GEORGE T O'CONNOR

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Characterization of regulatory T cells in urban newborns
    Ngoc P Ly
    Pediatric Pulmonary Medicine, University of California San Francisco Children s Hospital and UCSF Medical School, San Francisco, CA, USA
    Clin Mol Allergy 7:8. 2009
  2. pmc The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
    James E Gern
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Pulm Med 9:17. 2009
  3. pmc Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Am J Respir Crit Care Med 179:1159-64. 2009
  4. doi request reprint Acute respiratory health effects of air pollution on children with asthma in US inner cities
    GEORGE T O'CONNOR
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 121:1133-1139.e1. 2008
  5. ncbi request reprint Allergen avoidance in asthma: what do we do now?
    GEORGE T O'CONNOR
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    J Allergy Clin Immunol 116:26-30. 2005
  6. ncbi request reprint Airborne fungi in the homes of children with asthma in low-income urban communities: The Inner-City Asthma Study
    GEORGE T O'CONNOR
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 114:599-606. 2004
  7. pmc Framingham Heart Study genome-wide association: results for pulmonary function measures
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 8:S8. 2007
  8. pmc A genome-wide association study of pulmonary function measures in the Framingham Heart Study
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS Genet 5:e1000429. 2009
  9. pmc Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study
    Daniel J Gottlieb
    VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
    Circulation 122:352-60. 2010
  10. pmc Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areas
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Drive, Landmark Center, Suite 415, PO Box 15698, Boston, MA 02215, USA
    Am J Respir Crit Care Med 182:819-25. 2010

Research Grants

  1. Analysis of lipids, inflammation, and pulmonary function
    GEORGE O CONNOR; Fiscal Year: 2003
  2. SLEEP HEART HEALTH STUDY
    GEORGE O CONNOR; Fiscal Year: 2007
  3. Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype
    GEORGE T contact O apos CONNOR; Fiscal Year: 2010

Detail Information

Publications40

  1. pmc Characterization of regulatory T cells in urban newborns
    Ngoc P Ly
    Pediatric Pulmonary Medicine, University of California San Francisco Children s Hospital and UCSF Medical School, San Francisco, CA, USA
    Clin Mol Allergy 7:8. 2009
    ..The objective of this study was to compare Treg phenotype and function in cord blood (CB) of newborns to those in peripheral blood (PB) of a subset of participating mothers...
  2. pmc The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
    James E Gern
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Pulm Med 9:17. 2009
    ..This paper describes the study design, methods, and population of the Urban Environment and Childhood Asthma (URECA) study, which was established to investigate the immunologic causes of asthma among inner-city children...
  3. pmc Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Am J Respir Crit Care Med 179:1159-64. 2009
    ..Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension...
  4. doi request reprint Acute respiratory health effects of air pollution on children with asthma in US inner cities
    GEORGE T O'CONNOR
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 121:1133-1139.e1. 2008
    ..Children with asthma in inner-city communities may be particularly vulnerable to adverse effects of air pollution because of their airways disease and exposure to relatively high levels of motor vehicle emissions...
  5. ncbi request reprint Allergen avoidance in asthma: what do we do now?
    GEORGE T O'CONNOR
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    J Allergy Clin Immunol 116:26-30. 2005
    ..The role of allergen avoidance in infancy in the primary prevention of asthma is a subject of active investigation, but data remain too preliminary to make public health recommendations in this regard...
  6. ncbi request reprint Airborne fungi in the homes of children with asthma in low-income urban communities: The Inner-City Asthma Study
    GEORGE T O'CONNOR
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 114:599-606. 2004
    ..Despite growing evidence of the importance of exposure to fungi as an environmental risk factor for asthma, few data have been reported on the exposure to airborne fungi of asthmatic children living in US inner cities...
  7. pmc Framingham Heart Study genome-wide association: results for pulmonary function measures
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 8:S8. 2007
    ..We conducted genome-wide association (GWA) analyses (Affymetrix 100K SNP GeneChip) for measures of lung function in the Framingham Heart Study...
  8. pmc A genome-wide association study of pulmonary function measures in the Framingham Heart Study
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS Genet 5:e1000429. 2009
    ..Though it is unclear what gene or regulatory effect explains the association, the region warrants further investigation...
  9. pmc Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study
    Daniel J Gottlieb
    VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
    Circulation 122:352-60. 2010
    ..The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women...
  10. pmc Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areas
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Drive, Landmark Center, Suite 415, PO Box 15698, Boston, MA 02215, USA
    Am J Respir Crit Care Med 182:819-25. 2010
    ..S. adults, and may be more prevalent in poor urban environments. SDB and air pollution have been linked to increased cardiovascular diseases and mortality, but the association between pollution and SDB is poorly understood...
  11. pmc Genome-wide association of sleep and circadian phenotypes
    Daniel J Gottlieb
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S9. 2007
    ..More than 700 participants were genotyped using the Affymetrix 100K SNP GeneChip, providing a unique opportunity to assess genetic linkage and association of these traits...
  12. pmc Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness
    Nancy T Mendonça
    Department of Biomedical Engineering, 44 Cummington St, Boston University, Boston, MA 02215, USA
    Respir Res 12:96. 2011
    ..The goal of this study was to test the hypothesis that the minimal airway resistance achievable during a maximal inspiration (R(min)) is abnormally elevated in subjects with airway hyperresponsiveness...
  13. pmc Obesity in relation to lung cancer incidence in African American women
    Traci N Bethea
    Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA, 02215, USA
    Cancer Causes Control 24:1695-703. 2013
    ..Although a number of studies have found an inverse association between body mass index (BMI) and risk of lung cancer, there is little information on this relation in African Americans, who experience a higher incidence of lung cancer...
  14. pmc A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study
    Mark Granada
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 129:840-845.e21. 2012
    ..Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation...
  15. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
    ..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs...
  16. pmc Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing
    Hassan A Chami
    Department of Medicine, Boston University School of Medicine, The Pulmonary Center, VA Boston Healthcare System, Boston, MA 02118, USA
    Vasc Med 14:351-60. 2009
    ..This study does not support a link between SDB and endothelial dysfunction as measured by brachial artery flow-mediated dilation...
  17. pmc Abuse during childhood and adolescence and risk of adult-onset asthma in African American women
    Patricia F Coogan
    Slone Epidemiology Center, Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA 02215, USA
    J Allergy Clin Immunol 131:1058-63. 2013
    ..Experiences of violence contribute to the occurrence of childhood asthma, but there is little information on the effect of early-life abuse on adult-onset asthma...
  18. pmc Eosinophil and T cell markers predict functional decline in COPD patients
    JEANINE M D'ARMIENTO
    Department of Medicine, Columbia University, New York, NY, USA
    Respir Res 10:113. 2009
    ..We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease...
  19. pmc Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study
    Susan Redline
    Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115M, USA
    Am J Respir Crit Care Med 182:269-77. 2010
    ....
  20. pmc MUC5B promoter polymorphism and interstitial lung abnormalities
    Gary M Hunninghake
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    N Engl J Med 368:2192-200. 2013
    ..It is not known whether this polymorphism is associated with interstitial lung disease in the general population...
  21. pmc A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment
    Katrina Steiling
    Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Respir Crit Care Med 187:933-42. 2013
    ..Molecular phenotyping of chronic obstructive pulmonary disease (COPD) has been impeded in part by the difficulty in obtaining lung tissue samples from individuals with impaired lung function...
  22. pmc Vascular inflammation and sleep disordered breathing in a community-based cohort
    Hassan A Chami
    Department of Medicine, American University of Beirut, Beirut, Lebanon
    Sleep 36:763-768C. 2013
    ..The pathophysiologic mechanisms remain unclear, but enhanced vascular inflammation is implicated. We sought to evaluate the association of sleep disordered breathing with biomarkers of inflammation...
  23. ncbi request reprint Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study
    Augusto A Litonjua
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 90:422-8. 2003
    ..To confirm these findings, we tested the hypothesis that serum cytokines are associated with longitudinal lung function decline...
  24. pmc Replication and fine mapping of asthma-associated loci in individuals of African ancestry
    David B Kantor
    Division of Critical Care Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
    Hum Genet 132:1039-47. 2013
    ..These results improve the understanding of asthma genetics and further demonstrate the utility of genetic studies in populations other than those of largely European ancestry. ..
  25. pmc Network-guided sparse regression modeling for detection of gene-by-gene interactions
    Chen Lu
    Department of Biostatistics, Boston University School of Public Health, Pulmonary Center, Department of Medicine and Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Bioinformatics 29:1241-9. 2013
    ..We propose a novel approach to detect such interactions that uses penalized regression and sparse estimation principles, and incorporates outside biological knowledge through a network-based penalty...
  26. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  27. ncbi request reprint Systemic inflammation and COPD: the Framingham Heart Study
    Robert E Walter
    Section of Pulmonary, Allergy, and Critical Care Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Chest 133:19-25. 2008
    ..We examined the hypothesis that systemic inflammatory biomarkers are associated with impaired lung function, particularly among those with extensive cigarette smoking...
  28. pmc Body mass index and asthma incidence in the Black Women's Health Study
    Patricia F Coogan
    Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
    J Allergy Clin Immunol 123:89-95. 2009
    ..There are few data on this topic in black women, among whom the prevalence of obesity and asthma is high...
  29. ncbi request reprint Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart Study
    Jemma B Wilk
    Neurology Department, Boston University School of Medicine, Boston, MA 02118, USA
    Hum Mol Genet 12:2745-51. 2003
    ..This study supports the presence of a gene influencing pulmonary function on the q-terminus of chromosome 6 in the region of 184 cM (D6S503) to 190 cM (D6S281)...
  30. pmc Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses
    Diane R Gold
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass, USA
    J Allergy Clin Immunol 124:1078-87. 2009
    ....
  31. ncbi request reprint Variation in symptoms of sleep-disordered breathing with race and ethnicity: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Sleep 26:74-9. 2003
    ..To examine the relation of sleep-related symptoms to race and ethnicity in a diverse sample of middle-aged and older men and women...
  32. pmc Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, 02138, USA
    Am J Hum Genet 84:581-93. 2009
    ..Further study of PDE4D variants might lead to improved understanding of the role of PDE4D in asthma pathophysiology and the efficacy of PDE4 inhibitor medications...
  33. pmc Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction
    Jemma B Wilk
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Am J Respir Crit Care Med 186:622-32. 2012
    ..Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known...
  34. pmc Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD
    Nadia N Hansel
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hum Genet 132:79-90. 2013
    ..Genes within these regions were expressed in relevant lung cells and their expression related to airflow limitation suggesting they may represent novel candidate genes for COPD susceptibility...
  35. ncbi request reprint Association of asthma with a functional promoter polymorphism in the IL16 gene
    Kristin M Burkart
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 117:86-91. 2006
    ..A T-->C single nucleotide polymorphism (SNP) at the -295 position in the promoter region of the IL16 gene has been described...
  36. ncbi request reprint Predictors of heartburn during sleep in a large prospective cohort study
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
    Chest 127:1658-66. 2005
    ..The aim of this study was to determine the clinical predictors of heartburn during sleep in a large prospective cohort study...
  37. pmc The Vitamin D Antenatal Asthma Reduction Trial (VDAART): rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in children
    Augusto A Litonjua
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, United States Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, United States Harvard Medical School, Boston, MA, United States Electronic address
    Contemp Clin Trials 38:37-50. 2014
    ..Ancillary studies will investigate neonatal T-regulatory cell function, maternal vaginal flora, and maternal and child intestinal flora...
  38. pmc Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
    Xiaoling Zhang
    Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
    Physiol Genomics 41:1-8. 2010
    ..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
  39. ncbi request reprint Effect of medical conditions on improvement in self-reported and observed functional performance of elders
    Ram R Miller
    Geriatrics Section, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Geriatr Soc 52:217-23. 2004
    ..To evaluate the effect of nine disabling medical conditions upon recovery from functional limitations by elders...
  40. ncbi request reprint Association between glycemic state and lung function: the Framingham Heart Study
    Robert E Walter
    The Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Respir Crit Care Med 167:911-6. 2003
    ..The adverse effect of diabetes and glycemic level on pulmonary function was stronger among ever smokers than never smokers, suggesting an interaction between the level of fasting glycemia and tobacco smoking...

Research Grants3

  1. Analysis of lipids, inflammation, and pulmonary function
    GEORGE O CONNOR; Fiscal Year: 2003
    ..abstract_text> ..
  2. SLEEP HEART HEALTH STUDY
    GEORGE O CONNOR; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..
  3. Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype
    GEORGE T contact O apos CONNOR; Fiscal Year: 2010
    ....