M W Otto

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi Five sessions and counting: considering ultra-brief treatment for panic disorder
    Michael W Otto
    Boston University, Center for Anxiety and Related Disorders, Boston, Massachusetts 02215, USA
    Depress Anxiety 29:465-70. 2012
  2. ncbi Emotional exposure in the treatment of substance use disorders: conceptual model, evidence, and future directions
    Michael W Otto
    Boston University Center for Anxiety and Related Disorders, 648 Beacon Street Sixth Floor, Boston, MA 02215, USA
    Clin Psychol Rev 25:824-39. 2005
  3. ncbi Attending to emotional cues for drug abuse: bridging the gap between clinic and home behaviors
    Michael W Otto
    Boston University, Boston, MA 02215 2013, USA
    Sci Pract Perspect 3:48-56. 2007
  4. ncbi Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Br J Psychiatry 189:20-5. 2006
  5. ncbi Posttraumatic stress disorder symptoms following media exposure to tragic events: impact of 9/11 on children at risk for anxiety disorders
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, MA, United States
    J Anxiety Disord 21:888-902. 2007
  6. ncbi Rates of isolated sleep paralysis in outpatients with anxiety disorders
    Michael W Otto
    Center for Anxiety and Related Disorders, Boston University, 648 Beacon St, Floor 6, Boston, MA 02114, USA
    J Anxiety Disord 20:687-93. 2006
  7. ncbi Dysfunctional attitudes and episodes of major depression: Predictive validity and temporal stability in never-depressed, depressed, and recovered women
    Michael W Otto
    Center for Anxiety and Related Disorders, Boston University, MA 02215, USA
    J Abnorm Psychol 116:475-83. 2007
  8. ncbi Effects of D-cycloserine administration on weekly nonemotional memory tasks in healthy participants
    Michael W Otto
    Boston University, Harvard Medical School, Boston, MA 02215, USA
    Psychother Psychosom 78:49-54. 2009
  9. ncbi Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder
    Michael W Otto
    Center for Anxiety and Related Disorders at Boston University, Massachusetts 02215, USA
    Biol Psychiatry 67:365-70. 2010
  10. ncbi Posttraumatic stress disorder in patients with bipolar disorder: a review of prevalence, correlates, and treatment strategies
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Bipolar Disord 6:470-9. 2004

Research Grants

  1. 1/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
    Michael Otto; Fiscal Year: 2009
  2. Stress, Distress Intolerance, and Drug Dependence
    Michael Otto; Fiscal Year: 2007
  3. Context Effects in De Novo Fear Conditioning in Humans
    Michael Otto; Fiscal Year: 2006
  4. 1/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
    Michael W Otto; Fiscal Year: 2010

Collaborators

Detail Information

Publications98

  1. ncbi Five sessions and counting: considering ultra-brief treatment for panic disorder
    Michael W Otto
    Boston University, Center for Anxiety and Related Disorders, Boston, Massachusetts 02215, USA
    Depress Anxiety 29:465-70. 2012
    ..This manuscript evaluates the utility of brief cognitive-behavioral therapy for panic disorder...
  2. ncbi Emotional exposure in the treatment of substance use disorders: conceptual model, evidence, and future directions
    Michael W Otto
    Boston University Center for Anxiety and Related Disorders, 648 Beacon Street Sixth Floor, Boston, MA 02215, USA
    Clin Psychol Rev 25:824-39. 2005
    ..Hypothesized moderators and mediators of this treatment approach were discussed, as were similarities between this research agenda and an increasing focus on the role of emotional acceptance/tolerance in cognitive-behavioral treatments...
  3. ncbi Attending to emotional cues for drug abuse: bridging the gap between clinic and home behaviors
    Michael W Otto
    Boston University, Boston, MA 02215 2013, USA
    Sci Pract Perspect 3:48-56. 2007
    ..Clinical trials support the approach for patients with panic disorder who have trouble discontinuing benzodiazepines, and early trials suggest it may be useful for patients addicted to other drugs as well...
  4. ncbi Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Br J Psychiatry 189:20-5. 2006
    ..The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder...
  5. ncbi Posttraumatic stress disorder symptoms following media exposure to tragic events: impact of 9/11 on children at risk for anxiety disorders
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, MA, United States
    J Anxiety Disord 21:888-902. 2007
    ..Given the links between PTSD symptoms and viewing habits, parental monitoring of media exposure may be important for younger children...
  6. ncbi Rates of isolated sleep paralysis in outpatients with anxiety disorders
    Michael W Otto
    Center for Anxiety and Related Disorders, Boston University, 648 Beacon St, Floor 6, Boston, MA 02114, USA
    J Anxiety Disord 20:687-93. 2006
    ..Results are discussed relative to other variables predicting variability in the occurrence of ISP...
  7. ncbi Dysfunctional attitudes and episodes of major depression: Predictive validity and temporal stability in never-depressed, depressed, and recovered women
    Michael W Otto
    Center for Anxiety and Related Disorders, Boston University, MA 02215, USA
    J Abnorm Psychol 116:475-83. 2007
    ..N. Weissman & A. T. Beck, 1978) when the formerly depressed and never-depressed cohorts were considered separately. Implications for cognitive theories are discussed...
  8. ncbi Effects of D-cycloserine administration on weekly nonemotional memory tasks in healthy participants
    Michael W Otto
    Boston University, Harvard Medical School, Boston, MA 02215, USA
    Psychother Psychosom 78:49-54. 2009
    ..In this study, we investigated the relative benefit of DCS versus placebo for enhancing nonemotional verbal and nonverbal memory across weekly trials...
  9. ncbi Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder
    Michael W Otto
    Center for Anxiety and Related Disorders at Boston University, Massachusetts 02215, USA
    Biol Psychiatry 67:365-70. 2010
    ..Enhancement of cognitive-behavior therapy with d-cycloserine (DCS) pharmacotherapy represents a novel strategy for improving therapeutic learning from cognitive-behavior therapy that remains untested in panic disorder...
  10. ncbi Posttraumatic stress disorder in patients with bipolar disorder: a review of prevalence, correlates, and treatment strategies
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Bipolar Disord 6:470-9. 2004
    ..In this article, we review the evidence for, and implications of, a high rate of comorbid posttraumatic stress disorder (PTSD) in individuals with bipolar disorder...
  11. ncbi Prevalence and predictors of depressive symptoms in older premenopausal women: the Harvard Study of Moods and Cycles
    B L Harlow
    Harvard Medical School, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Arch Gen Psychiatry 56:418-24. 1999
    ..The Harvard Study of Moods and Cycles is a community-based cohort study designed to evaluate the relationship between major depression and changes in menstrual and ovarian function...
  12. ncbi Prevalence of body dysmorphic disorder in a community sample of women
    M W Otto
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:2061-3. 2001
    ..In a large population-based study, the authors examined the prevalence and correlates of body dysmorphic disorder, a debilitating and chronic condition characterized by an imagined defect in appearance...
  13. ncbi A comparison of the efficacy of clonazepam and cognitive-behavioral group therapy for the treatment of social phobia
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Anxiety Disord 14:345-58. 2000
    ....
  14. ncbi Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Wang ACC 815, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Am J Psychiatry 161:2222-9. 2004
    ..The authors provide a detailed perspective on the correlates of comorbid anxiety in a large, well-characterized sample of bipolar disorder patients...
  15. ncbi Next-step strategies for panic disorder refractory to initial pharmacotherapy: a 3-phase randomized clinical trial
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Simches Research Building, 2nd Floor, 185 Cambridge St, Boston, MA 02114, USA
    J Clin Psychiatry 70:1563-70. 2009
    ..More data are needed to guide next-step interventions for panic disorder refractory to initial intervention...
  16. ncbi Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  17. ncbi Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:512-20. 2004
    ..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity...
  18. ncbi Group cognitive-behavior therapy for patients failing to respond to pharmacotherapy for panic disorder: a clinical case series
    M W Otto
    Massachusetts General Hospital, Boston, USA
    Behav Res Ther 37:763-70. 1999
    ....
  19. ncbi Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 163:217-24. 2006
    ..The authors looked for the features associated with risk of recurrence...
  20. ncbi Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  21. ncbi Understanding the link between anxiety symptoms and suicidal ideation and behaviors in outpatients with bipolar disorder
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, United States
    J Affect Disord 97:91-9. 2007
    ..Prior studies suggest an association between anxiety comorbidity and suicidal ideation and behaviors in bipolar disorder. However, the nature of this association remains unclear...
  22. ncbi Paroxetine CR augmentation for posttraumatic stress disorder refractory to prolonged exposure therapy
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:400-5. 2008
    ..This study prospectively examines the relative efficacy of augmentation of continued prolonged exposure therapy (PE) with paroxetine CR versus placebo for individuals remaining symptomatic despite a course of PE...
  23. ncbi Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, 02114, USA
    Arch Gen Psychiatry 63:385-90. 2006
    ..However, it is unclear whether this period is one of increased risk for major depressive disorder, particularly for women who have not had a previous episode of depression...
  24. ncbi Novel treatment approaches for refractory anxiety disorders
    Mark H Pollack
    Harvard Medical School and Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 25:467-76. 2008
    ..Progress in the development of new treatments has great promise, but will only succeed through a concerted research effort that systematically evaluates potential areas of importance and properly uses scarce resources...
  25. ncbi Cognitive-behavioral therapy for panic disorder: a review of treatment elements, strategies, and outcomes
    Nadine Recker Rayburn
    Cognitive-Behavior Program, Department of Psychology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    CNS Spectr 8:356-62. 2003
    ..We also discuss some of the complex issues involved with combination-treatment strategies...
  26. ncbi Nefazodone for social phobia: a clinical case series
    J J Worthington
    Anxiety Disorders Program, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 8:131-3. 1998
    ..Results from this case series suggest that nefazodone may be an effective treatment for social phobia and that formal randomized trials are warranted...
  27. ncbi The anxiety sensitivity index: item analysis and suggestions for refinement
    M A Blais
    Inpatient Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Pers Assess 77:272-94. 2001
    ..The 11-item ASI appears to tap 2 primary aspects of anxiety sensitivity: fears of somatic sensations of anxiety and fears of loss of mental control. Suggestions for further development of the ASI are offered...
  28. ncbi Clinical perspectives on the combination of D-cycloserine and cognitive-behavioral therapy for the treatment of anxiety disorders
    Michael W Otto
    Center for Anxiety and Related Disorders, Department of Psychology, Boston University, Boston, MA 02215, USA
    CNS Spectr 12:51-6, 59-61. 2007
    ..This strategy is contrasted with the chronic-dosing applications of DCS for schizophrenia and Alzheimer's disease, and future directions for isolated-dosing strategies are discussed...
  29. ncbi Panic disorder and bipolar disorder: anxiety sensitivity as a potential mediator of panic during manic states
    Naomi M Simon
    Massachusetts General Hospital, WACC 815, 15 Parkman Street, Boston, Massachusetts 02114, United States
    J Affect Disord 87:101-5. 2005
    ..Anxiety sensitivity (AS), a risk factor for PD appears greater in bipolar disorder compared to unipolar depression, although the association of specific mood states with AS remains unknown...
  30. ncbi The relationship of anxiety disorders, anxiety sensitivity and pulmonary dysfunction with dyspnea-related distress and avoidance
    Naomi M Simon
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 194:951-7. 2006
    ....
  31. ncbi History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorder
    Steven A Safren
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, MGH Psychiatry, WACC 815, 15 Parkman Street, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 190:453-6. 2002
    ..These findings are discussed in terms of biological and behavioral factors that may influence the development of anxiety disorders after the experience of a traumatic event...
  32. ncbi Benzodiazepine use, cognitive impairment, and cognitive-behavioral therapy for anxiety disorders: issues in the treatment of a patient in need
    Michael W Otto
    Department of Psychology and Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
    J Clin Psychiatry 66:34-8. 2005
    ..This article addresses this concern and asserts that CBT is a valuable treatment option in these cases...
  33. ncbi Childhood history of anxiety disorders among adults with social phobia: rates, correlates, and comparisons with patients with panic disorder
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Depress Anxiety 14:209-13. 2001
    ....
  34. ncbi Internal cue exposure and the treatment of substance use disorders: lessons from the treatment of panic disorder
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman St, Boston, MA 02114, USA
    J Anxiety Disord 18:69-87. 2004
    ....
  35. ncbi Development and validation of the smoking cue appeal survey
    Heather W Murray
    Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    Subst Use Misuse 45:2152-61. 2010
    ..Limitations include a cross-sectional design, small sample size, and focus on trait factors. Future directions are discussed...
  36. ncbi Cost-efficacy of individual and combined treatments for panic disorder
    R Kathryn McHugh
    Department of Psychology, Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
    J Clin Psychiatry 68:1038-44. 2007
    ..As psychosocial, pharmacologic, and combined treatments have all demonstrated efficacy in the treatment of panic disorder, cost-efficacy analysis provides an additional source of information to guide clinical decision making...
  37. ncbi Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1467-73. 2005
    ....
  38. ncbi Cognitive behavioral therapy for substance use disorders
    R Kathryn McHugh
    Department of Psychology, Boston University, 648 Beacon Street, 6th Floor, Boston, MA 02215, USA
    Psychiatr Clin North Am 33:511-25. 2010
    ..These elements, and support for their efficacy, are discussed...
  39. ncbi Augmentation treatment of psychotherapy for anxiety disorders with D-cycloserine
    Stefan G Hofmann
    Department of Psychology, Center for Anxiety and Related Disorders, Boston University, Boston, Massachusetts 02215, USA
    CNS Drug Rev 12:208-17. 2006
    ..It remains to be seen whether these highly promising findings represent reliable pharmacological strategies to enhance exposure therapy of anxiety disorders...
  40. ncbi Attentional bias and craving in smokers: the impact of a single attentional training session
    R Kathryn McHugh
    Department of Psychology, Boston University, 648 Beacon Street, 6th Floor, Boston, MA 02215, USA
    Nicotine Tob Res 12:1261-4. 2010
    ..The current study evaluated the efficacy of an attentional training intervention for reducing attentional bias toward smoking cues and craving among cigarette smokers...
  41. ncbi Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 159:1155-9. 2002
    ..To assess the effect of abrupt change in lithium dose, the authors reanalyzed data from a previously reported, randomized, double-blind trial of standard- versus low-dose lithium for maintenance therapy in bipolar disorder...
  42. ncbi Augmentation of exposure therapy with D-cycloserine for social anxiety disorder
    Stefan G Hofmann
    Department of Psychology and Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
    Arch Gen Psychiatry 63:298-304. 2006
    ..Controlled effect sizes were in the medium to large range. CONCLUSION: The pilot data provide preliminary support for the use of short-term dosing of d-cycloserine as an adjunctive intervention to exposure therapy for SAD...
  43. ncbi A meta-analytic review of psychosocial interventions for substance use disorders
    Lissa Dutra
    Center for Anxiety and Related Disorders, 648 Beacon St, Fl 6, Boston, MA 02215, USA
    Am J Psychiatry 165:179-87. 2008
    ....
  44. ncbi Cognitive-behavioral therapy and the treatment of panic disorder: efficacy and strategies
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 66:28-32. 2005
    ..We review these findings as well as some newer developments in the field including research on emotional acceptance, the importance of context in extinction learning, and the use of CBT in combination with pharmacotherapy...
  45. ncbi Cortisol, stress, and attentional bias toward threat
    R Kathryn McHugh
    Department of Psychology, Center for Anxiety and Related Disorders, Boston University, Boston, MA, USA
    Anxiety Stress Coping 23:529-45. 2010
    ..These results imply that the association between cortisol and attentional bias may be moderated by additional factors, such as gender or presence of stress...
  46. ncbi Empirically supported treatments for panic disorder
    R Kathryn McHugh
    Department of Psychology, 648 Beacon Street, 6th Floor, Boston University, Boston, MA 02215, USA
    Psychiatr Clin North Am 32:593-610. 2009
    ..Predictors of non-response and mechanisms of action are considered, as are novel treatment strategies, including the use of memory enhancers to improve CBT outcome...
  47. ncbi Psychosocial predictors of the onset of anxiety disorders in women: results from a prospective 3-year longitudinal study
    Amanda W Calkins
    Boston University, Boston, MA 02215, USA
    J Anxiety Disord 23:1165-9. 2009
    ..These findings from a prospective longitudinal study are discussed in relation to the potential role of such predictors in primary or relapse prevention efforts...
  48. ncbi The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review
    R Kathryn McHugh
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Drug Alcohol Depend 108:1-6. 2010
    ..Therefore, although our review indicates that there is a significant association between 5HTTLPR and alcohol dependence diagnosis, this result should be interpreted with caution...
  49. ncbi The effects of prior cognitive control task exposure on responses to emotional tasks in healthy participants
    Amanda W Calkins
    Boston University, 648 Beacon Street, Boston, MA 02215, USA
    Behav Cogn Psychother 39:205-20. 2011
    ..This study examined whether exposure to cognitive tasks before an emotional challenge attenuated the effects of the emotional challenge...
  50. ncbi Anxiety sensitivity and illicit sedative use among opiate-dependent women and men
    Bridget A Hearon
    Department of Psychology, Boston University, Boston, Massachusetts, USA
    Am J Drug Alcohol Abuse 37:43-7. 2011
    ..Given these findings, we hypothesized that AS would be associated with illicit sedative use in an opioid-dependent sample and that gender would moderate this relationship, with a greater association among women...
  51. ncbi An effect-size analysis of the relative efficacy and tolerability of serotonin selective reuptake inhibitors for panic disorder
    M W Otto
    Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:1989-92. 2001
    ..In this study the authors used an effect-size analysis to provide an initial comparison...
  52. ncbi Is age at symptom onset associated with severity of memory impairment in adults with obsessive-compulsive disorder?
    A Henin
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129 2060, USA
    Am J Psychiatry 158:137-9. 2001
    ..Age at onset is a potentially important marker for neurobiological features of obsessive-compulsive disorder (OCD). This study examined the relationship between age at symptom onset and memory impairment in adults with OCD...
  53. ncbi Cognitive-behavioral therapy for depression. Applications and outcome
    T Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Psychiatr Clin North Am 23:795-809, VII. 2000
    ..This article discusses cognitive-behavioral therapy for depression, including evidence for its efficacy and how to choose between this therapy and antidepressants. The use of this therapy to prevent relapse also is presented...
  54. ncbi Two strategies to increase adherence to HIV antiretroviral medication: life-steps and medication monitoring
    S A Safren
    Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Behav Res Ther 39:1151-62. 2001
    ..Both interventions yielded improvement in adherence from baseline, and the Life-Steps intervention showed faster improvements in adherence for persons with extant adherence problems...
  55. ncbi Mechanisms of efficacy of CBT for Cambodian refugees with PTSD: improvement in emotion regulation and orthostatic blood pressure response
    Devon E Hinton
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, WACC 812, Boston, MA, USA
    CNS Neurosci Ther 15:255-63. 2009
    ..It also suggests that vagal tone is involved in emotion regulation, and that both vagal tone and emotion regulation improve across treatment...
  56. ncbi Once-weekly D-cycloserine effects on negative symptoms and cognition in schizophrenia: an exploratory study
    Donald C Goff
    Massachusetts General Hospital, Psychiatry Department, Freedom Trail Clinic, 25 Staniford St, 2nd Floor, Boston, MA 02114, USA
    Schizophr Res 106:320-7. 2008
    ..The objective of this exploratory study was to assess whether once-weekly dosing with d-cycloserine will produce persistent improvements in negative symptoms and cognition...
  57. ncbi Prediction of "fear" acquisition in healthy control participants in a de novo fear-conditioning paradigm
    Michael W Otto
    Center for Anxiety and Related Disorders, Boston University, MA, USA
    Behav Modif 31:32-51. 2007
    ..In contrast, the authors found that anxiety sensitivity was more linked to individual differences in orienting response than differences in conditioning per se...
  58. ncbi Psychoeducational and cognitive-behavioral strategies in the management of bipolar disorder
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Affect Disord 73:171-81. 2003
    ....
  59. ncbi Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder: Further evaluation
    Michael W Otto
    Department of Psychology, Boston University, 648 Beacon Street, 5th Floor, Boston, MA 02215, USA
    Behav Res Ther 48:720-7. 2010
    ..These findings suggest that CBT provides specific efficacy for the successful discontinuation from BZs, even when controlling for therapist contact and relaxation training...
  60. ncbi Effectiveness of adjunctive antidepressant treatment for bipolar depression
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 356:1711-22. 2007
    ..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania...
  61. ncbi A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:441-7. 2005
    ..This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine...
  62. ncbi CBT for Vietnamese refugees with treatment-resistant PTSD and panic attacks: a pilot study
    Devon E Hinton
    Southeast Asian Clinic, Arbour Counseling Services, Lowell, Massachusetts, USA
    J Trauma Stress 17:429-33. 2004
    ..2); and Hopkins Symptom Checklist-25, depression subscale (d = 2.0) scores. Likewise, the severity of (culturally related) headache-and orthostasis-cued panic attacks improved significantly across treatment..
  63. ncbi Exploring the psychometric properties and construct validity of the MCMI-III anxiety and avoidant personality scales
    Mark A Blais
    Department of Psychiatry, Blake 11, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Pers Assess 81:237-41. 2003
    ..We conclude that the MCMI-III measures of anxiety and avoidance are consistent with other measures of these constructs and may provide valuable clinical information in this regard...
  64. ncbi Early improvement predicts endpoint remission status in sertraline and placebo treatments of panic disorder
    Mark H Pollack
    Anxiety Disorders Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, WAC 812, 15 Parkman Street, Boston, MA 02114, USA
    J Psychiatr Res 36:229-36. 2002
    ....
  65. ncbi Anger-associated panic attacks in Cambodian refugees with PTSD; a multiple baseline examination of clinical data
    D Hinton
    Massachusetts General Hospital and Harvard Medical School, Revere, MA, USA
    Behav Res Ther 41:647-54. 2003
    ..Mechanisms for this high rate of fear of death during anger arousal are discussed with a focus on culture-specific catastrophic cognitions...
  66. ncbi Contributors to neuropsychological impairment in HIV-infected and HIV-uninfected opiate-dependent patients
    Allison J Applebaum
    Boston University, Boston, MA, USA
    J Clin Exp Neuropsychol 32:579-89. 2010
    ..These findings confirm NP impairment in HIV-infected substance abusing patients independent of comorbid depression and severity of substance use...
  67. ncbi A comparison of emotional approach coping (EAC) between individuals with anxiety disorders and nonanxious controls
    Luana Marques
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    CNS Neurosci Ther 15:100-6. 2009
    ..Overall, gender did not moderate the anxiety-EAC effect, but the results suggested that women utilize EAC to a greater degree than men. Clinical techniques designed to improve emotional coping may be beneficial to individuals with ADs...
  68. ncbi Demographic and diagnostic characteristics of the first 1000 patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Jane N Kogan
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Bipolar Disord 6:460-9. 2004
    ..The current report provides a context for interpreting studies resulting from STEP-BD by summarizing the baseline demographic and diagnostic characteristics of the first 1000 enrolled...
  69. ncbi The role and impact of psychotherapy in the management of bipolar disorder
    Michael W Otto
    Department of Psychology, Center for Anxiety and Related Disorders, Boston University, 648 Beacon St, 6th Floor, Boston, MA 02215-2013, USA
    CNS Spectr 9:27-32. 2004
    ..The available evidence suggests that interventions delivered in individual, group, or family settings, can provide significant benefit to patients undergoing pharmacotherapy for bipolar disorder...
  70. ncbi Cognitive behavior therapy and pharmacotherapy for insomnia: a randomized controlled trial and direct comparison
    Gregg D Jacobs
    Sleep Disorders Center, Beth Israel Deaconess Medical Center, Laboratory of Neurophysiology, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 164:1888-96. 2004
    ..The objective of this study was to evaluate the clinical efficacy of behavioral and pharmacological therapy, singly and in combination, for chronic sleep-onset insomnia...
  71. ncbi Quality of life in social anxiety disorder compared with panic disorder and the general population
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Psychiatr Serv 53:714-8. 2002
    ..Quality of life in a treatment-seeking cohort of patients with social anxiety disorder was compared with that of patients with panic disorder who were matched for age, comorbid illnesses, and gender and with population-based norms...
  72. ncbi Changes in anxiety sensitivity with pharmacotherapy for panic disorder
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
    J Psychiatr Res 38:491-5. 2004
    ..Implications of these findings are discussed relative to optimizing pharmacologic treatment of panic disorder...
  73. ncbi Hypothyroidism and hyperthyroidism in anxiety disorders revisited: new data and literature review
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
    J Affect Disord 69:209-17. 2002
    ..The need for thyroid screening of patients presenting with panic disorder (PD), social phobia (SP) or generalized anxiety disorder (GAD) remains uncertain...
  74. ncbi Predictors of psychological well-being in a diverse sample of HIV-positive patients receiving highly active antiretroviral therapy
    Steven A Safren
    Fenway Community Health, Boston, MA, USA
    Psychosomatics 43:478-85. 2002
    ..These results provide support for continued psychosocial interventions that target these variables among patients with HIV...
  75. ncbi Cognitive-behavioral therapy for ADHD in medication-treated adults with continued symptoms
    Steven A Safren
    Massachusetts General Hospital, MGH Psychiatry, Harvard Medical School, WACC 815, 15 Parkman Street, Boston, MA 02114, USA
    Behav Res Ther 43:831-42. 2005
    ..02). These data support the hypothesis that CBT for adults with ADHD with residual symptoms is a feasible, acceptable, and potentially efficacious next-step treatment approach, worthy of further testing...
  76. ncbi Prevalence and predictors of premenstrual dysphoric disorder (PMDD) in older premenopausal women. The Harvard Study of Moods and Cycles
    Lee S Cohen
    Harvard Medical School, Boston, MA, USA
    J Affect Disord 70:125-32. 2002
    ..Consistent data on the prevalence and predictors of premenstrual dysphoric disorder (PMDD) in the general population are lacking...
  77. ncbi Longitudinal outcome with pharmacotherapy in a naturalistic study of panic disorder
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
    J Affect Disord 69:201-8. 2002
    ..It is critically important to obtain more information on the effectiveness of medications over time for patients who initially responded to pharmacotherapy for panic disorder...
  78. ncbi The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder
    Naomi M Simon
    Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Suite 2200, Boston, MA 02114, USA
    J Psychiatr Res 41:255-64. 2007
    ....
  79. ncbi Benzodiazepine discontinuation difficulties in panic disorder: conceptual model and outcome for cognitive-behavior therapy
    M W Otto
    Harvard Medical School and Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Curr Pharm Des 8:75-80. 2002
    ..Outcome studies are reviewed, and are placed in the context of other evidence for the efficacy of CBT in patients with this disorder...
  80. ncbi Characteristics of women with premenstrual dysphoric disorder (PMDD) who did or did not report history of depression: a preliminary report from the Harvard Study of Moods and Cycles
    C N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    J Womens Health Gend Based Med 10:873-8. 2001
    ....
  81. ncbi Supportive therapy for schizophrenia: possible mechanisms and implications for adjunctive psychosocial treatments
    David L Penn
    University of North Carolina Chapel Hill, Department of Psychology, 27599 3270, USA
    Schizophr Bull 30:101-12. 2004
    ....
  82. ncbi Treatment of pharmacotherapy-refractory posttraumatic stress disorder among Cambodian refugees: a pilot study of combination treatment with cognitive-behavior therapy vs sertraline alone
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman St, Boston, MA 02114, USA
    Behav Res Ther 41:1271-6. 2003
    ....
  83. ncbi Computer-assisted cognitive therapy for depression: maintaining efficacy while reducing therapist time
    Jesse H Wright
    Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40232, USA
    Am J Psychiatry 162:1158-64. 2005
    ..The aim of this investigation was to compare the efficacy of computer-assisted cognitive therapy against standard cognitive therapy and a control group without treatment for outpatients with nonpsychotic major depressive disorder...
  84. ncbi Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Gary S Sachs
    Partners Bipolar Treatment Center, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1028-42. 2003
    ....
  85. ncbi Treating medication-resistant panic disorder: predictors and outcome of cognitive-behavior therapy in a Brazilian public hospital
    Elizeth Heldt
    Anxiety Disorder Program, , RS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Psychother Psychosom 72:43-8. 2003
    ..Among these patients, depression as well as neurotic defense style was associated with a poorer outcome. The use of CBT in Brazil for treatment-resistant and other panic patients is encouraged...
  86. ncbi Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorder
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Psychiatr Serv 57:959-65. 2006
    ..A one-year naturalistic-prospective design was used to examine the association between psychotherapy use and the symptomatic and functional outcomes of patients with bipolar disorder...
  87. ncbi Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participants
    Mark D Fossey
    Department of Psychiatry, University of Oklahoma College of Medicine Tulsa, Tulsa, Oklahoma 74135, USA
    Am J Addict 15:138-43. 2006
    ..The primary/secondary distinction for SUD is not valid when variations in the age of onset of the non-SUD are linked to course characteristics...
  88. ncbi Assay sensitivity, failed clinical trials, and the conduct of science
    Michael W Otto
    Psychother Psychosom 71:241-3. 2002
  89. ncbi Discussion: using benzodiazepines in clinical practice
    Samantha A Stewart
    J Clin Psychiatry 66:39-43; quiz 44-5. 2005
  90. ncbi Defense mechanisms after brief cognitive-behavior group therapy for panic disorder: one-year follow-up
    Elizeth Heldt
    Anxiety Disorders Program, Hospital de Clinicas de Porto Alegre, Rio Grande do Sul, Brazil
    J Nerv Ment Dis 195:540-3. 2007
    ..359; p = 0.047). These findings are consistent with the hypothesis that defense styles are malleable in short-term treatment and are, at least partially, symptom-state dependent...
  91. ncbi Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Am J Psychiatry 164:1340-7. 2007
    ..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode...
  92. ncbi Anxiety disorders among patients with co-occurring bipolar and substance use disorders
    Monika E Kolodziej
    The Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 80:251-7. 2005
    ..Our findings point to the importance of further investigating the ramifications of a trauma history among those who are dually diagnosed with bipolar and substance use disorders...
  93. ncbi Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study
    Steven E Bruce
    Department of Psychiatry and Human Behavior, Brown University, RI 02906, USA
    Am J Psychiatry 162:1179-87. 2005
    ....
  94. ncbi Learning and "unlearning" fears: preparedness, neural pathways, and patients
    Michael W Otto
    Biol Psychiatry 52:917-20. 2002
  95. ncbi Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Arch Gen Psychiatry 64:419-26. 2007
    ..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder...
  96. ncbi One-year follow-up of pharmacotherapy-resistant patients with panic disorder treated with cognitive-behavior therapy: Outcome and predictors of remission
    Elizeth Heldt
    Anxiety Disorders Program, , RS and Post-Graduate Program in Medical Sciences: Psychiatry, Universidade Federal do Rio Grande do Sul, Brazil
    Behav Res Ther 44:657-65. 2006
    ..Negative predictors of remission status included comorbid dysthymia, social phobia, and generalized anxiety disorder. These results provide additional evidence for the efficacy of CBT for medication non-responders with PD...
  97. ncbi Quality of life and treatment outcome in panic disorder: cognitive behavior group therapy effects in patients refractory to medication treatment
    Elizeth Heldt
    Program of Anxiety Disorders, , Porto Alegre, Brazil
    Psychother Psychosom 75:183-6. 2006
    ..094). CONCLUSIONS: CBGT was efficacious in the treatment of PD; the symptoms of anticipatory anxiety and avoidance appear to be more important than episodic panic episodes in affecting QoL...
  98. ncbi Do baseline client characteristics predict the therapeutic alliance in the treatment of schizophrenia?
    Shannon M Couture
    University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Nerv Ment Dis 194:10-4. 2006
    ..Low correlations between clients' and therapists' ratings of the alliance should be examined in future research...

Research Grants12

  1. 1/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
    Michael Otto; Fiscal Year: 2009
    ....
  2. Stress, Distress Intolerance, and Drug Dependence
    Michael Otto; Fiscal Year: 2007
    ..abstract_text> ..
  3. Context Effects in De Novo Fear Conditioning in Humans
    Michael Otto; Fiscal Year: 2006
    ..abstract_text> ..
  4. 1/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
    Michael W Otto; Fiscal Year: 2010
    ....