Research Topics
Species | Thomas PerlsSummaryAffiliation: Boston University Country: USA Publications
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Publications
Cancer in the oldest oldStacy L Andersen
The New England Centenarian Study, Geriatrics Section, Department of Medicine, Boston Medical Center, 88 East Newton Street, Robinson 2, Boston, MA 02118, USA
Mech Ageing Dev 126:263-7. 2005..Some cancers are very rare among these individuals suggesting that there are certain cancers that may be incompatible with survival to extreme old age...
Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life spanStacy L Andersen
New England Centenarian Study, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
J Gerontol A Biol Sci Med Sci 67:395-405. 2012..As the limit of human life span was effectively approached with supercentenarians, compression of morbidity was generally observed...- Imputation of missing genotypes: an empirical evaluation of IMPUTEZhenming Zhao
Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston MA 02118, USA
BMC Genet 9:85. 2008.... - A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samplesPaola Sebastiani
Department of Biostatistics, Boston University School of Public Health, Boston 02118 MA, USA
BMC Genet 9:6. 2008..One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations... - Clustering by genetic ancestry using genome-wide SNP dataNadia Solovieff
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
BMC Genet 11:108. 2010..An alternative solution is genetic matching of cases and controls that requires, however, well defined population strata for appropriate selection of cases and controls... - Understanding the determinants of exceptional longevityThomas Perls
Geriatrics Section, Boston University Medical Center, 88 East Newton Street, Boston, MA 02118, USA
Ann Intern Med 139:445-9. 2003..These studies and those of other mammals and lower organisms show great promise for the delineation of important environmental and genetic determinants of aging well... - The different paths to 100Thomas T Perls
New England Centenarian Study, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118 2393, USA
Am J Clin Nutr 83:484S-487S. 2006.... - Anti-aging quackery: human growth hormone and tricks of the trade--more dangerous than everThomas T Perls
Geriatrics Section, Boston Medical Center, Robinson 2400, Albany Street, Boston, MA 02118, USA
J Gerontol A Biol Sci Med Sci 59:682-91. 2004..In the case of some substances such as human growth hormone, adequate legal safeguards are impotent without adequate resources allocated to enforcement agencies... - Centenarians who avoid dementiaThomas Perls
New England Centenarian Study, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
Trends Neurosci 27:633-6. 2004..Centenarians are therefore of scientific interest as a human model of relative resistance to dementia... - Survival of parents and siblings of supercentenariansThomas Perls
New England Centenarian Study, Geriatrics Section, Boston Medical Center, 88 East Newton St, Boston, MA 02118, USA
J Gerontol A Biol Sci Med Sci 62:1028-34. 2007.... - The different paths to age one hundredThomas Perls
Geriatrics Section, New England Centenarian Study, Department of Medicine, Boston University Medical Center, Robinson 2400, 88 East Newton Street, Boston, MA 02118, USA
Ann N Y Acad Sci 1055:13-25. 2005.... - Provision or distribution of growth hormone for "antiaging": clinical and legal issuesThomas T Perls
Geriatrics Section, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Mass 02118, USA
JAMA 294:2086-90. 2005 - Genetics of exceptional longevityThomas Perls
Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, MA 02118, USA
Exp Gerontol 38:725-30. 2003..The children of centenarians are emerging as a promising model for the genetic and phenotypic study of aging relatively slowly and the delay and perhaps escape of important age-related diseases... - The genetics of exceptional human longevityThomas Perls
J Mol Neurosci 19:233-8. 2002.... 
Growth hormone and anabolic steroids: athletes are the tip of the icebergThomas T Perls
Geriatrics Section, Department of Medicine, Boston University School of Medicine and Boston Medical Center, 88 East Newton St, Boston, MA 02118, USA
Drug Test Anal 1:419-25. 2009..Although these drugs are often used in combination, this article focuses on growth hormone. Fuelling the demand for these drugs are drug manufacturers, pharmacies, websites, clinics and their doctors...- Dementia-free centenariansThomas Perls
Geriatrics Section, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA
Exp Gerontol 39:1587-93. 2004..Among those who are not cognitively intact at 100, approximately 90% delayed the onset of clinically evident impairment at least until the average age of 92 yr... - The genetics of aging-- implications for pharmacogenomicsThomas Perls
Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, MA 02118, USA
Pharmacogenomics 3:469-84. 2002.... - The genetics of agingThomas Perls
Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, Massachusetts 02118, USA
Curr Opin Genet Dev 12:362-9. 2002.... - Genetic and environmental influences on exceptional longevity and the AGE nomogramThomas Perls
Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Ann N Y Acad Sci 959:1-13. 2002..Recent studies indicate the likelihood that such factors will be elucidated in the near future... - The genetics of exceptional human longevityThomas Perls
Geriatrics Section, Boston Medical Center, Boston University Medical School, Massachusetts 02118, USA
J Am Geriatr Soc 50:359-68. 2002..Recent studies indicate the likelihood that such factors will be elucidated in the near future... - RNA editing genes associated with extreme old age in humans and with lifespan in C. elegansPaola Sebastiani
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
PLoS ONE 4:e8210. 2009..The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered... - Genome-wide association studies and the genetic dissection of complex traitsPaola Sebastiani
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
Am J Hematol 84:504-15. 2009..In this article, we will review the common approach to analysis of GWAS data and then discuss options to learn more from these data. We will use examples from our ongoing studies of sickle cell anemia and also GWAS in multigenic traits... - Association of longer telomeres with better health in centenariansDellara F Terry
New England Centenarian Study, Geriatrics Section of the Department of Medicine, Boston Medical Center, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA
J Gerontol A Biol Sci Med Sci 63:809-12. 2008..This raises the possibility that perhaps it is not exceptional longevity but one's function and health that may be associated with telomere length... - Centenarian offspring: start healthier and stay healthierEmily R Adams
Department of Epidemiology, School of Public Health, Boston University, Boston, Massachusetts, USA
J Am Geriatr Soc 56:2089-92. 2008..To assess the relative incidence of age-related diseases in a group of centenarian offspring who have thus far been considered to be predisposed to "healthy" aging... - Disentangling the roles of disability and morbidity in survival to exceptional old ageDellara F Terry
New England Centenarian Study, Geriatrics Section of the Department of Medicine, Boston University School of Medicine and Boston Medical Center, MA 02118, USA
Arch Intern Med 168:277-83. 2008..Therefore, we hypothesize that for some centenarians, compression of disability rather than morbidity is a key feature for survival to old age... - Cardiovascular disease delay in centenarian offspring: role of heat shock proteinsDellara F Terry
Deputy Chief, Center for Molecular Stress Response, Boston Medical Center and Boston University School of Medicine, 650 Albany Street, Boston, MA 02118
Ann N Y Acad Sci 1019:502-5. 2004..We hypothesize that low levels of circulating serum HSP70 may be an indicator of a healthy state and point to longevity of the host; therefore, our results suggest that levels of circulating serum HSP70 may be a marker for longevity... - Cardiovascular advantages among the offspring of centenariansDellara F Terry
The New England Centenarian Study, Geriatrics Section, Boston Medical Center, 88 East Newton Street, F 4, Boston, MA 02118, USA
J Gerontol A Biol Sci Med Sci 58:M425-31. 2003..A significant component of the ability to survive to exceptional old age may be familial. This study assessed the prevalence of age-related diseases in the offspring of centenarians... - Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspringDellara F Terry
Geriatrics Section, Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
J Am Geriatr Soc 52:2074-6. 2004..To assess the cause of death for centenarians' offspring and controls... - Cardiovascular disease delay in centenarian offspringDellara F Terry
Geriatrics Section, Department of Medicine, Boston Medical Center, Massachusetts 02118, USA
J Gerontol A Biol Sci Med Sci 59:385-9. 2004..Previously, the authors have shown that an important component of the ability to survive to exceptionally old age is family health history. This study assessed the age at onset of age-related diseases in centenarian offspring... - What does it take to live to 100?Thomas Perls
Gerontology Division, Harvard Division on Aging, Beth Israel Deaconess Medical Center, Boston, MA, USA
Mech Ageing Dev 123:231-42. 2002..Identifying such genes may yield new information about how people age differently and what modulates differences in susceptibilities to various diseases associated with aging... - First autopsy study of an Okinawan centenarian: absence of many age-related diseasesAdam M Bernstein
Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
J Gerontol A Biol Sci Med Sci 59:1195-9. 2004..Her late-life morbidity pattern is contrasted with that of white centenarians... - Life-long sustained mortality advantage of siblings of centenariansThomas T Perls
Geriatrics Section, Boston Medical Center and Boston University Medical School, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 99:8442-7. 2002..Compared with the U.S. 1900 cohort, male siblings of centenarians were at least 17 times as likely to attain age 100 themselves, while female siblings were at least 8 times as likely... - Distinguishing between neurodegenerative disease and disease-free aging: correlating neuropsychological evaluations and neuropathological studies in centenariansMargery H Silver
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Psychosom Med 64:493-501. 2002.... - Personality traits of centenarians' offspringJane L Givens
New England Centenarian Study, Geriatrics Section, School of Medicine, Boston University and Boston Medical Center, Boston, Massachusetts 02118, USA
J Am Geriatr Soc 57:683-5. 2009..To determine whether the offspring of centenarians have personality characteristics that are distinct from the general population... - The hype and the reality--part IS Jay Olshansky
School of Public Health, University of Illinois at Chicago, 1603 W. Taylor St, Rm. 885, Chicago, IL 60612, USA
J Gerontol A Biol Sci Med Sci 59:B513-4. 2004 - Robine and Michel's "Looking forward to a general theory on population aging": measuring functional decline in population aging in a changing world and an evolving biologyVincent Mor
Department of Community Health, and Brown University Center for Gerontology and Health Care Research, Box G-H1, Brown University, Providence, RI 02912, USA
J Gerontol A Biol Sci Med Sci 59:M609-11; author reply M616-20. 2004 - Characteristics of 32 supercentenariansEmily A Schoenhofen
Clinical Aging Program, Department of Psychology, University of Southern California, Los Angeles, USA
J Am Geriatr Soc 54:1237-40. 2006..A surprisingly substantial proportion of these individuals were still functionally independent or required minimal assistance... - Achieving and maintaining cognitive vitality with agingHoward M Fillit
Institute for the Study of Aging, Inc, New York, NY 10153, USA
Mayo Clin Proc 77:681-96. 2002..The data presented in this review should interest physicians who provide preventive care management to middle-aged and older individuals who seek to maintain cognitive vitality with aging... - New developments in the illegal provision of growth hormone for "anti-aging" and bodybuildingS Jay Olshansky
Division of Epidemiology and Biostatistics, University of Illinois, Chicago, 1603 W Taylor St, Room 885, Chicago, IL 60612, USA
JAMA 299:2792-4. 2008 - Hope drives antiaging hypeThomas T Perls
Cleve Clin J Med 73:1039-40, 1044. 2006 - Longevity genes: from primitive organisms to humansRobert N Butler
International Longevity Center-USA, New York, NY 10028, USA
J Gerontol A Biol Sci Med Sci 58:581-4. 2003 - Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespanBard J Geesaman
Elixir Pharmaceuticals, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 100:14115-20. 2003..This study provides proof of concept for the feasibility of using the genomes of LLI to identify genes impacting longevity... - DHEA and testosterone in the elderlyThomas T Perls
N Engl J Med 356:636; author reply 637. 2007 - Is there an antiaging medicine?Robert N Butler
International Longevity Center USA, New York, New York, USA
J Gerontol A Biol Sci Med Sci 57:B333-8. 2002..This article reports the findings of a consensus workshop that discussed what is known about existing and future interventions to slow, stop, or reverse aging in animals, and how these might be applied to humans through future research...
Research Grants
- CENTENARIAN OFFSPRING AND CONTROL FOR LONGITUDINAL STUDYThomas Perls; Fiscal Year: 2001..Our fifth aim is to continue our efforts in ascertaining and recruiting families highly clustered for longevity, in collecting phenotype data, and in establishing cell lines. ..
- Characterizing Human Exceptional LongevityThomas Perls; Fiscal Year: 2007..The applicant, Dr. Thomas Perls, is an Associate Professor of Medicine and Geriatrics and Founder and Director of the New England Centenarian ..
- Exceptional survival and longevity in New EnglandThomas Perls; Fiscal Year: 2007..abstract_text> ..