J F Keaney

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
  2. ncbi request reprint Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Whitaker Cardiovascular Institute, 715 Albany St, Rm W507, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 23:434-9. 2003
  3. ncbi request reprint Vascular oxidative stress and antioxidant protection in atherosclerosis: what do the clinical trials say?
    John F Keaney
    Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Room W507, Boston, MA 02118, USA
    J Cardiopulm Rehabil 22:225-33. 2002
  4. ncbi request reprint Vitamin E and vascular homeostasis: implications for atherosclerosis
    J F Keaney
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    FASEB J 13:965-75. 1999
  5. ncbi request reprint Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    J Am Coll Cardiol 44:168-73. 2004
  6. pmc L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease
    J A Vita
    Evans Memorial Department of Medicine, Cardiology Section and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 101:1408-14. 1998
  7. ncbi request reprint Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension
    S J Duffy
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Heart Circ Physiol 280:H528-34. 2001
  8. ncbi request reprint Iron chelation improves endothelial function in patients with coronary artery disease
    S J Duffy
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Circulation 103:2799-804. 2001
  9. pmc Serum myeloperoxidase levels independently predict endothelial dysfunction in humans
    Joseph A Vita
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Circulation 110:1134-9. 2004
  10. ncbi request reprint Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease
    S J Duffy
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 21:1084-9. 2001

Detail Information

Publications87

  1. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  2. ncbi request reprint Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Whitaker Cardiovascular Institute, 715 Albany St, Rm W507, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 23:434-9. 2003
    ..Thus, it has been difficult to evaluate the relative contribution of each cardiovascular risk factor to systemic oxidative stress and to determine whether such risk factors act independently and are applicable to the general population...
  3. ncbi request reprint Vascular oxidative stress and antioxidant protection in atherosclerosis: what do the clinical trials say?
    John F Keaney
    Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Room W507, Boston, MA 02118, USA
    J Cardiopulm Rehabil 22:225-33. 2002
  4. ncbi request reprint Vitamin E and vascular homeostasis: implications for atherosclerosis
    J F Keaney
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    FASEB J 13:965-75. 1999
    ..In the setting of atherosclerosis, inhibition of protein kinase C by vitamin E would be expected to maintain normal vascular homeostasis and thus reduce the clinical incidence of cardiovascular disease...
  5. ncbi request reprint Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    J Am Coll Cardiol 44:168-73. 2004
    ..We sought to determine the clinical factors and heritability associated with inflammation measured as circulating levels of soluble-intercellular adhesion molecule-1 (sICAM-1) in a community-based cohort...
  6. pmc L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease
    J A Vita
    Evans Memorial Department of Medicine, Cardiology Section and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 101:1408-14. 1998
    ..Cellular redox state may be an important regulator of EDNO action, and is a potential target for therapy in patients with coronary artery disease...
  7. ncbi request reprint Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension
    S J Duffy
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Heart Circ Physiol 280:H528-34. 2001
    ..The effects of this treatment on resistance vessel vasomotor function warrant further investigation...
  8. ncbi request reprint Iron chelation improves endothelial function in patients with coronary artery disease
    S J Duffy
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Circulation 103:2799-804. 2001
    ..These results suggest that iron availability contributes to impaired nitric oxide action in atherosclerosis...
  9. pmc Serum myeloperoxidase levels independently predict endothelial dysfunction in humans
    Joseph A Vita
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Circulation 110:1134-9. 2004
    ..We therefore hypothesized that circulating levels of myeloperoxidase would predict risk of endothelial dysfunction in human subjects...
  10. ncbi request reprint Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease
    S J Duffy
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 21:1084-9. 2001
    ..These findings suggest that an effect of tea flavonoids on platelet aggregation is unlikely to be the explanation for the reduction in risk of cardiovascular events noted in epidemiological studies...
  11. ncbi request reprint Enhanced nitric oxide-mediated vascular relaxation in radial artery compared with internal mammary artery or saphenous vein
    O M Shapira
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston, MA, USA
    Circulation 100:II322-7. 1999
    ..The purpose of this study was to compare the.NO-mediated vasomotor properties of the radial artery to those of the internal mammary artery and saphenous vein...
  12. ncbi request reprint Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease
    S J Duffy
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Circulation 104:151-6. 2001
    ..This finding may partly explain the association between tea intake and decreased cardiovascular disease events...
  13. ncbi request reprint Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome
    J A Vita
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University Medical Center, Massachusetts 02118, USA
    J Am Coll Cardiol 31:980-6. 1998
    ..This study sought to investigate the relations between plasma antioxidant status, extent of atherosclerosis and activity of coronary artery disease...
  14. ncbi request reprint Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 30:2529-35. 2007
    ..Systemic oxidative stress causes insulin resistance in rodents. We tested the hypothesis that oxidative stress and insulin resistance are associated in humans...
  15. ncbi request reprint Acute hypertriglyceridemia is associated with peripheral vasodilation and increased basal flow in healthy young adults
    N Gokce
    Evans Department of Medicine, Cardiology Section and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 88:153-9. 2001
    ..The dilator effect is not insulin-dependent and does not appear to be a direct effect of triglycerides on vascular tissue...
  16. pmc Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease
    Craig J McMackin
    Evans Department of Medicine and Whitaker Cardovascular Institute, Boston University School of Medicine, Boston, MA, USA
    J Clin Hypertens (Greenwich) 9:249-55. 2007
    ..Further studies are needed to confirm these findings and determine the clinical utility of alpha-lipoic acid/acetyl-L-carnitine as antihypertensive therapy...
  17. pmc Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery
    Alex L Huang
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2113-9. 2007
    ..The predictive value of reactive hyperemia for cardiovascular events in patients with atherosclerosis and the relative importance of reactive hyperemia compared with other measures of vascular function have not been previously studied...
  18. ncbi request reprint Relations of inflammation and novel risk factors to valvular calcification
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 97:1502-5. 2006
    ..In conclusion, inflammatory markers were elevated in patients with valvular calcium. Our findings suggest that much of the observed association between systemic inflammatory markers and valvular calcium may be due to shared risk factors...
  19. ncbi request reprint Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease
    Noyan Gokce
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 41:1769-75. 2003
    ..The goal of this study was to prospectively examine the long-term predictive value of brachial-artery endothelial dysfunction for future cardiovascular events...
  20. pmc Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease
    Michael E Widlansky
    Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    J Am Coll Nutr 26:95-102. 2007
    ..Recent studies with flavonoid-containing beverages suggest that the benefits of these nutrients may relate, in part, to improved endothelial function...
  21. ncbi request reprint Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:310-5. 2003
    ....
  22. pmc Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study
    Thomas M Tadros
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1039-45. 2010
    ..Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress...
  23. ncbi request reprint c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation
    K Chen
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 276:16045-50. 2001
    ..These data represent one potential pathway for mediating oxidative stress-induced phenotypic changes in the endothelium...
  24. ncbi request reprint Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study
    Joseph A Vita
    Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Circulation 110:3604-9. 2004
    ..The precise relations among risk factors, inflammation, and nitric oxide bioavailability remain uncertain...
  25. ncbi request reprint Systemic inflammation and COPD: the Framingham Heart Study
    Robert E Walter
    Section of Pulmonary, Allergy, and Critical Care Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Chest 133:19-25. 2008
    ..We examined the hypothesis that systemic inflammatory biomarkers are associated with impaired lung function, particularly among those with extensive cigarette smoking...
  26. ncbi request reprint Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 285:H2392-8. 2003
    ..Oral antioxidant therapy improves EDV in T1 but not T2 diabetes. These results are consistent with the lack of clinical benefit in studies that have included primarily T2 diabetic patients...
  27. ncbi request reprint Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients
    Noyan Gokce
    Evans Department of Medicine, Cardiology and Endocrinology Sections, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 95:266-8. 2005
    ..These data demonstrate that weight loss in markedly obese patients improves endothelial function and glycemic control that may represent important mechanisms of the cardiovascular benefit associated with weight reduction...
  28. ncbi request reprint Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Atherosclerosis 182:307-14. 2005
    ..09) less than 5cM from the interleukin-10 (IL10) gene. Multiple genes on chromosome 1 may influence inflammatory biomarker levels and may have a potential role in development of CVD...
  29. pmc Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study
    Joanne M Murabito
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, United States
    Atherosclerosis 203:509-14. 2009
    ..Emerging evidence suggests that different inflammatory biomarkers operate through distinct biologic mechanisms. We hypothesized that the relation to peripheral arterial disease (PAD) varies for individual markers...
  30. ncbi request reprint Cross-sectional correlates of serum heat shock protein 70 in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Hypertens 19:227-31; discussion 232-3. 2006
    ..It is unclear whether circulating heat shock protein 70 (HSP70) levels are related to CVD risk factors, echocardiographic indexes of left ventricular (LV) remodeling, and prevalent CVD in the population...
  31. ncbi request reprint The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure
    Eugene Kotlyar
    Cardiovascular Section, Evans Department of Medicine, Boston University, 88 E Newton Street D 8, Boston, MA, USA
    J Card Fail 12:122-7. 2006
    ..It is unknown if these findings are relevant to heart failure patients who may have much lower aldosterone levels...
  32. ncbi request reprint Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study)
    Avni H Thakore
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 99:1598-602. 2007
    ..In conclusion, there were modest associations of inflammatory markers, particularly IL-6, with carotid atherosclerosis. This association appears more pronounced in current smokers than in former smokers and nonsmokers...
  33. pmc Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers
    Naomi M Hamburg
    Section of Cardiology, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 27:2650-6. 2007
    ..Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance...
  34. ncbi request reprint Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study
    Karla M Pou
    Division of Endocrinology, Metabolism, and Diabetes, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 116:1234-41. 2007
    ..Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear...
  35. ncbi request reprint Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study
    Emelia J Benjamin
    Evans Department of Medicine, Boston University School of Medicine, Framingham Study, Boston, Mass 01702 5827, USA
    Circulation 109:613-9. 2004
    ..Studies in selected samples have linked impaired endothelial function with cardiovascular disease and its risk factors. The clinical correlates and heritability of endothelial function in the community have not been described...
  36. ncbi request reprint Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease
    Joseph A Vita
    Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts, USA
    Am J Cardiol 91:857-60. 2003
  37. pmc Expression of 5-lipoxygenase in pulmonary artery endothelial cells
    Ying Yi Zhang
    Whitaker Cardiovascular Institute, and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Biochem J 361:267-76. 2002
    ..However, increased expression of 5LO in PAECs can lead to the production of all downstream leukotrienes, which could potentially cause endothelial dysfunction in the pulmonary vasculature...
  38. ncbi request reprint Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm
    O M Shapira
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Massachusetts, USA
    Ann Thorac Surg 70:883-8; discussion 888-9. 2000
    ..However, recent in vitro and in vivo studies have shown that nitroglycerin is a superior conduit vasodilator compared to diltiazem. A clinical comparison of these agents in patients undergoing CABG has not been previously performed...
  39. ncbi request reprint Contrasting effects of thiol-modulating agents on endothelial NO bioactivity
    A Huang
    Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Cell Physiol 281:C719-25. 2001
    ..Thus thiol-modulating agents exert pleiotropic effects on endothelial NO bioactivity, and these data may help to resolve a number of conflicting previous studies linking GSH status with endothelial cell NO bioactivity...
  40. ncbi request reprint Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity -- role for iron-dependent oxidative stress
    Shane R Thomas
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Free Radic Biol Med 41:681-8. 2006
    ..The study highlights another way in which oxidative stress may impair NO bioactivity during vascular disease...
  41. ncbi request reprint Acute effects of vasoactive drug treatment on brachial artery reactivity
    Noyan Gokce
    Evans Department of Medicine, Cardiology Section and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 40:761-5. 2002
    ..The goal of this study was to investigate whether concomitant therapy with vasoactive medications alters the results of noninvasive assessment of endothelial function...
  42. ncbi request reprint Tamoxifen, esterified estradiol, and physiologic concentrations of estradiol inhibit oxidation of low-density lipoprotein by endothelial cells
    W Kuohung
    Department of Obstetrics and Gynecology and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts, USA
    Am J Obstet Gynecol 184:1060-3. 2001
    ..CONCLUSION: Under these experimental conditions, tamoxifen, esterified estradiol, and physiologic concentrations of exogenous estradiol inhibit oxidation of low-density lipoprotein by human umbilical vein endothelial cells...
  43. pmc Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study
    A L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 68:1032-8. 2007
    ..We hypothesized that inflammatory biomarkers would be associated with neuroimaging markers of ischemia (i.e., white matter hyperintensities [WMH]) and AD (i.e., total brain volume [TCB])...
  44. ncbi request reprint Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease
    Noyan Gokce
    Evans Department of Medicine, Cardiology Section, and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 90:124-7. 2002
    ..These findings suggest that exercise improves endothelial function in peripheral conduit arteries of patients with CAD and that the beneficial effect may be more marked in the vascular beds of the exercised limbs...
  45. ncbi request reprint The clinical implications of endothelial dysfunction
    Michael E Widlansky
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 42:1149-60. 2003
    ..This article will review this growing literature in an effort to evaluate the current clinical utility of endothelial dysfunction...
  46. ncbi request reprint Effect of short-term antibiotic treatment on Chlamydia pneumoniae and peripheral endothelial function
    Jeffrey T Kuvin
    Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 91:732-5. 2003
  47. ncbi request reprint Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study
    Noyan Gokce
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 105:1567-72. 2002
    ..However, the predictive value of brachial artery endothelial dysfunction for future cardiovascular events is unknown...
  48. ncbi request reprint Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols
    Elad Anter
    Evans Memorial Department of Medicine, The Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachussetts 02118, USA
    J Biol Chem 279:46637-43. 2004
    ..Taken together, these data identify the p38 MAPK as an upstream component of Akt-mediated eNOS activation...
  49. ncbi request reprint Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism
    Roland Stocker
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Mass 02118, USA
    Arterioscler Thromb Vasc Biol 24:2028-33. 2004
    ..To determine how hypochlorous acid (HOCl), the principal product of myeloperoxidase, modulates vascular function...
  50. pmc Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample
    Erik Ingelsson
    The Framingham Study, Boston University School of Medicine, Framingham, Massachusetts 01702 5803, USA
    J Clin Endocrinol Metab 93:3149-57. 2008
    ..The conjoint effects and relative importance of ghrelin, leptin, and soluble leptin receptor (sOB-R), adipokines involved in appetite control and energy expenditure in mediating cardiometabolic risk, is unknown...
  51. pmc Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study
    M Kyla Shea
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 167:313-20. 2008
    ..The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation...
  52. pmc Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice
    Yanli Song
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Circulation 112:553-62. 2005
    ..To understand the role of BMPR2 in the development of IPAH, we examined the phenotype of BMPR2(+/-) mice and their response to inflammatory stress...
  53. ncbi request reprint Oxidative stress, antioxidants, and endothelial function
    Eberhard Schulz
    Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Curr Med Chem 11:1093-104. 2004
    ..The purpose of this review is to discuss these data and suggest novel approaches for lowering the oxidative stress in the vasculature...
  54. ncbi request reprint Effects of race and hypertension on flow-mediated and nitroglycerin-mediated dilation of the brachial artery
    N Gokce
    Evans Department of Medicine, Cardiology Section and Whitaker Cardiovascular Institute, Boston University School of Medicine, MA, USA
    Hypertension 38:1349-54. 2001
    ..This later observation provides further evidence of racial differences in the responses to medical therapy that may be relevant to the treatment of patients with cardiovascular disease...
  55. ncbi request reprint Clinical correlates of circulating visfatin levels in a community-based sample
    Erik Ingelsson
    Framingham Study, Boston University School of Medicine, Framingham, Massachusetts, Framingham, MA 01702 5803, USA
    Diabetes Care 30:1278-80. 2007
  56. ncbi request reprint Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase
    Eberhard Schulz
    Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circulation 111:3473-80. 2005
    ..We therefore investigated whether AMPK is activated by estradiol in endothelial cells and plays a role in estradiol-induced eNOS activation...
  57. pmc Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension
    Mustali M Dohadwala
    Evans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Clin Nutr 92:1052-9. 2010
    ..Consumption of flavonoid-containing foods may be useful for the management of hypertension...
  58. ncbi request reprint Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway
    Shane R Thomas
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 USA
    J Biol Chem 277:6017-24. 2002
    ..This response may represent an attempt by endothelial cells to maintain NO bioactivity under conditions of enhanced oxidative stress...
  59. ncbi request reprint Oxidative stress and endothelial nitric oxide bioactivity
    Shane R Thomas
    Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Room W507, Boston, MA 02118, U S A
    Antioxid Redox Signal 5:181-94. 2003
    ..This review outlines how different forms of oxidative stress can impact on NO bioactivity and discusses strategies to prevent oxidative stress-induced endothelial dysfunction...
  60. ncbi request reprint Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Free Radic Biol Med 38:499-506. 2005
    ..Chronic dietary flavonoid status appears to relate to endothelial function, possibly suggesting that other flavonoids or polyphenolic components of tea favorably influence vascular health and risk for cardiovascular disease...
  61. ncbi request reprint Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Free Radic Biol Med 36:123-30. 2004
    ....
  62. ncbi request reprint Beyond LDL oxidation: ROS in vascular signal transduction
    Kai Chen
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Free Radic Biol Med 35:117-32. 2003
    ..In this review, the data linking ROS to cell signaling is discussed and the notion that ROS mediate a vascular "injury" response is proposed...
  63. ncbi request reprint AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells
    Jose M Cacicedo
    Diabetes and Metabolism Research Unit, Department of Medicine and Section of Endocrinology, Boston University School of Medicine, 650 Albany St, 8th Floor, Room 820, Boston, MA 02118, USA
    Biochem Biophys Res Commun 324:1204-9. 2004
    ....
  64. ncbi request reprint Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling
    Kai Chen
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, 715 Albany Street, MA 02118, USA
    J Biol Chem 279:35079-86. 2004
    ..These data establish a novel role for the mitochondrion as a proximal target specific to H(2)O(2)-induced signaling and growth factor transactivation...
  65. ncbi request reprint L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells
    Stanley J Heydrick
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University, School of Medicine, Boston, MA 02118, USA
    Free Radic Biol Med 36:632-40. 2004
    ..Thus, homocyst(e)ine actively promotes oxidative stress in endothelial cells via an eNOS-dependent mechanism...
  66. ncbi request reprint Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3
    Annong Huang
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 96:164-71. 2005
    ..Thus, IFN-gamma and TNF-alpha exert distinct but cooperative roles for BH4 biosynthesis in endothelium that may have important implications for vascular function during vascular inflammation...
  67. ncbi request reprint Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation
    Kai Chen
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:39527-33. 2003
    ..Thus, these data link PDGF beta receptor transactivation to H2O2-induced p53 phosphorylation and suggest a functional role for growth factor receptors in modulation of p53 function...
  68. pmc Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Am Heart J 156:1003-1009.e1. 2008
    ..Circulating soluble CD40L (sCD40L) concentration predicts cardiovascular risk in selected patient samples. The purpose of this study was to determine the predictors of sCD40L in a large, community-based sample...
  69. ncbi request reprint Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity
    Sandeep Gupta
    Diabetes and Metabolism Unit, Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Physiol Cell Physiol 282:C560-6. 2002
    ..These data suggest that hyperglycemia induces an increase in endothelial superoxide that inhibits the stimulatory effect of NO on vascular Na+-K+-ATPase activity...
  70. ncbi request reprint Measurements of redox control of nitric oxide bioavailability
    Annong Huang
    Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Methods Enzymol 359:209-16. 2002
    ..Used in combination, these assays can provide considerable insight into the effect of cellular redox status on NO bioactivity and provide the investigator with a good starting point for further mechanistic studies...
  71. ncbi request reprint Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting: functional and histologic assessment of the conduit
    Oz M Shapira
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston, Mass 02118, USA
    J Thorac Cardiovasc Surg 131:388-94. 2006
    ..The radial artery's propensity for vasospasm and vulnerability to surgical trauma are well known. A less invasive endoscopic method to harvest the radial artery was recently introduced, but its effect on radial artery integrity is unknown...
  72. ncbi request reprint EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis
    Nopparat Nuntharatanapong
    Evans Memorial Department of Medicine, Boston Univ School of Medicine, Whitaker Cardiovascular Institute, 715 Albany St, Rm W507, Boston, MA 02118, USA
    Am J Physiol Heart Circ Physiol 289:H99-H107. 2005
    ..Insofar as endothelial dysfunction promotes vascular disease, these data provide a mechanism for the increased incidence of cardiovascular disease due to arsenite exposure...
  73. pmc Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance
    Karsten Sydow
    The University Hospital Eppendorf, Division of Cardiology, Hamburg, Germany
    J Clin Invest 113:482-9. 2004
    ..Thus, GTN tolerance may be viewed as a metabolic syndrome characterized by mitochondrial dysfunction...
  74. ncbi request reprint Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 44:134-9. 2004
    ..The associations between many risk factors and brachial artery flow-mediated dilation may be attributable to reduced stimulus for dilation rather than impaired local conduit artery response during hyperemia...
  75. pmc Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection
    Renate Schnabel
    National Heart Lung and Blood Institute Framingham Study, Framingham, Mass, USA
    Hypertension 51:1651-7. 2008
    ..Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures...
  76. ncbi request reprint Role of oxidative modifications in atherosclerosis
    Roland Stocker
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    Physiol Rev 84:1381-478. 2004
    ..To address this issue, we have proposed an "oxidative response to inflammation" model as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis...
  77. ncbi request reprint The value of inflammation for predicting unstable angina
    John F Keaney
    N Engl J Med 347:55-7. 2002
  78. ncbi request reprint Endothelial function: a barometer for cardiovascular risk?
    Joseph A Vita
    Circulation 106:640-2. 2002
  79. ncbi request reprint Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy
    Mehdi H Shishehbor
    Department of Cell Biology, and the Center for Cardiovascular Diagnostics and Prevention, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 289:1675-80. 2003
    ..Nitrotyrosine, a specific marker for protein modification by nitric oxide-derived oxidants, is enriched in human atherosclerotic lesions and low-density lipoprotein (LDL) recovered from human atheroma...
  80. ncbi request reprint Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
    ..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  81. ncbi request reprint CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study
    David H McDermott
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
    Circulation 112:1113-20. 2005
    ..Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory...
  82. ncbi request reprint Influence of hyperhomocysteinemia on the cellular redox state--impact on homocysteine-induced endothelial dysfunction
    Norbert Weiss
    Medizinische Poliklinik Innenstadt, Klinikum der Universitat Munchen, Munich, Germany
    Clin Chem Lab Med 41:1455-61. 2003
    ..Taken together, these findings strongly suggest that the adverse vascular effects of homocysteine are at least partly mediated by oxidative inactivation of nitric oxide...
  83. ncbi request reprint Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4
    Maria C Wendt
    The University Clinics Eppendorf, Division of Cardiology, Hamburg, Germany
    Free Radic Biol Med 39:381-91. 2005
    ..We conclude that in addition to phagocytic NADPH oxidase, also nonphagocytic, vascular NADPH oxidase subunit nox1, uncoupled NOSIII, and plasma xanthine oxidase contribute to endothelial dysfunction in the setting of diabetes mellitus...
  84. pmc Regulation of ROS signal transduction by NADPH oxidase 4 localization
    Kai Chen
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 181:1129-39. 2008
    ..These data indicate that the specificity of intracellular ROS-mediated signal transduction may be modulated by the localization of Nox isoforms within specific subcellular compartments...
  85. ncbi request reprint Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status
    Francesco Visioli
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Redox Rep 7:223-7. 2002
    ..Thus, vitamin C and lipoic acid potentiate endothelial NO synthesis and bioactivity by mechanisms that appear to be independent of cellular GSH levels and redox environment...
  86. ncbi request reprint Oxidative stress and the vascular wall: NADPH oxidases take center stage
    John F Keaney
    Circulation 112:2585-8. 2005
  87. ncbi request reprint Circulating biomarkers in acute coronary syndromes: something different or more of the same?
    John F Keaney
    Circulation 112:778-80. 2005