Jason M Laramie

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome
    William G Dilley
    Department of Surgery, Washington University School of Medicine, St, Louis, MO, USA
    Mol Cancer 4:9. 2005
  2. ncbi request reprint Transcriptional profiles of human epithelial cells in response to heat: computational evidence for novel heat shock proteins
    Jason M Laramie
    Program in Bioinformatics, Boston University, Boston, MA 02118, USA
    Shock 29:623-30. 2008
  3. pmc HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Bioinformatics 23:2190-2. 2007
  4. pmc Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:17. 2006
  5. doi request reprint Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:2182-9. 2009
  6. pmc Framingham Heart Study genome-wide association: results for pulmonary function measures
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 8:S8. 2007
  7. pmc Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 9:46. 2008
  8. pmc Sepiapterin reductase expression is increased in Parkinson's disease brain tissue
    Jennifer E Tobin
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Brain Res 1139:42-7. 2007
  9. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  10. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008

Detail Information

Publications15

  1. pmc Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome
    William G Dilley
    Department of Surgery, Washington University School of Medicine, St, Louis, MO, USA
    Mol Cancer 4:9. 2005
    ..In vitro studies have shown menin binding to JunD, Pem, Smad3, NF-kappaB, nm23H1, and RPA2 proteins. However, none of these binding studies have led to a convincing theory of how loss-of-menin leads to neoplasia...
  2. ncbi request reprint Transcriptional profiles of human epithelial cells in response to heat: computational evidence for novel heat shock proteins
    Jason M Laramie
    Program in Bioinformatics, Boston University, Boston, MA 02118, USA
    Shock 29:623-30. 2008
    ..Additional experiments are required to validate these putative heat shock proteins and facilitate a deeper understanding of the mechanisms involved during the stress response...
  3. pmc HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Bioinformatics 23:2190-2. 2007
    ..This strategy permits HaploBuild to construct more biologically relevant haplotypes that are not constrained by arbitrary length and contiguous orientation. Availability: http://snp.bumc.bu.edu...
  4. pmc Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:17. 2006
    ..Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic linkage scans to identify quantitative trait loci...
  5. doi request reprint Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:2182-9. 2009
    ..002, and 0.03, respectively) and the case-control sample (P = 0.01, 0.0003, and 0.03, respectively), regardless of the genetic model tested. These findings suggest that several genes may be associated with BMI in the 7q31-34 region...
  6. pmc Framingham Heart Study genome-wide association: results for pulmonary function measures
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 8:S8. 2007
    ..We conducted genome-wide association (GWA) analyses (Affymetrix 100K SNP GeneChip) for measures of lung function in the Framingham Heart Study...
  7. pmc Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 9:46. 2008
    ..As part of a fine mapping study of the region, we evaluated the relationship of polymorphisms to fasting glucose levels and Type 2 diabetes...
  8. pmc Sepiapterin reductase expression is increased in Parkinson's disease brain tissue
    Jennifer E Tobin
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Brain Res 1139:42-7. 2007
    ..While the association of SPR to PD is not strong enough to support that this is the PARK3 gene, this study further implicates a role for SPR in idiopathic PD...
  9. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  10. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  11. ncbi request reprint Physiologic genomics
    Jonathan E McDunn
    Departments of Surgery, Genetics and Medicine, The Siteman Cancer Center, and Proteomics Center, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Surgery 139:133-9. 2006
  12. ncbi request reprint Sequence makes a difference: paradoxical effects of stress in vivo
    Joseph J Wizorek
    Cellular Injury and Adaptation Laboratory, Department of Surgery, Washington University, St Louis, Missouri 63130, USA
    Shock 22:229-33. 2004
    ..The cellular mechanisms responsible for these "stressor" paradoxes in vivo are not known, but do not involve altered sepsis-induced apoptosis...
  13. ncbi request reprint Gene expression profiles of livers from thermally injured rats
    Mohan R K Dasu
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Gene 327:51-60. 2004
    ..The genome wide changes observed may provide a rational therapeutic strategy to improve burn care...
  14. ncbi request reprint Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays
    J Perren Cobb
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 30:2711-21. 2002
    ....
  15. ncbi request reprint Functional genomics of critical illness and injury
    T Philip Chung
    Department of Surgery, Cellular Injury and Adaptation Laboratory, Burn, Trauma, and Surgical Critical Care Section, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Crit Care Med 30:S51-7. 2002