BARBARA SUSANNE NIKOLAJCZYK

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Regulation of cytokine transcription in the context of chromatin
    Barbara Nikolajczyk
    Department of Microbiology, Boston University School of Medicine, 715 Albany Street L 516, Boston, MA 02118, USA
    Arch Immunol Ther Exp (Warsz) 54:299-305. 2006
  2. pmc Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure
    Barbara S Nikolajczyk
    Departments of Microbiology and Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Immunol 44:3407-15. 2007
  3. pmc B cells as under-appreciated mediators of non-auto-immune inflammatory disease
    Barbara S Nikolajczyk
    Departments of Microbiology and Medicine, Boston University School of Medicine, 72 East Concord Street, L 516, Boston, MA 02118, USA
    Cytokine 50:234-42. 2010
  4. pmc The outliers become a stampede as immunometabolism reaches a tipping point
    Barbara S Nikolajczyk
    Department of Microbiology, Boston University, Boston, MA 02118, USA
    Immunol Rev 249:253-75. 2012
  5. doi request reprint State of the union between metabolism and the immune system in type 2 diabetes
    B S Nikolajczyk
    Departments of Microbiology and Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Genes Immun 12:239-50. 2011
  6. ncbi request reprint The Ig kappa 3' enhancer is activated by gradients of chromatin accessibility and protein association
    Daniel C McDevit
    Department of Medicine, Immunobiology Unit, Evans Memorial Department of Clinical Research, Boston Medical Center, Boston, MA 02118, USA
    J Immunol 174:2834-42. 2005
  7. pmc An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis
    Gerald V Denis
    Cancer Research Center, Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    FEBS Lett 584:3260-8. 2010
  8. ncbi request reprint Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation
    Daniel C McDevit
    Department of Medicine, Boston Medical Center, Boston, MA 02118, USA
    Mol Immunol 43:1541-8. 2006
  9. pmc TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients
    Madhumita Jagannathan
    Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 183:7461-70. 2009
  10. pmc B cells from periodontal disease patients express surface Toll-like receptor 4
    Hyunjin Shin
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    J Leukoc Biol 85:648-55. 2009

Research Grants

  1. Mechanisms regulating immunoglobulin gene transcription
    Barbara Nikolajczyk; Fiscal Year: 2007

Collaborators

  • T E Van Dyke
  • Raymond Reeves
  • Lisa M Ganley-Leal
  • GERALD DENIS
  • Gavin R Schnitzler
  • Daniel C McDevit
  • Hatice Hasturk
  • Hyunjin Shin
  • Alpdogan Kantarci
  • Madhumita Jagannathan
  • Yue Zhang
  • Kevin M McCarthy
  • Sylvia Marecki
  • Jeremy T Hetzel
  • Yanmei Liang
  • Ansu Mammen Noronha
  • Amy Andreucci
  • Michael D Liang
  • Daniel McDevit
  • Arthur Stucchi
  • Francis A Farraye
  • Daniel Rubin
  • Marie E McDonnell
  • Hongsheng Liu
  • Michael L Atchison
  • Leslie Perkins

Detail Information

Publications15

  1. ncbi request reprint Regulation of cytokine transcription in the context of chromatin
    Barbara Nikolajczyk
    Department of Microbiology, Boston University School of Medicine, 715 Albany Street L 516, Boston, MA 02118, USA
    Arch Immunol Ther Exp (Warsz) 54:299-305. 2006
    ....
  2. pmc Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure
    Barbara S Nikolajczyk
    Departments of Microbiology and Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Immunol 44:3407-15. 2007
    ..Furthermore, these findings raise the possibility that environmentally dependent regulation of kappa 3' enhancer structure underlies changes in kappa activation during B cell development...
  3. pmc B cells as under-appreciated mediators of non-auto-immune inflammatory disease
    Barbara S Nikolajczyk
    Departments of Microbiology and Medicine, Boston University School of Medicine, 72 East Concord Street, L 516, Boston, MA 02118, USA
    Cytokine 50:234-42. 2010
    ..Further analysis of the role B cells and B cell cytokines play in T2D, PD and other inflammatory diseases is required to justify testing B cell depletion therapies on a broader range of patients...
  4. pmc The outliers become a stampede as immunometabolism reaches a tipping point
    Barbara S Nikolajczyk
    Department of Microbiology, Boston University, Boston, MA 02118, USA
    Immunol Rev 249:253-75. 2012
    ....
  5. doi request reprint State of the union between metabolism and the immune system in type 2 diabetes
    B S Nikolajczyk
    Departments of Microbiology and Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Genes Immun 12:239-50. 2011
    ....
  6. ncbi request reprint The Ig kappa 3' enhancer is activated by gradients of chromatin accessibility and protein association
    Daniel C McDevit
    Department of Medicine, Immunobiology Unit, Evans Memorial Department of Clinical Research, Boston Medical Center, Boston, MA 02118, USA
    J Immunol 174:2834-42. 2005
    ..This analysis demonstrates kappa activation is a multistep process initiated in early B cell precursors before Igmu recombination and finalized only after the pre-B cell stage...
  7. pmc An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis
    Gerald V Denis
    Cancer Research Center, Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    FEBS Lett 584:3260-8. 2010
    ..The research effort is urgent because the obesity epidemic is serious; the medical community is ill prepared to cope with the anticipated excess morbidity and mortality associated with diet-induced obesity...
  8. ncbi request reprint Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation
    Daniel C McDevit
    Department of Medicine, Boston Medical Center, Boston, MA 02118, USA
    Mol Immunol 43:1541-8. 2006
    ....
  9. pmc TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients
    Madhumita Jagannathan
    Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 183:7461-70. 2009
    ..We conclude that disease-associated alteration of B cell TLR responses specifically regulates cytokine production and may influence chronic inflammation...
  10. pmc B cells from periodontal disease patients express surface Toll-like receptor 4
    Hyunjin Shin
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    J Leukoc Biol 85:648-55. 2009
    ..In contrast, B cell TLR4 was not activated by the prototypic TLR4 ligand Escherichia coli LPS. These findings raise the unexpected possibility that TLR4 engagement modulates B cell activation in PD patients...
  11. pmc Hyperactivated B cells in human inflammatory bowel disease
    Ansu Mammen Noronha
    Section of Infectious Disease, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Leukoc Biol 86:1007-16. 2009
    ....
  12. ncbi request reprint PU.1 as a chromatin accessibility factor for immunoglobulin genes
    Sylvia Marecki
    Department of Medicine, Boston University School of Medicine, 650 Albany Street X 438, Boston, MA 02118, USA
    Mol Immunol 40:723-31. 2004
    ..We conclude that PU.1 is a context-dependent chromatin accessibility factor that, alone, cannot establish widespread accessibility required for critical developmental processes such as antigen receptor recombination...
  13. ncbi request reprint HMGA1 co-activates transcription in B cells through indirect association with DNA
    Kevin M McCarthy
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    J Biol Chem 278:42106-14. 2003
    ..Furthermore, antisense HMGA1 substantially decreases mu enhancer activity in B cells. Taken together, these data suggest that HMGA1 functions as a transcriptional mu enhancer co-activator in B cells through indirect association with DNA...
  14. ncbi request reprint The interleukin-1beta gene is transcribed from a poised promoter architecture in monocytes
    Michael D Liang
    Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA
    J Biol Chem 281:9227-37. 2006
    ..We propose that this poised structure may generally characterize rapidly activated genes...
  15. ncbi request reprint Dominant-negative HMGA1 blocks mu enhancer activation through a novel mechanism
    Amy Andreucci
    Department of Medicine, Immunobiology Unit, Evans Memorial Department of Clinical Research, EBRC 438, Boston Medical Center, 650 Albany Street, Boston, Massachusetts 02118, USA
    Biochem Biophys Res Commun 292:427-33. 2002
    ....

Research Grants6

  1. Mechanisms regulating immunoglobulin gene transcription
    Barbara Nikolajczyk; Fiscal Year: 2007
    ..In addition understanding the rules for tissue-specific gene expression will allow exquisitely regulated delivery of treatments for a variety of single tissue syndromes from cancer to diabetes. ..