K M Kantak

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Anti-cocaine vaccines: antibody protection against relapse
    Kathleen M Kantak
    Department of Psychology, Boston University, 64 Cummington St, Boston, Massachusetts, USA
    Expert Opin Pharmacother 4:213-8. 2003
  2. pmc Impact of medial orbital cortex and medial subthalamic nucleus inactivation, individually and together, on the maintenance of cocaine self-administration behavior in rats
    K M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, MA 02215, USA
    Behav Brain Res 238:1-9. 2013
  3. pmc Pharmacological enhancement of drug cue extinction learning: translational challenges
    K M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 1216:122-37. 2011
  4. pmc Role of the orbitofrontal cortex and dorsal striatum in regulating the dose-related effects of self-administered cocaine
    Kathleen M Kantak
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Behav Brain Res 201:128-36. 2009
  5. doi request reprint Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorder
    K M Kantak
    Department of Psychology, CELEST Science of Learning Center, Boston University, MA 02215, USA
    Behav Neurosci 122:340-57. 2008
  6. ncbi request reprint Influence of sex, estrous cycle, and drug-onset age on cocaine self-administration in rats (Rattus norvegicus)
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Boston University, Boston, MA 02215, USA
    Exp Clin Psychopharmacol 15:37-47. 2007
  7. ncbi request reprint Cocaine-opioid interactions in groups of rats trained to discriminate different doses of cocaine
    K M Kantak
    Department of Psychology, Boston University, MA 02215, USA
    Psychopharmacology (Berl) 147:257-65. 1999
  8. ncbi request reprint Ethanol vapor self-administration in adult C57BL/6J male mice
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, United States
    Drug Alcohol Depend 86:123-31. 2007
  9. ncbi request reprint Influence of cocaine self-administration on learning related to prefrontal cortex or hippocampus functioning in rats
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, MA 02215, USA
    Psychopharmacology (Berl) 181:227-36. 2005
  10. ncbi request reprint Vaccines against drugs of abuse: a viable treatment option?
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, Massachusetts 02115, USA
    Drugs 63:341-52. 2003

Research Grants

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Anti-cocaine vaccines: antibody protection against relapse
    Kathleen M Kantak
    Department of Psychology, Boston University, 64 Cummington St, Boston, Massachusetts, USA
    Expert Opin Pharmacother 4:213-8. 2003
    ....
  2. pmc Impact of medial orbital cortex and medial subthalamic nucleus inactivation, individually and together, on the maintenance of cocaine self-administration behavior in rats
    K M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, MA 02215, USA
    Behav Brain Res 238:1-9. 2013
    ....
  3. pmc Pharmacological enhancement of drug cue extinction learning: translational challenges
    K M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 1216:122-37. 2011
    ..Finally, important considerations for the design and implementation of future studies evaluating exposure therapy combined with pharmacotherapy for substance use disorders are discussed...
  4. pmc Role of the orbitofrontal cortex and dorsal striatum in regulating the dose-related effects of self-administered cocaine
    Kathleen M Kantak
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Behav Brain Res 201:128-36. 2009
    ....
  5. doi request reprint Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorder
    K M Kantak
    Department of Psychology, CELEST Science of Learning Center, Boston University, MA 02215, USA
    Behav Neurosci 122:340-57. 2008
    ..Moreover, the current behavioral approach is appropriate to assess novel medications developed to target ADHD-associated neurocognitive deficits...
  6. ncbi request reprint Influence of sex, estrous cycle, and drug-onset age on cocaine self-administration in rats (Rattus norvegicus)
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Boston University, Boston, MA 02215, USA
    Exp Clin Psychopharmacol 15:37-47. 2007
    ..0-mg/kg unit dose and low FR) may be useful for evaluating potential sex or age differences in the consequences of cocaine self-administration more reliably, as cocaine intake would not be an uncontrolled factor...
  7. ncbi request reprint Cocaine-opioid interactions in groups of rats trained to discriminate different doses of cocaine
    K M Kantak
    Department of Psychology, Boston University, MA 02215, USA
    Psychopharmacology (Berl) 147:257-65. 1999
    ....
  8. ncbi request reprint Ethanol vapor self-administration in adult C57BL/6J male mice
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, United States
    Drug Alcohol Depend 86:123-31. 2007
    ..Nose-pokes at the FR port increased with increasing FR to maintain ethanol vapor intake at the reward port. These findings indicate that ethanol vapor is reinforcing in adult C57BL/6J male mice...
  9. ncbi request reprint Influence of cocaine self-administration on learning related to prefrontal cortex or hippocampus functioning in rats
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, MA 02215, USA
    Psychopharmacology (Berl) 181:227-36. 2005
    ..A preclinical means to investigate this issue is to use a yoked-triad procedure in which sets of three animals either contingently self-administer cocaine or receive passive administration of cocaine or saline in a noncontingent manner...
  10. ncbi request reprint Vaccines against drugs of abuse: a viable treatment option?
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, Massachusetts 02115, USA
    Drugs 63:341-52. 2003
    ..As such, the medical treatment of drug abuse will not be radically different from treatment of other chronic diseases...
  11. ncbi request reprint Stimulus-response functions of the lateral dorsal striatum and regulation of behavior studied in a cocaine maintenance/cue reinstatement model in rats
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington Street, MA 02215, USA
    Psychopharmacology (Berl) 161:278-87. 2002
    ..This region of the DST was investigated because it selectively regulates stimulus-response learning that is disrupted by 10 microg of bilaterally infused lidocaine...
  12. ncbi request reprint Evaluation of anti-cocaine antibodies and a cocaine vaccine in a rat self-administration model
    K M Kantak
    Department of Psychology, Boston University, Massachusetts 02215, USA
    Psychopharmacology (Berl) 148:251-62. 2000
    ..Previous pre-clinical studies with an anti-cocaine monoclonal antibody left open several issues critical to assessing the effectiveness of a vaccine for altering cocaine self-administration behavior...
  13. ncbi request reprint Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine-seeking behavior in rats
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience and Cognitive Neurobiology Laboratory, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 22:1126-36. 2002
    ..The basis for this dissociation might be related to neuroanatomical connections of the rBLA and cBLA with segregated, but parallel, corticostriatalpallidothalamic circuits...
  14. ncbi request reprint Cognitive task performance after lidocaine-induced inactivation of different sites within the basolateral amygdala and dorsal striatum
    K M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Massachusetts 02215, USA
    Behav Neurosci 115:589-601. 2001
    ....
  15. ncbi request reprint Time course of changes in cocaine self-administration behavior in rats during immunization with the cocaine vaccine IPC-1010
    K M Kantak
    Department of Psychology, Boston University, MA 02215, USA
    Psychopharmacology (Berl) 153:334-40. 2001
    ..The present studies were conducted to examine additional issues relevant to the clinical use of the vaccine...
  16. ncbi request reprint Hippocampal memory system function and the regulation of cocaine self-administration behavior in rats
    Yolanda D Black
    Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington Street, Boston, MA 02215, USA
    Behav Brain Res 151:225-38. 2004
    ....
  17. ncbi request reprint Differential effects of self-administered cocaine in adolescent and adult rats on stimulus-reward learning
    Kerry A Kerstetter
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington St, Boston, MA 02215, USA
    Psychopharmacology (Berl) 194:403-11. 2007
    ..Less clear is whether there are differences in the degree of impairment if cocaine use is initiated during adolescence rather than adulthood...
  18. pmc Alterations in expression and phosphorylation of GluA1 receptors following cocaine-cue extinction learning
    B A Nic Dhonnchadha
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Behav Brain Res 238:119-23. 2013
    ..We conclude that the BLA and vmPFC, in particular, appear to be loci for the inhibition of learned behavior induced via extinction training, but each site may have different signaling functions for cocaine-cue extinction learning...
  19. pmc Hippocampal regulation of contextual cue-induced reinstatement of cocaine-seeking behavior
    Alison L Atkins
    Department of Psychology, Boston University, Boston, MA 02215, United States
    Pharmacol Biochem Behav 90:481-91. 2008
    ..The hippocampus is important for acquisition of the association between cocaine and context and in maintaining discrimination between cocaine-relevant and -irrelevant contextual cues...
  20. pmc Interaction of the rostral basolateral amygdala and prelimbic prefrontal cortex in regulating reinstatement of cocaine-seeking behavior
    Yasmin Mashhoon
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, MA 02215, USA
    Pharmacol Biochem Behav 96:347-53. 2010
    ..Findings propose critical intrahemispheric interaction between the rBLA and plPFC in regulating reinstatement of cocaine-seeking behavior elicited by reexposure to drug-paired cues...
  21. ncbi request reprint Context-dependent prefrontal cortex regulation of cocaine self-administration and reinstatement behaviors in rats
    Nina C Di Pietro
    Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, USA
    Eur J Neurosci 24:3285-98. 2006
    ....
  22. pmc Effects of self-administered cocaine in adolescent and adult male rats on orbitofrontal cortex-related neurocognitive functioning
    Roxann C Harvey
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington Street, Boston, MA, 02215, USA
    Psychopharmacology (Berl) 206:61-71. 2009
    ..No deficits in stimulus-reward learning are produced by cocaine exposure initiated during adolescence...
  23. pmc Role of dopamine D1 receptors in the prefrontal dorsal agranular insular cortex in mediating cocaine self-administration in rats
    Nina C Di Pietro
    Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington St, Boston, MA 02215, USA
    Psychopharmacology (Berl) 200:81-91. 2008
    ..Orbital/insular areas of the prefrontal cortex (PFC) are implicated in cocaine addiction. However, the role of dopamine D1 receptors in mediating cocaine self-administration in these sub-regions remains unknown...
  24. pmc D-cycloserine deters reacquisition of cocaine self-administration by augmenting extinction learning
    Bríd A Nic Dhonnchadha
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Neuropsychopharmacology 35:357-67. 2010
    ..The results suggest that DCS combined with exposure therapy may constitute a rational strategy for the clinical management of cocaine relapse...
  25. ncbi request reprint Effects of persistent cocaine self-administration on amygdala-dependent and dorsal striatum-dependent learning in rats
    Tomoko Udo
    Laboratory of Behavioral Neuroscience1, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington Street, Boston, MA 02215, USA
    Psychopharmacology (Berl) 174:237-45. 2004
    ..The influence of persistent cocaine self-administration on learning and memory has never been evaluated...
  26. ncbi request reprint Temporal factors affecting cocaine-opioid interactions: a cocaine drug discrimination study in rats
    K Green-Jordan
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, MA 02215, USA
    Psychopharmacology (Berl) 156:427-34. 2001
    ..Increasing concomitant abuse of cocaine and morphine-like opioids has prompted a number of studies aimed at understanding how these drugs interact...
  27. pmc Dissociable effects of cocaine-seeking behavior following D1 receptor activation and blockade within the caudal and rostral basolateral amygdala in rats
    Yasmin Mashhoon
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, MA, USA
    Eur J Neurosci 29:1641-53. 2009
    ..Collectively, these findings indicate dissociable sensitivity to D(1) receptor ligands within the caudal and rostral basolateral amygdala for altering cocaine-seeking behavior under different conditions that model phases of addiction...
  28. doi request reprint Effects of D-cycloserine administration on weekly nonemotional memory tasks in healthy participants
    Michael W Otto
    Boston University, Harvard Medical School, Boston, MA 02215, USA
    Psychother Psychosom 78:49-54. 2009
    ..In this study, we investigated the relative benefit of DCS versus placebo for enhancing nonemotional verbal and nonverbal memory across weekly trials...
  29. doi request reprint The involvement of type IV phosphodiesterases in cocaine-induced sensitization and subsequent pERK expression in the mouse nucleus accumbens
    Amy C Janes
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Psychopharmacology (Berl) 206:177-85. 2009
    ....
  30. ncbi request reprint Complementary tasks to measure working memory in distinct prefrontal cortex subregions in rats
    Nina C Di Pietro
    Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, USA
    Behav Neurosci 118:1042-51. 2004
    ..The described methods provide a complementary means to study working memory in PFC subregions using a radial-arm maze...
  31. pmc Changes in expression of c-Fos protein following cocaine-cue extinction learning
    B A Nic Dhonnchadha
    Department of Psychology, Boston University, Boston, MA, USA
    Behav Brain Res 234:100-6. 2012
    ..Other sites are implicated in processing the significance of cues that are present early in extinction training...
  32. ncbi request reprint Effects of nitric oxide synthase inhibitors on the discriminative stimulus effects of cocaine in rats
    S L Collins
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington Street, Boston, Massachusetts, USA
    Psychopharmacology (Berl) 154:261-73. 2001
    ..CONCLUSIONS: These findings suggest that L-NAME and 7-NI may increase the potency of cocaine and other indirect DA agonists through a central mechanism whereby DA neurotransmission is directly enhanced by NOS inhibition...
  33. ncbi request reprint Neuronal nitric oxide synthase inhibition decreases cocaine self-administration behavior in rats
    Stephanie L Collins
    Laboratory of Behavioral Neuroscience, Department of Psychology, 64 Cummington Street, Boston University, Boston, MA 02215, USA
    Psychopharmacology (Berl) 159:361-9. 2002
    ..However, previous studies have largely used mixed-action NOS inhibitors and have not examined the effects of a neuronal NOS inhibitor on cocaine self-administration...
  34. ncbi request reprint The Type IV phosphodiesterase inhibitor rolipram interferes with drug-induced conditioned place preference but not immediate early gene induction in mice
    Barbara E Thompson
    Department of Psychology, 64 Cummington St, Boston, MA 02215, USA
    Eur J Neurosci 19:2561-8. 2004
    ..Thus, PDE4-mediated regulation of cAMP levels could underlie the establishment of reward valence to abused drugs...
  35. pmc Medial temporal lobe functioning and structure in the spontaneously hypertensive rat: comparison with Wistar-Kyoto normotensive and Wistar-Kyoto hypertensive strains
    Audrey M Wells
    Department of Psychology, Program in Neuroscience and CELEST Science of Learning Center, Boston University, Boston, Massachusetts 02215, USA
    Hippocampus 20:787-97. 2010
    ..The latter characteristics might be used to develop a new animal model of age- or disease-related decline in hippocampal functioning...

Research Grants19

  1. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen M Kantak; Fiscal Year: 2010
    ....
  2. Strategies for Enhancing Extinction of Drug-Seeking Behavior
    Kathleen Kantak; Fiscal Year: 2009
    ..This approach is especially relevant for research involving cognitive enhancing drugs, where non-human primates can serve as a key translational interface for the development of pharmacotherapies. ..
  3. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen Kantak; Fiscal Year: 2009
    ....
  4. Strategies for Enhancing Extinction of Drug-Seeking Behavior
    Kathleen Kantak; Fiscal Year: 2009
    ..This approach is especially relevant for research involving cognitive enhancing drugs, where non-human primates can serve as a key translational interface for the development of pharmacotherapies. ..
  5. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen Kantak; Fiscal Year: 2007
    ..abstract_text> ..
  6. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen Kantak; Fiscal Year: 2002
    ..This project may identify the unique cognitive challenges that face a drug-addicted individual ..
  7. Strategies for Enhancing Extinction of Drug-Seeking Behavior
    Kathleen M Kantak; Fiscal Year: 2010
    ..This approach is especially relevant for research involving cognitive enhancing drugs, where non-human primates can serve as a key translational interface for the development of pharmacotherapies. ..