Daniel Kirschner

Summary

Affiliation: Boston College
Country: USA

Publications

  1. ncbi request reprint Fiber diffraction as a screen for amyloid inhibitors
    Daniel A Kirschner
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Curr Alzheimer Res 5:288-307. 2008
  2. pmc Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis
    Melanie A McNally
    Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    J Negat Results Biomed 6:8. 2007
  3. pmc Rapid assessment of internodal myelin integrity in central nervous system tissue
    Daniel A Kirschner
    Biology Department, Boston College, Chestnut Hill, Massachusetts, USA
    J Neurosci Res 88:712-21. 2010
  4. doi request reprint Myelin structure and composition of myelinated tissue in the African lungfish
    Daniel A Kirschner
    Department of Neuropathology, Harvard Medical School, Boston, MA 02115, USA
    Neuron Glia Biol 4:59-70. 2008
  5. pmc Cytoplasmic domain of zebrafish myelin protein zero: adhesive role depends on beta-conformation
    XiaoYang Luo
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA
    Biophys J 93:3515-28. 2007
  6. ncbi request reprint Assemblies of Alzheimer's peptides A beta 25-35 and A beta 31-35: reverse-turn conformation and side-chain interactions revealed by X-ray diffraction
    Jeremy P Bond
    Department of Biology, Higgins Hall, Boston College, Chestnut Hill, MA 02467, USA
    J Struct Biol 141:156-70. 2003
  7. pmc Cytoplasmic domain of human myelin protein zero likely folded as beta-structure in compact myelin
    XiaoYang Luo
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA
    Biophys J 92:1585-97. 2007
  8. ncbi request reprint Myelin structure and composition in zebrafish
    Robin L Avila
    Biology Department, Boston College, Chestnut Hill, MA 02467 3811, USA
    Neurochem Res 32:197-209. 2007
  9. doi request reprint Differential effects of Phe19 and Phe20 on fibril formation by amyloidogenic peptide A beta 16-22 (Ac-KLVFFAE-NH2)
    Hideyo Inouye
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Proteins 78:2306-21. 2010
  10. ncbi request reprint Poly-(L-alanine) expansions form core beta-sheets that nucleate amyloid assembly
    Leonid M Shinchuk
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467 3811, USA
    Proteins 61:579-89. 2005

Research Grants

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Fiber diffraction as a screen for amyloid inhibitors
    Daniel A Kirschner
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    Curr Alzheimer Res 5:288-307. 2008
    ....
  2. pmc Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis
    Melanie A McNally
    Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    J Negat Results Biomed 6:8. 2007
    ....
  3. pmc Rapid assessment of internodal myelin integrity in central nervous system tissue
    Daniel A Kirschner
    Biology Department, Boston College, Chestnut Hill, Massachusetts, USA
    J Neurosci Res 88:712-21. 2010
    ....
  4. doi request reprint Myelin structure and composition of myelinated tissue in the African lungfish
    Daniel A Kirschner
    Department of Neuropathology, Harvard Medical School, Boston, MA 02115, USA
    Neuron Glia Biol 4:59-70. 2008
    ..The CNS myelin, by contrast, did not compact in acidic saline but did swell in the alkaline solution. This lability was more similar to that for the higher vertebrates than for teleost...
  5. pmc Cytoplasmic domain of zebrafish myelin protein zero: adhesive role depends on beta-conformation
    XiaoYang Luo
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA
    Biophys J 93:3515-28. 2007
    ..Our findings support the idea that the adhesive role of P0 at the cytoplasmic apposition in compact myelin depends on the cytoplasmic domain of P0 being in the beta-conformation...
  6. ncbi request reprint Assemblies of Alzheimer's peptides A beta 25-35 and A beta 31-35: reverse-turn conformation and side-chain interactions revealed by X-ray diffraction
    Jeremy P Bond
    Department of Biology, Higgins Hall, Boston College, Chestnut Hill, MA 02467, USA
    J Struct Biol 141:156-70. 2003
    ....
  7. pmc Cytoplasmic domain of human myelin protein zero likely folded as beta-structure in compact myelin
    XiaoYang Luo
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA
    Biophys J 92:1585-97. 2007
    ..We suggest that the cytoplasmic apposition (major dense line) in compact myelin may be stabilized via the hydrogen-bonding of beta-strands formed as a result of local P0-P0 aggregation...
  8. ncbi request reprint Myelin structure and composition in zebrafish
    Robin L Avila
    Biology Department, Boston College, Chestnut Hill, MA 02467 3811, USA
    Neurochem Res 32:197-209. 2007
    ....
  9. doi request reprint Differential effects of Phe19 and Phe20 on fibril formation by amyloidogenic peptide A beta 16-22 (Ac-KLVFFAE-NH2)
    Hideyo Inouye
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Proteins 78:2306-21. 2010
    ..IR observations for the same peptides in dilute solution showed a greater degree of hydrogen bonding for the nitrile groups in 20CN than in 19CN, supporting this interpretation...
  10. ncbi request reprint Poly-(L-alanine) expansions form core beta-sheets that nucleate amyloid assembly
    Leonid M Shinchuk
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467 3811, USA
    Proteins 61:579-89. 2005
    ..We postulate that a similar stabilization of an expanded polyalanine stretch could form a core beta-sheet structure that mediates the intermolecular association of mutant proteins into fibrillar inclusions in human pathologies...
  11. doi request reprint Internodal myelination during development quantitated using X-ray diffraction
    Deepika Agrawal
    Biology Department, Boston College, Chestnut Hill, MA 02467 3811, USA
    J Struct Biol 168:521-6. 2009
    ..We propose that the data obtained here can serve as a basis for rapidly detecting abnormal pathologies during myelination...
  12. pmc Molecular organization of amyloid protofilament-like assembly of betabellin 15D: helical array of beta-sandwiches
    Hideyo Inouye
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02467 3811, USA
    Biophys J 83:1716-27. 2002
    ..Multiple intersheet hydrogen bonds in the axial direction and intersandwich polar interactions in the lateral direction stabilize the array...
  13. pmc Structure of core domain of fibril-forming PHF/Tau fragments
    Hideyo Inouye
    Boston College, Biology Department, Chestnut Hill, Massachusetts, USA
    Biophys J 90:1774-89. 2006
    ..This particular contact, which may be involved in PHF fibril formation, is proposed here as a possible aromatic target for anti-tauopathy drugs...
  14. ncbi request reprint Polyglutamine homopolymers having 8-45 residues form slablike beta-crystallite assemblies
    Deepak Sharma
    Biology Department, Boston College, Chestnut Hill, Massachusetts, USA
    Proteins 61:398-411. 2005
    ..Moreover, the slab thickness indicates that K2Q45K2, rather than forming a water-filled nanotube, must form multiple reverse turns...
  15. ncbi request reprint Alzheimer's beta-amyloid: insights into fibril formation and structure from Congo red binding
    Hideyo Inouye
    Department of Biology, Boston College, Chestnut Hill, MA 02467 3811, USA
    Subcell Biochem 38:203-24. 2005
    ....
  16. ncbi request reprint Structure and stability of internodal myelin in mouse models of hereditary neuropathy
    Robin L Avila
    Biology Department, Boston College, Chestnut Hill, MA 02467, USA
    J Neuropathol Exp Neurol 64:976-90. 2005
    ..Our findings demonstrate that diffraction can provide a quantitative basis for understanding, at a molecular level, the membrane packing defects that occur in internodal myelin in demyelinating peripheral neuropathies...
  17. pmc Peripheral myelin of Xenopus laevis: role of electrostatic and hydrophobic interactions in membrane compaction
    XiaoYang Luo
    Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467 3811, USA
    J Struct Biol 162:170-83. 2008
    ..These results help clarify the present understanding of P0's adhesion role and the role of its acylation in compact PNS myelin...
  18. ncbi request reprint X-Ray fiber and powder diffraction of PrP prion peptides
    Hideyo Inouye
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Adv Protein Chem 73:181-215. 2006
    ..We discuss how the quarter-staggered beta-sheet assembly (like in polyalanine) and polar-zipper beta-sheet formation (like in polyglutamine) may be involved in the formation of the scrapie form of prion...
  19. ncbi request reprint Myelin protein zero exists as dimers and tetramers in native membranes of Xenopus laevis peripheral nerve
    Amanda J Thompson
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02467 3811, USA
    J Neurosci Res 67:766-71. 2002
    ..Native gels showed dimeric P0 without the appearance of monomer or tetramer, suggesting that dimeric P0, the most prominent form of the protein, is the most stable and likely occurs in the native myelin membrane array...
  20. pmc Formation of amyloid fibrils in vitro by human gammaD-crystallin and its isolated domains
    Katerina Papanikolopoulou
    Department of Materials Science and Technology, University of Crete, Heraklion, Crete, Greece
    Mol Vis 14:81-9. 2008
    ..We have investigated whether human gammaD-crystallin forms amyloid fibrils in vitro, when exposed to low pH partially denaturing conditions...
  21. ncbi request reprint Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model
    Marco Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Biol Chem 281:843-9. 2006
    ..e. the locking steps) appear to be faster and easier with PrP82-146 than with Abeta40. Such differences suggest that PrP82-146 has a greater propensity to polymerize and greater stability of the aggregates...
  22. ncbi request reprint Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein
    Mario Salmona
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    J Biol Chem 278:48146-53. 2003
    ..These data indicate that the intrinsic properties of PrP-(82-146) are dependent upon the integrity of the C-terminal region and account for the massive deposition of PrP amyloid in GSS...
  23. ncbi request reprint Filaments of the Ure2p prion protein have a cross-beta core structure
    Ulrich Baxa
    Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Struct Biol 150:170-9. 2005
    ..Local area electron diffraction and X-ray diffraction from partially aligned specimens showed that the 4.7A reflection is meridional and therefore the underlying structure is cross-beta...
  24. ncbi request reprint The formation of straight and twisted filaments from short tau peptides
    Warren J Goux
    Department of Chemistry, The University of Texas at Dallas, Richardson, Texas 75083 0688, USA
    J Biol Chem 279:26868-75. 2004
    ..Taken together these results suggest that the core of PHF6 is localized at VYK, and the interaction between small amphiphilic segments of tau may initiate nucleation and lead to filaments displaying paired helical filament morphology...
  25. pmc Evolution of a neuroprotective function of central nervous system myelin
    Xinghua Yin
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cell Biol 172:469-78. 2006
    ..These data support the hypothesis that the P0-PLP shift during vertebrate evolution provided a vital neuroprotective function to myelin-forming CNS glia...

Research Grants5

  1. MYELIN PO GLYCOPROTEIN: STRUCTURE & ADHESIVE MECHANISMS
    Daniel Kirschner; Fiscal Year: 2003
    ....