Thomas Perls

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Cancer in the oldest old
    Stacy L Andersen
    The New England Centenarian Study, Geriatrics Section, Department of Medicine, Boston Medical Center, 88 East Newton Street, Robinson 2, Boston, MA 02118, USA
    Mech Ageing Dev 126:263-7. 2005
  2. pmc Typologies of extreme longevity myths
    Robert D Young
    New England Centenarian Study, Geriatrics Division, Department of Medicine, Boston University Medical Center, Boston, MA 02493, USA
    Curr Gerontol Geriatr Res 2010:423087. 2010
  3. pmc Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span
    Stacy L Andersen
    New England Centenarian Study, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 67:395-405. 2012
  4. pmc Imputation of missing genotypes: an empirical evaluation of IMPUTE
    Zhenming Zhao
    Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston MA 02118, USA
    BMC Genet 9:85. 2008
  5. pmc A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston 02118 MA, USA
    BMC Genet 9:6. 2008
  6. pmc Clustering by genetic ancestry using genome-wide SNP data
    Nadia Solovieff
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Genet 11:108. 2010
  7. ncbi request reprint Understanding the determinants of exceptional longevity
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Ann Intern Med 139:445-9. 2003
  8. ncbi request reprint The different paths to 100
    Thomas T Perls
    New England Centenarian Study, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118 2393, USA
    Am J Clin Nutr 83:484S-487S. 2006
  9. ncbi request reprint Anti-aging quackery: human growth hormone and tricks of the trade--more dangerous than ever
    Thomas T Perls
    Geriatrics Section, Boston Medical Center, Robinson 2400, Albany Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 59:682-91. 2004
  10. ncbi request reprint Centenarians who avoid dementia
    Thomas Perls
    New England Centenarian Study, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Trends Neurosci 27:633-6. 2004

Research Grants

Detail Information

Publications45

  1. ncbi request reprint Cancer in the oldest old
    Stacy L Andersen
    The New England Centenarian Study, Geriatrics Section, Department of Medicine, Boston Medical Center, 88 East Newton Street, Robinson 2, Boston, MA 02118, USA
    Mech Ageing Dev 126:263-7. 2005
    ..Some cancers are very rare among these individuals suggesting that there are certain cancers that may be incompatible with survival to extreme old age...
  2. pmc Typologies of extreme longevity myths
    Robert D Young
    New England Centenarian Study, Geriatrics Division, Department of Medicine, Boston University Medical Center, Boston, MA 02493, USA
    Curr Gerontol Geriatr Res 2010:423087. 2010
    ..Conclusions. Understanding various causes of false extreme age claims is important for placing current, past, and future extreme longevity claims in context and for providing a necessary level of skepticism...
  3. pmc Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span
    Stacy L Andersen
    New England Centenarian Study, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 67:395-405. 2012
    ..As the limit of human life span was effectively approached with supercentenarians, compression of morbidity was generally observed...
  4. pmc Imputation of missing genotypes: an empirical evaluation of IMPUTE
    Zhenming Zhao
    Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston MA 02118, USA
    BMC Genet 9:85. 2008
    ....
  5. pmc A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston 02118 MA, USA
    BMC Genet 9:6. 2008
    ..One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations...
  6. pmc Clustering by genetic ancestry using genome-wide SNP data
    Nadia Solovieff
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    BMC Genet 11:108. 2010
    ..An alternative solution is genetic matching of cases and controls that requires, however, well defined population strata for appropriate selection of cases and controls...
  7. ncbi request reprint Understanding the determinants of exceptional longevity
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Ann Intern Med 139:445-9. 2003
    ..These studies and those of other mammals and lower organisms show great promise for the delineation of important environmental and genetic determinants of aging well...
  8. ncbi request reprint The different paths to 100
    Thomas T Perls
    New England Centenarian Study, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118 2393, USA
    Am J Clin Nutr 83:484S-487S. 2006
    ....
  9. ncbi request reprint Anti-aging quackery: human growth hormone and tricks of the trade--more dangerous than ever
    Thomas T Perls
    Geriatrics Section, Boston Medical Center, Robinson 2400, Albany Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 59:682-91. 2004
    ..In the case of some substances such as human growth hormone, adequate legal safeguards are impotent without adequate resources allocated to enforcement agencies...
  10. ncbi request reprint Centenarians who avoid dementia
    Thomas Perls
    New England Centenarian Study, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Trends Neurosci 27:633-6. 2004
    ..Centenarians are therefore of scientific interest as a human model of relative resistance to dementia...
  11. pmc Survival of parents and siblings of supercentenarians
    Thomas Perls
    New England Centenarian Study, Geriatrics Section, Boston Medical Center, 88 East Newton St, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 62:1028-34. 2007
    ....
  12. ncbi request reprint The different paths to age one hundred
    Thomas Perls
    Geriatrics Section, New England Centenarian Study, Department of Medicine, Boston University Medical Center, Robinson 2400, 88 East Newton Street, Boston, MA 02118, USA
    Ann N Y Acad Sci 1055:13-25. 2005
    ....
  13. ncbi request reprint Provision or distribution of growth hormone for "antiaging": clinical and legal issues
    Thomas T Perls
    Geriatrics Section, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Mass 02118, USA
    JAMA 294:2086-90. 2005
  14. ncbi request reprint Genetics of exceptional longevity
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, MA 02118, USA
    Exp Gerontol 38:725-30. 2003
    ..The children of centenarians are emerging as a promising model for the genetic and phenotypic study of aging relatively slowly and the delay and perhaps escape of important age-related diseases...
  15. ncbi request reprint Dementia-free centenarians
    Thomas Perls
    Geriatrics Section, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
    Exp Gerontol 39:1587-93. 2004
    ..Among those who are not cognitively intact at 100, approximately 90% delayed the onset of clinically evident impairment at least until the average age of 92 yr...
  16. doi request reprint Growth hormone and anabolic steroids: athletes are the tip of the iceberg
    Thomas T Perls
    Geriatrics Section, Department of Medicine, Boston University School of Medicine and Boston Medical Center, 88 East Newton St, Boston, MA 02118, USA
    Drug Test Anal 1:419-25. 2009
    ..Although these drugs are often used in combination, this article focuses on growth hormone. Fuelling the demand for these drugs are drug manufacturers, pharmacies, websites, clinics and their doctors...
  17. ncbi request reprint The genetics of exceptional human longevity
    Thomas Perls
    J Mol Neurosci 19:233-8. 2002
    ....
  18. ncbi request reprint The genetics of aging-- implications for pharmacogenomics
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, MA 02118, USA
    Pharmacogenomics 3:469-84. 2002
    ....
  19. ncbi request reprint The genetics of aging
    Thomas Perls
    Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, Massachusetts 02118, USA
    Curr Opin Genet Dev 12:362-9. 2002
    ....
  20. ncbi request reprint The genetics of exceptional human longevity
    Thomas Perls
    Geriatrics Section, Boston Medical Center, Boston University Medical School, Massachusetts 02118, USA
    J Am Geriatr Soc 50:359-68. 2002
    ..Recent studies indicate the likelihood that such factors will be elucidated in the near future...
  21. ncbi request reprint Genetic and environmental influences on exceptional longevity and the AGE nomogram
    Thomas Perls
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 959:1-13. 2002
    ..Recent studies indicate the likelihood that such factors will be elucidated in the near future...
  22. pmc RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 4:e8210. 2009
    ..The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered...
  23. pmc Association of longer telomeres with better health in centenarians
    Dellara F Terry
    New England Centenarian Study, Geriatrics Section of the Department of Medicine, Boston Medical Center, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 63:809-12. 2008
    ..This raises the possibility that perhaps it is not exceptional longevity but one's function and health that may be associated with telomere length...
  24. pmc Centenarian offspring: start healthier and stay healthier
    Emily R Adams
    Department of Epidemiology, School of Public Health, Boston University, Boston, Massachusetts, USA
    J Am Geriatr Soc 56:2089-92. 2008
    ..To assess the relative incidence of age-related diseases in a group of centenarian offspring who have thus far been considered to be predisposed to "healthy" aging...
  25. pmc Genome-wide association studies and the genetic dissection of complex traits
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Am J Hematol 84:504-15. 2009
    ..In this article, we will review the common approach to analysis of GWAS data and then discuss options to learn more from these data. We will use examples from our ongoing studies of sickle cell anemia and also GWAS in multigenic traits...
  26. pmc Disentangling the roles of disability and morbidity in survival to exceptional old age
    Dellara F Terry
    New England Centenarian Study, Geriatrics Section of the Department of Medicine, Boston University School of Medicine and Boston Medical Center, MA 02118, USA
    Arch Intern Med 168:277-83. 2008
    ..Therefore, we hypothesize that for some centenarians, compression of disability rather than morbidity is a key feature for survival to old age...
  27. ncbi request reprint Cardiovascular disease delay in centenarian offspring
    Dellara F Terry
    Geriatrics Section, Department of Medicine, Boston Medical Center, Massachusetts 02118, USA
    J Gerontol A Biol Sci Med Sci 59:385-9. 2004
    ..Previously, the authors have shown that an important component of the ability to survive to exceptionally old age is family health history. This study assessed the age at onset of age-related diseases in centenarian offspring...
  28. pmc Cardiovascular disease delay in centenarian offspring: role of heat shock proteins
    Dellara F Terry
    Deputy Chief, Center for Molecular Stress Response, Boston Medical Center and Boston University School of Medicine, 650 Albany Street, Boston, MA 02118
    Ann N Y Acad Sci 1019:502-5. 2004
    ..We hypothesize that low levels of circulating serum HSP70 may be an indicator of a healthy state and point to longevity of the host; therefore, our results suggest that levels of circulating serum HSP70 may be a marker for longevity...
  29. ncbi request reprint Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring
    Dellara F Terry
    Geriatrics Section, Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 52:2074-6. 2004
    ..To assess the cause of death for centenarians' offspring and controls...
  30. ncbi request reprint Cardiovascular advantages among the offspring of centenarians
    Dellara F Terry
    The New England Centenarian Study, Geriatrics Section, Boston Medical Center, 88 East Newton Street, F 4, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 58:M425-31. 2003
    ..A significant component of the ability to survive to exceptional old age may be familial. This study assessed the prevalence of age-related diseases in the offspring of centenarians...
  31. ncbi request reprint What does it take to live to 100?
    Thomas Perls
    Gerontology Division, Harvard Division on Aging, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Mech Ageing Dev 123:231-42. 2002
    ..Identifying such genes may yield new information about how people age differently and what modulates differences in susceptibilities to various diseases associated with aging...
  32. ncbi request reprint First autopsy study of an Okinawan centenarian: absence of many age-related diseases
    Adam M Bernstein
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Gerontol A Biol Sci Med Sci 59:1195-9. 2004
    ..Her late-life morbidity pattern is contrasted with that of white centenarians...
  33. pmc Personality traits of centenarians' offspring
    Jane L Givens
    New England Centenarian Study, Geriatrics Section, School of Medicine, Boston University and Boston Medical Center, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 57:683-5. 2009
    ..To determine whether the offspring of centenarians have personality characteristics that are distinct from the general population...
  34. ncbi request reprint Distinguishing between neurodegenerative disease and disease-free aging: correlating neuropsychological evaluations and neuropathological studies in centenarians
    Margery H Silver
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Psychosom Med 64:493-501. 2002
    ....
  35. pmc Life-long sustained mortality advantage of siblings of centenarians
    Thomas T Perls
    Geriatrics Section, Boston Medical Center and Boston University Medical School, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 99:8442-7. 2002
    ..Compared with the U.S. 1900 cohort, male siblings of centenarians were at least 17 times as likely to attain age 100 themselves, while female siblings were at least 8 times as likely...
  36. ncbi request reprint Achieving and maintaining cognitive vitality with aging
    Howard M Fillit
    Institute for the Study of Aging, Inc, New York, NY 10153, USA
    Mayo Clin Proc 77:681-96. 2002
    ..The data presented in this review should interest physicians who provide preventive care management to middle-aged and older individuals who seek to maintain cognitive vitality with aging...
  37. ncbi request reprint DHEA and testosterone in the elderly
    Thomas T Perls
    N Engl J Med 356:636; author reply 637. 2007
  38. ncbi request reprint Longevity genes: from primitive organisms to humans
    Robert N Butler
    International Longevity Center USA, New York, NY 10028, USA
    J Gerontol A Biol Sci Med Sci 58:581-4. 2003
  39. pmc Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan
    Bard J Geesaman
    Elixir Pharmaceuticals, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:14115-20. 2003
    ..This study provides proof of concept for the feasibility of using the genomes of LLI to identify genes impacting longevity...
  40. ncbi request reprint Robine and Michel's "Looking forward to a general theory on population aging": measuring functional decline in population aging in a changing world and an evolving biology
    Vincent Mor
    Department of Community Health, and Brown University Center for Gerontology and Health Care Research, Box G H1, Brown University, Providence, RI 02912, USA
    J Gerontol A Biol Sci Med Sci 59:M609-11; author reply M616-20. 2004
  41. ncbi request reprint The hype and the reality--part I
    S Jay Olshansky
    School of Public Health, University of Illinois at Chicago, 1603 W Taylor St, Rm 885, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 59:B513-4. 2004
  42. pmc Characteristics of 32 supercentenarians
    Emily A Schoenhofen
    Clinical Aging Program, Department of Psychology, University of Southern California, Los Angeles, USA
    J Am Geriatr Soc 54:1237-40. 2006
    ..To report phenotypic characteristics of 32 age-validated supercentenarians...
  43. ncbi request reprint Hope drives antiaging hype
    Thomas T Perls
    Cleve Clin J Med 73:1039-40, 1044. 2006
  44. doi request reprint New developments in the illegal provision of growth hormone for "anti-aging" and bodybuilding
    S Jay Olshansky
    Division of Epidemiology and Biostatistics, University of Illinois, Chicago, 1603 W Taylor St, Room 885, Chicago, IL 60612, USA
    JAMA 299:2792-4. 2008
  45. ncbi request reprint Is there an antiaging medicine?
    Robert N Butler
    International Longevity Center USA, New York, New York, USA
    J Gerontol A Biol Sci Med Sci 57:B333-8. 2002
    ..This article reports the findings of a consensus workshop that discussed what is known about existing and future interventions to slow, stop, or reverse aging in animals, and how these might be applied to humans through future research...

Research Grants8

  1. CENTENARIAN OFFSPRING AND CONTROL FOR LONGITUDINAL STUDY
    Thomas Perls; Fiscal Year: 2001
    ..Our fifth aim is to continue our efforts in ascertaining and recruiting families highly clustered for longevity, in collecting phenotype data, and in establishing cell lines. ..
  2. Characterizing Human Exceptional Longevity
    Thomas Perls; Fiscal Year: 2007
    ..The applicant, Dr. Thomas Perls, is an Associate Professor of Medicine and Geriatrics and Founder and Director of the New England Centenarian ..
  3. Exceptional survival and longevity in New England
    Thomas Perls; Fiscal Year: 2007
    ..abstract_text> ..