Elise Morgan

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Vascular development during distraction osteogenesis proceeds by sequential intramuscular arteriogenesis followed by intraosteal angiogenesis
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 51:535-45. 2012
  2. pmc Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized
    David J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Avenue, Boston, MA 02120, USA
    Arthritis Res Ther 11:R11. 2009
  3. doi request reprint Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 43:1031-8. 2008
  4. pmc Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 44:335-44. 2009
  5. pmc Correlations between local strains and tissue phenotypes in an experimental model of skeletal healing
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    J Biomech 43:2418-24. 2010
  6. pmc Relationships between tissue dilatation and differentiation in distraction osteogenesis
    Elise F Morgan
    Biomechanical Engineering Division, Mechanical Engineering Department, Durand Building, Room 215, Stanford University, Stanford, CA 94305, USA
    Matrix Biol 25:94-103. 2006
  7. ncbi request reprint Damage in trabecular bone at small strains
    Elise F Morgan
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA, 94720, USA
    Eur J Morphol 42:13-21. 2005
  8. ncbi request reprint Sensitivity of multiple damage parameters to compressive overload in cortical bone
    Elise F Morgan
    Orthopedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA
    J Biomech Eng 127:557-62. 2005
  9. ncbi request reprint Contribution of inter-site variations in architecture to trabecular bone apparent yield strains
    Elise F Morgan
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA
    J Biomech 37:1413-20. 2004
  10. pmc Mechanotransduction and fracture repair
    Elise F Morgan
    Department of Aerospace and Mechanical Engineering, Boston University, 110 Cummington Street, Boston, MA 02215, USA
    J Bone Joint Surg Am 90:25-30. 2008

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc Vascular development during distraction osteogenesis proceeds by sequential intramuscular arteriogenesis followed by intraosteal angiogenesis
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 51:535-45. 2012
    ..The results further suggest the presence of morphogenetic factors that coordinate the development of vascular tissues from the intramuscular compartment into the regions of osseous regeneration...
  2. pmc Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized
    David J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Avenue, Boston, MA 02120, USA
    Arthritis Res Ther 11:R11. 2009
    ..The aim of the present study was to evaluate the architecture of subchondral bone in regions with and without BMLs from the same individual using bone histomorphometry...
  3. doi request reprint Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 43:1031-8. 2008
    ..The combination of both agents led to greater bone volume as well as better microstructural organization and integration of this bone with the surrounding tissues...
  4. pmc Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 44:335-44. 2009
    ..These findings form the basis for developing non-invasive assessments of fracture healing and for identifying biological and biomechanical mechanisms that lead to impaired or enhanced healing...
  5. pmc Correlations between local strains and tissue phenotypes in an experimental model of skeletal healing
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    J Biomech 43:2418-24. 2010
    ..These results indicate that shear strain may be an important regulator of tissue fate during skeletal healing...
  6. pmc Relationships between tissue dilatation and differentiation in distraction osteogenesis
    Elise F Morgan
    Biomechanical Engineering Division, Mechanical Engineering Department, Durand Building, Room 215, Stanford University, Stanford, CA 94305, USA
    Matrix Biol 25:94-103. 2006
    ..These results are used to suggest experiments that can provide a more mechanistic understanding of the role of tissue dilatation in bone regeneration...
  7. ncbi request reprint Damage in trabecular bone at small strains
    Elise F Morgan
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA, 94720, USA
    Eur J Morphol 42:13-21. 2005
    ....
  8. ncbi request reprint Sensitivity of multiple damage parameters to compressive overload in cortical bone
    Elise F Morgan
    Orthopedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA
    J Biomech Eng 127:557-62. 2005
    ..These results suggest that efforts to relate microcrack density and morphology to changes in compressive mechanical properties of cortical bone may benefit from considering alternative parameters to modulus reductions...
  9. ncbi request reprint Contribution of inter-site variations in architecture to trabecular bone apparent yield strains
    Elise F Morgan
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA
    J Biomech 37:1413-20. 2004
    ..These findings indicate the importance of incorporating large deformation capabilities in computational analyses of trabecular bone. This may be critical when investigating the biomechanical consequences of trabecular thinning and loss...
  10. pmc Mechanotransduction and fracture repair
    Elise F Morgan
    Department of Aerospace and Mechanical Engineering, Boston University, 110 Cummington Street, Boston, MA 02215, USA
    J Bone Joint Surg Am 90:25-30. 2008
    ..A better understanding of the effect of mechanical factors on bone-healing will also benefit the study of healing, regeneration, and engineering of other skeletal tissues...
  11. ncbi request reprint Trabecular bone modulus-density relationships depend on anatomic site
    Elise F Morgan
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, 6175 Etcheverry Hall, Berkeley, CA 94720 1740, USA
    J Biomech 36:897-904. 2003
    ..15), suggesting that the site-specificity in apparent modulus-density relationships may be attributed to differences in architecture...
  12. ncbi request reprint Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing
    Eleftherios Tsiridis
    Department of Orthopaedic Surgery, Boston University Medical Center, Laboratory of Orthopaedic Research, 715 Albany Street, R 205, Boston, Massachusetts 02118, USA
    J Orthop Res 25:1193-203. 2007
    ..In addition, differences in systemic versus local effects of PTH and OP-1 in accelerating metaphyseal fracture healing were found...
  13. ncbi request reprint Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue
    Harun H Bayraktar
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, 2166 Etcheverry Hall, Berkeley, CA 94720 1740, USA
    J Biomech 37:27-35. 2004
    ....
  14. ncbi request reprint Quantitative computed tomography estimates of the mechanical properties of human vertebral trabecular bone
    David L Kopperdahl
    Department of Mechanical Engineering, University of California, Berkeley 94720 1740, USA
    J Orthop Res 20:801-5. 2002
    ..Use of these QCT density-mechanical property regressions should improve the fidelity of QCT-based biomechanical models of the human spine for whole bone and bone-implant analyses...
  15. doi request reprint Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, 715 Albany Street, R 205, Boston, MA 02118, USA
    J Bone Joint Surg Am 90:120-7. 2008
    ....
  16. pmc Mechanical stimulation alters tissue differentiation and molecular expression during bone healing
    Kristy T Salisbury Palomares
    Department of Mechanical Engineering, Boston University, Boston, Massachusetts 02215, USA
    J Orthop Res 27:1123-32. 2009
    ..These findings illustrate that mechanical cues can selectively modulate osteogenesis and chondrogenesis in vivo, and suggest a potential basis for treatment regimens for injured or diseased cartilaginous tissues...
  17. doi request reprint Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing
    Louis C Gerstenfeld
    Orthopaedic Research Laboratory, Department of Orthopedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Bone Miner Res 24:196-208. 2009
    ..In contrast, strength and stiffness were enhanced in these treatment groups compared with control bones...
  18. pmc Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity
    Rayyan A Kayal
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Bone Miner Res 22:560-8. 2007
    ..Increased cartilage turnover was associated with elevated osteoclast numbers, a higher expression of genes that promote osteoclastogenesis, and diminished primary bone formation...
  19. pmc Accuracy and precision of digital volume correlation in quantifying displacements and strains in trabecular bone
    Li Liu
    Boston University, 110 Cummington Street, Boston, MA 02215, USA
    J Biomech 40:3516-20. 2007
    ..In these cases, DVC is a viable technique for measuring pre- and post-yield strains throughout trabecular bone specimens and the trabecular compartment of whole bones...
  20. ncbi request reprint Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures
    Sanjeev Kakar
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts, USA
    J Bone Miner Res 22:1903-12. 2007
    ....
  21. pmc Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling
    Kimberly A Jacobsen
    Orthopaedic Research Laboratory Department of Orthopedic Surgery, Boston University School of Medicine, Boston, Massachusetts, USA
    J Bone Miner Res 23:596-609. 2008
    ..Distraction osteogenesis (DO) is characterized by the induction of highly vascularized new bone formation through an intramembranous process largely devoid of the formation of cartilage...
  22. pmc Combined effects of microtopography and cyclic strain on vascular smooth muscle cell orientation
    Graham R Houtchens
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Biomech 41:762-9. 2008
    ..The results suggest that there is a range of microgroove dimensions that is most effective at maintaining the orientation of the cells in the presence of an opposing stimulus induced by cyclic strain...
  23. pmc Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model
    Kristy T Salisbury Palomares
    Boston University and Boston University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 62:1108-18. 2010
    ..To characterize patterns of molecular expression that lead to cartilage formation in vivo in a postnatal setting, by profiling messenger RNA expression across the time course of mechanically induced chondrogenesis...

Research Grants9

  1. High-Resolution Desktop Micro-Computed Tomograpy System
    Elise Morgan; Fiscal Year: 2005
    ....
  2. Inducing Skeletal Repair by Mechanical Stimulation
    Elise Morgan; Fiscal Year: 2007
    ..Taken together, these experiments represent the first steps in defining the mechano-regulated processes involved in the postnatal formation of functional hyaline cartilage. ..
  3. 3-D Visualization and Prediction of Spine Fractures
    Elise F Morgan; Fiscal Year: 2010
    ..One in three women and one in six men over age 50 will suffer a spine fracture in their remaining lifetime. This project focuses on developing methods for obtaining more accurate predictions of bone strength in the spine. ..
  4. Inducing Skeletal Repair by Mechanical Stimulation
    Elise Morgan; Fiscal Year: 2009
    ..Taken together, these experiments represent the first steps in defining the mechano-regulated processes involved in the postnatal formation of functional hyaline cartilage. ..