Thomas Perls

Summary

Affiliation: Boston University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Genetic and environmental influences on exceptional longevity and the AGE nomogram
    Thomas Perls
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 959:1-13. 2002
  2. pmc Life-long sustained mortality advantage of siblings of centenarians
    Thomas T Perls
    Geriatrics Section, Boston Medical Center and Boston University Medical School, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 99:8442-7. 2002
  3. ncbi request reprint The genetics of aging
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, Massachusetts 02118, USA
    Curr Opin Genet Dev 12:362-9. 2002
  4. ncbi request reprint The genetics of aging-- implications for pharmacogenomics
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, MA 02118, USA
    Pharmacogenomics 3:469-84. 2002
  5. pmc Survival of parents and siblings of supercentenarians
    Thomas Perls
    New England Centenarian Study, Geriatrics Section, Boston Medical Center, 88 East Newton St, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 62:1028-34. 2007
  6. ncbi request reprint Genetics of exceptional longevity
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, MA 02118, USA
    Exp Gerontol 38:725-30. 2003
  7. ncbi request reprint Understanding the determinants of exceptional longevity
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Ann Intern Med 139:445-9. 2003
  8. ncbi request reprint What does it take to live to 100?
    Thomas Perls
    Gerontology Division, Harvard Division on Aging, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Mech Ageing Dev 123:231-42. 2002
  9. ncbi request reprint Dementia-free centenarians
    Thomas Perls
    Geriatrics Section, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Exp Gerontol 39:1587-93. 2004
  10. ncbi request reprint Centenarians who avoid dementia
    Thomas Perls
    New England Centenarian Study, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Trends Neurosci 27:633-6. 2004

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Genetic and environmental influences on exceptional longevity and the AGE nomogram
    Thomas Perls
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 959:1-13. 2002
    ..Recent studies indicate the likelihood that such factors will be elucidated in the near future...
  2. pmc Life-long sustained mortality advantage of siblings of centenarians
    Thomas T Perls
    Geriatrics Section, Boston Medical Center and Boston University Medical School, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 99:8442-7. 2002
    ..Compared with the U.S. 1900 cohort, male siblings of centenarians were at least 17 times as likely to attain age 100 themselves, while female siblings were at least 8 times as likely...
  3. ncbi request reprint The genetics of aging
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, Massachusetts 02118, USA
    Curr Opin Genet Dev 12:362-9. 2002
    ....
  4. ncbi request reprint The genetics of aging-- implications for pharmacogenomics
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, MA 02118, USA
    Pharmacogenomics 3:469-84. 2002
    ....
  5. pmc Survival of parents and siblings of supercentenarians
    Thomas Perls
    New England Centenarian Study, Geriatrics Section, Boston Medical Center, 88 East Newton St, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 62:1028-34. 2007
    ....
  6. ncbi request reprint Genetics of exceptional longevity
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, MA 02118, USA
    Exp Gerontol 38:725-30. 2003
    ..The children of centenarians are emerging as a promising model for the genetic and phenotypic study of aging relatively slowly and the delay and perhaps escape of important age-related diseases...
  7. ncbi request reprint Understanding the determinants of exceptional longevity
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Ann Intern Med 139:445-9. 2003
    ..These studies and those of other mammals and lower organisms show great promise for the delineation of important environmental and genetic determinants of aging well...
  8. ncbi request reprint What does it take to live to 100?
    Thomas Perls
    Gerontology Division, Harvard Division on Aging, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Mech Ageing Dev 123:231-42. 2002
    ..Identifying such genes may yield new information about how people age differently and what modulates differences in susceptibilities to various diseases associated with aging...
  9. ncbi request reprint Dementia-free centenarians
    Thomas Perls
    Geriatrics Section, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Exp Gerontol 39:1587-93. 2004
    ..Among those who are not cognitively intact at 100, approximately 90% delayed the onset of clinically evident impairment at least until the average age of 92 yr...
  10. ncbi request reprint Centenarians who avoid dementia
    Thomas Perls
    New England Centenarian Study, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Trends Neurosci 27:633-6. 2004
    ..Centenarians are therefore of scientific interest as a human model of relative resistance to dementia...
  11. ncbi request reprint The genetics of exceptional human longevity
    Thomas Perls
    Geriatrics Section, Boston Medical Center, Boston University Medical School, Massachusetts 02118, USA
    J Am Geriatr Soc 50:359-68. 2002
    ..Recent studies indicate the likelihood that such factors will be elucidated in the near future...
  12. ncbi request reprint The different paths to age one hundred
    Thomas Perls
    Geriatrics Section, New England Centenarian Study, Department of Medicine, Boston University Medical Center, Robinson 2400, 88 East Newton Street, Boston, MA 02118, USA
    Ann N Y Acad Sci 1055:13-25. 2005
    ....
  13. ncbi request reprint Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring
    Dellara F Terry
    Geriatrics Section, Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 52:2074-6. 2004
    ..To assess the cause of death for centenarians' offspring and controls...
  14. ncbi request reprint The hype and the reality--part I
    S Jay Olshansky
    School of Public Health, University of Illinois at Chicago, 1603 W Taylor St, Rm 885, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 59:B513-4. 2004
  15. ncbi request reprint Longevity genes: from primitive organisms to humans
    Robert N Butler
    International Longevity Center USA, New York, NY 10028, USA
    J Gerontol A Biol Sci Med Sci 58:581-4. 2003
  16. pmc Characteristics of 32 supercentenarians
    Emily A Schoenhofen
    Clinical Aging Program, Department of Psychology, University of Southern California, Los Angeles, USA
    J Am Geriatr Soc 54:1237-40. 2006
    ..To report phenotypic characteristics of 32 age-validated supercentenarians...
  17. ncbi request reprint The different paths to 100
    Thomas T Perls
    New England Centenarian Study, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118 2393, USA
    Am J Clin Nutr 83:484S-487S. 2006
    ....
  18. ncbi request reprint Hope drives antiaging hype
    Thomas T Perls
    Cleve Clin J Med 73:1039-40, 1044. 2006
  19. ncbi request reprint DHEA and testosterone in the elderly
    Thomas T Perls
    N Engl J Med 356:636; author reply 637. 2007
  20. doi request reprint New developments in the illegal provision of growth hormone for "anti-aging" and bodybuilding
    S Jay Olshansky
    Division of Epidemiology and Biostatistics, University of Illinois, Chicago, 1603 W Taylor St, Room 885, Chicago, IL 60612, USA
    JAMA 299:2792-4. 2008
  21. ncbi request reprint Provision or distribution of growth hormone for "antiaging": clinical and legal issues
    Thomas T Perls
    Geriatrics Section, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Mass 02118, USA
    JAMA 294:2086-90. 2005
  22. ncbi request reprint Cancer in the oldest old
    Stacy L Andersen
    The New England Centenarian Study, Geriatrics Section, Department of Medicine, Boston Medical Center, 88 East Newton Street, Robinson 2, Boston, MA 02118, USA
    Mech Ageing Dev 126:263-7. 2005
    ..Some cancers are very rare among these individuals suggesting that there are certain cancers that may be incompatible with survival to extreme old age...
  23. ncbi request reprint First autopsy study of an Okinawan centenarian: absence of many age-related diseases
    Adam M Bernstein
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Gerontol A Biol Sci Med Sci 59:1195-9. 2004
    ..Her late-life morbidity pattern is contrasted with that of white centenarians...
  24. pmc Cardiovascular disease delay in centenarian offspring: role of heat shock proteins
    Dellara F Terry
    Deputy Chief, Center for Molecular Stress Response, Boston Medical Center and Boston University School of Medicine, 650 Albany Street, Boston, MA 02118
    Ann N Y Acad Sci 1019:502-5. 2004
    ..We hypothesize that low levels of circulating serum HSP70 may be an indicator of a healthy state and point to longevity of the host; therefore, our results suggest that levels of circulating serum HSP70 may be a marker for longevity...
  25. ncbi request reprint Robine and Michel's "Looking forward to a general theory on population aging": measuring functional decline in population aging in a changing world and an evolving biology
    Vincent Mor
    Department of Community Health, and Brown University Center for Gerontology and Health Care Research, Box G H1, Brown University, Providence, RI 02912, USA
    J Gerontol A Biol Sci Med Sci 59:M609-11; author reply M616-20. 2004
  26. ncbi request reprint Cardiovascular disease delay in centenarian offspring
    Dellara F Terry
    Geriatrics Section, Department of Medicine, Boston Medical Center, Massachusetts 02118, USA
    J Gerontol A Biol Sci Med Sci 59:385-9. 2004
    ..Previously, the authors have shown that an important component of the ability to survive to exceptionally old age is family health history. This study assessed the age at onset of age-related diseases in centenarian offspring...
  27. pmc Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan
    Bard J Geesaman
    Elixir Pharmaceuticals, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:14115-20. 2003
    ..This study provides proof of concept for the feasibility of using the genomes of LLI to identify genes impacting longevity...
  28. ncbi request reprint Cardiovascular advantages among the offspring of centenarians
    Dellara F Terry
    The New England Centenarian Study, Geriatrics Section, Boston Medical Center, 88 East Newton Street, F 4, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 58:M425-31. 2003
    ..A significant component of the ability to survive to exceptional old age may be familial. This study assessed the prevalence of age-related diseases in the offspring of centenarians...
  29. ncbi request reprint Is there an antiaging medicine?
    Robert N Butler
    International Longevity Center USA, New York, New York, USA
    J Gerontol A Biol Sci Med Sci 57:B333-8. 2002
    ..This article reports the findings of a consensus workshop that discussed what is known about existing and future interventions to slow, stop, or reverse aging in animals, and how these might be applied to humans through future research...
  30. ncbi request reprint Achieving and maintaining cognitive vitality with aging
    Howard M Fillit
    Institute for the Study of Aging, Inc, New York, NY 10153, USA
    Mayo Clin Proc 77:681-96. 2002
    ..The data presented in this review should interest physicians who provide preventive care management to middle-aged and older individuals who seek to maintain cognitive vitality with aging...
  31. pmc Association of longer telomeres with better health in centenarians
    Dellara F Terry
    New England Centenarian Study, Geriatrics Section of the Department of Medicine, Boston Medical Center, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 63:809-12. 2008
    ..This raises the possibility that perhaps it is not exceptional longevity but one's function and health that may be associated with telomere length...