Research Topics
Genomes and GenesSpecies | Jennifer LuebkeSummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Age-related increase of sI(AHP) in prefrontal pyramidal cells of monkeys: relationship to cognitionJ I Luebke
Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord St, Boston, MA 02118, USA
Neurobiol Aging 33:1085-95. 2012..Thus, in monkey dlPFC layer 3 cells, an increase in sI(AHP) is associated with age-related cognitive decline; however, this increase is not associated with a reduction in excitability...
Prenatal protein malnutrition results in increased frequency of miniature inhibitory synaptic currents in rat CA1 pyramidal cellsJ Luebke
Department of Psychiatry, Boston University School of Medicine, MA 02118, USA
Synapse 37:23-31. 2000..The increased frequency of mIPSCs together with the lack of a change in amplitude, kinetics, or modulation by benzodiazepines of mIPSCs in response to prenatal protein malnutrition indicate a presynaptic locus of effect of this insult...- Effects of normal aging on prefrontal area 46 in the rhesus monkeyJennifer Luebke
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
Brain Res Rev 62:212-32. 2010..These factors contribute to alterations in the intrinsic and network physiological properties of cortical neurons. As more details emerge, it is to be hoped that effective interventions to retard cognitive decline can be proposed... - Effects of aging on the electrophysiological properties of layer 5 pyramidal cells in the monkey prefrontal cortexJ I Luebke
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
Neuroscience 150:556-62. 2007..This study demonstrates that layer 5 pyramidal cells, unlike layer 2/3 pyramidal cells, undergo only modest electrophysiological changes with aging, and that these changes are unlikely to contribute to age-related cognitive decline... - Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse modelsJennifer I Luebke
M949, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA
Brain Struct Funct 214:181-99. 2010.... - Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortexJ I Luebke
Center for Behavioral Development, Department of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA
Neuroscience 125:277-88. 2004..The observed change in excitatory-inhibitory synaptic balance likely leads to significantly altered signaling properties of layer 2/3 pyramidal cells in the PFC with age... - Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkeyJennifer I Luebke
Center for Behavioral Development, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Comp Neurol 460:573-84. 2003..Nevertheless, these changes in dendritic morphology, input resistance, and inhibitory signaling properties may be part of a constellation of subtle functional changes contributing to age-associated cognitive impairment... - Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeysYu-Ming Chang
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
Cereb Cortex 15:409-18. 2005..These data indicate that an increase in AP firing rate may be responsible, in part, for age-related PFC dysfunction... - Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 miceAnne B Rocher
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
Neurobiol Dis 32:309-18. 2008..Thus, overexpression of mutated APP in young Tg2576 mice leads to significant changes in neuronal morphological properties which do not have readily apparent functional consequences... - GABAA receptor-mediated neurotransmission in the dentate gyrus of the rhesus monkey: comparison with the ratDouglas L Rosene
Center for Behavioral Development, Boston University School of Medicine, 85 E. Newton Street, Boston, MA 02118, USA
Synapse 49:287-9. 2003 - Electrophysiological diversity of layer 5 pyramidal cells in the prefrontal cortex of the rhesus monkey: in vitro slice studiesYu Ming Chang
Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA
J Neurophysiol 98:2622-32. 2007..The distinctive firing patterns of these diverse layer 5 pyramidal cells may reflect different roles played by these cells in the mediation of subcortical neuronal activity by the dorsolateral PFC... - Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortexTara L Moore
Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA
Behav Brain Res 160:208-21. 2005..Further analysis revealed a significant relationship between monoamine receptor binding and cognitive performance on three tasks: delayed non-matching to sample, delayed recognition span test and the conceptual set-shifting task... - Prenatal protein malnutrition results in increased frequency of miniature inhibitory postsynaptic currents in rat CA3 interneuronsYu-Ming Chang
Center for Behavioral Development and Mental Retardation, M923, Boston University School of Medicine, 85 E. Newton Street, Boston, MA 02118, USA
Nutr Neurosci 6:263-7. 2003..Thus, while the basic membrane properties of interneurons are preserved, there is a significant increase in the probability of GABA release from interneurons following prenatal protein malnutrition... 
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicityEmiliano Biasini
Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 33:2408-18. 2013..A similar mechanism may operate in other neurodegenerative disorders attributable to toxic, β-rich oligomers that bind to PrP(C)...- Changes in the structural complexity of the aged brainDara L Dickstein
Department of Neuroscience, Mount Sinai School of Medicine, New York 10029, USA
Aging Cell 6:275-84. 2007..Together these multiple alterations in the brain may constitute the substrate for age-related loss of cognitive function...
Research Grants
- AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLSJennifer Luebke; Fiscal Year: 2009..Such information is vital to the development of a detailed understanding of the cellular mechanisms of cognitive decline, and a prerequisite for the future development of therapeutic interventions. ..