Noriyuki Ouchi

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Adiponectin as an anti-inflammatory factor
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Clin Chim Acta 380:24-30. 2007
  2. pmc Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:32802-11. 2008
  3. pmc Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
    Noriyuki Ouchi
    Molecular Cardiology and Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Science 329:454-7. 2010
  4. ncbi request reprint Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street W611, Boston, Massachusetts 02118, USA
    J Biol Chem 279:28670-4. 2004
  5. pmc Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
    Masayuki Shimano
    Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, MA, USA
    J Mol Cell Cardiol 49:210-20. 2010
  6. pmc Adiponectin-mediated modulation of hypertrophic signals in the heart
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, Massachusetts 02118, USA
    Nat Med 10:1384-9. 2004
  7. pmc Adiponectin protects against the development of systolic dysfunction following myocardial infarction
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    J Mol Cell Cardiol 42:1065-74. 2007
  8. pmc Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism
    Koji Ohashi
    Molecular Cardiology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Mol Cell Biol 29:3487-99. 2009
  9. pmc Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury
    Yuichi Oshima
    Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, Mass 02118, USA
    Circulation 120:1606-15. 2009
  10. pmc Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload
    Masayuki Shimano
    Whitaker Cardiovascular Institute, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 108:E899-906. 2011

Collaborators

Detail Information

Publications44

  1. pmc Adiponectin as an anti-inflammatory factor
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Clin Chim Acta 380:24-30. 2007
    ..In this review, we focus on the role of adiponectin in regulation of inflammatory response and discuss its potential as an anti-inflammatory marker...
  2. pmc Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:32802-11. 2008
    ....
  3. pmc Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
    Noriyuki Ouchi
    Molecular Cardiology and Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Science 329:454-7. 2010
    ..Thus, in the setting of obesity, Sfrp5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue...
  4. ncbi request reprint Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street W611, Boston, Massachusetts 02118, USA
    J Biol Chem 279:28670-4. 2004
    ..Therefore, adiponectin may be useful in the treatment for obesity-related vascular deficiency diseases...
  5. pmc Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
    Masayuki Shimano
    Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, MA, USA
    J Mol Cell Cardiol 49:210-20. 2010
    ..Collectively, these data show that adiponectin deficiency can accelerate the transition from cardiac hypertrophy to heart failure during pressure overload through disruption of AMPK-dependent angiogenic regulatory axis...
  6. pmc Adiponectin-mediated modulation of hypertrophic signals in the heart
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, Massachusetts 02118, USA
    Nat Med 10:1384-9. 2004
    ..Adiponectin may have utility for the treatment of hypertrophic cardiomyopathy associated with diabetes and other obesity-related diseases...
  7. pmc Adiponectin protects against the development of systolic dysfunction following myocardial infarction
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    J Mol Cell Cardiol 42:1065-74. 2007
    ....
  8. pmc Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism
    Koji Ohashi
    Molecular Cardiology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Mol Cell Biol 29:3487-99. 2009
    ..Thus, disruption of the adiponectin-COX-2 regulatory axis in endothelial cells could participate in the pathogenesis of obesity-related vascular diseases...
  9. pmc Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury
    Yuichi Oshima
    Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, Mass 02118, USA
    Circulation 120:1606-15. 2009
    ..Follistatin-like 3 (Fstl3) is an extracellular regulator of activin A protein, and its function in the heart is also unknown...
  10. pmc Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload
    Masayuki Shimano
    Whitaker Cardiovascular Institute, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 108:E899-906. 2011
    ....
  11. pmc Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling
    Eric E Essick
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Heart Circ Physiol 301:H984-93. 2011
    ..Its effects on ROS and ultimately on MMP expression define the protective role of APN against ROS-induced cardiac remodeling...
  12. pmc Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure
    Flora Sam
    Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Endocrinology 151:322-31. 2010
    ..Therefore, hypoadiponectinemia in hypertension-induced diastolic HF exacerbates LVH, diastolic dysfunction, and diastolic HF. Whether or not adiponectin replacement prevents the progression to diastolic HF will warrant further study...
  13. pmc Adiponectin suppresses pathological microvessel formation in retina through modulation of tumor necrosis factor-alpha expression
    Akiko Higuchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Circ Res 104:1058-65. 2009
    ..These data provide evidence that adiponectin protects against retinal vessel injury following pathological stimuli through modulation of TNF-alpha inflammatory responses...
  14. pmc Thiazolidinediones reduce pathological neovascularization in ischemic retina via an adiponectin-dependent mechanism
    Akiko Higuchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany St, W611, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 30:46-53. 2010
    ..However, little is known about the effects of TZDs on retinal microvessel disorders...
  15. pmc Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart
    Yuichi Oshima
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University Medical School, 700 Albany St, W611, Boston, MA 02118, USA
    Circulation 117:3099-108. 2008
    ..To identify factors with novel therapeutic applications in cardiac diseases, we focused on the identification of factors secreted from Akt1-activated cells that have cardioprotective effects through autocrine/paracrine mechanisms...
  16. pmc Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 11:1096-103. 2005
    ..These data suggest that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2-dependent mechanisms...
  17. pmc Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype
    Koji Ohashi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:6153-60. 2010
    ....
  18. pmc DIP2A functions as a FSTL1 receptor
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:7127-34. 2010
    ..These data indicate that DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1...
  19. pmc FGF21 is an Akt-regulated myokine
    Yasuhiro Izumiya
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, United States
    FEBS Lett 582:3805-10. 2008
    ..These data indicate that skeletal muscle is a source of FGF21 and that its expression is regulated by a phosphatidylinosistol 3-kinase (PI3-kinase)/Akt1 signaling pathway-dependent mechanism...
  20. pmc Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy
    Masayuki Shimano
    Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, Massachusetts 02118, USA
    J Biol Chem 286:9840-8. 2011
    ..These findings identify Fstl3 as a stress-induced regulator of hypertrophy that controls myocyte size via regulation of Smad signaling...
  21. pmc Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction
    Gennaro Galasso
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Circ Res 98:254-61. 2006
    ..These data suggest that EPC dysfunction is a mechanism by which elevated levels of ROS can contribute to vascular disease...
  22. pmc LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis
    Koji Ohashi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:22291-8. 2010
    ..These observations suggest that the LKB1-AMPK signaling axis in endothelial cells is a positive regulator of the revascularization response to tissue ischemia...
  23. ncbi request reprint Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Cardiovasc Res 74:471-9. 2007
    ..This study investigated the expression and myocardial accumulation of adiponectin in a murine model of ischemia-reperfusion injury...
  24. pmc Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes
    Yasumasa Ikeda
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    FEBS Lett 582:1147-50. 2008
    ..These findings suggest that APN is a physiological regulator of COX-2 signaling in the heart and that this regulation occurs in part via a SphK-1-S1P receptor dependent mechanism in cardiac myocytes...
  25. pmc Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies
    Yukihiro Takemura
    Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 117:375-86. 2007
    ..We propose that adiponectin protects the organism from systemic inflammation by promoting the clearance of early apoptotic cells by macrophages through a receptor-dependent pathway involving calreticulin...
  26. pmc Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease
    Ross Summer
    The Pulmonary Center, R 304, Boston Univ School of Medicine, 80 East Concord St, Boston, MA 02118, USA
    Am J Physiol Lung Cell Mol Physiol 297:L432-8. 2009
    ....
  27. pmc Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure
    Anthony G Garcia
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Heart Circ Physiol 303:H587-96. 2012
    ..These findings suggest that IFNγ may mediate adaptive downstream responses and challenge the concept that inflammatory cytokines mediate only adverse effects...
  28. pmc Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation
    Jason M Konter
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 188:854-63. 2012
    ..g., obesity) predispose to development of ALI through exaggerated inflammatory response in pulmonary vascular endothelium...
  29. ncbi request reprint Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms
    Masaki Nishimura
    Stroke and Neurovascular Regulation Laboratory, Boston University School of Medicine, Boston, MA, USA
    Circulation 117:216-23. 2008
    ..A low level of plasma adiponectin is associated with increased mortality after ischemic stroke; however, the causal role of adiponectin in ischemic stroke is unknown...
  30. pmc Insulin-like 6 is induced by muscle injury and functions as a regenerative factor
    Ling Zeng
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University Medical Campus, Boston, Massachusetts 02118, USA
    J Biol Chem 285:36060-9. 2010
    ..Conversely, knockdown of Insl6 reduced proliferation and increased apoptosis. These data indicate that Insl6 is an injury-regulated myokine that functions as a myogenic regenerative factor...
  31. pmc Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice
    Yasuhiro Izumiya
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Cell Metab 7:159-72. 2008
    ..Our findings indicate that an increase in fast/glycolytic muscle mass can result in the regression of obesity and metabolic improvement through its ability to alter fatty acid oxidation in remote tissues...
  32. pmc Adiponectin modulates oxidative stress-induced autophagy in cardiomyocytes
    Eric E Essick
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 8:e68697. 2013
    ..These findings demonstrate the anti-oxidant potential of APN in oxidative stress-associated cardiovascular diseases, such as hypertension-induced HF-preserved EF...
  33. ncbi request reprint Adiponectin and cardiovascular inflammatory responses
    Yukihiro Takemura
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Curr Atheroscler Rep 9:238-43. 2007
    ..This review focuses on the anti-inflammatory properties of adiponectin in various experimental systems, especially with respect to cardiovascular diseases...
  34. pmc Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure
    Allan J Walkey
    Department of Medicine, The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA
    Crit Care Med 38:2329-34. 2010
    ..We examined the association between plasma adiponectin and clinical outcomes in critically ill patients with acute respiratory failure...
  35. doi request reprint Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism
    Yuichi Akasaki
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, 02118, USA Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Aging Cell 13:80-91. 2014
    ....
  36. pmc The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice
    Fuzhong Qin
    Cardiovascular Medicine Section, Department of Medicine, and the Myocardial and Vascular Biology Units, Boston University Medical Center, Boston, MA 02118, USA
    Circulation 125:1757-64, S1-6. 2012
    ..Polyphenols such as resveratrol and the synthetic flavonoid derivative S17834 exert beneficial systemic and cardiovascular effects in a variety of settings including diabetes mellitus and chronic hemodynamic overload...
  37. pmc Adiponectin actions in the cardiovascular system
    Teresa A Hopkins
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Cardiovasc Res 74:11-8. 2007
    ..This review will discuss the epidemiological and experimental studies that have elucidated the role of adiponectin in a variety of cardiovascular diseases...
  38. ncbi request reprint Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1304-9. 2004
    ..These data indicate that adiponectin can function to stimulate the new blood vessel growth by promoting cross-talk between AMP-activated protein kinase and Akt signaling within endothelial cells...
  39. ncbi request reprint AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 96:838-46. 2005
    ..These data indicate that AMPK-p38 MAPK signaling cascade can increase VEGF production in muscle and promote angiogenesis in response to ischemic injury...
  40. pmc Cardioprotection by adiponectin
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Trends Cardiovasc Med 16:141-6. 2006
    ..This review focuses on the role of adiponectin in the regulation of myocardial remodeling and acute cardiac injury...
  41. ncbi request reprint Targeting adiponectin for cardioprotection
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Expert Opin Ther Targets 10:573-81. 2006
    ..Thus, adiponectin could emerge as a potential cardioprotective agent for the treatment of several pathological heart conditions...
  42. ncbi request reprint Adiponectin in essential hypertension
    Francesca Mallamaci
    CNR, Center of Clinical Physiology, Reggio Calabria, Italy
    J Nephrol 15:507-11. 2002
    ..High levels in essential hypertensives may be the expression of a counter-regulatory response aimed at mitigating endothelial damage and cardiovascular risk associated with high arterial pressure...
  43. doi request reprint Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction
    Rei Shibata
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Cardiol 101:1712-5. 2008
    ....
  44. ncbi request reprint Circulating adiponectin levels in patients with atrial fibrillation
    Masayuki Shimano
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Circ J 72:1120-4. 2008
    ....