ROBERT CHRISTOPHER PIERCE

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?
    R Christopher Pierce
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603 Boston, MA 02118, USA
    Neurosci Biobehav Rev 30:215-38. 2006
  2. ncbi request reprint Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking
    Heath D Schmidt
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Eur J Pharmacol 526:65-76. 2005
  3. pmc Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking
    Vidhya Kumaresan
    Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, United States
    Behav Brain Res 202:238-44. 2009
  4. pmc Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking
    Katie R Famous
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 28:11061-70. 2008
  5. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats
    Fair M Vassoler
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 28:8735-9. 2008
  6. doi request reprint CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
    Sharon M Anderson
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603, Boston, Massachusetts 02118, USA
    Nat Neurosci 11:344-53. 2008
  7. ncbi request reprint Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat
    Heath D Schmidt
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, L 603, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Eur J Neurosci 23:219-28. 2006
  8. ncbi request reprint Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking
    Sharon M Anderson
    Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Neuropsychopharmacology 31:1452-61. 2006
  9. ncbi request reprint Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat
    Heath D Schmidt
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, L 603, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Behav Brain Res 175:189-94. 2006
  10. pmc When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat
    Katie R Famous
    Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurosci Lett 420:169-73. 2007

Research Grants

  1. Ephrins and Repeated Cocaine
    Robert Pierce; Fiscal Year: 2006
  2. Psychostimulant-Induced Craving and Toxicity
    Robert Pierce; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?
    R Christopher Pierce
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603 Boston, MA 02118, USA
    Neurosci Biobehav Rev 30:215-38. 2006
    ....
  2. ncbi request reprint Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking
    Heath D Schmidt
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Eur J Pharmacol 526:65-76. 2005
    ..Maladaptive changes in the processing of motivationally relevant stimuli by these circuits following cocaine self-administration result in drug craving and compulsive drug seeking upon re-exposure to cocaine...
  3. pmc Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking
    Vidhya Kumaresan
    Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, United States
    Behav Brain Res 202:238-44. 2009
    ..Importantly, the current findings also suggest that activation of mGluR5s specifically in the nucleus accumbens shell may promote the reinstatement of cocaine seeking...
  4. pmc Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking
    Katie R Famous
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 28:11061-70. 2008
    ..The present results also demonstrate that the reinstatement of cocaine seeking is associated with increases in the phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens...
  5. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats
    Fair M Vassoler
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 28:8735-9. 2008
    ..Together, these results suggest that DBS of the nucleus accumbens shell may be a potential therapeutic option in the treatment of severe cocaine addiction...
  6. doi request reprint CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
    Sharon M Anderson
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603, Boston, Massachusetts 02118, USA
    Nat Neurosci 11:344-53. 2008
    ..Thus, CaMKII may be an essential link between accumbens shell dopamine and glutamate systems involved in the neuronal plasticity underlying cocaine craving and relapse...
  7. ncbi request reprint Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat
    Heath D Schmidt
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, L 603, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Eur J Neurosci 23:219-28. 2006
    ....
  8. ncbi request reprint Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking
    Sharon M Anderson
    Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Neuropsychopharmacology 31:1452-61. 2006
    ..Collectively, these findings indicate that activation of D2 dopamine receptors mediates cocaine priming-induced reinstatement of cocaine seeking in a region-specific manner within the nucleus accumbens...
  9. ncbi request reprint Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat
    Heath D Schmidt
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, L 603, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Behav Brain Res 175:189-94. 2006
    ..These results suggest that increases in extracellular concentrations of dopamine, specifically in the nucleus accumbens shell, are primarily responsible for promoting cocaine priming-induced reinstatement of drug seeking in rats...
  10. pmc When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat
    Katie R Famous
    Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurosci Lett 420:169-73. 2007
    ..This study provides evidence that pharmacological antagonism of NMDA receptors in the nucleus accumbens core or shell promotes the reinstatement of cocaine seeking...
  11. ncbi request reprint The roles of calcium/calmodulin-dependent and Ras/mitogen-activated protein kinases in the development of psychostimulant-induced behavioral sensitization
    Stephanie C Licata
    Laboratory of Neuropsychopharmacology, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 85:14-22. 2003
    ....
  12. ncbi request reprint Neutralization of neutrophin-3 in the ventral tegmental area or nucleus accumbens differentially modulates cocaine-induced behavioral plasticity in rats
    Antoinette Y Freeman
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Synapse 46:57-65. 2002
    ....
  13. ncbi request reprint Repeated cocaine injections have no influence on tyrosine hydroxylase activity in the rat nucleus accumbens core or shell
    Stephanie C Licata
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Brain Res 1012:119-26. 2004
    ..These data indicate that dopamine synthesis is not altered by cocaine administration...
  14. ncbi request reprint Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats
    Sharon M Anderson
    Department of Pharmacology, Laboratory of Neuropsychopharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Psychopharmacology (Berl) 168:132-8. 2003
    ..A growing literature indicates that increased dopamine transmission in the nucleus accumbens contributes to priming-induced reinstatement of cocaine-seeking behavior...
  15. ncbi request reprint Suppressing calcium/calmodulin-dependent protein kinase II activity in the ventral tegmental area enhances the acute behavioural response to cocaine but attenuates the initiation of cocaine-induced behavioural sensitization in rats
    Stephanie C Licata
    Department of Pharmacology, Laboratory of Neuropsychopharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Eur J Neurosci 19:405-14. 2004
    ....
  16. ncbi request reprint Repeated administration of AMPA or a metabotropic glutamate receptor agonist into the rat ventral tegmental area augments the subsequent behavioral hyperactivity induced by cocaine
    Justin M Dunn
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA, 02118, USA
    Psychopharmacology (Berl) 179:172-80. 2005
    ..Glutamate receptors and their related second messengers in the ventral tegmental area (VTA) are known to play critical roles in the initiation of behavioral sensitization to cocaine...
  17. ncbi request reprint Locomotor behavior
    R Christopher Pierce
    Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Protoc Neurosci . 2007
    ..The protocols provided are designed for rats, although they can easily be adapted for use with mice and other rodents...
  18. ncbi request reprint Subchronic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata
    Noriko Yamamoto
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Room L1001, Boston, MA 02118, USA
    Brain Res 1123:196-200. 2006
    ..These results show that the subchronic administration of L-DOPA results in a sensitization of enhanced extracellular GABA levels in the SNr...

Research Grants2

  1. Ephrins and Repeated Cocaine
    Robert Pierce; Fiscal Year: 2006
    ..Rats will be used as subjects in all of these experiments. ..
  2. Psychostimulant-Induced Craving and Toxicity
    Robert Pierce; Fiscal Year: 2007
    ..Pierce to devote more attention to his existing research and also expand his research collaborations with Drs. Rowlett, Ronen, Yamamoto and Soghomonian, which will have a significant positive impact on his career development. ..