Research Topics
| J A KayeSummaryAffiliation: Boston University Country: USA Publications
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Publications
Incidence of risk factors for myocardial infarction and other vascular diseases in patients with psoriasisJ A Kaye
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA
Br J Dermatol 159:895-902. 2008..Recent cross-sectional studies reported a higher prevalence of diabetes and other risk factors for cardiovascular disease in patients with psoriasis than in the general population...
Antibiotics and the risk of breast cancerJames A Kaye
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA, USA
Epidemiology 16:688-90. 2005..Two recent studies found a positive association between antibiotic use and the risk of breast cancer...
Statin use, hyperlipidaemia, and the risk of breast cancerJ A Kaye
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Br J Cancer 86:1436-9. 2002..8; 95% confidence interval 0.9-3.4). We found no evidence for an increasing trend in breast cancer risk with increasing duration of statin use (median duration 1.8 years, maximum 8.6 years)...
Epidemiology of lower limb fractures in general practice in the United KingdomJ A Kaye
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Inj Prev 10:368-74. 2004..Study..
Statin use and cancer risk in the General Practice Research DatabaseJ A Kaye
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA
Br J Cancer 90:635-7. 2004..Untreated hyperlipidaemia was associated with slightly increased risks of colon cancer (relative risk 1.8; 95% confidence interval 1.2-2.8), prostate cancer (1.5; 1.1-2.0), and bladder cancer (1.9; 1.2-3.1)...
Incidence of erectile dysfunction and characteristics of patients before and after the introduction of sildenafil in the United Kingdom: cross sectional study with comparison patientsJames A Kaye
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA
BMJ 326:424-5. 2003
The incidence of breast cancer in the General Practice Research Database compared with national cancer registration dataJ A Kaye
Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Br J Cancer 83:1556-8. 2000..The GPRD is a valuable and up-to-date resource for further study of the incidence of breast cancer in the UK as well as changes in cancer treatment and their relation to survival trends...
Mumps, measles, and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysisJ A Kaye
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA
BMJ 322:460-3. 2001..To estimate changes in the risk of autism and assess the relation of autism to the mumps, measles, and rubella (MMR) vaccine...
Risk of venous thromboembolism among users of third generation oral contraceptives compared with users of oral contraceptives with levonorgestrel before and after 1995: cohort and case-control analysisH Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
BMJ 321:1190-5. 2000..To compare the risk of idiopathic venous thromboembolism among women taking third generation oral contraceptives (with gestodene or desogestrel) with that among women taking oral contraceptives with levonorgestrel...
Acetaminophen and the risk of renal and bladder cancer in the general practice research databaseJ A Kaye
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Epidemiology 12:690-4. 2001..These results support previous findings from our group and are consistent with a slight increase in the risk of renal cancer, but not bladder cancer, with heavy acetaminophen use...
Validity of the general practice research databaseSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Pharmacotherapy 23:686-9. 2003..We reviewed evidence related to the validity of the GPRD. Specifically, with our extensive experience with this automated database, we evaluated the quality and completeness of the data that it contains...
Cesarean delivery in the United Kingdom: time trends in the general practice research databaseCorri Black
Department of Public Health, University of Aberdeen, Scotland
Obstet Gynecol 106:151-5. 2005..To estimate recent temporal trends in delivery by cesarean during the past decade and the proportion of vaginal deliveries after prior caesarean in the United Kingdom...
Obesity and the risk of prostate cancer (United States)Brian D Bradbury
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA
Cancer Causes Control 16:637-41. 2005..This study provides modest support for a protective association between obesity and the risk of incident prostate cancer...
Incidence of autism over timeHershel Jick
Epidemiology 17:120-1. 2006
Risk of nonfatal venous thromboembolism in women using a contraceptive transdermal patch and oral contraceptives containing norgestimate and 35 microg of ethinyl estradiolSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Contraception 73:223-8. 2006..There is concern that a new transdermal contraceptive patch containing ethinyl estradiol (EE) and the progestin norelgestromin increases the risk for venous thromboembolism (VTE) compared to previously marketed oral contraceptives (OCs)...
Risk of nonfatal venous thromboembolism with oral contraceptives containing norgestimate or desogestrel compared with oral contraceptives containing levonorgestrelSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Contraception 73:566-70. 2006..Estimates of the risk for VTE among users of norgestimate-containing OCs compared to other OCs, however, are lacking...
Nonsteroidal antiinflammatory drugs and acute myocardial infarction in patients with no major risk factorsHershel Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Pharmacotherapy 26:1379-87. 2006..To assess the risk of long-term use of five nonsteroidal antiinflammatory drugs (NSAIDs)--rofecoxib, celecoxib, ibuprofen, naproxen, and diclofenac--in relation to acute myocardial infarction...
Cardiovascular safety of cyclo-oxygenase-2 inhibitorsSusan S Jick
Lancet 369:555-6; author reply 556. 2007
Diclofenac and acute myocardial infarction in patients with no major risk factorsSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Br J Clin Pharmacol 64:662-7. 2007..To explore further a recent finding that long-term users of diclofenac are at increased risk of acute myocardial infarction (AMI) similar to users of rofecoxib and celecoxib...
Further results on the risk of nonfatal venous thromboembolism in users of the contraceptive transdermal patch compared to users of oral contraceptives containing norgestimate and 35 microg of ethinyl estradiolSusan Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Contraception 76:4-7. 2007....
Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: cohort study using data from the UK General Practice Research DatabaseStefan Russmann
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Br J Clin Pharmacol 60:76-82. 2005..To provide additional quantification of the risk of flucloxacillin-related liver disease and to describe time trends in flucloxacillin prescribing in the UK...
Tamoxifen-treated breast carcinoma patients and the risk of acute myocardial infarction and newly-diagnosed anginaBrian D Bradbury
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA
Cancer 103:1114-21. 2005..The effect persisted with increasing cumulative dose and length of use. CONCLUSIONS: The treatment of breast carcinoma with tamoxifen was found to reduce a woman's risk of acute MI or angina during the 5 years of recommended therapy...
Changes in risk of autism in the U.K. for birth cohorts 1990-1998Hershel Jick
Epidemiology 14:630-2. 2003
Epidemiology and possible causes of autismHershel Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Pharmacotherapy 23:1524-30. 2003....
Incidence and prevalence of drug-treated attention deficit disorder among boys in the UKHershel Jick
Boston University School of Medicine, Boston University, Lexington, MA, USA
Br J Gen Pract 54:345-7. 2004..Since no quantitative data on the incidence and prevalence of drug-treated ADD are available in the UK, we used the general practice research database (GPRD) to obtain such information...
Incidence of thrombotic thrombocytopenic purpura/hemolytic uremic syndromeDavid P Miller
Ingenix, Newton, Massachusetts 02466, USA
Epidemiology 15:208-15. 2004..Apparent international differences in incidence could be the result of imprecision in identifying thrombotic thrombocytopenia purpura and hemolytic uremic syndrome in large research databases...
Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research DatabaseCorri Black
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, MA 02421, USA
BMJ 325:419-21. 2002..To assess whether children with autism are more likely to have a history of gastrointestinal disorders than children without autism...
Antidepressants and the risk of suicidal behaviorsHershel Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Mass 02421, USA
JAMA 292:338-43. 2004..The use of such drugs among teenagers has been of particular concern...
Tamoxifen and cataracts: a null associationBrian D Bradbury
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
Breast Cancer Res Treat 87:189-96. 2004..We assessed whether breast cancer patients treated with tamoxifen were at increased risk of developing cataracts compared to women not prescribed tamoxifen...
Clinical risk factors for venous thromboembolus in users of the combined oral contraceptive pillCorri Black
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA
Br J Clin Pharmacol 53:637-40. 2002....
Autism and DPT vaccination in the United KingdomHershel Jick
N Engl J Med 350:2722-3. 2004
MMR vaccine and idiopathic thrombocytopaenic purpuraCorri Black
Department of Public Health, Aberdeen University, Aberdeen, UK
Br J Clin Pharmacol 55:107-11. 2003....
Changes in antipsychotic drug prescribing by general practitioners in the United Kingdom from 1991 to 2000: a population-based observational studyJames A Kaye
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
Br J Clin Pharmacol 56:569-75. 2003..It will be of interest to see whether the use of thioridazine, which was the most widely prescribed antipsychotic during 1991-2000, decreases during the next decade in response to the recent CSM recommendation...
