Research Topics
| Conan KornetskySummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Medial forebrain stimulation enhances intracranial nociception and attenuates morphine analgesia suggesting the existence of an endogenous opioid antagonistConan Kornetsky
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, United States
Pharmacol Biochem Behav 95:273-7. 2010..These findings, which mimic the effects of the opiate antagonist naloxone, i.e., potentiating of pain and antagonism of morphine's analgesic effects, suggest the presence of an endogenous opiate receptor antagonist...
Brain-stimulation reward, morphine-induced oral stereotypy, and sensitization: implications for abuseConan Kornetsky
Departments of Psychiatry and Pharmacology, Boston University School of Medicine, 715 Albany Street, L 602 Boston, MA 02118, USA
Neurosci Biobehav Rev 27:777-86. 2004..Finally we asked the question 'Do old rats have as much fun as young rats?'..- Deep brain stimulation of the nucleus accumbens reduces ethanol consumption in ratsClifford M Knapp
Division of Psychiatry, Boston University School of Medicine, 72 East Concord Street, R 620, Boston, MA 02118, USA
Pharmacol Biochem Behav 92:474-9. 2009..These results provide evidence that DBS delivered either to the nucleus accumbens core or shell subregions can significantly reduce ethanol intake in the rat... - Increased sensitization to morphine-induced oral stereotypy in aged ratsClifford M Knapp
Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, R-620, Boston, MA 02118, USA
Pharmacol Biochem Behav 79:491-7. 2004..Age-related enhanced sensitivity to morphine-induced oral stereotypy might be related to age-induced increases in vulnerability to opioid-induced insults to the basal ganglia, and may be a model for certain diseases of this pathway... - Nociceptive threshold and analgesic response to morphine in aged and young adult rats as determined by thermal radiation and intracerebral electrical stimulationSteven J Crosby
Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, R-620, Boston, MA 02118, USA
Pharmacol Biochem Behav 84:148-57. 2006.... - Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in ratsFair M Vassoler
Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 28:8735-9. 2008..Together, these results suggest that DBS of the nucleus accumbens shell may be a potential therapeutic option in the treatment of severe cocaine addiction... 
Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating ratsAttilio Iemolo
Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Behav Pharmacol 23:593-602. 2012....- Effects of morphine on brain-stimulation reward thresholds in young and aged ratsShivkumar H Jha
Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, R-620, Boston, MA 02118, USA
Pharmacol Biochem Behav 79:483-90. 2004.... - Effects of cue exposure on brain glucose utilization 8 days after repeated cocaine administrationClifford M Knapp
Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, L 602 Boston, MA 02118, USA
Brain Res 950:119-26. 2002..These findings indicate that repeated cocaine administration can cause protracted decreases in basal LCMR(glu), decreases that are more widespread in the brain during exposure to cocaine-associated cues... - Zonisamide decreases ethanol intake in rats and miceClifford M Knapp
Division of Psychiatry, Boston University School of Medicine, Boson, MA 02118, USA
Pharmacol Biochem Behav 87:65-72. 2007..These results provide evidence that zonisamide administration will decrease ethanol consumption by both mice and rats in limited access models of drinking, and might, like topiramate, be useful as a medication for alcoholism... - The effects of cocaine on the rate independent brain stimulation reward threshold in the mouseBrian M Gill
Laboratory of Behavioral Pharmacology, Boston University School of Medicine, 715 Albany Street, L-620, Boston, MA 02118, USA
Pharmacol Biochem Behav 79:165-70. 2004..0-mg/kg dose. These findings indicate that cocaine increases the sensitivity of the mouse to BSR, and that BSR thresholds can be determined using rate-independent methods in this species... - Conversation with Conan KornetskyConan Kornetsky
Addiction 98:875-82. 2003
Research Grants
- OPIATE ABUSE, REWARD AND AGINGConan Kornetsky; Fiscal Year: 2002..The findings of this study may have implications with regard to both pain management and opiate abuse in the elderly. ..
- DRUGS OF ABUSE AND BRAIN STIMULATION REWARD IN THE MOUSEConan Kornetsky; Fiscal Year: 2003..Successful development of these procedures in mice will allow a more specific understanding of the nature of specific phenotypes that may have relationships to the human condition. ..
- Ethanol: Protracted Changes in Brain Glucose MetabolismConan Kornetsky; Fiscal Year: 2004....
- BRAIN STIMULATION MODELS OF DRUG ABUSEConan Kornetsky; Fiscal Year: 2007..In addition to the research experiments it is proposed to write a historical review of the behavioral methods that have been used in the study of abused substances. ..