Michael J O'Brien

Summary

Affiliation: Boston University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype
    Michael J O'Brien
    Department of Pathology, Boston Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 28:423-34. 2004
  2. ncbi request reprint Hyperplastic and serrated polyps of the colorectum
    Michael J O'Brien
    Boston University School of Medicine, Robinson Building, Room 904, 80 East Concord Street, Boston, MA 02118, USA
    Gastroenterol Clin North Am 36:947-68, viii. 2007
  3. ncbi request reprint Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points
    Michael J O'Brien
    Department of Pathology, Boston University Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 30:1491-501. 2006
  4. ncbi request reprint Flat adenomas in the National Polyp Study: is there increased risk for high-grade dysplasia initially or during surveillance?
    Michael J O'Brien
    Department of Pathology, Boston Medical Center, Boston, Massachusetts 02118, USA
    Clin Gastroenterol Hepatol 2:905-11. 2004
  5. doi request reprint The clinical significance of serrated polyps
    Christopher S Huang
    Department of Medicine, Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Gastroenterol 106:229-40; quiz 241. 2011
  6. ncbi request reprint BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status
    Shi Yang
    Department of Pathology, Boston Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 28:1452-9. 2004
  7. doi request reprint Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer
    Earl Gillespie
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, United States
    J Crohns Colitis 7:403-11. 2013
  8. doi request reprint Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort
    Jeremy T Hetzel
    Department of Medicine, Section of Gastroenterology, Boston Medical Center, Boston, Massachusetts 02118, USA
    Am J Gastroenterol 105:2656-64. 2010
  9. pmc Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer
    Earl Gillespie
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 108:17420-5. 2011
  10. pmc Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival
    Vesela P Kovacheva
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    FASEB J 23:1054-63. 2009

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype
    Michael J O'Brien
    Department of Pathology, Boston Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 28:423-34. 2004
    ..We postulate that MVSP and GCSP may be precursor lesions that, if proximally located or larger, can progress to SPAP. Frequent K-ras mutations and infrequent CIMP distinguish the distal GCSP variant...
  2. ncbi request reprint Hyperplastic and serrated polyps of the colorectum
    Michael J O'Brien
    Boston University School of Medicine, Robinson Building, Room 904, 80 East Concord Street, Boston, MA 02118, USA
    Gastroenterol Clin North Am 36:947-68, viii. 2007
    ..Clinical studies are needed to elucidate the natural history of serrated neoplasia, and provide evidence-based guidance for risk assessment and surveillance of individuals discovered to harbor its various serrated polyp precursors...
  3. ncbi request reprint Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points
    Michael J O'Brien
    Department of Pathology, Boston University Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 30:1491-501. 2006
    ....
  4. ncbi request reprint Flat adenomas in the National Polyp Study: is there increased risk for high-grade dysplasia initially or during surveillance?
    Michael J O'Brien
    Department of Pathology, Boston Medical Center, Boston, Massachusetts 02118, USA
    Clin Gastroenterol Hepatol 2:905-11. 2004
    ..Sessile adenomas from the National Polyp Study cohort were reclassified histopathologically as flat or polypoid and compared with initial and surveillance pathology...
  5. doi request reprint The clinical significance of serrated polyps
    Christopher S Huang
    Department of Medicine, Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Gastroenterol 106:229-40; quiz 241. 2011
    ..This article focuses on the characteristics and significance of clinically relevant serrated polyps and addresses implications for CRC prevention practices...
  6. ncbi request reprint BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status
    Shi Yang
    Department of Pathology, Boston Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 28:1452-9. 2004
    ..In contrast, the association of higher levels of CpG island methylation with more advanced histologic changes suggests that CpG island methylation plays a role in serrated polyp progression toward colorectal carcinoma...
  7. doi request reprint Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer
    Earl Gillespie
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, United States
    J Crohns Colitis 7:403-11. 2013
    ..Patients with long-term ulcerative colitis are at risk for developing colorectal cancer...
  8. doi request reprint Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort
    Jeremy T Hetzel
    Department of Medicine, Section of Gastroenterology, Boston Medical Center, Boston, Massachusetts 02118, USA
    Am J Gastroenterol 105:2656-64. 2010
    ..This study assessed the variation of serrated polyp detection among endoscopists and pathologists in an average risk-screening cohort and trends in detection over time...
  9. pmc Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer
    Earl Gillespie
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 108:17420-5. 2011
    ..The tr-NK-1R could prove useful as a diagnostic marker to identify patients at risk for neoplasia and may serve as a useful therapeutic target in the treatment of colitis-associated cancer...
  10. pmc Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival
    Vesela P Kovacheva
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    FASEB J 23:1054-63. 2009
    ..Our results suggest a role for adequate maternal choline nutrition during pregnancy in prevention/alleviation of breast cancer in daughters...
  11. ncbi request reprint Prognostic significance of superficial fissuring ulceration in patients with severe "indeterminate" colitis
    Rhonda K Yantiss
    Department of Pathology, University of Massachusetts Medical School UMass Memorial Health Care, Worcester, MA, USA
    Am J Surg Pathol 30:165-70. 2006
    ..Nevertheless, the presence of superficial fissuring-type ulcers in patients with severe chronic active UC denotes a subgroup with a higher risk of pouchitis following surgical resection...
  12. ncbi request reprint MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice
    Kianoosh Katchar
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston University School of Medicine, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1263-71. 2007
    ....