S M Levitz

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation
    S M Levitz
    The Evans Memorial Department of Clinical Research and the Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Clin Invest 100:1640-6. 1997
  2. pmc gamma Interferon gene expression and release in human lymphocytes directly activated by Cryptococcus neoformans and Candida albicans
    S M Levitz
    Evans Memorial Department of Clinical Research, Boston, Massachusetts, USA
    Infect Immun 64:1595-9. 1996
  3. pmc Variables affecting production of monocyte chemotactic factor 1 from human leukocytes stimulated with Cryptococcus neoformans
    S M Levitz
    Evans Memorial Department of Clinical Research, Boston Medical Center, Massachusetts 02118, USA
    Infect Immun 65:903-8. 1997
  4. pmc Binding of Cryptococcus neoformans to heterologously expressed human complement receptors
    S M Levitz
    Evans Memorial Department of Clinical Research, Boston Medical Center, Massachusetts 02118, USA
    Infect Immun 65:931-5. 1997
  5. ncbi Lymphoproliferation and cytokine profiles in human peripheral blood mononuclear cells stimulated by Cryptococcus neoformans
    S M Levitz
    Evans Memorial Department of Clinical Research, Boston Medical Center, Massachusetts 02118, USA
    J Med Vet Mycol 35:229-36. 1997
  6. ncbi Chloroquine antagonizes the proinflammatory cytokine response to opportunistic fungi by alkalizing the fungal phagolysosome
    S M Weber
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA
    J Infect Dis 183:935-42. 2001
  7. pmc Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages
    S M Levitz
    Evans Memorial Department of Clinical Research and Department of Medicine, Boston University Medical Center, Boston, Massachusetts
    Infect Immun 67:885-90. 1999
  8. ncbi Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule
    S Shoham
    The Evans Memorial Department of Clinical Research and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 166:4620-6. 2001
  9. pmc Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans
    S M Levitz
    Evans Memorial Department of Clinical Research and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 98:10422-7. 2001
  10. ncbi Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans
    F G Oppenheim
    Department of Oral Biology, Goldman School of Graduate Dentistry, Boston, Massachusetts
    J Biol Chem 263:7472-7. 1988

Collaborators

Detail Information

Publications10

  1. pmc Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation
    S M Levitz
    The Evans Memorial Department of Clinical Research and the Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Clin Invest 100:1640-6. 1997
    ..neoformans by iron-independent, pH-dependent mechanisms and is therapeutic in murine models of cryptococcosis. Chloroquine might have clinical utility for the prophylaxis and treatment of human cryptococcosis...
  2. pmc gamma Interferon gene expression and release in human lymphocytes directly activated by Cryptococcus neoformans and Candida albicans
    S M Levitz
    Evans Memorial Department of Clinical Research, Boston, Massachusetts, USA
    Infect Immun 64:1595-9. 1996
    ..Moreover, to our knowledge, this is the first demonstration of direct stimulation of T-cell cytokine release by microbial pathogens...
  3. pmc Variables affecting production of monocyte chemotactic factor 1 from human leukocytes stimulated with Cryptococcus neoformans
    S M Levitz
    Evans Memorial Department of Clinical Research, Boston Medical Center, Massachusetts 02118, USA
    Infect Immun 65:903-8. 1997
    ..The failure of C. neoformans to stimulate MCP-1 in BAM, if occurring in vivo, could result in a diminished cell-mediated inflammatory response following inhalation of airborne fungi...
  4. pmc Binding of Cryptococcus neoformans to heterologously expressed human complement receptors
    S M Levitz
    Evans Memorial Department of Clinical Research, Boston Medical Center, Massachusetts 02118, USA
    Infect Immun 65:931-5. 1997
    ..neoformans opsonized with fragments of C3. Moreover, our study demonstrates the usefulness of transfected cell lines as a powerful tool for identifying the contribution of individual receptors to the binding of a microbial pathogen...
  5. ncbi Lymphoproliferation and cytokine profiles in human peripheral blood mononuclear cells stimulated by Cryptococcus neoformans
    S M Levitz
    Evans Memorial Department of Clinical Research, Boston Medical Center, Massachusetts 02118, USA
    J Med Vet Mycol 35:229-36. 1997
    ..Moreover, the capacity of patient PBMC to respond to soluble mannoprotein lends support to studies of mannoprotein components as vaccine candidates...
  6. ncbi Chloroquine antagonizes the proinflammatory cytokine response to opportunistic fungi by alkalizing the fungal phagolysosome
    S M Weber
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA
    J Infect Dis 183:935-42. 2001
    ..This contrasts with CQ's reported pH-independent inhibition of LPS-stimulated TNF-alpha release and suggests that the mechanism of CQ's anti-inflammatory effects is stimulus specific...
  7. pmc Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages
    S M Levitz
    Evans Memorial Department of Clinical Research and Department of Medicine, Boston University Medical Center, Boston, Massachusetts
    Infect Immun 67:885-90. 1999
    ..Thus, unlike many other intracellular pathogens, C. neoformans does not avoid fusion with macrophage lysosomal compartments but rather resides and survives in an acidic phagolysosome...
  8. ncbi Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule
    S Shoham
    The Evans Memorial Department of Clinical Research and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 166:4620-6. 2001
    ..Taken together, these observations suggest a novel scenario whereby GXM stimulates cells via CD14 and TLR4, resulting in an incomplete activation of pathways necessary for TNF-alpha production...
  9. pmc Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans
    S M Levitz
    Evans Memorial Department of Clinical Research and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 98:10422-7. 2001
    ..Thus, a C. neoformans mannoprotein has been characterized that stimulates T cell responses and has molecular properties of a chitin deacetylase...
  10. ncbi Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans
    F G Oppenheim
    Department of Oral Biology, Goldman School of Graduate Dentistry, Boston, Massachusetts
    J Biol Chem 263:7472-7. 1988
    ..All three histatins exhibit the ability to kill the pathogenic yeast, Candida albicans...