Affiliation: Boston University
- Pathway analysis following association studyJulius S Ngwa
Department of Biostatistics, School of Public Health, Boston University, 715 Albany Street, Boston, MA 02118, USA
BMC Proc 5:S18. 2011..The empirical enrichment method had lower power and higher type I error. Thus pathway analysis approaches may be useful in identifying biological pathways that influence disease outcomes...
- Network-guided sparse regression modeling for detection of gene-by-gene interactionsChen Lu
Department of Biostatistics, Boston University School of Public Health, Pulmonary Center, Department of Medicine and Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Bioinformatics 29:1241-9. 2013..We propose a novel approach to detect such interactions that uses penalized regression and sparse estimation principles, and incorporates outside biological knowledge through a network-based penalty...