc Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence
    Dan Yang
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Aging Cell 6:257-60. 2007
    ..Moreover, the polyploid cells exhibit limited proliferative capacity in comparison to their diploid counterparts. This study is the first to demonstrate in vivo that polyploid VSMC adopt a senescent phenotype...
  21. doi request reprint Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-α signaling
    Hongjie Chen
    Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Exp Hematol 39:525-30. 2011
    ..Considering the influences of TNF-α on MMP-9 expression and activity, here we examined the effect of the A2bAR on the expression of MMP-9 and its potential dependency on TNF-α...
  22. ncbi request reprint A selective effect of Mpl ligand on mRNA stabilization during megakaryocyte differentiation
    Yulia Kaluzhny
    Department of Biochemistry, K225, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    FEBS Lett 527:279-83. 2002
    ..Our study is the first to suggest that Mpl ligand-induced lineage specification is also determined by message stabilization...
  23. pmc Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling
    Yong Xu
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    J Biol Chem 283:14213-20. 2008
    ..Therefore, our data establish possible cross-talk between the adenosine signaling through cAMP and IFN-gamma during regulation of CIITA expression...
  24. pmc Mechanisms of induction of adenosine receptor genes and its functional significance
    Cynthia St Hilaire
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Physiol 218:35-44. 2009
    ....
  25. pmc A2b adenosine receptor regulates hyperlipidemia and atherosclerosis
    Milka Koupenova
    Department of Medicine, Boston University School of Medicine, 700 Albany St, CVI, W 601, Boston, MA 02118, USA
    Circulation 125:354-63. 2012
    ..The cAMP-elevating A(2b) adenosine receptor (A(2b)AR) controls inflammation via its expression in bone marrow cells...
  26. doi request reprint Hypertension in transgenic mice with brain-selective overexpression of the alpha(2B)-adrenoceptor
    Ekaterina Kintsurashvili
    Hypertension and Atherosclerosis Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Hypertens 22:41-5. 2009
    ..The purpose of this project was to develop a novel hyperadrenergic model, a transgenic (TG) mouse model with brain-selective overexpression of the alpha(2B)-adrenergic receptor (alpha(2B)-AR)...
  27. pmc Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells
    Hector A Lucero
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Biol Chem 283:24103-17. 2008
    ..These novel findings suggest that LOX activity is essential to generate optimal chemotactic sensitivity of cells to chemoattractants by oxidizing specific cell surface proteins, such as PDGFR-beta...
  28. pmc Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation
    Paola A Hurtado
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Division of Oral Biology, 700 Albany Street, W 210 Boston, MA 02118, USA
    Biochem Biophys Res Commun 366:156-61. 2008
    ..These novel data suggest that LOX-PP may provide a feedback control mechanism that serves to inhibit properties associated with the development of vascular pathology...
  29. doi request reprint Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors
    Shannon H Carroll
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Expert Rev Mol Med 15:e1. 2013
    ..Focus has been given to how these regulators influence the commitment of the osteochondroprogenitor to these separate lineages...
  30. ncbi request reprint Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression
    Matthew R Jones
    Department of Biochemistry, Boston University, Boston, Massachusetts 02118, USA
    J Biol Chem 279:5306-13. 2004
    ..Our study is the first to describe aortic ploidy level as a biomarker for aging and to indicate that changes associated with increased DNA content per cell may selectively suppress the expression of specific genes...
  31. doi request reprint Physiological implications of adenosine receptor-mediated platelet aggregation
    Hillary A Johnston-Cox
    Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Evans Center for Interdisciplinary Biomedical Research, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Physiol 226:46-51. 2011
    ....
  32. pmc A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo
    Shannon H Carroll
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 287:15718-27. 2012
    ..Thus, our study identified the A2BAR as a new regulator of osteoblast differentiation, bone formation, and fracture repair...
  33. ncbi request reprint BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation
    Yulia Kaluzhny
    Department of Biochemistry and Whittaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Blood 100:1670-8. 2002
    ..Our study indicates that regulated expression of BclxL in megakaryocytes is important for the development of cells with a high potential to fragment into platelets...
  34. doi request reprint A2 adenosine receptors and vascular pathologies
    Hillary A Johnston-Cox
    Department of Medicine, Boston University School of Medicine, MA 02118, USA
    Arterioscler Thromb Vasc Biol 32:870-8. 2012
    ..Understanding the pathogenesis of vascular disease mediated by these receptors is important to the development of therapeutics and to the prevention and management of disease...
  35. pmc Role of lysyl oxidase propeptide in secretion and enzyme activity
    Jessica L Grimsby
    Division of Oral Biology, Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 111:1231-43. 2010
    ..Taken together, our study points out the requirement of the LOX-PP for pro-LOX exit from the ER and is the first to highlight the influence of LOX-PP glycosylation on LOX enzyme activity...
  36. ncbi request reprint Polyploidy: mechanisms and cancer promotion in hematopoietic and other cells
    Hao G Nguyen
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Adv Exp Med Biol 676:105-22. 2010
    ..This finding has suggested that DNA content per se might affect cellular functions...
  37. pmc Properties of ets-1 binding to chromatin and its effect on platelet factor 4 gene expression
    Jun Lu
    Department of Biochemistry, Cancer Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Mol Cell Biol 24:428-41. 2004
    ....
  38. doi request reprint Vascular smooth muscle cell polyploidy: an adaptive or maladaptive response?
    Donald J McCrann
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Cell Physiol 215:588-92. 2008
    ..Additionally, we will explore new investigations in polyploidization of VSMCs involving the rapidly expanding fields of oxidative stress and senescence. J. Cell. Physiol. 215: 588-592, 2008. (c) 2008 Wiley-Liss, Inc...
  39. ncbi request reprint An adenosine analogue, IB-MECA, down-regulates estrogen receptor alpha and suppresses human breast cancer cell proliferation
    Jun Lu
    Department of Biochemistry and Cancer Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Cancer Res 63:6413-23. 2003
    ..Our studies indicate that IB-MECA can down-regulate ERalpha and inhibit proliferation or induce apoptosis in different breast cancer cell types and raise the possibility of using this and related compounds in breast cancer treatment...
  40. pmc Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance
    Libin Liu
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Cell Metab 8:310-7. 2008
    ..Our results underscore the multiorgan role of caveolae in metabolic regulation and the obligate presence of Cavin for caveolae formation...
  41. ncbi request reprint A(3) adenosine receptor deficiency does not influence atherogenesis
    Matthew R Jones
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 92:1034-43. 2004
    ..We conclude that the contributions of the A(3)AR to inflammation and to modulating LO levels are not significant enough to control vascular response to injury...
  42. pmc Oxidases and reactive oxygen species during hematopoiesis: a focus on megakaryocytes
    Alexia Eliades
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    J Cell Physiol 227:3355-62. 2012
    ..The importance of ROS-generating oxidases in MK biology and pathology, including myelofibrosis, is also described...
  43. pmc Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property
    Hao G Nguyen
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, K225, Boston, MA 02118, USA
    Mol Cell Biol 25:4977-92. 2005
    ..Hence, we identified the degradation pathway for Aurora-B as well as critical regions for its clearance. Intriguingly, overexpression of a stable form of Aurora-B alone induces aneuploidy and anchorage-independent growth...
  44. pmc Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature
    Yehonathan Hazony
    College of Engineering, Boston University, Boston, MA, USA
    Nucleic Acids Res 34:4416-28. 2006
    ..The data also point to an intrinsic cross-species difference in the organization of 5' non-coding sequences within the mammalian genomes. This methodology may be used for the identification of regulatory sequences in other lineages...
  45. ncbi request reprint Activity of the A3 adenosine receptor gene promoter in transgenic mice: characterization of previously unidentified sites of expression
    Ron Yaar
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, K225, 715 Albany Street, Boston, MA 02118, USA
    FEBS Lett 532:267-72. 2002
    ..Our study suggests that this promoter may be useful in the selective targeting of gene expression to specific tissues...
  46. pmc Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine
    David L Coleman
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trans Am Clin Climatol Assoc 124:275-82. 2013
    ..The ECIBR and the Section of Computational Biomedicine represent new organizational approaches to stimulating innovation in research in a DOM. ..
  47. ncbi request reprint Role of apoptotic processes in platelet biogenesis
    Yulia Kaluzhny
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Acta Haematol 111:67-77. 2004
    ..Studies point to a unique biological system in which programmed cell death may be linked with biogenesis of new cells...
  48. ncbi request reprint Animal models for the study of adenosine receptor function
    R Yaar
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Cell Physiol 202:9-20. 2005
    ..Furthermore, it illustrates the need for multiple adenosine receptor subtype deficiency studies in mice and the deletion of the A2b subtype...
  49. pmc Regulation of atherosclerosis and associated risk factors by adenosine and adenosine receptors
    Milka Koupenova
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Curr Atheroscler Rep 14:460-8. 2012
    ..Potential therapeutic applications are reviewed, as well as reasons for phenotypic differences occasionally observed between receptor knockout and pharmacological inhibition via drug administration...
  50. ncbi request reprint Signaling by the Mpl receptor involves IKK and NF-kappaB
    Ying Zhang
    Department of Biochemistry, Whitaker Cardiovascular Institute, Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 85:523-35. 2002
    ....
  51. ncbi request reprint Roads to polyploidy: the megakaryocyte example
    Katya Ravid
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Cell Physiol 190:7-20. 2002
    ..Future studies will aim to further explore these two groups of genes...
  52. doi request reprint G protein-coupled receptors and adipogenesis: a focus on adenosine receptors
    Anna Eisenstein
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts
    J Cell Physiol 229:414-21. 2014
    ..This review will highlight GPCRs and their downstream messengers as significant players controlling adipocyte differentiation...
  53. pmc Adenosine and blood platelets
    Hillary A Johnston-Cox
    Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, and Evans Center for Interdisciplinary Biomedical Research, Boston University School of Medicine, CVI, 700 Albany St, Boston, MA, 02118, USA
    Purinergic Signal 7:357-65. 2011
    ..The effect of adenosine receptors on platelet activation during aging is also discussed, as well as potential therapeutic applications...

Research Grants12

  1. Mechanisms Regulating Megakaryocyte Endomitosis
    Katya Ravid; Fiscal Year: 2007
    ..Taken together, pursuing these aims of research should enhance our understanding of the molecular mechanisms of megakaryocyte polyploidization, a process that impacts platelet biogenesis and hence, blood hemostasis. ..
  2. Mechanisms Regulating Megakaryocyte Endomitosis
    Katya Ravid; Fiscal Year: 2010
    ..Taken together, pursuing these aims of research should enhance our understanding of the molecular mechanisms of megakaryocyte polyploidization, a process that impacts platelet biogenesis and hence, blood hemostasis. ..
  3. MECHANISMS REGULATING ENDOMITOSIS IN MEGAKARYOCYTES
    Katya Ravid; Fiscal Year: 2001
    ..3) To determine the roles of MegNIMA-like, NIMA kinases and CD3 in megakaryocytopoiesis and thrombocytopoiesis in cultured cells and in vivo. The in vitro studies will be done with both rat megakaryocytes and with cell lines. ..
  4. Mechanisms Regulating Megakaryocyte Endomitosis
    Katya Ravid; Fiscal Year: 2009
    ..Taken together, pursuing these aims of research should enhance our understanding of the molecular mechanisms of megakaryocyte polyploidization, a process that impacts platelet biogenesis and hence, blood hemostasis. ..
  5. Adenosine Receptors and Atherogenesis
    Katya Ravid; Fiscal Year: 2010
    ..The mechanisms leading to this protection and the control of expression of this receptor gene are the focus of research in this proposal. ..