Assen Marintchev

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Roles of helicases in translation initiation: a mechanistic view
    Assen Marintchev
    Dept of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Biochim Biophys Acta 1829:799-809. 2013
  2. pmc Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation
    Assen Marintchev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
    Cell 136:447-60. 2009
  3. pmc PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains
    Chikako Suzuki
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:3274-9. 2008
  4. pmc Structural basis for the enhancement of eIF4A helicase activity by eIF4G
    Monika Oberer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2212-23. 2005
  5. ncbi NMR methods for studying protein-protein interactions involved in translation initiation
    Assen Marintchev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 430:283-331. 2007
  6. pmc Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance
    Vladimir Gelev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Mol Biol 364:352-63. 2006
  7. pmc Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface
    Boriana Marintcheva
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:1855-60. 2008
  8. ncbi eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4G
    Assen Marintchev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Biochemistry 44:12265-72. 2005
  9. pmc The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β
    Rafael E Luna
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 1:689-702. 2012
  10. ncbi Translation initiation: structures, mechanisms and evolution
    Assen Marintchev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston 02115, USA
    Q Rev Biophys 37:197-284. 2004

Collaborators

Detail Information

Publications11

  1. pmc Roles of helicases in translation initiation: a mechanistic view
    Assen Marintchev
    Dept of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    Biochim Biophys Acta 1829:799-809. 2013
    ..The evidence in favor of this hypothesis and its possible implications for the mechanisms of translation initiation is discussed. This article is part of a Special Issue entitled: The biology of RNA helicases - Modulation for life...
  2. pmc Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation
    Assen Marintchev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
    Cell 136:447-60. 2009
    ..The topology of the complex and the spatial arrangement of the RNA-binding surfaces offer insights into their roles in stimulation of helicase activity and the mechanisms of mRNA unwinding and scanning...
  3. pmc PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains
    Chikako Suzuki
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:3274-9. 2008
    ..The PDCD4 MA3 domains act synergistically to form a tighter and more stable complex with eIF4A, which explains the need for two tandem MA3 domains...
  4. pmc Structural basis for the enhancement of eIF4A helicase activity by eIF4G
    Monika Oberer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2212-23. 2005
    ..This model can explain the cooperativity between all binding partners of eIF4A (eIF4G, RNA, ATP) and stimulation of eIF4A activity in the eIF4F complex...
  5. ncbi NMR methods for studying protein-protein interactions involved in translation initiation
    Assen Marintchev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 430:283-331. 2007
    ....
  6. pmc Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance
    Vladimir Gelev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Mol Biol 364:352-63. 2006
    ..The observed chemical shift changes extend from the eIF2alpha binding site into the kinase N-lobe and inside the active site, consistent with weak interactions between the N-terminal part of the RBD and the kinase...
  7. pmc Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface
    Boriana Marintcheva
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:1855-60. 2008
    ..This mechanism prevents random binding of charged molecules to the nucleic acid-binding pocket and coordinates nucleic acid-protein and protein-protein interactions...
  8. ncbi eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4G
    Assen Marintchev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Biochemistry 44:12265-72. 2005
    ....
  9. pmc The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β
    Rafael E Luna
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 1:689-702. 2012
    ..This study provides mechanistic insight into the role of eIF5-CTD's dynamic interplay with eIF1 and eIF2β in switching PICs from an open to a closed state at start codons...
  10. ncbi Translation initiation: structures, mechanisms and evolution
    Assen Marintchev
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston 02115, USA
    Q Rev Biophys 37:197-284. 2004
    ..We will conclude with a summary of the available information on the kinetic and thermodynamic aspects of translation initiation...
  11. ncbi Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B
    Takuhiro Ito
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Structure 12:1693-704. 2004
    ..It further indicates a previously unrecognized evolutionary lineage of eIF2alpha/gamma from the functionally related elongation factor eEF1Balpha/eEF1A complex...