G D Offner

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions
    G D Offner
    Departments of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    Biochem Biophys Res Commun 251:350-5. 1998
  2. ncbi Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B
    A C Keates
    Section of Gastroenterology, Department of Medicine, Boston University School of Medicine and Boston City Hospital, Boston, MA 02118, USA
    Biochem J 324:295-303. 1997
  3. ncbi Molecular characterization of a major high molecular weight mucin from human sublingual gland
    R F Troxler
    Department of Biochemistry, Boston University Medical Center, MA 02118, USA
    Glycobiology 7:965-73. 1997
  4. ncbi MG2 and lactoferrin form a heterotypic complex in salivary secretions
    R V Soares
    Department of Periodontology and Oral Biology, Boston University Medical Center, 02118, USA
    J Dent Res 82:471-5. 2003
  5. ncbi The effects of duration and intensity of stimulation on total protein and mucin concentrations in resting and stimulated whole saliva
    S A Rayment
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University School of Medicine, Boston University Medical Center, MA 02118, USA
    J Dent Res 80:1584-7. 2001
  6. ncbi Heterogeneity of high-molecular-weight human salivary mucins
    G D Offner
    Department of Medicine, Boston University Medical Center, MA 02118, USA
    Adv Dent Res 14:69-75. 2000
  7. ncbi Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland
    R F Troxler
    Department of Biochemistry, Boston University Medical Center, MA 02118, USA
    Biochem Biophys Res Commun 217:1112-9. 1995
  8. ncbi The Amount of MUC5B mucin in cervical mucus peaks at midcycle
    I K Gipson
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:594-600. 2001
  9. ncbi Pro-inflammatory cytokines up-regulate MUC1 gene expression in oral epithelial cells
    X Li
    Department of Periodontology and Oral Biology, Boston University Medical Center, MA 02118, USA
    J Dent Res 82:883-7. 2003
  10. ncbi Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system
    I Iontcheva
    Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    J Dent Res 79:732-9. 2000

Collaborators

  • A C Keates
  • L Wang
  • B Liu
  • X Li
  • F Zhang
  • J A Hill
  • I K Gipson
  • R F Troxler
  • F G Oppenheim
  • R V Soares
  • I Iontcheva
  • S A Rayment
  • D P Nunes
  • L S Bruno
  • C C Siqueira
  • N H Afdhal
  • K Schmid
  • T Marti
  • J H Collins
  • J Schaller
  • P C Trackman
  • K Takagaki
  • M A Hediger
  • H Haupt
  • R Brossmer
  • M T Walsh
  • C Franzblau
  • S S Tang
  • P J Mogayzel
  • H M Kagan
  • A M Pratt
  • N M Colannino
  • A Wolanski
  • B Faris
  • C A Pratt

Detail Information

Publications14

  1. ncbi The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions
    G D Offner
    Departments of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    Biochem Biophys Res Commun 251:350-5. 1998
    ..The N-terminal D domains in MUC5B are likely to have important roles in both mucin assembly and in the protective functions of the secreted mucin...
  2. ncbi Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B
    A C Keates
    Section of Gastroenterology, Department of Medicine, Boston University School of Medicine and Boston City Hospital, Boston, MA 02118, USA
    Biochem J 324:295-303. 1997
    ....
  3. ncbi Molecular characterization of a major high molecular weight mucin from human sublingual gland
    R F Troxler
    Department of Biochemistry, Boston University Medical Center, MA 02118, USA
    Glycobiology 7:965-73. 1997
    ....
  4. ncbi MG2 and lactoferrin form a heterotypic complex in salivary secretions
    R V Soares
    Department of Periodontology and Oral Biology, Boston University Medical Center, 02118, USA
    J Dent Res 82:471-5. 2003
    ..This complex may enhance the properties of these salivary components in the oral environment...
  5. ncbi The effects of duration and intensity of stimulation on total protein and mucin concentrations in resting and stimulated whole saliva
    S A Rayment
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University School of Medicine, Boston University Medical Center, MA 02118, USA
    J Dent Res 80:1584-7. 2001
    ....
  6. ncbi Heterogeneity of high-molecular-weight human salivary mucins
    G D Offner
    Department of Medicine, Boston University Medical Center, MA 02118, USA
    Adv Dent Res 14:69-75. 2000
    ....
  7. ncbi Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland
    R F Troxler
    Department of Biochemistry, Boston University Medical Center, MA 02118, USA
    Biochem Biophys Res Commun 217:1112-9. 1995
    ..This study provides the first primary sequence data on human salivary mucin MG1 and the significance of the results is discussed with respect to the biosynthesis and differential expression of MG1 in human salivary glands...
  8. ncbi The Amount of MUC5B mucin in cervical mucus peaks at midcycle
    I K Gipson
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:594-600. 2001
    ..This peak in MUC5B content coincides with the change in mucus character that occurs at midcycle, suggesting that this large mucin species may be important to sperm transit to the uterus...
  9. ncbi Pro-inflammatory cytokines up-regulate MUC1 gene expression in oral epithelial cells
    X Li
    Department of Periodontology and Oral Biology, Boston University Medical Center, MA 02118, USA
    J Dent Res 82:883-7. 2003
    ..85-fold increase in MUC1 transcript levels. These results suggest that increased MUC1 synthesis may be a key element in the host response to infection with oral pathogens...
  10. ncbi Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system
    I Iontcheva
    Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    J Dent Res 79:732-9. 2000
    ..A ProDom blast search revealed that sequences in Cys1, Cys2, and Cys8a exhibit similarity to domains in evolutionarily diverse extracellular proteins known to participate in a wide variety of protein-protein interactions...
  11. ncbi Bovine gall-bladder mucin contains two distinct tandem repeating sequences: evidence for scavenger receptor cysteine-rich repeats
    D P Nunes
    Department of Medicine, Boston University School of Medicine, MA, USA
    Biochem J 310:41-8. 1995
    ..By analogy with other proteins containing these cysteine-rich repeats, it is possible that, in gall-bladder mucin, this domain serves as a binding site for hydrophobic ligands such as bilirubin, cholesterol and other biliary lipids...
  12. ncbi Role of tropoelastin fragmentation in elastogenesis in rat smooth muscle cells
    C Franzblau
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118
    J Biol Chem 264:15115-9. 1989
    ....
  13. ncbi Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence
    P C Trackman
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118
    Biochemistry 29:4863-70. 1990
    ..A 258-bp segment of the 3'-untranslated region of lysyl oxidase cDNA is 93% identical with a highly conserved region of the 3'-untranslated sequence of rat elastin cDNA.(ABSTRACT TRUNCATED AT 250 WORDS)..
  14. ncbi Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin)
    K Schmid
    Department of Biochemistry, Boston University School of Medicine, MA 02118
    Proc Natl Acad Sci U S A 89:663-7. 1992
    ....