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Genomes and GenesSpecies | Jeanne C LatourelleSummaryAffiliation: Boston University Country: USA Publications
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Publications
The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD studyJeanne C Latourelle
Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
BMC Med 6:32. 2008..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...- Evaluation of Parkinson disease risk variants as expression-QTLsJeanne C Latourelle
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
PLoS ONE 7:e46199. 2012..These findings provide additional context for the interpretation of PD associated SNPs identified in recent GWAS as well as potential insight into the mechanisms underlying the observed SNP associations... - Genomewide linkage study of modifiers of LRRK2-related Parkinson's diseaseJeanne C Latourelle
Boston University School of Medicine, Boston, Massachusetts, USA
Mov Disord 26:2039-44. 2011.... - Risk of Parkinson's disease after tamoxifen treatmentJeanne C Latourelle
Department of Neurology, Boston University School of Medicine, 85 East Concord Street, Boston, MA 02118, USA
BMC Neurol 10:23. 2010..We compared the rate of PD in Danish breast cancer patients treated with tamoxifen to the rate among those not treated with tamoxifen... - Genomewide association study for onset age in Parkinson diseaseJeanne C Latourelle
Boston University School of Medicine, Boston, MA, USA
BMC Med Genet 10:98. 2009..There have been previous genomewide association studies (GWAS) to identify genes influencing PD susceptibility, but this is the first to identify genes contributing to the variation in onset age... - Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD studyChristopher F McNicoll
Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
Mov Disord 23:1596-601. 2008..No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD... 
Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart StudyJason M Laramie
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Obesity (Silver Spring) 17:2182-9. 2009..002, and 0.03, respectively) and the case-control sample (P = 0.01, 0.0003, and 0.03, respectively), regardless of the genetic model tested. These findings suggest that several genes may be associated with BMI in the 7q31-34 region...- Assessment of cortical and striatal involvement in 523 Huntington disease brainsTiffany C Hadzi
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
Neurology 79:1708-15. 2012..To evaluate the relationship of striatal involvement in Huntington disease (HD) to involvement in other brain regions, CAG repeat size, onset age, and other factors... - Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulationAlexandra Dumitriu
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
PLoS Genet 8:e1002794. 2012..These results implicate FOXO1 as a PD-relevant gene and warrant further functional analyses of its transcriptional regulatory mechanisms... - Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease BrainAlexandra Dumitriu
Department of Neurology, Boston University School of Medicine, Boston, MA 02119, USA
Parkinsons Dis 2012:614212. 2012..For short PMI, SNCA expression was increased in PD relative to control samples, whereas for long PMI, SNCA expression in PD was decreased relative to control samples... - Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD StudyAlexandra Dumitriu
Department of Neurology, Boston University School of Medicine, 72 East Concord Street, E 304, Boston, MA 02118, USA
Hum Mol Genet 20:1478-87. 2011..This, combined with GAK's observed relationship to the levels of α-synuclein expression and toxicity, suggests that the protein is an attractive therapeutic target for the treatment of PD... - Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onsetEliana Marisa Ramos
Center for Human Genetic Research, Massachusetts General Hospital, Simches Research Building, Room 5414, 185 Cambridge Street, Boston, MA 02114, USA
Hum Genet 131:1833-40. 2012..A significantly older AO in Southern Europe may reflect population differences in genetic or environmental factors that warrant further investigation... - Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart StudyJason M Laramie
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
BMC Med Genet 9:46. 2008..As part of a fine mapping study of the region, we evaluated the relationship of polymorphisms to fasting glucose levels and Type 2 diabetes... - Sepiapterin reductase expression is increased in Parkinson's disease brain tissueJennifer E Tobin
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
Brain Res 1139:42-7. 2007..While the association of SPR to PD is not strong enough to support that this is the PARK3 gene, this study further implicates a role for SPR in idiopathic PD... - Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG)Audrey E Hendricks
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
Am J Med Genet A 149:1375-81. 2009..These estimates may be useful in genetic counseling for male high normal allele carriers... - Estrogen-related and other disease diagnoses preceding Parkinson's diseaseJeanne C Latourelle
Department of Neurology, Boston University School of Medicine, Boston MA, USA
Clin Epidemiol 2:153-70. 2010..Indeed, the association between diseases need not be due only to estrogen-related factors, but due to similar disease processes from a variety of mechanisms... - Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstructionJemma B Wilk
Division of Aging, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
Am J Respir Crit Care Med 186:622-32. 2012..Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known...