WILLIAM J LEHMAN

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Structure and dynamics of the actin-based smooth muscle contractile and cytoskeletal apparatus
    William Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    J Muscle Res Cell Motil 33:461-9. 2012
  2. pmc Structural basis for the activation of muscle contraction by troponin and tropomyosin
    William Lehman
    Department of Physiology and Biophysics, Boston University, School of Medicine, Boston, MA 02118, USA
    J Mol Biol 388:673-81. 2009
  3. ncbi request reprint Tropomyosin and the steric mechanism of muscle regulation
    William Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Adv Exp Med Biol 644:95-109. 2008
  4. ncbi request reprint The structure of the vertebrate striated muscle thin filament: a tribute to the contributions of Jean Hanson
    William Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Muscle Res Cell Motil 25:455-66. 2004
  5. ncbi request reprint Troponin organization on relaxed and activated thin filaments revealed by electron microscopy and three-dimensional reconstruction
    W Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Mol Biol 307:739-44. 2001
  6. ncbi request reprint An open or closed case for the conformation of calponin homology domains on F-actin?
    William Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Muscle Res Cell Motil 25:351-8. 2004
  7. pmc The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments
    Agnieszka Galinska
    Department of Physiology and Biophysics, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA
    Circ Res 106:705-11. 2010
  8. ncbi request reprint Single particle analysis of relaxed and activated muscle thin filaments
    Alnoor Pirani
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Mol Biol 346:761-72. 2005
  9. ncbi request reprint An atomic model of the thin filament in the relaxed and Ca2+-activated states
    Alnoor Pirani
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    J Mol Biol 357:707-17. 2006
  10. pmc Structural basis for the regulation of muscle contraction by troponin and tropomyosin
    Agnieszka Galinska-Rakoczy
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Mol Biol 379:929-35. 2008

Research Grants

  1. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2007
  2. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2006
  3. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2003
  4. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2002

Collaborators

Detail Information

Publications18

  1. pmc Structure and dynamics of the actin-based smooth muscle contractile and cytoskeletal apparatus
    William Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    J Muscle Res Cell Motil 33:461-9. 2012
    ..As a way of honoring the memory of these two pioneer members of the muscle research community, we review data on distribution and remodeling of thin filaments in smooth muscle cells, one of the many research topics that intrigued them...
  2. pmc Structural basis for the activation of muscle contraction by troponin and tropomyosin
    William Lehman
    Department of Physiology and Biophysics, Boston University, School of Medicine, Boston, MA 02118, USA
    J Mol Biol 388:673-81. 2009
    ....
  3. ncbi request reprint Tropomyosin and the steric mechanism of muscle regulation
    William Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Adv Exp Med Biol 644:95-109. 2008
    ..This process either blocks or uncovers myosin crossbridge binding sites on actin and consequently regulates crossbridge cycling on thin filaments, the sliding of thin and thick filaments and muscle shortening and force production...
  4. ncbi request reprint The structure of the vertebrate striated muscle thin filament: a tribute to the contributions of Jean Hanson
    William Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Muscle Res Cell Motil 25:455-66. 2004
    ..We focus, in particular, on the crucial role played by Jean Hanson in these studies and on later contributions from those whose work she influenced...
  5. ncbi request reprint Troponin organization on relaxed and activated thin filaments revealed by electron microscopy and three-dimensional reconstruction
    W Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Mol Biol 307:739-44. 2001
    ..In addition, we find that on Ca(2+) activation the actin-troponin connection is broken, allowing tropomyosin to assume a second position, initiating actomyosin ATPase and thus permitting contraction to proceed...
  6. ncbi request reprint An open or closed case for the conformation of calponin homology domains on F-actin?
    William Lehman
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Muscle Res Cell Motil 25:351-8. 2004
    ..In the case of the actin-binding protein utrophin, for example, several models have been proposed for the binding of utrophin's calponin homology domains to actin. We review and evaluate these models and their supporting data...
  7. pmc The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments
    Agnieszka Galinska
    Department of Physiology and Biophysics, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA
    Circ Res 106:705-11. 2010
    ..Mutations within this region are associated with restrictive cardiomyopathy, and C-terminal deletion of cTnI, in some species, has been associated with myocardial stunning...
  8. ncbi request reprint Single particle analysis of relaxed and activated muscle thin filaments
    Alnoor Pirani
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Mol Biol 346:761-72. 2005
    ..This flexibility in the localization of tropomyosin may provide a means of sterically regulating contraction at low energy cost...
  9. ncbi request reprint An atomic model of the thin filament in the relaxed and Ca2+-activated states
    Alnoor Pirani
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    J Mol Biol 357:707-17. 2006
    ..Our observations suggest a simple model for muscle regulation in which troponin affects the charge balance on actin and hence tropomyosin position...
  10. pmc Structural basis for the regulation of muscle contraction by troponin and tropomyosin
    Agnieszka Galinska-Rakoczy
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Mol Biol 379:929-35. 2008
    ..Thus, the observations reported reveal the structural mechanism responsible for troponin-tropomyosin-mediated steric interference of actin-myosin interaction that regulates muscle contraction...
  11. pmc Electron microscopy and three-dimensional reconstruction of native thin filaments reveal species-specific differences in regulatory strand densities
    Anthony Cammarato
    Department of Physiology and Biophysics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Biochem Biophys Res Commun 391:193-7. 2010
    ..Such an arrangement potentially alters the physical properties of the regulatory strands and may help establish contractile characteristics unique to certain arthropod muscles...
  12. pmc The relationship between curvature, flexibility and persistence length in the tropomyosin coiled-coil
    Xiaochuan Edward Li
    Department of Physiology and Biophysics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    J Struct Biol 170:313-8. 2010
    ..The measured bending and twisting flexibilities are used to evaluate different models of tropomyosin motion on F-actin...
  13. ncbi request reprint E93K charge reversal on actin perturbs steric regulation of thin filaments
    Anthony Cammarato
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Mol Biol 347:889-94. 2005
    ..These results highlight the importance of actin's surface charges in determining the distribution of tropomyosin positions on thin filaments derived from troponin-regulated striated muscles...
  14. pmc Curvature variation along the tropomyosin molecule
    Xiaochuan Edward Li
    Department of Physiology and Biophysics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA Computational Biochemistry Group, University of Heidelberg, Im Neuenheimer Feld 368, Heidelberg D 69120, Germany
    J Struct Biol 170:307-12. 2010
    ..Rather than just causing specific local structural effects, the overall influence of alanine clusters is complex and delocalized, leading to a gradually changing bending pattern along the length of tropomyosin...
  15. ncbi request reprint Cortactin binding to F-actin revealed by electron microscopy and 3D reconstruction
    Kiran Pant
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Mol Biol 359:840-7. 2006
    ..In addition, cortactin may act as a structural adapter protein, stabilizing nascent filament branches while mediating the simultaneous recruitment of Arp2/3 and WASP...
  16. doi request reprint The shape and flexibility of tropomyosin coiled coils: implications for actin filament assembly and regulation
    Xiaochuan Edward Li
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA
    J Mol Biol 395:327-39. 2010
    ..Further, we propose that once bound to thin filaments, tropomyosin will be stiff enough to act as a cooperative unit and move on actin in a concerted way between known regulatory states...
  17. pmc Drosophila muscle regulation characterized by electron microscopy and three-dimensional reconstruction of thin filament mutants
    Anthony Cammarato
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Biophys J 86:1618-24. 2004
    ..The interaction of mutant troponin I with Drosophila troponin C is discussed, along with functional differences between troponin C from Drosophila and vertebrates...
  18. pmc Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands
    Duncan Sousa
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, USA
    Biophys J 99:862-8. 2010
    ....

Research Grants18

  1. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2007
    ..g., hypertension and asthma. The wider significance of our goals is underscored by the role of actin and associated proteins indiverse and vital cellular mechanisms that can become aberrant in malignancy. ..
  2. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2006
    ..g., hypertension and asthma. The wider significance of our goals is underscored by the role of actin and associated proteins in diverse and vital cellular mechanisms that can become aberrant in malignancy. ..
  3. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2003
    ..g., hypertension and asthma. The wider significance of our goals is underscored by the role of actin and associated proteins in diverse and vital cellular mechanisms that can become aberrant in malignancy. ..
  4. THIN FILAMENTS AND MUSCLE REGULATION
    William Lehman; Fiscal Year: 2002
    ..e. processes that are essential to all normal cells and that can become aberrant in malignancy. ..