KIMBERLY A MCCALL
Affiliation: Boston University
Mondragon A, Yalonetskaya A, Ortega A, Zhang Y, Naranjo O, Elguero J, et al
. Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death. Cell Rep. 2019;27:11-19.e3 pubmed publisher
..Our results reveal a role for lysosomal machinery acting at the plasma membrane to cause the death of neighboring cells, providing insight into mechanisms driving non-autonomous cell death. ..
Yalonetskaya A, Mondragon A, Elguero J, McCall K. I Spy in the Developing Fly a Multitude of Ways to Die. J Dev Biol. 2018;6: pubmed publisher
..These and other examples discussed here demonstrate the versatility of Drosophila as a model organism for elucidating the diverse modes of programmed cell death. ..
Peterson J, Timmons A, Mondragon A, McCall K. The End of the Beginning: Cell Death in the Germline. Curr Top Dev Biol. 2015;114:93-119 pubmed publisher
..These examples of cell death in the fly ovary share many similarities to the types of cell death seen in the mammalian germline. Recent progress in elucidating the molecular mechanisms of cell death in the germline is discussed. ..
Meehan T, Serizier S, Kleinsorge S, McCall K. Analysis of Phagocytosis in the Drosophila Ovary. Methods Mol Biol. 2016;1457:79-95 pubmed publisher
..LysoTracker labels highly acidified compartments, marking phagolysosomes. Together these labels can be used to mark the progression of engulfment in Drosophila follicle cells. ..
Santoso C, Meehan T, Peterson J, Cedano T, Turlo C, McCall K. The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary. G3 (Bethesda). 2018;8:833-843 pubmed publisher
..melanogaster, and demonstrates a role for Eato in Drpr accumulation and phagocytic membrane extensions during NC clearance in the ovary. ..
McCall K. Genetic control of necrosis - another type of programmed cell death. Curr Opin Cell Biol. 2010;22:882-8 pubmed publisher
..This review highlights recent findings from C. elegans, yeast, Dictyostelium, Drosophila, and mammals that collectively provide evidence for conserved mechanisms of necrosis. ..
Meehan T, Kleinsorge S, Timmons A, Taylor J, McCall K. Polarization of the epithelial layer and apical localization of integrins are required for engulfment of apoptotic cells in the Drosophila ovary. Dis Model Mech. 2015;8:1603-14 pubmed publisher
..This study also establishes the epithelial follicle cells of the Drosophila ovary as a powerful model for understanding the molecular changes required for engulfment by a polarized epithelium. ..
Timmons A, Mondragon A, Schenkel C, Yalonetskaya A, Taylor J, Moynihan K, et al
. Phagocytosis genes nonautonomously promote developmental cell death in the Drosophila ovary. Proc Natl Acad Sci U S A. 2016;113:E1246-55 pubmed publisher
..Developmental PCD in the Drosophila ovary is an intriguing example of nonapoptotic, nonautonomous PCD, providing insight on the diversity of cell death mechanisms. ..
Etchegaray J, Elguero E, Tran J, Sinatra V, Feany M, McCall K. Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 Activation. J Neurosci. 2016;36:3170-83 pubmed publisher
..Our data indicate that corpses persist because of defective degradation of cells rather than recognition of dead cells. ..