Research Topics
| K M KantakSummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Anti-cocaine vaccines: antibody protection against relapseKathleen M Kantak
Department of Psychology, Boston University, 64 Cummington St, Boston, Massachusetts, USA
Expert Opin Pharmacother 4:213-8. 2003....
Impact of medial orbital cortex and medial subthalamic nucleus inactivation, individually and together, on the maintenance of cocaine self-administration behavior in ratsK M Kantak
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, MA 02215, USA
Behav Brain Res 238:1-9. 2013....- Pharmacological enhancement of drug cue extinction learning: translational challengesK M Kantak
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
Ann N Y Acad Sci 1216:122-37. 2011..Finally, important considerations for the design and implementation of future studies evaluating exposure therapy combined with pharmacotherapy for substance use disorders are discussed... - Role of the orbitofrontal cortex and dorsal striatum in regulating the dose-related effects of self-administered cocaineKathleen M Kantak
Department of Psychology, Boston University, Boston, MA 02215, USA
Behav Brain Res 201:128-36. 2009.... 
Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorderK M Kantak
Department of Psychology, CELEST Science of Learning Center, Boston University, MA 02215, USA
Behav Neurosci 122:340-57. 2008..Moreover, the current behavioral approach is appropriate to assess novel medications developed to target ADHD-associated neurocognitive deficits...- Influence of sex, estrous cycle, and drug-onset age on cocaine self-administration in rats (Rattus norvegicus)Kathleen M Kantak
Laboratory of Behavioral Neuroscience, Boston University, Boston, MA 02215, USA
Exp Clin Psychopharmacol 15:37-47. 2007..0-mg/kg unit dose and low FR) may be useful for evaluating potential sex or age differences in the consequences of cocaine self-administration more reliably, as cocaine intake would not be an uncontrolled factor... - Cocaine-opioid interactions in groups of rats trained to discriminate different doses of cocaineK M Kantak
Department of Psychology, Boston University, MA 02215, USA
Psychopharmacology (Berl) 147:257-65. 1999.... - Ethanol vapor self-administration in adult C57BL/6J male miceKathleen M Kantak
Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, United States
Drug Alcohol Depend 86:123-31. 2007..Nose-pokes at the FR port increased with increasing FR to maintain ethanol vapor intake at the reward port. These findings indicate that ethanol vapor is reinforcing in adult C57BL/6J male mice... - Influence of cocaine self-administration on learning related to prefrontal cortex or hippocampus functioning in ratsKathleen M Kantak
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, MA 02215, USA
Psychopharmacology (Berl) 181:227-36. 2005..A preclinical means to investigate this issue is to use a yoked-triad procedure in which sets of three animals either contingently self-administer cocaine or receive passive administration of cocaine or saline in a noncontingent manner... - Vaccines against drugs of abuse: a viable treatment option?Kathleen M Kantak
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, Massachusetts 02115, USA
Drugs 63:341-52. 2003..As such, the medical treatment of drug abuse will not be radically different from treatment of other chronic diseases... - Stimulus-response functions of the lateral dorsal striatum and regulation of behavior studied in a cocaine maintenance/cue reinstatement model in ratsKathleen M Kantak
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington Street, MA 02215, USA
Psychopharmacology (Berl) 161:278-87. 2002..This region of the DST was investigated because it selectively regulates stimulus-response learning that is disrupted by 10 microg of bilaterally infused lidocaine... - Cognitive task performance after lidocaine-induced inactivation of different sites within the basolateral amygdala and dorsal striatumK M Kantak
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Massachusetts 02215, USA
Behav Neurosci 115:589-601. 2001.... - Time course of changes in cocaine self-administration behavior in rats during immunization with the cocaine vaccine IPC-1010K M Kantak
Department of Psychology, Boston University, MA 02215, USA
Psychopharmacology (Berl) 153:334-40. 2001..The present studies were conducted to examine additional issues relevant to the clinical use of the vaccine... - Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine-seeking behavior in ratsKathleen M Kantak
Laboratory of Behavioral Neuroscience and Cognitive Neurobiology Laboratory, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 22:1126-36. 2002..The basis for this dissociation might be related to neuroanatomical connections of the rBLA and cBLA with segregated, but parallel, corticostriatalpallidothalamic circuits... - Evaluation of anti-cocaine antibodies and a cocaine vaccine in a rat self-administration modelK M Kantak
Department of Psychology, Boston University, Massachusetts 02215, USA
Psychopharmacology (Berl) 148:251-62. 2000..Previous pre-clinical studies with an anti-cocaine monoclonal antibody left open several issues critical to assessing the effectiveness of a vaccine for altering cocaine self-administration behavior... - Hippocampal memory system function and the regulation of cocaine self-administration behavior in ratsYolanda D Black
Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington Street, Boston, MA 02215, USA
Behav Brain Res 151:225-38. 2004.... - Differential effects of self-administered cocaine in adolescent and adult rats on stimulus-reward learningKerry A Kerstetter
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington St, Boston, MA 02215, USA
Psychopharmacology (Berl) 194:403-11. 2007..Less clear is whether there are differences in the degree of impairment if cocaine use is initiated during adolescence rather than adulthood... - Interaction of the rostral basolateral amygdala and prelimbic prefrontal cortex in regulating reinstatement of cocaine-seeking behaviorYasmin Mashhoon
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, MA 02215, USA
Pharmacol Biochem Behav 96:347-53. 2010..Findings propose critical intrahemispheric interaction between the rBLA and plPFC in regulating reinstatement of cocaine-seeking behavior elicited by reexposure to drug-paired cues... - Hippocampal regulation of contextual cue-induced reinstatement of cocaine-seeking behaviorAlison L Atkins
Department of Psychology, Boston University, Boston, MA 02215, United States
Pharmacol Biochem Behav 90:481-91. 2008..The hippocampus is important for acquisition of the association between cocaine and context and in maintaining discrimination between cocaine-relevant and -irrelevant contextual cues... - Effects of self-administered cocaine in adolescent and adult male rats on orbitofrontal cortex-related neurocognitive functioningRoxann C Harvey
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington Street, Boston, MA, 02215, USA
Psychopharmacology (Berl) 206:61-71. 2009..No deficits in stimulus-reward learning are produced by cocaine exposure initiated during adolescence... - Context-dependent prefrontal cortex regulation of cocaine self-administration and reinstatement behaviors in ratsNina C Di Pietro
Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, USA
Eur J Neurosci 24:3285-98. 2006.... - Role of dopamine D1 receptors in the prefrontal dorsal agranular insular cortex in mediating cocaine self-administration in ratsNina C Di Pietro
Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington St, Boston, MA 02215, USA
Psychopharmacology (Berl) 200:81-91. 2008..Orbital/insular areas of the prefrontal cortex (PFC) are implicated in cocaine addiction. However, the role of dopamine D1 receptors in mediating cocaine self-administration in these sub-regions remains unknown... - D-cycloserine deters reacquisition of cocaine self-administration by augmenting extinction learningBríd A Nic Dhonnchadha
Department of Psychology, Boston University, Boston, MA 02215, USA
Neuropsychopharmacology 35:357-67. 2010..The results suggest that DCS combined with exposure therapy may constitute a rational strategy for the clinical management of cocaine relapse... - Effects of persistent cocaine self-administration on amygdala-dependent and dorsal striatum-dependent learning in ratsTomoko Udo
Laboratory of Behavioral Neuroscience1, Department of Psychology and Program in Neuroscience, Boston University, 64 Cummington Street, Boston, MA 02215, USA
Psychopharmacology (Berl) 174:237-45. 2004.... - Alterations in expression and phosphorylation of GluA1 receptors following cocaine-cue extinction learningB A Nic Dhonnchadha
Department of Psychology, Boston University, Boston, MA, USA
Behav Brain Res 238:119-23. 2013..We conclude that the BLA and vmPFC, in particular, appear to be loci for the inhibition of learned behavior induced via extinction training, but each site may have different signaling functions for cocaine-cue extinction learning... - Temporal factors affecting cocaine-opioid interactions: a cocaine drug discrimination study in ratsK Green-Jordan
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, MA 02215, USA
Psychopharmacology (Berl) 156:427-34. 2001..Increasing concomitant abuse of cocaine and morphine-like opioids has prompted a number of studies aimed at understanding how these drugs interact... - Dissociable effects of cocaine-seeking behavior following D1 receptor activation and blockade within the caudal and rostral basolateral amygdala in ratsYasmin Mashhoon
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, MA, USA
Eur J Neurosci 29:1641-53. 2009..Collectively, these findings indicate dissociable sensitivity to D(1) receptor ligands within the caudal and rostral basolateral amygdala for altering cocaine-seeking behavior under different conditions that model phases of addiction... - Effects of D-cycloserine administration on weekly nonemotional memory tasks in healthy participantsMichael W Otto
Boston University, Harvard Medical School, Boston, MA 02215, USA
Psychother Psychosom 78:49-54. 2009..In this study, we investigated the relative benefit of DCS versus placebo for enhancing nonemotional verbal and nonverbal memory across weekly trials... - The involvement of type IV phosphodiesterases in cocaine-induced sensitization and subsequent pERK expression in the mouse nucleus accumbensAmy C Janes
Department of Psychology, Boston University, Boston, MA 02215, USA
Psychopharmacology (Berl) 206:177-85. 2009.... - Complementary tasks to measure working memory in distinct prefrontal cortex subregions in ratsNina C Di Pietro
Laboratory of Behavioral Neuroscience, Department of Psychology and Program in Neuroscience, Boston University, Boston, MA 02215, USA
Behav Neurosci 118:1042-51. 2004..The described methods provide a complementary means to study working memory in PFC subregions using a radial-arm maze... - Changes in expression of c-Fos protein following cocaine-cue extinction learningB A Nic Dhonnchadha
Department of Psychology, Boston University, Boston, MA, USA
Behav Brain Res 234:100-6. 2012..Other sites are implicated in processing the significance of cues that are present early in extinction training... - Effects of nitric oxide synthase inhibitors on the discriminative stimulus effects of cocaine in ratsS L Collins
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, 64 Cummington Street, Boston, Massachusetts, USA
Psychopharmacology (Berl) 154:261-73. 2001..CONCLUSIONS: These findings suggest that L-NAME and 7-NI may increase the potency of cocaine and other indirect DA agonists through a central mechanism whereby DA neurotransmission is directly enhanced by NOS inhibition... - Neuronal nitric oxide synthase inhibition decreases cocaine self-administration behavior in ratsStephanie L Collins
Laboratory of Behavioral Neuroscience, Department of Psychology, 64 Cummington Street, Boston University, Boston, MA 02215, USA
Psychopharmacology (Berl) 159:361-9. 2002..CONCLUSIONS: By selectively reducing drug-seeking behavior, these data suggest that 7-NI may enhance the reinforcing effects of cocaine... - The Type IV phosphodiesterase inhibitor rolipram interferes with drug-induced conditioned place preference but not immediate early gene induction in miceBarbara E Thompson
Department of Psychology, 64 Cummington St, Boston, MA 02215, USA
Eur J Neurosci 19:2561-8. 2004..Thus, PDE4-mediated regulation of cAMP levels could underlie the establishment of reward valence to abused drugs... - Medial temporal lobe functioning and structure in the spontaneously hypertensive rat: comparison with Wistar-Kyoto normotensive and Wistar-Kyoto hypertensive strainsAudrey M Wells
Department of Psychology, Program in Neuroscience and CELEST Science of Learning Center, Boston University, Boston, Massachusetts 02215, USA
Hippocampus 20:787-97. 2010..The latter characteristics might be used to develop a new animal model of age- or disease-related decline in hippocampal functioning...
Research Grants
- COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIORKathleen M Kantak; Fiscal Year: 2010....
- Strategies for Enhancing Extinction of Drug-Seeking BehaviorKathleen Kantak; Fiscal Year: 2009..This approach is especially relevant for research involving cognitive enhancing drugs, where non-human primates can serve as a key translational interface for the development of pharmacotherapies. ..
- COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIORKathleen Kantak; Fiscal Year: 2009....
- Strategies for Enhancing Extinction of Drug-Seeking BehaviorKathleen Kantak; Fiscal Year: 2009..This approach is especially relevant for research involving cognitive enhancing drugs, where non-human primates can serve as a key translational interface for the development of pharmacotherapies. ..
- COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIORKathleen Kantak; Fiscal Year: 2007..abstract_text> ..
- COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIORKathleen Kantak; Fiscal Year: 2002..This project may identify the unique cognitive challenges that face a drug-addicted individual ..
- Strategies for Enhancing Extinction of Drug-Seeking BehaviorKathleen M Kantak; Fiscal Year: 2010..This approach is especially relevant for research involving cognitive enhancing drugs, where non-human primates can serve as a key translational interface for the development of pharmacotherapies. ..