Jeanne C Latourelle

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
  2. pmc Evaluation of Parkinson disease risk variants as expression-QTLs
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e46199. 2012
  3. pmc Genomewide linkage study of modifiers of LRRK2-related Parkinson's disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, Massachusetts, USA
    Mov Disord 26:2039-44. 2011
  4. pmc Risk of Parkinson's disease after tamoxifen treatment
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, 85 East Concord Street, Boston, MA 02118, USA
    BMC Neurol 10:23. 2010
  5. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
  6. pmc Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study
    Christopher F McNicoll
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    Mov Disord 23:1596-601. 2008
  7. doi request reprint Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:2182-9. 2009
  8. pmc Assessment of cortical and striatal involvement in 523 Huntington disease brains
    Tiffany C Hadzi
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Neurology 79:1708-15. 2012
  9. pmc Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002794. 2012
  10. pmc Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset
    Eliana Marisa Ramos
    Center for Human Genetic Research, Massachusetts General Hospital, Simches Research Building, Room 5414, 185 Cambridge Street, Boston, MA, 02114, USA
    Neurogenetics 14:173-9. 2013

Detail Information

Publications20

  1. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  2. pmc Evaluation of Parkinson disease risk variants as expression-QTLs
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e46199. 2012
    ..These findings provide additional context for the interpretation of PD associated SNPs identified in recent GWAS as well as potential insight into the mechanisms underlying the observed SNP associations...
  3. pmc Genomewide linkage study of modifiers of LRRK2-related Parkinson's disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, Massachusetts, USA
    Mov Disord 26:2039-44. 2011
    ....
  4. pmc Risk of Parkinson's disease after tamoxifen treatment
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, 85 East Concord Street, Boston, MA 02118, USA
    BMC Neurol 10:23. 2010
    ..We compared the rate of PD in Danish breast cancer patients treated with tamoxifen to the rate among those not treated with tamoxifen...
  5. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
    ..There have been previous genomewide association studies (GWAS) to identify genes influencing PD susceptibility, but this is the first to identify genes contributing to the variation in onset age...
  6. pmc Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study
    Christopher F McNicoll
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    Mov Disord 23:1596-601. 2008
    ..No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD...
  7. doi request reprint Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:2182-9. 2009
    ..002, and 0.03, respectively) and the case-control sample (P = 0.01, 0.0003, and 0.03, respectively), regardless of the genetic model tested. These findings suggest that several genes may be associated with BMI in the 7q31-34 region...
  8. pmc Assessment of cortical and striatal involvement in 523 Huntington disease brains
    Tiffany C Hadzi
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Neurology 79:1708-15. 2012
    ..To evaluate the relationship of striatal involvement in Huntington disease (HD) to involvement in other brain regions, CAG repeat size, onset age, and other factors...
  9. pmc Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002794. 2012
    ..These results implicate FOXO1 as a PD-relevant gene and warrant further functional analyses of its transcriptional regulatory mechanisms...
  10. pmc Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset
    Eliana Marisa Ramos
    Center for Human Genetic Research, Massachusetts General Hospital, Simches Research Building, Room 5414, 185 Cambridge Street, Boston, MA, 02114, USA
    Neurogenetics 14:173-9. 2013
    ..The results of this candidate-genetic study therefore do not provide strong evidence to support a modulatory role for these variations within glutamatergic and dopaminergic genes in the AO of HD motor manifestations. ..
  11. pmc Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, Boston, MA 02119, USA
    Parkinsons Dis 2012:614212. 2012
    ..For short PMI, SNCA expression was increased in PD relative to control samples, whereas for long PMI, SNCA expression in PD was decreased relative to control samples...
  12. pmc Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study
    Alexandra Dumitriu
    Department of Neurology, Boston University School of Medicine, 72 East Concord Street, E 304, Boston, MA 02118, USA
    Hum Mol Genet 20:1478-87. 2011
    ..This, combined with GAK's observed relationship to the levels of α-synuclein expression and toxicity, suggests that the protein is an attractive therapeutic target for the treatment of PD...
  13. pmc Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset
    Eliana Marisa Ramos
    Center for Human Genetic Research, Massachusetts General Hospital, Simches Research Building, Room 5414, 185 Cambridge Street, Boston, MA 02114, USA
    Hum Genet 131:1833-40. 2012
    ..A significantly older AO in Southern Europe may reflect population differences in genetic or environmental factors that warrant further investigation...
  14. pmc Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 9:46. 2008
    ..As part of a fine mapping study of the region, we evaluated the relationship of polymorphisms to fasting glucose levels and Type 2 diabetes...
  15. pmc Sepiapterin reductase expression is increased in Parkinson's disease brain tissue
    Jennifer E Tobin
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Brain Res 1139:42-7. 2007
    ..While the association of SPR to PD is not strong enough to support that this is the PARK3 gene, this study further implicates a role for SPR in idiopathic PD...
  16. pmc Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG)
    Audrey E Hendricks
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Am J Med Genet A 149:1375-81. 2009
    ..These estimates may be useful in genetic counseling for male high normal allele carriers...
  17. doi request reprint MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis
    Andrew G Hoss
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America Graduate Program in Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 10:e1004188. 2014
    ..Recently, miRNAs have shown promise as biomarkers for human diseases and given their relationship to disease expression, these miRNAs are biomarker candidates in HD. ..
  18. pmc Estrogen-related and other disease diagnoses preceding Parkinson's disease
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston MA, USA
    Clin Epidemiol 2:153-70. 2010
    ..Indeed, the association between diseases need not be due only to estrogen-related factors, but due to similar disease processes from a variety of mechanisms...
  19. pmc MUC5B promoter polymorphism and interstitial lung abnormalities
    Gary M Hunninghake
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    N Engl J Med 368:2192-200. 2013
    ..It is not known whether this polymorphism is associated with interstitial lung disease in the general population...
  20. pmc Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction
    Jemma B Wilk
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Am J Respir Crit Care Med 186:622-32. 2012
    ..Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known...