Conan Kornetsky

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Medial forebrain stimulation enhances intracranial nociception and attenuates morphine analgesia suggesting the existence of an endogenous opioid antagonist
    Conan Kornetsky
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, United States
    Pharmacol Biochem Behav 95:273-7. 2010
  2. ncbi request reprint Brain-stimulation reward, morphine-induced oral stereotypy, and sensitization: implications for abuse
    Conan Kornetsky
    Departments of Psychiatry and Pharmacology, Boston University School of Medicine, 715 Albany Street, L 602 Boston, MA 02118, USA
    Neurosci Biobehav Rev 27:777-86. 2004
  3. pmc Deep brain stimulation of the nucleus accumbens reduces ethanol consumption in rats
    Clifford M Knapp
    Division of Psychiatry, Boston University School of Medicine, 72 East Concord Street, R 620, Boston, MA 02118, USA
    Pharmacol Biochem Behav 92:474-9. 2009
  4. ncbi request reprint Increased sensitization to morphine-induced oral stereotypy in aged rats
    Clifford M Knapp
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, R 620, Boston, MA 02118, USA
    Pharmacol Biochem Behav 79:491-7. 2004
  5. ncbi request reprint Nociceptive threshold and analgesic response to morphine in aged and young adult rats as determined by thermal radiation and intracerebral electrical stimulation
    Steven J Crosby
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, R 620, Boston, MA 02118, USA
    Pharmacol Biochem Behav 84:148-57. 2006
  6. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats
    Fair M Vassoler
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 28:8735-9. 2008
  7. doi request reprint Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats
    Attilio Iemolo
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Behav Pharmacol 23:593-602. 2012
  8. ncbi request reprint Effects of morphine on brain-stimulation reward thresholds in young and aged rats
    Shivkumar H Jha
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, R 620, Boston, MA 02118, USA
    Pharmacol Biochem Behav 79:483-90. 2004
  9. ncbi request reprint Effects of cue exposure on brain glucose utilization 8 days after repeated cocaine administration
    Clifford M Knapp
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, L 602 Boston, MA 02118, USA
    Brain Res 950:119-26. 2002
  10. pmc Zonisamide decreases ethanol intake in rats and mice
    Clifford M Knapp
    Division of Psychiatry, Boston University School of Medicine, Boson, MA 02118, USA
    Pharmacol Biochem Behav 87:65-72. 2007

Research Grants

  1. OPIATE ABUSE, REWARD AND AGING
    Conan Kornetsky; Fiscal Year: 2002
  2. DRUGS OF ABUSE AND BRAIN STIMULATION REWARD IN THE MOUSE
    Conan Kornetsky; Fiscal Year: 2003
  3. Ethanol: Protracted Changes in Brain Glucose Metabolism
    Conan Kornetsky; Fiscal Year: 2004
  4. BRAIN STIMULATION MODELS OF DRUG ABUSE
    Conan Kornetsky; Fiscal Year: 2007

Collaborators

Detail Information

Publications12

  1. pmc Medial forebrain stimulation enhances intracranial nociception and attenuates morphine analgesia suggesting the existence of an endogenous opioid antagonist
    Conan Kornetsky
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, United States
    Pharmacol Biochem Behav 95:273-7. 2010
    ..These findings, which mimic the effects of the opiate antagonist naloxone, i.e., potentiating of pain and antagonism of morphine's analgesic effects, suggest the presence of an endogenous opiate receptor antagonist...
  2. ncbi request reprint Brain-stimulation reward, morphine-induced oral stereotypy, and sensitization: implications for abuse
    Conan Kornetsky
    Departments of Psychiatry and Pharmacology, Boston University School of Medicine, 715 Albany Street, L 602 Boston, MA 02118, USA
    Neurosci Biobehav Rev 27:777-86. 2004
    ..Finally we asked the question 'Do old rats have as much fun as young rats?'..
  3. pmc Deep brain stimulation of the nucleus accumbens reduces ethanol consumption in rats
    Clifford M Knapp
    Division of Psychiatry, Boston University School of Medicine, 72 East Concord Street, R 620, Boston, MA 02118, USA
    Pharmacol Biochem Behav 92:474-9. 2009
    ..These results provide evidence that DBS delivered either to the nucleus accumbens core or shell subregions can significantly reduce ethanol intake in the rat...
  4. ncbi request reprint Increased sensitization to morphine-induced oral stereotypy in aged rats
    Clifford M Knapp
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, R 620, Boston, MA 02118, USA
    Pharmacol Biochem Behav 79:491-7. 2004
    ..Age-related enhanced sensitivity to morphine-induced oral stereotypy might be related to age-induced increases in vulnerability to opioid-induced insults to the basal ganglia, and may be a model for certain diseases of this pathway...
  5. ncbi request reprint Nociceptive threshold and analgesic response to morphine in aged and young adult rats as determined by thermal radiation and intracerebral electrical stimulation
    Steven J Crosby
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, R 620, Boston, MA 02118, USA
    Pharmacol Biochem Behav 84:148-57. 2006
    ....
  6. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats
    Fair M Vassoler
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 28:8735-9. 2008
    ..Together, these results suggest that DBS of the nucleus accumbens shell may be a potential therapeutic option in the treatment of severe cocaine addiction...
  7. doi request reprint Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats
    Attilio Iemolo
    Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Behav Pharmacol 23:593-602. 2012
    ....
  8. ncbi request reprint Effects of morphine on brain-stimulation reward thresholds in young and aged rats
    Shivkumar H Jha
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, R 620, Boston, MA 02118, USA
    Pharmacol Biochem Behav 79:483-90. 2004
    ....
  9. ncbi request reprint Effects of cue exposure on brain glucose utilization 8 days after repeated cocaine administration
    Clifford M Knapp
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, L 602 Boston, MA 02118, USA
    Brain Res 950:119-26. 2002
    ..These findings indicate that repeated cocaine administration can cause protracted decreases in basal LCMR(glu), decreases that are more widespread in the brain during exposure to cocaine-associated cues...
  10. pmc Zonisamide decreases ethanol intake in rats and mice
    Clifford M Knapp
    Division of Psychiatry, Boston University School of Medicine, Boson, MA 02118, USA
    Pharmacol Biochem Behav 87:65-72. 2007
    ..These results provide evidence that zonisamide administration will decrease ethanol consumption by both mice and rats in limited access models of drinking, and might, like topiramate, be useful as a medication for alcoholism...
  11. ncbi request reprint The effects of cocaine on the rate independent brain stimulation reward threshold in the mouse
    Brian M Gill
    Laboratory of Behavioral Pharmacology, Boston University School of Medicine, 715 Albany Street, L 620, Boston, MA 02118, USA
    Pharmacol Biochem Behav 79:165-70. 2004
    ..0-mg/kg dose. These findings indicate that cocaine increases the sensitivity of the mouse to BSR, and that BSR thresholds can be determined using rate-independent methods in this species...
  12. ncbi request reprint Conversation with Conan Kornetsky
    Conan Kornetsky
    Addiction 98:875-82. 2003

Research Grants5

  1. OPIATE ABUSE, REWARD AND AGING
    Conan Kornetsky; Fiscal Year: 2002
    ..The findings of this study may have implications with regard to both pain management and opiate abuse in the elderly. ..
  2. DRUGS OF ABUSE AND BRAIN STIMULATION REWARD IN THE MOUSE
    Conan Kornetsky; Fiscal Year: 2003
    ..Successful development of these procedures in mice will allow a more specific understanding of the nature of specific phenotypes that may have relationships to the human condition. ..
  3. Ethanol: Protracted Changes in Brain Glucose Metabolism
    Conan Kornetsky; Fiscal Year: 2004
    ....
  4. BRAIN STIMULATION MODELS OF DRUG ABUSE
    Conan Kornetsky; Fiscal Year: 2007
    ..In addition to the research experiments it is proposed to write a historical review of the behavioral methods that have been used in the study of abused substances. ..