Michael J Pencina

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation
    Michael J Pencina
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, 111 Cummington St, MA 02215, USA
    Stat Med 23:2109-23. 2004
  2. pmc Understanding increments in model performance metrics
    Michael J Pencina
    Department of Biostatistics, Harvard Clinical Research Institute, Boston University, CrossTown, 801 Massachusetts Ave, Boston, MA 02118, USA
    Lifetime Data Anal 19:202-18. 2013
  3. pmc Interpreting incremental value of markers added to risk prediction models
    Michael J Pencina
    Department of Biostatistics, Boston University, Massachusetts, USA
    Am J Epidemiol 176:473-81. 2012
  4. pmc Quantifying discrimination of Framingham risk functions with different survival C statistics
    Michael J Pencina
    Department of Biostatistics, Boston University, Boston, MA, USA
    Stat Med 31:1543-53. 2012
  5. doi request reprint Thoroughly modern risk prediction?
    Michael J Pencina
    Department of Biostatistics, Boston University, Harvard Clinical Research Institute, Boston, MA 02118, USA
    Sci Transl Med 4:131fs10. 2012
  6. ncbi request reprint Estimating lifetime risk of developing high serum total cholesterol: adjustment for baseline prevalence and single-occasion measurements
    Michael J Pencina
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Am J Epidemiol 165:464-72. 2007
  7. pmc Predicting the 30-year risk of cardiovascular disease: the framingham heart study
    Michael J Pencina
    Department of Biostatistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    Circulation 119:3078-84. 2009
  8. pmc Novel metrics for evaluating improvement in discrimination: net reclassification and integrated discrimination improvement for normal variables and nested models
    Michael J Pencina
    Department of Biostatistics, Boston University, Cross Town, Boston, MA, USA
    Stat Med 31:101-13. 2012
  9. ncbi request reprint Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    Michael J Pencina
    Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
    Stat Med 27:157-72; discussion 207-12. 2008
  10. pmc Performance of a method for identifying the unique dietary patterns of adult women and men: the Framingham nutrition studies
    Michael J Pencina
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    J Am Diet Assoc 108:1453-60. 2008

Detail Information

Publications86

  1. ncbi request reprint Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation
    Michael J Pencina
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, 111 Cummington St, MA 02215, USA
    Stat Med 23:2109-23. 2004
    ..Then we investigate via simulations the length and coverage probability of this interval. Finally, we present a real life example evaluating the performance of a Framingham Heart Study model...
  2. pmc Understanding increments in model performance metrics
    Michael J Pencina
    Department of Biostatistics, Harvard Clinical Research Institute, Boston University, CrossTown, 801 Massachusetts Ave, Boston, MA 02118, USA
    Lifetime Data Anal 19:202-18. 2013
    ..The theoretical results are illustrated using a Framingham Heart Study example of a model for predicting the 10-year incidence of atrial fibrillation...
  3. pmc Interpreting incremental value of markers added to risk prediction models
    Michael J Pencina
    Department of Biostatistics, Boston University, Massachusetts, USA
    Am J Epidemiol 176:473-81. 2012
    ....
  4. pmc Quantifying discrimination of Framingham risk functions with different survival C statistics
    Michael J Pencina
    Department of Biostatistics, Boston University, Boston, MA, USA
    Stat Med 31:1543-53. 2012
    ..We suggest researchers report which C statistic they are using, provide a rationale for their selection, and be aware that comparing different indices across studies may not be meaningful...
  5. doi request reprint Thoroughly modern risk prediction?
    Michael J Pencina
    Department of Biostatistics, Boston University, Harvard Clinical Research Institute, Boston, MA 02118, USA
    Sci Transl Med 4:131fs10. 2012
    ..Researchers use a data-driven technique called statistical learning to fashion risk prediction algorithms for clinical situations with low event rates...
  6. ncbi request reprint Estimating lifetime risk of developing high serum total cholesterol: adjustment for baseline prevalence and single-occasion measurements
    Michael J Pencina
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Am J Epidemiol 165:464-72. 2007
    ....
  7. pmc Predicting the 30-year risk of cardiovascular disease: the framingham heart study
    Michael J Pencina
    Department of Biostatistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    Circulation 119:3078-84. 2009
    ..Clustering of risk factors at younger ages and increasing life expectancy suggest the need for longer-term risk prediction tools...
  8. pmc Novel metrics for evaluating improvement in discrimination: net reclassification and integrated discrimination improvement for normal variables and nested models
    Michael J Pencina
    Department of Biostatistics, Boston University, Cross Town, Boston, MA, USA
    Stat Med 31:101-13. 2012
    ..Our theoretical developments are illustrated with an example based on the Framingham Heart Study risk assessment model for high-risk men in primary prevention of cardiovascular disease...
  9. ncbi request reprint Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    Michael J Pencina
    Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
    Stat Med 27:157-72; discussion 207-12. 2008
    ..We illustrate the use of these measures with an example from the Framingham Heart Study. We propose that scientists consider these types of measures in addition to the AUC when assessing the performance of newer biomarkers...
  10. pmc Performance of a method for identifying the unique dietary patterns of adult women and men: the Framingham nutrition studies
    Michael J Pencina
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    J Am Diet Assoc 108:1453-60. 2008
    ..Essential in this task is the evaluation of methods to accurately identify these unique dietary patterns...
  11. doi request reprint Evaluation of the Framingham risk score in the European Prospective Investigation of Cancer-Norfolk cohort--invited commentary
    Michael J Pencina
    Statistical Consulting Unit, Boston University, 111 Cummington St, Boston, MA 02215, USA
    Arch Intern Med 168:1216-8. 2008
  12. ncbi request reprint Choice of time scale and its effect on significance of predictors in longitudinal studies
    Michael J Pencina
    Department of Mathematics and Statistics, Boston University, Boston, MA, USA
    Stat Med 26:1343-59. 2007
    ..These findings are supported by four practical examples from the Framingham Heart Study...
  13. pmc Statistical methods for assessment of added usefulness of new biomarkers
    Michael J Pencina
    Department of Biostatistics, Boston University, Boston, MA 02115, USA
    Clin Chem Lab Med 48:1703-11. 2010
    ..Reporting of standard metrics, including measures of relative risk and the c statistic, is still recommended. These concepts are illustrated with a risk prediction example using data from the Framingham Heart Study...
  14. pmc Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
    Michael J Pencina
    Department of Biostatistics, Boston University, 801 Massachusetts Ave, Boston, MA 02118, USA
    Stat Med 30:11-21. 2011
    ..We recommend that researchers clearly define and justify the choices they make when choosing NRI for their application...
  15. pmc Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 58:134-7. 2009
    ..Parental obesity is a risk factor for offspring obesity. It is unclear whether parental obesity also confers risk for obesity-associated conditions (e.g., a proinflammatory or prothrombotic state) in the absence of offspring obesity...
  16. ncbi request reprint A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study
    Nisha I Parikh
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 148:102-10. 2008
    ..Risk stratification may facilitate cost-effective approaches to management...
  17. pmc Risk assessment for incident heart failure in individuals with atrial fibrillation
    Renate B Schnabel
    NHLBI s and Boston University s Framingham Heart Study, Framingham, MA, USA
    Eur J Heart Fail 15:843-9. 2013
    ..Risk factors that predict HF in individuals with AF in the community are not well established...
  18. pmc Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Eur J Cardiovasc Prev Rehabil 18:664-73. 2011
    ..Recent experimental studies have highlighted the potential role of the natriuretic peptides and aldosterone in mediating salt sensitivity...
  19. ncbi request reprint Characteristics of Framingham offspring participants with long-lived parents
    Dellara F Terry
    Boston University School of Medicine, Geriatrics Section, Boston Medical Center, 88 E Newton St, Robinson 2, Boston, MA 02118, USA
    Arch Intern Med 167:438-44. 2007
    ..Prior research has suggested that delay or avoidance of cardiovascular disease and cardiovascular disease risk factors plays an important role in longevity...
  20. pmc Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study
    Guneet Kaur Jasuja
    Department of Mathematics, Boston University, Massachusetts, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:733-40. 2013
    ....
  21. pmc Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 52:381-6. 2008
    ..In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk...
  22. pmc Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study
    Marion Dietrich
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Stroke Cerebrovasc Dis 20:155-61. 2011
    ..For CCA-IMT, no significant trends were observed in any of the analyses. The segment-specific association between elevated tHcy level and ICA/bulb-IMT suggests an association between tHcy and plaque formation...
  23. pmc Left ventricular hypertrophy patterns and incidence of heart failure with preserved versus reduced ejection fraction
    Raghava S Velagaleti
    Framingham Heart Study, Framingham, Massachusetts Division of Cardiology, University of Massachusetts Medical School, Worcester, Massachusetts
    Am J Cardiol 113:117-22. 2014
    ..09 to 2.51). In conclusion, in this large community-based sample, HF risk varied by LV hypertrophy pattern, with eccentric and concentric hypertrophy predisposing to HF with reduced and preserved ejection fraction, respectively...
  24. ncbi request reprint Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Circulation 116:984-92. 2007
    ..We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways to the incidence of MetS and to longitudinal changes of its constituent risk factors...
  25. pmc Diet quality, physical activity, smoking status, and weight fluctuation are associated with weight change in women and men
    Ruth W Kimokoti
    Department of Family Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Nutr 140:1287-93. 2010
    ..Women who stopped smoking over follow-up and had poor diet quality gained the most weight. Preventive interventions need to be sex-specific and consider lifestyle factors...
  26. doi request reprint General cardiovascular risk profile for use in primary care: the Framingham Heart Study
    RALPH B D'AGOSTINO
    Boston University, Department of Mathematics and Statistics, 111 Cummington St, Boston, MA 02215, USA
    Circulation 117:743-53. 2008
    ..The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents...
  27. pmc Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community
    Jacob Joseph
    Cardiology Section 111, VA Boston Healthcare System, Boston, Massachusetts, USA
    J Hypertens 27:1317-24. 2009
    ..Hence, we related a panel of biomarkers representing these pathways to plasma markers of collagen metabolism in a large community-based sample...
  28. ncbi request reprint Nutritional risk and the metabolic syndrome in women: opportunities for preventive intervention from the Framingham Nutrition Study
    Barbara E Millen
    Department of Family Medicine and the Graduate Medical Sciences Division, Boston University School of Medicine, Boston, MA, USA
    Am J Clin Nutr 84:434-41. 2006
    ..Diet is recognized as a key factor in the cause and management of the metabolic syndrome (MetS). However, policies to guide preventive clinical nutrition interventions of the condition are limited...
  29. pmc Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study
    Renate B Schnabel
    Framingham Heart Study, Framingham, MA, USA Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Lancet 373:739-45. 2009
    ..We aimed to develop a risk score to predict individuals' absolute risk of developing the condition, and to provide a framework for researchers to assess new risk markers...
  30. pmc Diet quality and obesity in women: the Framingham Nutrition Studies
    Dolores M Wolongevicz
    Department of Family Medicine and the Graduate Medical Sciences Division, Boston University School of Medicine, Boston, MA, USA
    Br J Nutr 103:1223-9. 2010
    ..This finding suggests that overall diet quality be considered a key component in planning and implementing programmes for obesity risk reduction and treatment recommendations...
  31. pmc Carotid-wall intima-media thickness and cardiovascular events
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
    N Engl J Med 365:213-21. 2011
    ..Intima-media thickness of the walls of the common carotid artery and internal carotid artery may add to the Framingham risk score for predicting cardiovascular events...
  32. ncbi request reprint Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 113:2914-8. 2006
    ..Recent studies indicate that the prevalence of type 2 diabetes mellitus is increasing in the United States; less is known about trends in the incidence of type 2 diabetes mellitus...
  33. ncbi request reprint Increasing trends in incidence of overweight and obesity over 5 decades
    Nisha I Parikh
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Am J Med 120:242-50. 2007
    ..We evaluated trends in the incidence of overweight and obesity over the past 50 years...
  34. pmc Interindividual variation in serum sodium and longitudinal blood pressure tracking in the Framingham Heart Study
    Rodrigo M Lago
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    J Hypertens 26:2121-5. 2008
    ..Recent cross-sectional studies have suggested that higher serum sodium levels may be a marker of elevated blood pressure. It is unclear whether serum sodium levels are related to the risk of developing hypertension in the community...
  35. pmc Aortic root diameter and longitudinal blood pressure tracking
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, Massachusetts 01702 5803, USA
    Hypertension 52:473-7. 2008
    ..Our prospective study does not support the notion that a smaller AoR predisposes to hypertension...
  36. pmc Cross-sectional relations of lipid concentrations to left ventricular structural attributes
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Am J Cardiol 105:1297-9. 2010
    ..In conclusion, these data do not support an independent association between lipid concentrations and left ventricular structure...
  37. pmc Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study
    Tulio Diaz
    Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA
    Echocardiography 26:247-53. 2009
    ..Adjusting for cardiovascular risk factors, DUST was not associated with CVD or mortality risk (P > 0.30 for both). The follow-up component of our study suggests that DUST is not independently associated with adverse prognosis...
  38. pmc Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community
    Jennifer E Ho
    National Heart, Lung, and Blood Institute, Framingham Heart Study, MA, USA
    Eur Heart J 33:1734-41. 2012
    ..Of patients presenting with HF, 30-55% have a preserved ejection fraction (HFPEF) rather than a reduced ejection fraction (HFREF). Our objective was to examine discriminating clinical features in new-onset HFPEF vs. HFREF...
  39. pmc Common carotid artery intima-media thickness progression as a predictor of stroke in multi-ethnic study of atherosclerosis
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stroke 42:3017-21. 2011
    ..Carotid artery intima-media thickness (IMT) is a marker of cardiovascular disease associated with incident stroke. We studied whether IMT rate of change is associated with stroke...
  40. pmc Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT
    Joseph F Polak
    Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA
    J Ultrasound Med 29:1759-68. 2010
    ..The goal of this study was to compare internal carotid artery (ICA) intima-media thickness (IMT) with common carotid artery (CCA) IMT as global markers of cardiovascular disease (CVD)...
  41. pmc Vitamin D deficiency and risk of cardiovascular disease
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Circulation 117:503-11. 2008
    ..A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking...
  42. pmc Atrial fibrillation patterns and risks of subsequent stroke, heart failure, or death in the community
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA
    J Am Heart Assoc 2:e000126. 2013
    ..We developed a novel AF classification algorithm and examined AF patterns and outcomes in the community...
  43. pmc Prognostic value of stress myocardial perfusion positron emission tomography: results from a multicenter observational registry
    Sharmila Dorbala
    Brigham and Women s Hospital, Department of Radiology and Division of Cardiology, Noninvasive Cardiovascular Imaging Section, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 61:176-84. 2013
    ....
  44. pmc Association of smoking cessation and weight change with cardiovascular disease among adults with and without diabetes
    Carole Clair
    Tobacco Research and Treatment Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    JAMA 309:1014-21. 2013
    ..Smoking cessation reduces the risks of cardiovascular disease (CVD), but weight gain that follows quitting smoking may weaken the CVD benefit of quitting...
  45. pmc Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 120:2414-20. 2009
    ..Data relating circulating CETP concentrations to CVD incidence in the community are conflicting...
  46. pmc Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 119:3085-92. 2009
    ..Information is limited on the longitudinal tracking of left ventricular (LV) mass over the adult life course and the determinants of such change...
  47. ncbi request reprint Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study
    Ravi Dhingra
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Hypertension 47:861-7. 2006
    ..In our community-based sample, longer electrocardiographic QRS was associated with increased CHF risk, consistent with the hypothesis that depolarization delay may increase CHF risk...
  48. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
    ..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...
  49. pmc Validation of a breast cancer risk prediction model developed for Black women
    Deborah A Boggs
    Slone Epidemiology Center, 1010 Commonwealth Ave, Boston, MA 02215, USA
    J Natl Cancer Inst 105:361-7. 2013
    ....
  50. pmc Misuse of DeLong test to compare AUCs for nested models
    Olga V Demler
    Department of Biostatistics, Boston University School of Public Health Crosstown, Boston, MA 02118, USA
    Stat Med 31:2577-87. 2012
    ....
  51. pmc Variations in common carotid artery intima-media thickness during the cardiac cycle: implications for cardiovascular risk assessment
    Joseph F Polak
    Tufts Medical Center, Department of Radiology, 800 Washington Street, Box 299, Boston, MA 02111, USA
    J Am Soc Echocardiogr 25:1023-8. 2012
    ..Common carotid artery intima-media thickness (IMT), a measure of atherosclerosis, varies between peak systole and end-diastole. This difference might affect cardiovascular risk assessment...
  52. doi request reprint Equivalence of improvement in area under ROC curve and linear discriminant analysis coefficient under assumption of normality
    Olga V Demler
    Department of Biostatistics, Boston University, 801 Massachusetts Avenue, Boston, MA 02118, USA
    Stat Med 30:1410-8. 2011
    ..However, our practical example from the Framingham Heart Study data suggests that the finding might be sensitive to the assumption of normality...
  53. pmc Association between familial atrial fibrillation and risk of new-onset atrial fibrillation
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    JAMA 304:2263-9. 2010
    ..Although the heritability of atrial fibrillation (AF) is established, the contribution of familial AF to predicting new-onset AF remains unknown...
  54. pmc Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study
    Joanne B Krasnoff
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, 670 Albany Street, Second Floor, Boston, Massachusetts 02118 2393, USA
    J Clin Endocrinol Metab 95:2790-9. 2010
    ..Mobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood...
  55. ncbi request reprint Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants
    Dellara F Terry
    Department of Geriatrics, Boston Medical Center, School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 53:1944-50. 2005
    ..To examine whether midlife cardiovascular risk factors predict survival and survival free of major comorbidities to the age of 85...
  56. pmc Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community
    Justin P Zachariah
    Framingham Heart Study, Framingham, MA 01702 5803, USA
    J Hypertens 29:863-8. 2011
    ..We evaluated the relations of baseline plasma CETP activity and longitudinal BP change...
  57. doi request reprint Trends in the association of parental history of obesity over 60 years
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA Department of Endocrinology, Hypertension, and Diabetes, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 22:919-24. 2014
    ..The association of familial as compared to genetic factors in the current obesogenic environment, compared with earlier, leaner time periods, is uncertain...
  58. pmc Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 31:1582-4. 2008
    ..We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes...
  59. pmc Temporal trends in self-reported functional limitations and physical disability among the community-dwelling elderly population: the Framingham heart study
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Am J Public Health 98:1256-62. 2008
    ..We sought to determine change in the prevalence of functional limitations and physical disability among the community-dwelling elderly population across 3 decades...
  60. pmc Associations of edge-detected and manual-traced common carotid intima-media thickness measurements with Framingham risk factors: the multi-ethnic study of atherosclerosis
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stroke 42:1912-6. 2011
    ..In most outcome studies, human readers identify and trace the key IMT interfaces. We evaluate an alternate approach using automated edge detection...
  61. pmc Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community
    Jennifer E Ho
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    J Am Coll Cardiol 60:1249-56. 2012
    ..The aim of this study was to examine the relation of galectin-3 (Gal-3), a marker of cardiac fibrosis, with incident heart failure (HF) in the community...
  62. pmc Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms
    Jose M de Miguel-Yanes
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 34:121-5. 2011
    ..To test if knowledge of type 2 diabetes genetic variants improves disease prediction...
  63. ncbi request reprint Lifetime risk for developing dyslipidemia: the Framingham Offspring Study
    Mark R Cobain
    Department of Mathematics Statistics and Biostatistics, Boston University, Boston, Mass, USA
    Am J Med 120:623-30. 2007
    ..National surveys indicate that 40% of individuals in the United States have borderline-high LDL cholesterol, and 13-34% have low HDL. The lifetime risk of developing dyslipidemia is unknown, however...
  64. ncbi request reprint Relations of insulin sensitivity to longitudinal blood pressure tracking: variations with baseline age, body mass index, and blood pressure
    Johan Arnlov
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 112:1719-27. 2005
    ..The relations of insulin sensitivity (IS) to hypertension incidence may vary according to baseline age, body mass index (BMI), and blood pressure (BP)...
  65. doi request reprint Efficacy of dose increase among nonresponders to low-dose aripiprazole augmentation in patients with inadequate response to antidepressant treatment: a randomized, double-blind, placebo-controlled, efficacy trial
    David Mischoulon
    Depression Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 73:353-7. 2012
    ....
  66. ncbi request reprint Compliance with expert population-based dietary guidelines and lower odds of carotid atherosclerosis in women: the Framingham Nutrition Studies
    Barbara E Millen
    Department of Social and Behavioral Sciences, School of Public Health, Boston University, Boston, MA 02118, USA
    Am J Clin Nutr 82:174-80. 2005
    ..The relation between diet and stenosis is relatively unexplored, particularly in women...
  67. ncbi request reprint Clinical utility of different lipid measures for prediction of coronary heart disease in men and women
    Erik Ingelsson
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803
    JAMA 298:776-85. 2007
    ..Evidence is conflicting regarding the performance of apolipoproteins vs traditional lipids for predicting coronary heart disease (CHD) risk...
  68. ncbi request reprint Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    JAMA 294:3117-23. 2005
    ..While parental cardiovascular disease (CVD) doubles the risk for CVD in offspring, the extent of increased risk associated with sibling CVD is unclear...
  69. ncbi request reprint Estimated risks for developing obesity in the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham 01702 5803, USA
    Ann Intern Med 143:473-80. 2005
    ..The short- and long-term risks for developing overweight or obesity are unknown...
  70. pmc Genotype prediction of adult type 2 diabetes from adolescence in a multiracial population
    Jason L Vassy
    General Medicine Division, and jCenter for Child and Adolescent Health Research and Policy, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pediatrics 130:e1235-42. 2012
    ..Understanding the risk for type 2 diabetes (T2D) early in the life course is important for prevention. Whether genetic information improves prediction models for diabetes from adolescence into adulthood is unknown...
  71. pmc On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data
    Hajime Uno
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA
    Stat Med 30:1105-17. 2011
    ..We provide a large sample approximation to the distribution of this estimator for making inferences about the concordance measure. Results from numerical studies suggest that the new procedure performs well in finite sample...
  72. doi request reprint Invited commentary: Clinical usefulness of the Framingham cardiovascular risk profile beyond its statistical performance
    RALPH B D'AGOSTINO
    Department of Mathematics and Statistics, Boston University, Massachusetts 02215, USA
    Am J Epidemiol 176:187-9. 2012
    ..There are both useful and negative aspects of this application, and caution is advised against a too enthusiastic acceptance of it to evaluate prediction rules for primary prevention of cardiovascular disease...
  73. pmc Improved cardiac risk assessment with noninvasive measures of coronary flow reserve
    Venkatesh L Murthy
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 124:2215-24. 2011
    ..It is unknown whether noninvasive assessment of coronary vasodilator function in patients with suspected or known coronary artery disease carries incremental prognostic significance...
  74. doi request reprint Comparison of academic and nonacademic sites in multi-center clinical trials
    Christina M Dording
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 32:65-8. 2012
    ..Our findings suggest that academic and nonacademic sites are equally effective in their ability to identify and retain appropriate study participants...
  75. doi request reprint Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease
    Jessica L Mega
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 306:2221-8. 2011
    ..Variants in the CYP2C19 gene influence the pharmacologic and clinical response to the standard 75-mg daily maintenance dose of the antiplatelet drug clopidogrel...
  76. ncbi request reprint Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
    ..The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting...
  77. ncbi request reprint Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 115:1544-50. 2007
    ..We tested the hypothesis that the relative burden of CVD attributable to diabetes mellitus (DM) has increased over the past 5 decades...
  78. ncbi request reprint One-year cardiovascular event rates in outpatients with atherothrombosis
    Ph Gabriel Steg
    Departement de Cardiologie, Hopital Bichat Claude Bernard, Paris, France
    JAMA 297:1197-206. 2007
    ....
  79. doi request reprint Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702, USA
    Arch Intern Med 168:587-92. 2008
    ..Overt hypothyroidism and hyperthyroidism may be associated with weight gain and loss. We assessed whether variations in thyroid function within the reference (physiologic) range are associated with body weight...
  80. ncbi request reprint Endogenous sex hormones and cardiovascular disease incidence in men
    Johan Arnlov
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Bethesda, Maryland, USA
    Ann Intern Med 145:176-84. 2006
    ..Yet, prospective studies relating sex hormones to CVD incidence in men have yielded inconsistent results...
  81. doi request reprint BMI vs. waist circumference for identifying vascular risk
    Matthew S Freiberg
    Center for Research on Health Care, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Obesity (Silver Spring) 16:463-9. 2008
    ..0 and 34.9 kg/m(2). We investigated the relative contributions of BMI and WC toward identifying risk of adverse vascular events in a community-based sample...
  82. doi request reprint Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    J Am Coll Cardiol 51:264-70. 2008
    ..We sought to determine whether impaired fasting glucose (IFG) predicts cardiovascular disease (CVD) events...
  83. ncbi request reprint Algorithms for assessing cardiovascular risk in women
    Michael J Pencina
    JAMA 298:175-6; author reply 177-8. 2007
  84. doi request reprint Embolic protection and platelet inhibition during renal artery stenting
    Christopher J Cooper
    Cardiovascular Division, University of Toledo, 3000 Arlington Ave, MS 1036, Toledo, OH 43614, USA
    Circulation 117:2752-60. 2008
    ..Although atheroembolization can cause renal dysfunction during renal stent procedures, whether adjunctive use of embolic protection devices or glycoprotein IIb/IIIa inhibitors improves renal function is unknown...
  85. pmc Advance care planning and health care preferences of community-dwelling elders: the Framingham Heart Study
    Ellen P McCarthy
    Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, 1309 Beacon Street, Suite 220, Brookline, MA 02446, USA
    J Gerontol A Biol Sci Med Sci 63:951-9. 2008
    ..The study objective was to describe self-reported advance care planning, health care preferences, use of advance directives, and health perceptions in a very elderly community-dwelling sample...
  86. ncbi request reprint Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study
    Ravi Dhingra
    National Heart, Lung, and Blood Institute Framingham Heart Study, Bethesda, Maryland, USA
    Am J Hypertens 17:891-6. 2004
    ..We tested the hypothesis that sodium intake is associated with left ventricular (LV) mass and left ventricular hypertrophy (LVH), independent of BP, in the community...