Research Topics
| JEROME C MERTZSummaryAffiliation: Boston University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Nonlinear microscopy: new techniques and applicationsJerome Mertz
Boston University, Department of Biomedical Engineering, 44 Cummington Street, Boston, Massachusetts 02215, USA
Curr Opin Neurobiol 14:610-6. 2004..Along with novel strategies to image over exceptionally long durations and with increased depth penetration in living brains, these advances are opening new opportunities in neurobiology that were previously unavailable...
Scanning light-sheet microscopy in the whole mouse brain with HiLo background rejectionJerome Mertz
Boston University, Department of Biomedical Engineering, Boston, Massachusetts 02215, USA
J Biomed Opt 15:016027. 2010....
Widefield fluorescence sectioning with HiLo microscopyJerome Mertz
Boston University, Department of Biomedical Engineering, 44 Cummington St, Boston, MA, 02215, USA
Conf Proc IEEE Eng Med Biol Soc 2009:3229-30. 2009..We discuss the theory of this technique and a variety of practical implementations in brain-tissue imaging and fluorescence endomicroscopy...- Optical sectioning microscopy with planar or structured illuminationJerome Mertz
Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
Nat Methods 8:811-9. 2011..In this Review, I examine two such techniques, based on planar illumination or structured illumination. The goal is to describe the advantages and disadvantages of these techniques... - Wide-field fluorescence sectioning with hybrid speckle and uniform-illumination microscopyDaryl Lim
Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
Opt Lett 33:1819-21. 2008..This hybrid illumination method is fast, robust, and generalizable to a variety of illumination and imaging configurations... - Fluorescence endomicroscopy with structured illuminationNenad Bozinovic
Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
Opt Express 16:8016-25. 2008..To establish the potential of our endomicroscope for preclinical or clinical applications, we provide images of BCECF-AM labeled rat colonic mucosa... - Dynamic speckle illumination microscopy with translated versus randomized speckle patternsCathie Ventalon
Boston University, Department of Biomedical Engineering, 44 Cummington St, Boston, MA 02215, USA
Opt Express 14:7198-209. 2006..We present a theory valid for arbitrary point-spread-functions, which we corroborate with experimental results... - Rejection of two-photon fluorescence background in thick tissue by differential aberration imagingAymeric Leray
Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
Opt Express 14:10565-73. 2006..We present a heuristic description of our technique, which we corroborate with experiment. An added benefit of our technique is that it leads to somewhat improved image resolution... - Dynamic speckle illumination microscopy with wavelet prefilteringCathie Ventalon
Boston University, Department of Biomedical Engineering, Boston, Massachusetts 02215, USA
Opt Lett 32:1417-9. 2007..The resultant gain in sectioning strength leads to a fundamentally improved scaling law for the out-of-focus background rejection... - Two-photon imaging of spatially extended neuronal network dynamics with high temporal resolutionKyle P Lillis
Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States
J Neurosci Methods 172:178-84. 2008..Finally, we provide the code to make our technique generally available... - Enhanced weak-signal sensitivity in two-photon microscopy by adaptive illuminationKengyeh K Chu
Department of Biomedical Engineering, Boston University, MA 02215, USA
Opt Lett 32:2846-8. 2007..We analyze and demonstrate the benefits of adaptive illumination in two-photon fluorescence microscopy... - Autoconfocal microscopy with a cw laser and thermionic detectionDaryl Lim
Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
Opt Lett 33:1345-7. 2008..Our technique of thermionic-detection autoconfocal microscopy is further implemented with graded-field contrast to obtain enhanced phase-gradient sensitivity in unlabeled samples, such as rat hippocampal brain slices...
Research Grants
- Thick tissue imaging with auto-confocal microscopyJerome Mertz; Fiscal Year: 2004..abstract_text> ..
- Deep ultraviolet nonlinear microscopy in thick tissueJerome Mertz; Fiscal Year: 2006..Ultimately, we hope to confirm our hypothesis that intrinsic optical signals in the DUV spectral window, which has largely been overlooked so far, can provide useful and clinically relevant information. ..
- Widefield fluorescence macroscopy with out-of-focus blur rejectionJerome Mertz; Fiscal Year: 2007..Our goal is to build a new tool for cancer research that can eventually be implemented in the clinic. ..
- The development of hybrid widefield imaging for out-of-focus background rejectionJEROME C MERTZ; Fiscal Year: 2010..We propose to develop an endomicroscope and a widefield macroscope based on this technology for pre-clinical small-animal cancer-model imaging and diagnosis. ..