H Y Park

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes
    Hee Young Park
    Department of Dermatology, School of Medicine, Boston University, Boston, MA 02118, USA
    Int J Cell Biol 2009:750482. 2009
  2. ncbi request reprint Cellular mechanisms regulating human melanogenesis
    H Y Park
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    Cell Mol Life Sci 66:1493-506. 2009
  3. ncbi request reprint The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-beta on melanosomes
    Hee Young Park
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    J Cell Sci 117:3659-68. 2004
  4. ncbi request reprint Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation
    Hee Young Park
    Department of Dermatology, Boston University School of Medicine, Massachusetts 02118, USA
    J Invest Dermatol 122:159-66. 2004
  5. ncbi request reprint Signaling pathways mediating melanogenesis
    H Y Park
    Department of Dermatology, Boston University School of Medicine, MA 02118 2394, USA
    Cell Mol Biol (Noisy-le-grand) 45:919-30. 1999
  6. ncbi request reprint Detection of UV-induced pigmentary and epidermal changes over time using in vivo reflectance confocal microscopy
    Maritza A Middelkamp-Hup
    Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Invest Dermatol 126:402-7. 2006
  7. ncbi request reprint Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C
    H Y Park
    Department of Dermatology, Boston University School of Medicine, Massachusetts 02118, USA
    Exp Cell Res 227:70-9. 1996
  8. ncbi request reprint Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain
    H Y Park
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 274:16470-8. 1999
  9. ncbi request reprint Protein kinase C-beta-mediated complex formation between tyrosinase and TRP-1
    Heng Wu
    Department of Hematology Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Biochem Biophys Res Commun 311:948-53. 2003
  10. pmc MITF mediates cAMP-induced protein kinase C-beta expression in human melanocytes
    Hee Young Park
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street J 205, Boston, MA 02118 2394, USA
    Biochem J 395:571-8. 2006

Collaborators

Detail Information

Publications13

  1. pmc Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes
    Hee Young Park
    Department of Dermatology, School of Medicine, Boston University, Boston, MA 02118, USA
    Int J Cell Biol 2009:750482. 2009
    ....
  2. ncbi request reprint Cellular mechanisms regulating human melanogenesis
    H Y Park
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    Cell Mol Life Sci 66:1493-506. 2009
    ..These events are tightly regulated by a variety of paracrine and autocrine factors in response to endogenous and exogenous stimuli, principally UV irradiation...
  3. ncbi request reprint The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-beta on melanosomes
    Hee Young Park
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    J Cell Sci 117:3659-68. 2004
    ..Taken together, these results demonstrate that RACK-I anchors activated PKC-beta on the melanosome membrane, allowing PKC-beta to phosphorylate tyrosinase...
  4. ncbi request reprint Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation
    Hee Young Park
    Department of Dermatology, Boston University School of Medicine, Massachusetts 02118, USA
    J Invest Dermatol 122:159-66. 2004
    ..These results demonstrate that inhibiting PKC activity in vivo selectively blocks tanning and reduces basal pigmentation in the epidermis and in anagen hair shafts...
  5. ncbi request reprint Signaling pathways mediating melanogenesis
    H Y Park
    Department of Dermatology, Boston University School of Medicine, MA 02118 2394, USA
    Cell Mol Biol (Noisy-le-grand) 45:919-30. 1999
    ..This article reviews recent progress in identifying signal transduction pathways that mediate melanogenesis...
  6. ncbi request reprint Detection of UV-induced pigmentary and epidermal changes over time using in vivo reflectance confocal microscopy
    Maritza A Middelkamp-Hup
    Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Invest Dermatol 126:402-7. 2006
    ..This technique should greatly enhance our appreciation of dynamic pigmentary changes in human or animal skin over time and in response to specific stimuli...
  7. ncbi request reprint Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C
    H Y Park
    Department of Dermatology, Boston University School of Medicine, Massachusetts 02118, USA
    Exp Cell Res 227:70-9. 1996
    ....
  8. ncbi request reprint Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain
    H Y Park
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 274:16470-8. 1999
    ..We conclude that PKC-beta activates tyrosinase directly by phosphorylating serine residues at positions 505 and 509 in the cytoplasmic domain of this melanosome-associated protein...
  9. ncbi request reprint Protein kinase C-beta-mediated complex formation between tyrosinase and TRP-1
    Heng Wu
    Department of Hematology Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Biochem Biophys Res Commun 311:948-53. 2003
    ..These results suggest that phosphorylation of tyrosinase by PKC-beta induces a complex formation between tyrosinase and TRP-1...
  10. pmc MITF mediates cAMP-induced protein kinase C-beta expression in human melanocytes
    Hee Young Park
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street J 205, Boston, MA 02118 2394, USA
    Biochem J 395:571-8. 2006
    ..Together, these results demonstrate that MITF, specifically MITF-M, is a key transcription factor for PKC-beta, linking the PKC- and cAMP-dependent pathways in regulation of melanogenesis...
  11. ncbi request reprint Bone morphogenetic protein-4, a novel modulator of melanogenesis
    Mina Yaar
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 281:25307-14. 2006
    ..Our data provide evidence of a novel regulatory pathway for melanogenesis in human skin...
  12. ncbi request reprint More on MITF
    Hee Young Park
    Boston University School of Medicine, Boston, MA, USA
    J Invest Dermatol 119:1218-9. 2002
  13. ncbi request reprint Modulation of vascular endothelial growth factor receptors in melanocytes
    Ellen J Kim
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
    Exp Dermatol 14:625-33. 2005
    ..Prolonged culture (>8 weeks) in the presence of phorbol ester abrogates VEGFR-2 expression, explaining previous reports that Mc do not express VEGFR-1 and VEGFR-2. These data suggest that VEGF may play a role in Mc behavior in skin...