Jennifer Luebke

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Age-related increase of sI(AHP) in prefrontal pyramidal cells of monkeys: relationship to cognition
    J I Luebke
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord St, Boston, MA 02118, USA
    Neurobiol Aging 33:1085-95. 2012
  2. ncbi request reprint Prenatal protein malnutrition results in increased frequency of miniature inhibitory synaptic currents in rat CA1 pyramidal cells
    J Luebke
    Department of Psychiatry, Boston University School of Medicine, MA 02118, USA
    Synapse 37:23-31. 2000
  3. pmc Effects of normal aging on prefrontal area 46 in the rhesus monkey
    Jennifer Luebke
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    Brain Res Rev 62:212-32. 2010
  4. pmc Effects of aging on the electrophysiological properties of layer 5 pyramidal cells in the monkey prefrontal cortex
    J I Luebke
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neuroscience 150:556-62. 2007
  5. pmc Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models
    Jennifer I Luebke
    M949, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA
    Brain Struct Funct 214:181-99. 2010
  6. ncbi request reprint Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex
    J I Luebke
    Center for Behavioral Development, Department of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA
    Neuroscience 125:277-88. 2004
  7. ncbi request reprint Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey
    Jennifer I Luebke
    Center for Behavioral Development, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 460:573-84. 2003
  8. ncbi request reprint Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys
    Yu Ming Chang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Cereb Cortex 15:409-18. 2005
  9. pmc Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice
    Anne B Rocher
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Dis 32:309-18. 2008
  10. ncbi request reprint GABAA receptor-mediated neurotransmission in the dentate gyrus of the rhesus monkey: comparison with the rat
    Susan O'Brien
    Center for Behavioral Development, Boston University School of Medicine, 85 E Newton Street, Boston, MA 02118, USA
    Synapse 49:287-9. 2003

Research Grants

Detail Information

Publications15

  1. pmc Age-related increase of sI(AHP) in prefrontal pyramidal cells of monkeys: relationship to cognition
    J I Luebke
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord St, Boston, MA 02118, USA
    Neurobiol Aging 33:1085-95. 2012
    ..Thus, in monkey dlPFC layer 3 cells, an increase in sI(AHP) is associated with age-related cognitive decline; however, this increase is not associated with a reduction in excitability...
  2. ncbi request reprint Prenatal protein malnutrition results in increased frequency of miniature inhibitory synaptic currents in rat CA1 pyramidal cells
    J Luebke
    Department of Psychiatry, Boston University School of Medicine, MA 02118, USA
    Synapse 37:23-31. 2000
    ..The increased frequency of mIPSCs together with the lack of a change in amplitude, kinetics, or modulation by benzodiazepines of mIPSCs in response to prenatal protein malnutrition indicate a presynaptic locus of effect of this insult...
  3. pmc Effects of normal aging on prefrontal area 46 in the rhesus monkey
    Jennifer Luebke
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
    Brain Res Rev 62:212-32. 2010
    ..These factors contribute to alterations in the intrinsic and network physiological properties of cortical neurons. As more details emerge, it is to be hoped that effective interventions to retard cognitive decline can be proposed...
  4. pmc Effects of aging on the electrophysiological properties of layer 5 pyramidal cells in the monkey prefrontal cortex
    J I Luebke
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neuroscience 150:556-62. 2007
    ..This study demonstrates that layer 5 pyramidal cells, unlike layer 2/3 pyramidal cells, undergo only modest electrophysiological changes with aging, and that these changes are unlikely to contribute to age-related cognitive decline...
  5. pmc Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models
    Jennifer I Luebke
    M949, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA
    Brain Struct Funct 214:181-99. 2010
    ....
  6. ncbi request reprint Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex
    J I Luebke
    Center for Behavioral Development, Department of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA
    Neuroscience 125:277-88. 2004
    ..The observed change in excitatory-inhibitory synaptic balance likely leads to significantly altered signaling properties of layer 2/3 pyramidal cells in the PFC with age...
  7. ncbi request reprint Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey
    Jennifer I Luebke
    Center for Behavioral Development, Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 460:573-84. 2003
    ..Nevertheless, these changes in dendritic morphology, input resistance, and inhibitory signaling properties may be part of a constellation of subtle functional changes contributing to age-associated cognitive impairment...
  8. ncbi request reprint Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys
    Yu Ming Chang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Cereb Cortex 15:409-18. 2005
    ..These data indicate that an increase in AP firing rate may be responsible, in part, for age-related PFC dysfunction...
  9. pmc Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice
    Anne B Rocher
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurobiol Dis 32:309-18. 2008
    ..Thus, overexpression of mutated APP in young Tg2576 mice leads to significant changes in neuronal morphological properties which do not have readily apparent functional consequences...
  10. ncbi request reprint GABAA receptor-mediated neurotransmission in the dentate gyrus of the rhesus monkey: comparison with the rat
    Susan O'Brien
    Center for Behavioral Development, Boston University School of Medicine, 85 E Newton Street, Boston, MA 02118, USA
    Synapse 49:287-9. 2003
  11. pmc Electrophysiological diversity of layer 5 pyramidal cells in the prefrontal cortex of the rhesus monkey: in vitro slice studies
    Yu Ming Chang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA
    J Neurophysiol 98:2622-32. 2007
    ..The distinctive firing patterns of these diverse layer 5 pyramidal cells may reflect different roles played by these cells in the mediation of subcortical neuronal activity by the dorsolateral PFC...
  12. ncbi request reprint Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex
    Tara L Moore
    Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA
    Behav Brain Res 160:208-21. 2005
    ..Further analysis revealed a significant relationship between monoamine receptor binding and cognitive performance on three tasks: delayed non-matching to sample, delayed recognition span test and the conceptual set-shifting task...
  13. ncbi request reprint Prenatal protein malnutrition results in increased frequency of miniature inhibitory postsynaptic currents in rat CA3 interneurons
    Yu Ming Chang
    Center for Behavioral Development and Mental Retardation, M923, Boston University School of Medicine, 85 E Newton Street, Boston, MA 02118, USA
    Nutr Neurosci 6:263-7. 2003
    ..Thus, while the basic membrane properties of interneurons are preserved, there is a significant increase in the probability of GABA release from interneurons following prenatal protein malnutrition...
  14. pmc A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
    Emiliano Biasini
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 33:2408-18. 2013
    ..A similar mechanism may operate in other neurodegenerative disorders attributable to toxic, β-rich oligomers that bind to PrP(C)...
  15. pmc Changes in the structural complexity of the aged brain
    Dara L Dickstein
    Department of Neuroscience, Mount Sinai School of Medicine, New York 10029, USA
    Aging Cell 6:275-84. 2007
    ..Together these multiple alterations in the brain may constitute the substrate for age-related loss of cognitive function...

Research Grants5

  1. AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS
    Jennifer Luebke; Fiscal Year: 2005
    ..Such information is vital to the development of a detailed understanding of the cellular mechanisms of cognitive decline, and a prerequisite for the future development of therapeutic interventions. ..
  2. AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS
    Jennifer Luebke; Fiscal Year: 2006
    ..Such information is vital to the development of a detailed understanding of the cellular mechanisms of cognitive decline, and a prerequisite for the future development of therapeutic interventions. ..
  3. AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS
    Jennifer Luebke; Fiscal Year: 2007
    ..Such information is vital to the development of a detailed understanding of the cellular mechanisms of cognitive decline, and a prerequisite for the future development of therapeutic interventions. ..
  4. AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS
    Jennifer Luebke; Fiscal Year: 2009
    ..Such information is vital to the development of a detailed understanding of the cellular mechanisms of cognitive decline, and a prerequisite for the future development of therapeutic interventions. ..