Joanne Murabito

..We expect these ongoing collaborations and the translational work with basic scientists to accelerate the identification of genes that delay aging and promote a healthy life span...

..To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts...

..We conducted a genome-wide association study (GWAS) for SCA measurements in the community-based Framingham Heart Study...

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..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...

..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...

..There have been no genome-wide association and linkage studies for these traits using high-density genotyping platforms...

..Emerging evidence suggests that different inflammatory biomarkers operate through distinct biologic mechanisms. We hypothesized that the relation to peripheral arterial disease (PAD) varies for individual markers...

..IC incidence has declined since 1950, but mortality has remained high and unchanged. Factors contributing to the declining incidence of IC need clarification...

..To identify chromosomal regions linked to age at natural menopause...

..While parental cardiovascular disease (CVD) doubles the risk for CVD in offspring, the extent of increased risk associated with sibling CVD is unclear...

..We sought to estimate heritability of age at natural menopause in women participating in the multigenerational Framingham Heart Study, a community-based epidemiological study...

..27 (standard error, 0.06), 0.30 (standard error, 0.06), and 0.21 (standard error, 0.06), respectively (all p values < 0.0001). A modest proportion of the variability in ABI is explained by genetic factors...

..Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified...

..We sought to determine change in the prevalence of functional limitations and physical disability among the community-dwelling elderly population across 3 decades...

..Peripheral arterial disease (PAD) is associated with an increased risk for mortality. We sought to assess the prevalence of PAD and its risk factors in a population-based sample...

..Additional studies addressing the pathogenesis, prevention, and optimal management of the joint occurrence of AF and CHF appear warranted...

..We hypothesized that this paradox is due partly to the advent of increasingly sensitive biomarkers for AMI diagnosis...

..Congestive heart failure (CHF) is an increasing public health problem...

..1) or death (hazards ratio, 1.4; 95% confidence interval, 0.9-2.1) was observed. CONCLUSIONS: A low ABI is associated with risk of stroke or transient ischemic attack in the elderly. These results need to be confirmed in larger studies...

..CONCLUSIONS: MA was associated with metabolic risk factors, but most of these associations were lost after adjustment for BMI or VAT. However, a unique association remained for metabolic syndrome in women and lipids in men...

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..Factors contributing to these trends need further clarification...

..We related validated parental premature CVD with the subclinical measures of coronary artery (CAC) and abdominal aortic (AAC) calcification in the community...

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..93 [1.15-3.24]). In our community-based sample, individuals with MetS have a high prevalence of subclinical atherosclerosis that likely contributes to the increased risk of overt CVD associated with the condition...

..Prior research has suggested that delay or avoidance of cardiovascular disease and cardiovascular disease risk factors plays an important role in longevity...

..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...

..Family history is used to infer the risk for heart disease; however, little is known about the accuracy of family history reports...

..To examine whether midlife cardiovascular risk factors predict survival and survival free of major comorbidities to the age of 85...

..AAC appears to be useful for risk stratification in patients at intermediate CHD risk...

..We sought to determine whether impaired fasting glucose (IFG) predicts cardiovascular disease (CVD) events...

..We hypothesized that persons with greater amounts of periaortic fat are more likely to have clinical PAD and a low ankle-brachial index...

..Additional investigations are warranted to confirm these findings...

..Yet, prospective studies relating sex hormones to CVD incidence in men have yielded inconsistent results...

..The burden and prognostic importance of subclinical cardiovascular disease (CVD) in obesity has not been investigated systematically...

..Weight gain adversely affects blood pressure, lipids, and glycemia. The genetic contribution to weight change is unknown...

..Several prior studies relating breastfeeding to cardiovascular risk factors have been limited by lack of adjustment for maternal and participant confounding factors...

..Compared with those with health insurance, the uninsured receive less care for chronic conditions, such as hypertension and diabetes, and experience higher mortality...

..Overt hypothyroidism and hyperthyroidism may be associated with weight gain and loss. We assessed whether variations in thyroid function within the reference (physiologic) range are associated with body weight...

..Polymorphisms in estrogen receptor-alpha (ESR1) may be associated with variation in body mass index and waist circumference. However, most prior studies have been limited by sample size and power...

..Published 2010 Wiley-Liss, Inc...

..We investigated the environmental and genetic sources of interindividual variability in serum aldosterone level in a large, community-based sample...

..Our objective was to determine the incidence and natural history of RP not associated with a connective tissue disease in a large, community-based population...

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..Our objective was to determine whether smoking and alcohol are independently associated with Raynaud's in a large, community-based cohort...

..These data also support further research into genetic determinants of cardiovascular risk...

..To evaluate the effect of nine disabling medical conditions upon recovery from functional limitations by elders...

..The study objective was to describe self-reported advance care planning, health care preferences, use of advance directives, and health perceptions in a very elderly community-dwelling sample...

..Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear...

..To explore potential mechanisms by which these gene variants may contribute to cardiovascular disease, we tested the hypothesis that the polymorphisms were associated with endogenous steroid hormone levels...

..Knowledge gained from this proposal may lead to interventions that prevent age-related disease and disability so that older persons spend more time in good health. ..