Affiliation: Boston University
- Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophagesJ Keane
Pulmonary Center, Boston University School of Medicine, Boston MA 02118, USA
J Immunol 164:2016-20. 2000....
- Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agentJ Keane
Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
N Engl J Med 345:1098-104. 2001..There is no direct evidence of a protective role of TNF-alpha in patients with tuberculosis...
- TNF-dependent BALB/c murine macrophage apoptosis following Mycobacterium tuberculosis infection inhibits bacillary growth in an IFN-gamma independent mannerJ Keane
Pulmonary Center, Boston University School of Medicine, Boston, MA, USA
Tuberculosis (Edinb) 82:55-61. 2002..In vitro model of murine macrophage M. tuberculosis infection...
- Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responsesT K Means
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 166:4074-82. 2001..Together, these data suggest that Mtb-induced TNF-alpha production is largely dependent on TLR signaling. In contrast, Mtb-induced NO production may be either TLR independent or mediated by TLR proteins in a MyD88-independent manner...
- Identification of Mycobacterium avium DNA sequences that encode exported proteins by using phoA gene fusionsJ D Carroll
Department of Medicine, Boston University School of Medicine, Boston, USA
Tuber Lung Dis 80:117-30. 2000..Objective: In order to identify M. avium genes that may be involved in bacterial uptake and intracellular survival, a phoA -based reporter system was used to identify genes that encoded surface-expressed or exported proteins...
- Conservation of structure and function between human and murine IL-16J Keane
The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
J Immunol 160:5945-54. 1998..The data suggest cross-species conservation of IL-16 receptor structures as well. Inhibitory peptides may be useful in disease states where the proinflammatory functions of IL-16 are detrimental to the host...
- Usual interstitial pneumonitis responsive to corticosteroids following varicella pneumoniaJ Keane
Pulmonary Center, Boston University School of Medicine, MA 02118, USA
Chest 113:249-51. 1998..In this case, usual interstitial pneumonitis (UIP) developed. The pneumonitis responded well clinically and radiographically to corticosteroid treatment. The role of viral pneumonia in the cause of UIP is discussed...
- ROLE & MECHANISM OF APOPTOSIS IN THE HOST RESPONCE TO TBJoseph Keane; Fiscal Year: 2002..A better understanding of protective response to TB and the virulence factors that control them will contribute to developing new treatments for TB patients and the genetic design of improved vaccines. ..