Genomes and Genes
Affiliation: Boston University
- Profiles of impaired, spared, and recovered neuropsychologic processes in alcoholismMarlene Oscar-Berman
Boston University School of Medicine and VA Boston Healthcare System, Boston, MA, USA Electronic address
Handb Clin Neurol 125:183-210. 2014....
- Frontal brain dysfunction in alcoholism with and without antisocial personality disorderMarlene Oscar-Berman
Department of Veterans Affairs Healthcare System, Boston Campus, Boston, MA, USA
Neuropsychiatr Dis Treat 5:309-26. 2009..These effects were different for men and women. The findings suggested that the combination of alcoholism and ASPD leads to greater deficits than the sum of each...
- Brain volumetric measures in alcoholics: a comparison of two segmentation methodsMarlene Oscar-Berman
Department of Psychiatry
Neuropsychiatr Dis Treat 7:65-75. 2011..These results suggest that although many brain structures can be segmented reliably by CMA and FreeSurfer, low correlations between methods in some regions may be due to morphological changes in the brains of alcoholics...
- Attention-deficit-hyperactivity disorder and reward deficiency syndromeKenneth Blum
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC
Neuropsychiatr Dis Treat 4:893-918. 2008..Moreover, it is concluded that dopamine and serotonin releasers might be useful therapeutic adjuncts for the treatment of other RDS behavioral subtypes, including addictions...
- Function and dysfunction of prefrontal brain circuitry in alcoholic Korsakoff's syndromeMarlene Oscar-Berman
Department of Neurology and Division of Psychiatry, Boston University School of Medicine, Boston, MA, USA
Neuropsychol Rev 22:154-69. 2012..More specifically, we examine the role of damage to prefrontal brain systems in the neuropsychological profile of alcoholic KS...
- Comparisons of Korsakoff and non-Korsakoff alcoholics on neuropsychological tests of prefrontal brain functioningMarlene Oscar-Berman
Psychology Service, Department of Veterans Affairs Healthcare System, Boston Campus, Boston, Massachusetts, USA
Alcohol Clin Exp Res 28:667-75. 2004..Evidence suggests that alcoholics exhibit particular deficits in brain systems involving the prefrontal cortex, but few studies have directly compared patients with and without Korsakoff's syndrome on measures of prefrontal integrity...
- Alcohol: effects on neurobehavioral functions and the brainMarlene Oscar-Berman
Department of Anatomy and Neurobiology, Boston University School of Medicine, L 815, 715 Albany Street, Boston, MA 02118, USA
Neuropsychol Rev 17:239-57. 2007..In that way, relevant experimental techniques can be applied to assist in determining the degree to which abstinence and treatment contribute to the reversal of atrophy and dysfunction...
- Frontal white matter and cingulum diffusion tensor imaging deficits in alcoholismGordon J Harris
Department of Neurology, Athinoula A Martinos Center, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Alcohol Clin Exp Res 32:1001-13. 2008..In the present study, we examined the integrity of white matter tracts that are critical to frontal and limbic connectivity...
- Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART)Kenneth Blum
Department of Psychiatry, School of Medicine and McKnight Brain Institute, University of Florida, Gainsville, FL, USA
Postgrad Med 121:176-96. 2009..This seems to lead to receptor proliferation to normal levels and results in significantly better treatment compliance only in A1 carriers...
- Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentaryKenneth Blum
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
Theor Biol Med Model 5:24. 2008..In essence, D2 receptor stimulation signals negative feedback mechanisms in the mesolimbic system to induce mRNA expression causing proliferation of D2 receptors...
- Drinking history associations with regional white matter volumes in alcoholic men and womenSusan Mosher Ruiz
Graduate Program in Neuroscience, Boston University, Boston, MA 02118, USA
Alcohol Clin Exp Res 37:110-22. 2013..Although neuroimaging has shown alcoholism-related brain volume reductions and axonal compromise, the integrity of white matter volumes in chronic alcoholism has been challenging to measure on a regional level...
- Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviorsKenneth Blum
Department of Psychiatry, School of Medicine and McKnight Brain Institute, University of Florida, Gainesville, FL 32601, USA
Int J Environ Res Public Health 8:4425-59. 2011..We evaluated the potential association of four variants of dopaminergic candidate genes in RDS (dopamine D1 receptor gene [DRD1]; dopamine D2 receptor gene [DRD2]; dopamine transporter gene [DAT1]; dopamine beta-hydroxylase gene [DBH])...
- Sex, drugs, and rock 'n' roll: hypothesizing common mesolimbic activation as a function of reward gene polymorphismsKenneth Blum
Department of Psychiatry, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, FL 32610 0256, USA
J Psychoactive Drugs 44:38-55. 2012....
- Social cognition deficits and associations with drinking history in alcoholic men and womenMary M Valmas
Psychology Research Service, VA Boston Healthcare System, Boston, Massachusetts Department of Psychology, Suffolk University, Boston, Massachusetts Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts
Alcohol Clin Exp Res 38:2998-3007. 2014..We used the ACS Social Perception and Faces subtests to assess alcoholism-related impairments in social cognition...
- Alcoholism and judgments of affective stimuliUraina S Clark
Department of Psychology, Boston University, Boston, MA, USA
Neuropsychology 21:346-62. 2007....
- Decreased volume of the brain reward system in alcoholismNikos Makris
Athinoula A Martinos Center, Harvard Medical School Department of Neurology, Boston, Massachusetts, USA
Biol Psychiatry 64:192-202. 2008..We examined whether reward-network brain volumes are reduced in alcoholics and how volumes of subcomponents within this system are correlated with memory and drinking history...
- Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorderAriel B Brown
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples...
- Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndromeAbdalla Bowirrat
Department of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA
Am J Med Genet B Neuropsychiatr Genet 132:29-37. 2005..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
- Alcoholism and the brain: an overviewMarlene Oscar-Berman
Department of Anatomy and Neurobiology, Boston University School of Medicine, Massachusetts, USA
Alcohol Res Health 27:125-33. 2003....