J Keane

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages
    J Keane
    Pulmonary Center, Boston University School of Medicine, Boston MA 02118, USA
    J Immunol 164:2016-20. 2000
  2. ncbi Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    J Keane
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    N Engl J Med 345:1098-104. 2001
  3. ncbi TNF-dependent BALB/c murine macrophage apoptosis following Mycobacterium tuberculosis infection inhibits bacillary growth in an IFN-gamma independent manner
    J Keane
    Pulmonary Center, Boston University School of Medicine, Boston, MA, USA
    Tuberculosis (Edinb) 82:55-61. 2002
  4. ncbi Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses
    T K Means
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 166:4074-82. 2001
  5. ncbi Identification of Mycobacterium avium DNA sequences that encode exported proteins by using phoA gene fusions
    J D Carroll
    Department of Medicine, Boston University School of Medicine, Boston, USA
    Tuber Lung Dis 80:117-30. 2000
  6. ncbi Conservation of structure and function between human and murine IL-16
    J Keane
    The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Immunol 160:5945-54. 1998
  7. ncbi Usual interstitial pneumonitis responsive to corticosteroids following varicella pneumonia
    J Keane
    Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    Chest 113:249-51. 1998

Research Grants

  1. ROLE & MECHANISM OF APOPTOSIS IN THE HOST RESPONCE TO TB
    Joseph Keane; Fiscal Year: 2002

Collaborators

Detail Information

Publications7

  1. ncbi Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages
    J Keane
    Pulmonary Center, Boston University School of Medicine, Boston MA 02118, USA
    J Immunol 164:2016-20. 2000
    ....
  2. ncbi Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    J Keane
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    N Engl J Med 345:1098-104. 2001
    ..There is no direct evidence of a protective role of TNF-alpha in patients with tuberculosis...
  3. ncbi TNF-dependent BALB/c murine macrophage apoptosis following Mycobacterium tuberculosis infection inhibits bacillary growth in an IFN-gamma independent manner
    J Keane
    Pulmonary Center, Boston University School of Medicine, Boston, MA, USA
    Tuberculosis (Edinb) 82:55-61. 2002
    ..In vitro model of murine macrophage M. tuberculosis infection...
  4. ncbi Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses
    T K Means
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 166:4074-82. 2001
    ..Together, these data suggest that Mtb-induced TNF-alpha production is largely dependent on TLR signaling. In contrast, Mtb-induced NO production may be either TLR independent or mediated by TLR proteins in a MyD88-independent manner...
  5. ncbi Identification of Mycobacterium avium DNA sequences that encode exported proteins by using phoA gene fusions
    J D Carroll
    Department of Medicine, Boston University School of Medicine, Boston, USA
    Tuber Lung Dis 80:117-30. 2000
    ..Objective: In order to identify M. avium genes that may be involved in bacterial uptake and intracellular survival, a phoA -based reporter system was used to identify genes that encoded surface-expressed or exported proteins...
  6. ncbi Conservation of structure and function between human and murine IL-16
    J Keane
    The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Immunol 160:5945-54. 1998
    ..The data suggest cross-species conservation of IL-16 receptor structures as well. Inhibitory peptides may be useful in disease states where the proinflammatory functions of IL-16 are detrimental to the host...
  7. ncbi Usual interstitial pneumonitis responsive to corticosteroids following varicella pneumonia
    J Keane
    Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    Chest 113:249-51. 1998
    ..In this case, usual interstitial pneumonitis (UIP) developed. The pneumonitis responded well clinically and radiographically to corticosteroid treatment. The role of viral pneumonia in the cause of UIP is discussed...

Research Grants1

  1. ROLE & MECHANISM OF APOPTOSIS IN THE HOST RESPONCE TO TB
    Joseph Keane; Fiscal Year: 2002
    ..A better understanding of protective response to TB and the virulence factors that control them will contribute to developing new treatments for TB patients and the genetic design of improved vaccines. ..