Kathryn L Lunetta

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
  2. pmc Two-stage approach for identifying single-nucleotide polymorphisms associated with rheumatoid arthritis using random forests and Bayesian networks
    Yan Meng
    Genetics Program, Department of Medicine, School of Medicine, Boston University, 715 Albany Street, Boston, Massachusetts 02118 USA
    BMC Proc 1:S56. 2007
  3. doi request reprint Genetic association studies
    Kathryn L Lunetta
    Department of Biostatistics, Boston University School of Public Health, 715 Albany St, Crosstown Center, 3rd Floor, Boston, MA 02118, USA
    Circulation 118:96-101. 2008
  4. ncbi request reprint Heritability of magnetic resonance imaging (MRI) traits in Alzheimer disease cases and their siblings in the MIRAGE study
    Kathryn L Lunetta
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 21:85-91. 2007
  5. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
  6. pmc Screening large-scale association study data: exploiting interactions using random forests
    Kathryn L Lunetta
    Oscient Pharmaceuticals, Inc, formerly Genome Therapeutics Corporation, Waltham, Massachusetts, USA
    BMC Genet 5:32. 2004
  7. pmc The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations
    Renate B Schnabel
    NHLBIs Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circ Cardiovasc Genet 2:229-37. 2009
  8. pmc Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study
    Renate Schnabel
    The NHLBI s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Atherosclerosis 204:601-7. 2009
  9. ncbi request reprint Informative-transmission disequilibrium test (i-TDT): combined linkage and association mapping that includes unaffected offspring as well as affected offspring
    Chao Yu Guo
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Genet Epidemiol 31:115-33. 2007
  10. pmc Comprehensive search for Alzheimer disease susceptibility loci in the APOE region
    Gyungah Jun
    Department of Medicine Biomedical Genetics, Boston University Schools of Medicine and Public Health, Boston, MA, USA
    Arch Neurol 69:1270-9. 2012

Detail Information

Publications51

  1. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
    ..Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown...
  2. pmc Two-stage approach for identifying single-nucleotide polymorphisms associated with rheumatoid arthritis using random forests and Bayesian networks
    Yan Meng
    Genetics Program, Department of Medicine, School of Medicine, Boston University, 715 Albany Street, Boston, Massachusetts 02118 USA
    BMC Proc 1:S56. 2007
    ..We evaluated the performance of this method using independent test data sets for up to 100 replicates...
  3. doi request reprint Genetic association studies
    Kathryn L Lunetta
    Department of Biostatistics, Boston University School of Public Health, 715 Albany St, Crosstown Center, 3rd Floor, Boston, MA 02118, USA
    Circulation 118:96-101. 2008
  4. ncbi request reprint Heritability of magnetic resonance imaging (MRI) traits in Alzheimer disease cases and their siblings in the MIRAGE study
    Kathryn L Lunetta
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 21:85-91. 2007
    ..In the Multi-Institutional Research in Alzheimer's Genetic Epidemiology Study of AD-discordant siblings, MRI traits are heritable and are potential endophenotypes for genetic association studies...
  5. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
    ..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...
  6. pmc Screening large-scale association study data: exploiting interactions using random forests
    Kathryn L Lunetta
    Oscient Pharmaceuticals, Inc, formerly Genome Therapeutics Corporation, Waltham, Massachusetts, USA
    BMC Genet 5:32. 2004
    ....
  7. pmc The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations
    Renate B Schnabel
    NHLBIs Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circ Cardiovasc Genet 2:229-37. 2009
    ..In the family-based Framingham Heart Study, we investigated heritability and candidate gene associations of systemic inflammatory biomarkers...
  8. pmc Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study
    Renate Schnabel
    The NHLBI s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Atherosclerosis 204:601-7. 2009
    ..Higher circulating Lp-PLA(2) predicts cardiovascular disease risk, but sources of inter-individual variability are incompletely understood...
  9. ncbi request reprint Informative-transmission disequilibrium test (i-TDT): combined linkage and association mapping that includes unaffected offspring as well as affected offspring
    Chao Yu Guo
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Genet Epidemiol 31:115-33. 2007
    ..Applying the i-TDT to the Framingham Heart Study data, we found that the apolipoprotein E (APOE) gene is significantly linked and associated with cross-sectional measures and longitudinal changes in total cholesterol...
  10. pmc Comprehensive search for Alzheimer disease susceptibility loci in the APOE region
    Gyungah Jun
    Department of Medicine Biomedical Genetics, Boston University Schools of Medicine and Public Health, Boston, MA, USA
    Arch Neurol 69:1270-9. 2012
    ....
  11. pmc Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease
    Porat M Erlich
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Aging 33:1015.e7-23. 2012
    ..Our results suggest that low serum paraoxonase activity is a risk factor for AD. Furthermore, multiple variants in PON influence serum paraoxonase activity and their effects may be synergistic...
  12. pmc Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families
    Karen T Cuenco
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Neurobiol Aging 32:249-56. 2011
    ..Results for the other MRI traits were unremarkable. This study highlights the potential value of neuroimaging endophenotypes as a tool for finding genes influencing AD pathogenesis...
  13. pmc Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese
    Steven A Lubitz
    Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts Electronic address
    J Am Coll Cardiol 63:1200-10. 2014
    ..This study sought to identify nonredundant atrial fibrillation (AF) genetic susceptibility signals and examine their cumulative relations with AF risk...
  14. pmc Meta-analysis identifies six new susceptibility loci for atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:670-5. 2012
    ..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules...
  15. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  16. pmc Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Douglas P Kiel
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S14. 2007
    ..There have been no genome-wide association and linkage studies for these traits using high-density genotyping platforms...
  17. pmc Assessment of cortical and striatal involvement in 523 Huntington disease brains
    Tiffany C Hadzi
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Neurology 79:1708-15. 2012
    ..To evaluate the relationship of striatal involvement in Huntington disease (HD) to involvement in other brain regions, CAG repeat size, onset age, and other factors...
  18. pmc Performance of random forest when SNPs are in linkage disequilibrium
    Yan A Meng
    Department of Medicine, Boston University, MA, USA
    BMC Bioinformatics 10:78. 2009
    ....
  19. ncbi request reprint Polymorphisms in the PON gene cluster are associated with Alzheimer disease
    Porat M Erlich
    Department of Medicine Genetics Program, Boston University School of Medicine, Boston, MA 02118, USA
    Hum Mol Genet 15:77-85. 2006
    ..The most significantly associated haplotype comprised SNPs in the region spanning the -161[C/T] SNP (P=0.00009). Our results demonstrate association between AD and variants in the PON gene cluster in Caucasians and African Americans...
  20. pmc Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection
    Renate Schnabel
    National Heart Lung and Blood Institute Framingham Study, Framingham, Mass, USA
    Hypertension 51:1651-7. 2008
    ..Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures...
  21. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  22. pmc Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease
    Karen T Cuenco
    Genetics Program, Department of Medicine, Room L320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Arch Neurol 65:1640-8. 2008
    ....
  23. doi request reprint Evaluation of methods accounting for population structure with pedigree data and continuous outcomes
    Gina M Peloso
    Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA
    Genet Epidemiol 35:427-36. 2011
    ..efficient score test performs very well. When computational time is not an issue, a linear mixed effects model adjusting for genetic principal components tends to have slightly better power than the score test and may be preferred...
  24. pmc Whole blood gene expression and atrial fibrillation: the Framingham Heart Study
    Honghuang Lin
    Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts, United States of America
    PLoS ONE 9:e96794. 2014
    ..Atrial fibrillation (AF) involves substantial electrophysiological, structural and contractile remodeling. We hypothesize that characterizing gene expression might uncover important pathways related to AF...
  25. pmc A comparison of gene region simulation methods
    Audrey E Hendricks
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e40925. 2012
    ..Here we compare the ability of three approaches to accurately simulate the LD within a gene region: HapSim (2005), Hapgen (2009), and a minor extension to simple haplotype resampling...
  26. pmc Multiple loci influencing hippocampal degeneration identified by genome scan
    Scott A Melville
    Department of Medicine, Boston University School of Medicine, MA, USA
    Ann Neurol 72:65-75. 2012
    ..We conducted a 2-stage GWAS for AD-related quantitative measures of hippocampal volume (HV), total cerebral volume (TCV), and white matter hyperintensities (WMH)...
  27. pmc Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circ Cardiovasc Genet 4:557-64. 2011
    ..The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated...
  28. pmc Common variants in KCNN3 are associated with lone atrial fibrillation
    Patrick T Ellinor
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 4 These authors contributed equally to this work
    Nat Genet 42:240-4. 2010
    ..52, 95% CI 1.40-1.64; P = 1.83 x 10(-21)). rs13376333 is intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization...
  29. ncbi request reprint Identifying SNPs predictive of phenotype using random forests
    Alexandre Bureau
    Department of Human Genetics, Oscient Pharmaceuticals, Waltham, Massachusetts, USA
    Genet Epidemiol 28:171-82. 2005
    ..SNPs and SNP pairs highly associated with asthma tend to have the highest importance index value, but predictive importance and association do not always coincide...
  30. pmc Combined haplotype relative risk (CHRR): a general and simple genetic association test that combines trios and unrelated case-controls
    Chao Yu Guo
    Clinical Research Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Genet Epidemiol 33:54-62. 2009
    ..J. Hum. Genet. 64:1186-1193). In addition, simulation results suggest that the combined haplotype relative risk is more powerful than Epstein et al.'s method regardless of the disease prevalence in a homogeneous population...
  31. pmc A search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways
    Mark W Logue
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Neurobiol Aging 35:1510.e7-18. 2014
    ..34, OR = 0.89, p = 1.17 × 10(-5)), which is a member of the atherosclerosis signaling and the LXR/RXR activation pathways. Our results suggest that AMD and AD share genetic mechanisms...
  32. pmc Targeted sequencing in candidate genes for atrial fibrillation: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study
    Honghuang Lin
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts The NHLBI s Framingham Heart Study, Framingham, Massachusetts Electronic address
    Heart Rhythm 11:452-7. 2014
    ..Genome-wide association studies (GWAS) have identified common genetic variants that predispose to atrial fibrillation (AF). It is unclear whether rare and low-frequency variants in genes implicated by such GWAS confer additional risk of AF...
  33. pmc A comprehensive genetic association study of Alzheimer disease in African Americans
    Mark W Logue
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arch Neurol 68:1569-79. 2011
    ..To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide association studies of whites...
  34. pmc The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
    Joanne M Murabito
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    J Gerontol A Biol Sci Med Sci 67:470-9. 2012
    ..We expect these ongoing collaborations and the translational work with basic scientists to accelerate the identification of genes that delay aging and promote a healthy life span...
  35. pmc Choice of population structure informative principal components for adjustment in a case-control study
    Gina M Peloso
    Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston MA 02118, USA
    BMC Genet 12:64. 2011
    ..A thorough examination of selecting PCs for adjustment in a case-control study across the possible structure scenarios that could occur in a genome-wide association study has not been previously reported...
  36. pmc Correction for multiple testing in a gene region
    Audrey E Hendricks
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Eur J Hum Genet 22:414-8. 2014
    ..We find Gao et al and extreme tail theory to be efficient alternatives to more computationally intensive approaches to control for multiple testing in gene regions. ..
  37. ncbi request reprint Expectation maximization algorithm based haplotype relative risk (EM-HRR): test of linkage disequilibrium using incomplete case-parents trios
    Chao Yu Guo
    Department of Mathematics and Statistics, Boston University, Boston, Mass 02215, USA
    Hum Hered 59:125-35. 2005
    ..We illustrate the proposed method with an application to the Framingham Heart Study...
  38. pmc Common variants at 30 loci contribute to polygenic dyslipidemia
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:56-65. 2009
    ..These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia...
  39. pmc Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG)
    Audrey E Hendricks
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Am J Med Genet A 149:1375-81. 2009
    ..These estimates may be useful in genetic counseling for male high normal allele carriers...
  40. doi request reprint Frailty models: Applications to biomedical and genetic studies
    Usha S Govindarajulu
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Stat Med 30:2754-64. 2011
    ..Examples of analyses using multivariate frailty models in a non-parametric hazards setting on biomedical datasets are provided, and the implications of choosing to use frailty and relevance to genetic applications are discussed...
  41. pmc Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
    Emelia J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:879-81. 2009
    ..19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15))...
  42. ncbi request reprint Demonstrating stratification in a European American population
    Catarina D Campbell
    Program in Genomics and Division of Endocrinology, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 37:868-72. 2005
    ..The failure of standard methods to detect this stratification indicates that new methods may be required...
  43. pmc Gene expression and genetic variation in human atria
    Honghuang Lin
    National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts Electronic address
    Heart Rhythm 11:266-71. 2014
    ..The human left and right atria have different susceptibilities to develop atrial fibrillation (AF). However, the molecular events related to structural and functional changes that enhance AF susceptibility are still poorly understood...
  44. ncbi request reprint A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation
    Vincenzo Macri
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts Harvard Medical School, Boston, Massachusetts
    Heart Rhythm 11:1055-62. 2014
    ..HCN4 encodes for the cardiac pacemaker channel, and HCN4 mutations are associated with familial sinus bradycardia and AF...
  45. doi request reprint Methods for meta-analysis of genetic data
    Kathryn L Lunetta
    Boston University School of Public Health, Boston, MA, USA
    Curr Protoc Hum Genet . 2013
    ..The commentary discusses the interpretation of GWAS meta-analysis results, complications, and some of the possible next steps once a GWAS meta-analysis has successfully identified regions associated with a trait...
  46. pmc A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation
    Andrea D Coviello
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002805. 2012
    ..The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance...
  47. pmc Functional polymorphisms in UDP-glucuronosyl transferases and recurrence in tamoxifen-treated breast cancer survivors
    Thomas P Ahern
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:1937-43. 2011
    ..We measured the association between functional polymorphisms in key UGTs (UGT2B15*2, UGT2B7*2, and UGT1A8*3) and the recurrence rate among breast cancer survivors...
  48. pmc Principal-component-based population structure adjustment in the North American Rheumatoid Arthritis Consortium data: impact of single-nucleotide polymorphism set and analysis method
    Gina M Peloso
    Department of Biostatistics, Boston University School of Public Heath, Crosstown Center, 801 Massachusetts Avenue, 3rd Floor, Boston, Massachusetts 02118 USA
    BMC Proc 3:S108. 2009
    ....
  49. pmc Testing for population subdivision and association in four case-control studies
    Kristin G Ardlie
    Genomics Collaborative, 99 Erie Street, Cambridge, MA, 02139, USA
    Am J Hum Genet 71:304-11. 2002
    ..We explore the role that extreme differences in power among studies, due to sample size and risk-allele frequency differences, may play in the replication problem...
  50. pmc The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, Department, University of Toronto, Toronto, Ontario, Canada
    Nat Genet 39:168-77. 2007
    ..These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease...
  51. ncbi request reprint Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 98:590-2. 2006
    ..44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63)...