JOSEPH MIZGERD

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Zcchc11-dependent uridylation of microRNA directs cytokine expression
    Matthew R Jones
    The Pulmonary Center, Boston University School of Medicine, MA 102118, USA
    Nat Cell Biol 11:1157-63. 2009
  2. pmc Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival
    Matthew R Jones
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1003105. 2012
  3. pmc Respiratory infection and the impact of pulmonary immunity on lung health and disease
    Joseph P Mizgerd
    Boston University School of Medicine, The Pulmonary Center, 72 East Concord Street, Boston, MA 02118, USA
    Am J Respir Crit Care Med 186:824-9. 2012
  4. pmc Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia
    Lynnelle A Pittet
    Pulmonary Center, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA
    Am J Respir Cell Mol Biol 45:573-81. 2011

Research Grants

  1. NF-KB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2003
  2. Regulation and function of STAT3 during pneumonia
    JOSEPH MIZGERD; Fiscal Year: 2009
  3. NF-kappaB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2009
  4. NF-kappaB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2007
  5. Regulation and function of STAT3 during pneumonia
    JOSEPH MIZGERD; Fiscal Year: 2007
  6. Regulation and function of STAT3 during pneumonia
    JOSEPH MIZGERD; Fiscal Year: 2006
  7. NF-KB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2006
  8. Regulation and function of STAT3 during pneumonia
    JOSEPH MIZGERD; Fiscal Year: 2005
  9. NF-kappaB and Innate Immunity in the Lungs
    Joseph P Mizgerd; Fiscal Year: 2010

Collaborators

  • George Q Daley
  • Matthew R Jones
  • Lee J Quinton
  • Lynnelle A Pittet
  • Matthew T Blahna
  • Samantha A Morris
  • John T Powers
  • Elyse Kozlowski
  • Kori Y Matsuura
  • Joseph D Ferrari
  • Bryanne E Robson
  • Hana Alg├╝l
  • J Daniel Ferrari
  • Roland M Schmid
  • Kazuko Yamamoto
  • Alexander R Ivanov
  • Dieter A Wolf
  • Joel R Neilson
  • Suneng Fu

Detail Information

Publications4

  1. pmc Zcchc11-dependent uridylation of microRNA directs cytokine expression
    Matthew R Jones
    The Pulmonary Center, Boston University School of Medicine, MA 102118, USA
    Nat Cell Biol 11:1157-63. 2009
    ..Thus, Zcchc11 fine tunes IL-6 production by uridylating miR-26a, which we propose is an enzymatic modification of the terminal nucleotide sequence of mature miRNA as a means to regulate gene expression...
  2. pmc Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival
    Matthew R Jones
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1003105. 2012
    ..We propose that the miRNA 3' terminus is a regulatory node upon which multiple enzymes converge to direct silencing activity and tune gene expression...
  3. pmc Respiratory infection and the impact of pulmonary immunity on lung health and disease
    Joseph P Mizgerd
    Boston University School of Medicine, The Pulmonary Center, 72 East Concord Street, Boston, MA 02118, USA
    Am J Respir Crit Care Med 186:824-9. 2012
    ..Further advances in pulmonary immunity and elucidation of the cellular and molecular responses to microbes in the lung are needed to develop novel approaches to predicting, preventing, and curing respiratory disease...
  4. pmc Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia
    Lynnelle A Pittet
    Pulmonary Center, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA
    Am J Respir Cell Mol Biol 45:573-81. 2011
    ..Thus, during pneumococcal pneumonia, only the earliest induction of the cytokines measured depended on transcription by RelA in myeloid cells, and this transcriptional activity contributed to effective immunity...

Research Grants11

  1. NF-KB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2003
    ..The results from these studies will provide new insights into how gene expression and innate immunity are limited in order to prevent inflammatory injury to the lung. ..
  2. Regulation and function of STAT3 during pneumonia
    JOSEPH MIZGERD; Fiscal Year: 2009
    ..Elucidating the regulation and function of IL-6 and STAT3 during pneumonia will provide molecular targets for improving host defense and preventing lung injury in patients with or at risk for lung infections. ..
  3. NF-kappaB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2009
    ..Such knowledge will be essential to guiding future studies aiming to manipulate innate immune signaling in order to prevent or treat lung infections. ..
  4. NF-kappaB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..Such knowledge will be essential to guiding future studies aiming to manipulate innate immune signaling in order to prevent or treat lung infections. ..
  5. Regulation and function of STAT3 during pneumonia
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..Elucidating the regulation and function of IL-6 and STAT3 during pneumonia will provide molecular targets for improving host defense and preventing lung injury in patients with or at risk for lung infections. ..
  6. Regulation and function of STAT3 during pneumonia
    JOSEPH MIZGERD; Fiscal Year: 2006
    ..Elucidating the regulation and function of IL-6 and STAT3 during pneumonia will provide molecular targets for improving host defense and preventing lung injury in patients with or at risk for lung infections. ..
  7. NF-KB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2006
    ..The results from these studies will provide new insights into how gene expression and innate immunity are limited in order to prevent inflammatory injury to the lung. ..
  8. Regulation and function of STAT3 during pneumonia
    JOSEPH MIZGERD; Fiscal Year: 2005
    ..Elucidating the regulation and function of IL-6 and STAT3 during pneumonia will provide molecular targets for improving host defense and preventing lung injury in patients with or at risk for lung infections. ..
  9. NF-kappaB and Innate Immunity in the Lungs
    Joseph P Mizgerd; Fiscal Year: 2010
    ..Such knowledge will be essential to guiding future studies aiming to manipulate innate immune signaling in order to prevent or treat lung infections. ..