Stephen I Pelton

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Otitis media: re-evaluation of diagnosis and treatment in the era of antimicrobial resistance, pneumococcal conjugate vaccine, and evolving morbidity
    Stephen I Pelton
    Departments of Pediatrics and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA 02118, USA
    Pediatr Clin North Am 52:711-28, v-vi. 2005
  2. doi request reprint Expanding prevention of invasive meningococcal disease
    Stephen I Pelton
    Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    Expert Rev Vaccines 8:717-27. 2009
  3. pmc Modeling the impact of the 13-valent pneumococcal conjugate vaccine serotype catch-up program using United States claims data
    David R Strutton
    Vaccines Market Access and Outcomes Research Specialty Care Business Unit, Pfizer Inc, 500 Arcola Road, Dock D, COL D4555, Collegeville, PA 19426 3930, USA
    BMC Infect Dis 12:175. 2012
  4. ncbi request reprint Panel 6: Vaccines
    Stephen I Pelton
    Boston University School of Medicine, Boston, Massachusetts, USA
    Otolaryngol Head Neck Surg 148:E90-101. 2013
  5. pmc Regulation of bacterial trafficking in the nasopharynx
    Stephen I Pelton
    Boston University Schools of Medicine and Public Health, USA
    Paediatr Respir Rev 13:150-3. 2012
  6. pmc Sialic acid mediated transcriptional modulation of a highly conserved sialometabolism gene cluster in Haemophilus influenzae and its effect on virulence
    Gaynor A Jenkins
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX39DS, UK
    BMC Microbiol 10:48. 2010
  7. ncbi request reprint The decline in invasive pneumococcal disease
    Stephen I Pelton
    Section of Pediatric Infectious Diseases, Boston Medical Center, 774 Albany St, Finland 5, Boston, MA 02118 2393, USA
    Pediatrics 113:617-8. 2004
  8. pmc Improving the outcome of pneumococcal meningitis
    S I Pelton
    Section of Pediatric Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA
    Arch Dis Child 90:333-4. 2005
  9. ncbi request reprint Switch from ritonavir to indinavir in combination therapy for HIV-1-infected children
    Stephen I Pelton
    Boston Medical Center, Boston, MA 02118, USA
    Clin Infect Dis 40:1181-7. 2005
  10. ncbi request reprint Acute otitis media in the era of effective pneumococcal conjugate vaccine: will new pathogens emerge?
    S I Pelton
    Section of Pediatric Infectious Diseases, Boston Medical Center, Boston University School of Medicine, 774 Albany Street Suite 512, Boston, MA 02118, USA
    Vaccine 19:S96-9. 2000

Detail Information

Publications70

  1. ncbi request reprint Otitis media: re-evaluation of diagnosis and treatment in the era of antimicrobial resistance, pneumococcal conjugate vaccine, and evolving morbidity
    Stephen I Pelton
    Departments of Pediatrics and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA 02118, USA
    Pediatr Clin North Am 52:711-28, v-vi. 2005
    ....
  2. doi request reprint Expanding prevention of invasive meningococcal disease
    Stephen I Pelton
    Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    Expert Rev Vaccines 8:717-27. 2009
    ....
  3. pmc Modeling the impact of the 13-valent pneumococcal conjugate vaccine serotype catch-up program using United States claims data
    David R Strutton
    Vaccines Market Access and Outcomes Research Specialty Care Business Unit, Pfizer Inc, 500 Arcola Road, Dock D, COL D4555, Collegeville, PA 19426 3930, USA
    BMC Infect Dis 12:175. 2012
    ..Analysis of US claims data from April 2010 to June 2011 estimated that 39% of the 13-valent pneumococcal conjugate vaccine (PCV13) catch-up eligible cohort would ever receive the catch-up vaccination; a previous analysis assumed 87%...
  4. ncbi request reprint Panel 6: Vaccines
    Stephen I Pelton
    Boston University School of Medicine, Boston, Massachusetts, USA
    Otolaryngol Head Neck Surg 148:E90-101. 2013
    ....
  5. pmc Regulation of bacterial trafficking in the nasopharynx
    Stephen I Pelton
    Boston University Schools of Medicine and Public Health, USA
    Paediatr Respir Rev 13:150-3. 2012
    ..Understanding the significant bacterial interactions as well as how bacteria work in concert to regulate density, expression of virulence factors and capacity to produce disease are likely to provide new approaches to disease prevention...
  6. pmc Sialic acid mediated transcriptional modulation of a highly conserved sialometabolism gene cluster in Haemophilus influenzae and its effect on virulence
    Gaynor A Jenkins
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX39DS, UK
    BMC Microbiol 10:48. 2010
    ..This study aimed to characterise the expression of genes required for the metabolism of sialic acid and to investigate the role of these genes in virulence...
  7. ncbi request reprint The decline in invasive pneumococcal disease
    Stephen I Pelton
    Section of Pediatric Infectious Diseases, Boston Medical Center, 774 Albany St, Finland 5, Boston, MA 02118 2393, USA
    Pediatrics 113:617-8. 2004
  8. pmc Improving the outcome of pneumococcal meningitis
    S I Pelton
    Section of Pediatric Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA
    Arch Dis Child 90:333-4. 2005
  9. ncbi request reprint Switch from ritonavir to indinavir in combination therapy for HIV-1-infected children
    Stephen I Pelton
    Boston Medical Center, Boston, MA 02118, USA
    Clin Infect Dis 40:1181-7. 2005
    ....
  10. ncbi request reprint Acute otitis media in the era of effective pneumococcal conjugate vaccine: will new pathogens emerge?
    S I Pelton
    Section of Pediatric Infectious Diseases, Boston Medical Center, Boston University School of Medicine, 774 Albany Street Suite 512, Boston, MA 02118, USA
    Vaccine 19:S96-9. 2000
    ..Since non-vaccine serotypes are already present in the community as the etiology of acute purulent OM, it is predictable that these non-vaccine serotypes will become more common especially in children less than two years of age...
  11. doi request reprint 7-Valent pneumococcal conjugate vaccine and lower respiratory tract infections: effectiveness of a 2-dose versus 3-dose primary series
    Stephen I Pelton
    Boston University Schools of Medicine and Public Health and Boston Medical Center, Boston, MA, United States
    Vaccine 28:1575-82. 2010
    ....
  12. pmc Efficacy of linezolid in experimental otitis media
    S I Pelton
    Section of Pediatric Infectious Diseases, Maxwell Finland Laboratory for Infectious Diseases, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 44:654-7. 2000
    ..pneumoniae from the middle ear and nasopharynx. Experimental infection and nasopharyngeal colonization due to NTHI persisted despite achievement of concentrations in the middle ear that were above the MIC (for NTHI)...
  13. ncbi request reprint Emergence of 19A as virulent and multidrug resistant Pneumococcus in Massachusetts following universal immunization of infants with pneumococcal conjugate vaccine
    Stephen I Pelton
    Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine, Boston, MA, USA
    Pediatr Infect Dis J 26:468-72. 2007
    ..Ongoing surveillance is necessary to identify emerging invasive serotypes and antimicrobial susceptibilities...
  14. ncbi request reprint Acute otitis media in an era of increasing antimicrobial resistance and universal administration of pneumococcal conjugate vaccine
    Stephen I Pelton
    Boston University School of Medicine, and Department of Pediatrics, Boston Medical Center, MA 02118, USA
    Pediatr Infect Dis J 21:599-604; discussion 613-4. 2002
    ..With these events as the background, I have reviewed the strategies most likely to be successful for the treatment of AOM in 2002...
  15. ncbi request reprint Prospects for prevention of otitis media
    Stephen I Pelton
    Boston University Schools of Medicine and Public Health, Pediatric Infectious Disease, Boston Medical Center, Boston, MA, USA
    Pediatr Infect Dis J 26:S20-2. 2007
    ..A vaccine candidate (Pnc-PD) that encompasses these "attributes" is discussed from the perspective of how it may provide additional protection from middle ear disease if further studies confirm initial data on efficacy...
  16. doi request reprint Recent advances in otitis media
    Stephen I Pelton
    Department of Pediatrics, Boston University School of Medicine, Boston, MA, USA
    Pediatr Infect Dis J 28:S133-7. 2009
    ..Optimal strategy for the prevention of AOM recurrences requires sterilization of the middle ear and eradication of nasopharyngeal carriage of otopathogens during antimicrobial therapy...
  17. pmc Pneumococcal carriage and antibiotic resistance in young children before 13-valent conjugate vaccine
    Peter C Wroe
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Pediatr Infect Dis J 31:249-54. 2012
    ....
  18. ncbi request reprint Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004
    Susan S Huang
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pediatrics 116:e408-13. 2005
    ..Analysis of colonizing serotypes among healthy children in the community provides critical data on such changes...
  19. pmc Multiple consecutive lavage samplings reveal greater burden of disease and provide direct access to the nontypeable Haemophilus influenzae biofilm in experimental otitis media
    Magali Leroy
    Section of Molecular Genetics, Division of Pediatric Infectious Diseases, The Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine, Boston Medical Center, 774 Albany Street, Boston, MA 02118, USA
    Infect Immun 75:4158-72. 2007
    ..Such findings may have direct implications for antibiotic treatment and vaccine development against NTHi...
  20. pmc Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA
    Gili Regev-Yochay
    Division of Infectious Diseases, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Vaccine 28:4842-6. 2010
    ..These emerging piliated non-VT strains are mostly novel clones, with some exceptions. The rise in pilus type 1 frequency across multiple distinct genetic backgrounds suggests that the pilus may confer an intrinsic advantage...
  21. ncbi request reprint Seven valent pneumococcal conjugate vaccine immunization in two Boston communities: changes in serotypes and antimicrobial susceptibility among Streptococcus pneumoniae isolates
    Stephen I Pelton
    Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA
    Pediatr Infect Dis J 23:1015-22. 2004
    ..Seven valent pneumococcal conjugate vaccine (PCV7) was licensed and introduced in 2000 for universal administration of children younger than 2 years of age and for selective immunization of children 2-5 years of age...
  22. doi request reprint Changing serotypes causing childhood invasive pneumococcal disease: Massachusetts, 2001-2007
    Katherine K Hsu
    Section of Pediatric Infectious Diseases, Boston University School of Public Health, Boston University Medical Center, Boston, MA 02118, USA
    Pediatr Infect Dis J 29:289-93. 2010
    ..Statewide surveillance was begun in October 2001 to monitor incidence of invasive disease, serotypes causing disease, antimicrobial susceptibility, and risk features associated with ongoing childhood invasive pneumococcal disease (IPD)...
  23. pmc Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting
    Kunjal Patel
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Infect Dis 46:1751-60. 2008
    ....
  24. pmc Virulence of Streptococcus pneumoniae serotype 6C in experimental otitis media
    Vishakha Sabharwal
    Section of Pediatric Infectious Diseases, Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, 670 Albany Street, 6th Floor, Boston, MA 02118, USA
    Microbes Infect 14:712-8. 2012
    ..Our findings demonstrate that challenge with serotype 6C results in EOM less frequently than 19A. These data support the need for greater knowledge regarding differences among serotypes to produce AOM...
  25. pmc Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era
    Grace M Lee
    Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA
    BMC Infect Dis 9:110. 2009
    ..aureus and MRSA colonization in young children in the context of widespread use of PCV7; and (2) examine risk factors for S. aureus colonization in the post-PCV7 era, including the absence of vaccine-type S. pneumoniae colonization...
  26. pmc Role of complement in host defense against pneumococcal otitis media
    Vishakha Sabharwal
    Section of Pediatric Infectious Diseases, Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston, Massachusetts 02118, USA
    Infect Immun 77:1121-7. 2009
    ..Thus, limiting C3 deposition on the surface of S. pneumoniae correlates with increased incidence of EOM following NP colonization and barotrauma in the animal model...
  27. pmc Population genomics of post-vaccine changes in pneumococcal epidemiology
    Nicholas J Croucher
    Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 45:656-63. 2013
    ..These alterations resulted in little overall effect on accessory genome composition at the population level, contrasting with the decrease in pneumococcal disease rates after the vaccine's introduction...
  28. ncbi request reprint Antibiotic-resistant Streptococcus pneumoniae in the heptavalent pneumococcal conjugate vaccine era: predictors of carriage in a multicommunity sample
    Jonathan A Finkelstein
    Department of Ambulatory Care and Prevention, Harvard Medical School HPHC, Boston, Massachusetts 02215, USA
    Pediatrics 112:862-9. 2003
    ..Data on carriage of resistant organisms by healthy children in communities in which immunization with PCV7 has been implemented will help to define and decrease these risks further...
  29. ncbi request reprint Immunogenicity, safety, and predictors of response after a pneumococcal conjugate and pneumococcal polysaccharide vaccine series in human immunodeficiency virus-infected children receiving highly active antiretroviral therapy
    Mark J Abzug
    University of Colorado School of Medicine, Pediatric Infectious Disease, The Children s Hospital, Denver, CO 80218, USA
    Pediatr Infect Dis J 25:920-9. 2006
    ....
  30. ncbi request reprint Modifying acute otitis media: implications of immunization with pneumococcal conjugate vaccine
    Stephen I Pelton
    Department of Pediatrics, Boston Medical Center, Boston, MA, USA
    Pediatr Infect Dis J 23:839-41. 2004
  31. ncbi request reprint Neuropsychological functioning and viral load in stable antiretroviral therapy-experienced HIV-infected children
    Rita J Jeremy
    Pediatric Clinical Research Center, Department of Pediatrics, School of Medicine, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0105, USA
    Pediatrics 115:380-7. 2005
    ..Neuropsychological functioning and its correlation with viral load were investigated for previously treated HIV-infected children who underwent a change in treatment regimen...
  32. pmc Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media
    Valerie Bouchet
    Maxwell Finland Laboratory for Infectious Diseases, Division of Pediatric Infectious Diseases, Boston University School of Medicine, Boston Medical Center, 774 Albany Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 100:8898-903. 2003
    ..We conclude that sialylated LPS glycoforms play a key role in pathogenicity of nontypeable H. influenzae and depend on scavenging the essential precursors from the host during the infection...
  33. doi request reprint Evolving picture of invasive pneumococcal disease in massachusetts children: a comparison of disease in 2007-2009 with earlier periods
    Inci Yildirim
    Department of Pediatrics, Yale New Haven Children s Hospital, New Haven, CT 06525, USA
    Pediatr Infect Dis J 31:1016-21. 2012
    ..In addition to the substantial decline in IPD, increased disease due to nonvaccine serotypes and a changing clinical presentation emerged. The objective of this study is to describe these trends in IPD in the late PCV7-era...
  34. pmc Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants
    Marisol A Figueira
    Section of Pediatric Infectious Diseases, Maxwell Finland Laboratory for Infectious Diseases, Room 508, 774 Albany Street, Boston Medical Center, Boston, MA 02118, USA
    Infect Immun 75:325-33. 2007
    ..influenzae strains, which in turn may impact their virulence. These data demonstrate a central role for complement in innate immune defenses against NT H. influenzae infections and specifically EOM...
  35. pmc Prevalence and genetic diversity of nontypeable haemophilus influenzae in the respiratory tract of infants and primary caregivers
    Sandra K Schumacher
    Department of Pediatric Infectious Diseases, Boston University Medical Center, Boston, MA 02118, USA
    Pediatr Infect Dis J 31:145-9. 2012
    ..Colonization, strain diversity, transmission, and antimicrobial susceptibility have implications for both children and their caregivers...
  36. pmc Impact of HAART and CNS-penetrating antiretroviral regimens on HIV encephalopathy among perinatally infected children and adolescents
    Kunjal Patel
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    AIDS 23:1893-901. 2009
    ....
  37. ncbi request reprint Recent advances in otitis media. 6. Vaccine
    G Scott Giebink
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, USA
    Ann Otol Rhinol Laryngol Suppl 194:86-103. 2005
  38. pmc Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era
    Sharon A Nachman
    Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794 8111, USA
    Arch Pediatr Adolesc Med 163:164-71. 2009
    ....
  39. pmc Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study
    Paige L Williams
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Am J Epidemiol 167:1375-86. 2008
    ..Although participant characteristics are difficult to modify, the authors identified several potentially modifiable site practices that could be targeted to improve retention...
  40. doi request reprint Clinically based surveillance of invasive meningococcal disease in young children admitted to selected US hospitals between January 2000 and June 2009: a retrospective cohort study
    Ariel Berger
    Policy Analysis Inc, Brookline, MA, USA
    Hum Vaccin Immunother 8:384-9. 2012
    ....
  41. pmc Differential occurrence of Streptococcus pneumoniae serotype 11E between asymptomatic carriage and invasive pneumococcal disease isolates reflects a unique model of pathogen microevolution
    Juan J Calix
    Department of Microbiology, Boston University Medical Center, Massachusetts, USA
    Clin Infect Dis 54:794-9. 2012
    ..We investigated whether the presumed lack of transmission of serotype 11E is consistent with its inability to survive in the NP...
  42. ncbi request reprint HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response
    Margaret E Feeney
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 174:7524-30. 2005
    ..Taken together, these findings indicate that the developing immune system of children may exhibit greater plasticity in responding to a continually evolving chronic viral infection...
  43. ncbi request reprint Pneumococcal conjugate vaccines: proceedings from an interactive symposium at the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy
    Stephen I Pelton
    Boston University School of Medicine, Boston Medical Center, Boston, MA, USA
    Vaccine 21:1562-71. 2003
    ....
  44. ncbi request reprint Heptavalent pneumococcal conjugate vaccine: current and future impact
    Katherine K Hsu
    Boston University Medical Center, Section of Pediatric Infectious Diseases, 774 Albany Street, Finland Labs 5th Floor, Boston, MA 02118 2393, USA
    Expert Rev Vaccines 2:619-31. 2003
    ....
  45. pmc Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children
    Katherine Tassiopoulos
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 47:607-14. 2008
    ..Antiretroviral therapy has been associated with hypercholesterolemia in HIV-infected children. Few longitudinal studies have been conducted to examine this association, however...
  46. doi request reprint Underlying conditions in children with invasive pneumococcal disease in the conjugate vaccine era
    Katherine K Hsu
    Section of Pediatric Infectious Diseases, Boston University School of Public Health, Boston University Medical Center, Boston, MA, USA
    Pediatr Infect Dis J 30:251-3. 2011
    ..HR/PHR cases tended to be older and were more likely to be hospitalized than were children with NKR. Children with asthma presented with pneumonia more often than children with NKR...
  47. ncbi request reprint Overcoming current obstacles in the management of bacterial community-acquired pneumonia in ambulatory children
    Stephen I Pelton
    Boston Medical Center, Boston, MA 02118, USA
    Clin Pediatr (Phila) 44:1-17. 2005
  48. doi request reprint Capsular switching as a strategy to increase pneumococcal virulence in experimental otitis media model
    Vishakha Sabharwal
    Section of Pediatric Infectious Diseases, Boston Medical Center, Boston, MA 02118, USA Electronic address
    Microbes Infect 16:292-9. 2014
    ..Our observations though limited to two serotypes demonstrate that capsular switch events can result in Streptococcus pneumoniae strains of enhanced virulence for respiratory tract infection. ..
  49. ncbi request reprint Effectiveness of abbreviated and delayed 7-valent pneumococcal conjugate vaccine dosing regimens
    Barbara E Mahon
    Departments of Epidemiology and Pediatrics, T3E, Boston University School of Public Health and Medicine, 715 Albany Street, Boston, MA 02118, USA
    Vaccine 24:2514-20. 2006
    ..Data for regimens begun at 12-23 months were inconclusive. These data support the use of the 2-dose and 3-dose infant PCV7 regimens when the full series cannot be delivered and detail the limitations of abbreviated dosing regimens...
  50. pmc Experimental acute otitis media due to nontypeable Haemophilus influenzae: comparison of high and low azithromycin doses with placebo
    Franz E Babl
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Antimicrob Agents Chemother 46:2194-9. 2002
    ....
  51. ncbi request reprint The future of pneumococcal conjugate vaccines for prevention of pneumococcal diseases in infants and children
    Stephen I Pelton
    Department of Pediatrics, Boston University School of Medicine, and Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston, Massachusetts 02118, USA
    Pediatrics 110:805-14. 2002
    ....
  52. ncbi request reprint Immune response to pneumococcal conjugate and polysaccharide vaccines in otitis-prone and otitis-free children
    E D Barnett
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, and Boston University School of Public Health, Massachusetts 02118, USA
    Clin Infect Dis 29:191-2. 1999
    ..Pneumococcal conjugate vaccine has the potential to reduce the incidence of disease due to vaccine serotypes, even among children with recurrent otitis media...
  53. pmc Serotype specific invasive capacity and persistent reduction in invasive pneumococcal disease
    Inci Yildirim
    Department of Pediatrics, Boston University, School of Medicine, Boston, MA, USA
    Vaccine 29:283-8. 2010
    ..g. 33F, 22F) as successful colonizers resulting in increased IPD incidence due to replacement serotypes...
  54. ncbi request reprint Direct and indirect effects of PCV13 on nasopharyngeal carriage of PCV13 unique pneumococcal serotypes in Massachusetts' children
    Anita M Loughlin
    From the Boston University School of Medicine and Boston Medical Center, Boston, MA
    Pediatr Infect Dis J 33:504-10. 2014
    ..The direct impact of 13-valent pneumococcal conjugate vaccine (PCV13) on colonization with unique PCV13 serotypes and the uptake of vaccine necessary to create indirect protection in nonimmunized children were assessed...
  55. pmc Variability of outer membrane protein P1 and its evaluation as a vaccine candidate against experimental otitis media due to nontypeable Haemophilus influenzae: an unambiguous, multifaceted approach
    G R Bolduc
    The Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Infect Immun 68:4505-17. 2000
    ....
  56. doi request reprint Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM]
    Marisol Figueira
    Section of Pediatric Infectious Diseases, Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 9:e83798. 2014
    ....
  57. pmc Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens
    Colette Cywes-Bentley
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E2209-18. 2013
    ..Vaccination targeting PNAG could contribute to immunity against serious and diverse prokaryotic and eukaryotic pathogens, and the conserved production of PNAG suggests that it is a critical factor in microbial biology...
  58. pmc Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice
    Lee J Quinton
    The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA
    J Clin Invest 122:1758-63. 2012
    ....
  59. ncbi request reprint Detection of group B streptococcal bacteremia in simulated intrapartum antimicrobial prophylaxis
    Katherine K Hsu
    Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine and Boston Medical Center, Boston, MA, 02118, USA
    Diagn Microbiol Infect Dis 45:23-7. 2003
    ..agalactiae than did either of two non-resin-containing media, in the presence of antibiotic levels likely present in fetal sera following intrapartum antimicrobial prophylaxis...
  60. ncbi request reprint Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection
    Margaret E Feeney
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 171:6968-75. 2003
    ..009) and of greater magnitude (p = 0.002). These data suggest that children may have a greater intrinsic capacity to reconstitute HIV-1-specific immunity than adults, and may be excellent candidates for immune-based therapies...
  61. ncbi request reprint Case records of the Massachusetts General Hospital. Case 27-2006. A 17-year-old boy with fever and lesions in the liver and spleen
    Stephen I Pelton
    Department of Pediatric Infectious Disease, Boston Medical Center, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 355:941-8. 2006
  62. ncbi request reprint Constancy of distribution of serogroups of invasive pneumococcal isolates among children: experience during 4 decades
    F E Babl
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    Clin Infect Dis 32:1155-61. 2001
    ..A comparison of these findings with historical pediatric data from our institution showed serogroup stability dating back to 1957...
  63. pmc Formulations for trans-tympanic antibiotic delivery
    Xiaojuan Khoo
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 34:1281-8. 2013
    ..CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases...
  64. ncbi request reprint Xanthomas and hyperlipidemia in a human immunodeficiency virus-infected child receivng highly active antiretroviral therapy
    Franz E Babl
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, MA, USA
    Pediatr Infect Dis J 21:259-60. 2002
    ....
  65. pmc Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors
    Brian L Robbins
    St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Antimicrob Agents Chemother 52:3276-83. 2008
    ....
  66. doi request reprint Replacement pneumococcal disease in perspective
    Stephen I Pelton
    Clin Infect Dis 46:1353-5. 2008
  67. ncbi request reprint Diversity and antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae carriage isolates in the post-heptavalent conjugate vaccine era
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College, London, UK
    J Infect Dis 195:347-52. 2007
    ..Possible mechanisms include de novo acquisition of resistance, serotype switching, introduction of new clones, and expansion of existing clones...
  68. ncbi request reprint Multinational study of pneumococcal serotypes causing acute otitis media in children
    William P Hausdorff
    Wyeth Vaccines, West Henrietta, NY 14586, USA
    Pediatr Infect Dis J 21:1008-16. 2002
    ..More than 90 immunologically distinct pneumococcal serotypes have been identified, but limited information is available regarding their relative importance in AOM...
  69. ncbi request reprint Pediatric respiratory tract infections: etiology, microbiology and resistance trends. Introduction
    Stephen I Pelton
    Pediatr Infect Dis J 22:S107-8. 2003
  70. ncbi request reprint Pertussis booster vaccination in HIV-infected children receiving highly active antiretroviral therapy
    Mark J Abzug
    School of Medicine, University of Colorado and Children s Hospital, Denver, Colorado, USA
    Pediatrics 120:e1190-202. 2007
    ..Our goal was to evaluate the immunogenicity and safety of pertussis booster vaccination in children infected with HIV on highly active antiretroviral therapy (HAART)...