Research Topics
| S S JickSummaryAffiliation: Boston University Country: USA Publications
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Publications
The risk of adverse outcomes in association with use of testosterone products: a cohort study using the UK-based general practice research databaseSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Br J Clin Pharmacol 75:260-70. 2013....
Drospirenone- and levonorgestrel-containing oral contraceptives and the risk of gallbladder diseaseSusan Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Contraception 86:220-3. 2012..This study evaluated this relation as well as the role of progestogen on the risk of gallbladder disease among users of drospirenone-containing OCs compared to users of levonorgestrel-containing OCs...
Association of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective studyAlvaro Alonso
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
BMC Neurol 10:6. 2010..Moreover, limited information exists on the association between smoking and survival in ALS patients. We evaluated the association of smoking with ALS incidence and survival in a population-based cohort...
Validity of the general practice research databaseSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Pharmacotherapy 23:686-9. 2003..We reviewed evidence related to the validity of the GPRD. Specifically, with our extensive experience with this automated database, we evaluated the quality and completeness of the data that it contains...
Postmenopausal estrogen-containing hormone therapy and the risk of breast cancerSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts, USA
Obstet Gynecol 113:74-80. 2009..To investigate the relation of various estrogen-containing hormone therapies to the risk of breast cancer, emphasizing the use of the combination of estrogen and testosterone...
Antidepressant drug use and risk of venous thromboembolismSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Pharmacotherapy 28:144-50. 2008..To evaluate the risk of idiopathic venous thromboembolism associated with antidepressant use and to further assess the risk by class of antidepressant and by individual antidepressant drug...
Further results on the risk of nonfatal venous thromboembolism in users of the contraceptive transdermal patch compared to users of oral contraceptives containing norgestimate and 35 microg of ethinyl estradiolSusan Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Contraception 76:4-7. 2007....
Diclofenac and acute myocardial infarction in patients with no major risk factorsSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Br J Clin Pharmacol 64:662-7. 2007..To explore further a recent finding that long-term users of diclofenac are at increased risk of acute myocardial infarction (AMI) similar to users of rofecoxib and celecoxib...
Statins and newly diagnosed diabetesSusan S Jick
Boston Collaborative Drug Surveillance Program, 11 Muzzey Street, Lexington, MA 02421, USA
Br J Clin Pharmacol 58:303-9. 2004....
The contraceptive patch in relation to ischemic stroke and acute myocardial infarctionSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Pharmacotherapy 27:218-20. 2007..To compare rates of stroke and acute myocardial infarction in users of the Ortho EVRA contraceptive patch with these rates in users of norgestimate-containing oral contraceptives (OCs) with 35 microg of ethinyl estradiol...
Cerebral venous sinus thrombosis in users of four hormonal contraceptives: levonorgestrel-containing oral contraceptives, norgestimate-containing oral contraceptives, desogestrel-containing oral contraceptives and the contraceptive patchSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Contraception 74:290-2. 2006..It has been suggested that the risk for cerebral venous sinus thrombosis (CVST) may be greater among users of the contraceptive patch than among users of oral contraceptives (OCs)...
Risk of nonfatal venous thromboembolism with oral contraceptives containing norgestimate or desogestrel compared with oral contraceptives containing levonorgestrelSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Contraception 73:566-70. 2006..Estimates of the risk for VTE among users of norgestimate-containing OCs compared to other OCs, however, are lacking...
The risk of unintended pregnancies in users of the contraceptive patch compared to users of oral contraceptives in the UK General Practice Research DatabaseSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Contraception 80:142-51. 2009..The transdermal contraceptive patch EVRA has been marketed since 2002 as an alternative to oral contraceptives (OCs), but large follow-up studies of effectiveness are lacking...
Frequency of liver disease in type 2 diabetic patients treated with oral antidiabetic agentsS S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Diabetes Care 22:2067-71. 1999..We evaluated liver disease in conventionally treated type 2 diabetic patients to provide a reference against which reports of liver disease related to novel oral antidiabetic treatments could be compared...
The risk of gastrointestinal bleed, myocardial infarction, and newly diagnosed hypertension in users of meloxicam, diclofenac, naproxen, and piroxicamS S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts, USA
Pharmacotherapy 20:741-4. 2000..To obtain formally quantified data on the relation of meloxicam to newly diagnosed gastrointestinal problems, myocardial infarction, or treated hypertension...
Isotretinoin use and risk of depression, psychotic symptoms, suicide, and attempted suicideS S Jick
Boston Collaborative Drug Surveillance Program, 11 Muzzey St, Lexington, MA 02421, USA
Arch Dermatol 136:1231-6. 2000..It has been suggested that there is a causal association between isotretinoin therapy and the risk of depression, psychotic symptoms, suicide, and attempted suicide...
Hyperlipidaemia, statin use and the risk of developing rheumatoid arthritisS S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Ann Rheum Dis 68:546-51. 2009..To evaluate whether statins are associated with a protective effect on the development of rheumatoid arthritis (RA)...
Risk of non-fatal venous thromboembolism in women using oral contraceptives containing drospirenone compared with women using oral contraceptives containing levonorgestrel: case-control study using United States claims dataSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
BMJ 342:d2151. 2011..To compare the risk of non-fatal venous thromboembolism in women receiving oral contraceptives containing drospirenone with that in women receiving oral contraceptives containing levonorgestrel...
Postmarketing study of ORTHO EVRA and levonorgestrel oral contraceptives containing hormonal contraceptives with 30 mcg of ethinyl estradiol in relation to nonfatal venous thromboembolismSusan S Jick
Boston Collaborative Drug Surveillance Program, Department of Epidemiology, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA
Contraception 81:16-21. 2010..Concern has been raised that the risk of venous thromboembolism (VTE) in users of the ORTHO EVRA patch is higher compared to users of oral contraceptives (OCs)...
Risk of nonfatal venous thromboembolism in women using a contraceptive transdermal patch and oral contraceptives containing norgestimate and 35 microg of ethinyl estradiolSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Contraception 73:223-8. 2006..There is concern that a new transdermal contraceptive patch containing ethinyl estradiol (EE) and the progestin norelgestromin increases the risk for venous thromboembolism (VTE) compared to previously marketed oral contraceptives (OCs)...
Risk of venous thromboembolism among users of third generation oral contraceptives compared with users of oral contraceptives with levonorgestrel before and after 1995: cohort and case-control analysisH Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
BMJ 321:1190-5. 2000..To compare the risk of idiopathic venous thromboembolism among women taking third generation oral contraceptives (with gestodene or desogestrel) with that among women taking oral contraceptives with levonorgestrel...
The risk of venous thromboembolism in users of postcoital contraceptive pillsC Vasilakis
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Contraception 59:79-83. 1999..7 (95% CI 0.3-10.5) for second generation OC, 4.4 (95% CI 1.0-18.7) for third generation OC, and 6.3 (95% CI 1.2-33.5) for pregnancy. Short-term use of PCP is not associated with a substantially increased risk for developing VTE...
Antibiotics and risk of subsequent first-time acute myocardial infarctionC R Meier
Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, Mass 02421, USA
JAMA 281:427-31. 1999..If such a causal association exists, subjects who used antibiotics active against the bacteria, regardless of indication, might be at lower risk of developing acute myocardial infarction than nonusers...
Tamoxifen-treated breast carcinoma patients and the risk of acute myocardial infarction and newly-diagnosed anginaBrian D Bradbury
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA
Cancer 103:1114-21. 2005..The effect persisted with increasing cumulative dose and length of use. CONCLUSIONS: The treatment of breast carcinoma with tamoxifen was found to reduce a woman's risk of acute MI or angina during the 5 years of recommended therapy...
The risk of cataract among users of inhaled steroidsS S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Epidemiology 12:229-34. 2001..This trend was not evident in those under age 40...
Angiotensin-converting enzyme inhibitors, calcium channel blockers, and breast cancerC R Meier
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Mass, USA
Arch Intern Med 160:349-53. 2000....
Antibiotic use and risk of multiple sclerosisAlvaro Alonso
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 163:997-1002. 2006..pneumoniae was not associated with a decreased risk of short-term multiple sclerosis. The observed lower risk of multiple sclerosis for penicillin users needs to be confirmed in other populations...
Tamoxifen and cataracts: a null associationBrian D Bradbury
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
Breast Cancer Res Treat 87:189-96. 2004..We assessed whether breast cancer patients treated with tamoxifen were at increased risk of developing cataracts compared to women not prescribed tamoxifen...
Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: cohort study using data from the UK General Practice Research DatabaseStefan Russmann
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA
Br J Clin Pharmacol 60:76-82. 2005..To provide additional quantification of the risk of flucloxacillin-related liver disease and to describe time trends in flucloxacillin prescribing in the UK...
Antidepressants and the risk of suicidal behaviorsHershel Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Mass 02421, USA
JAMA 292:338-43. 2004..The use of such drugs among teenagers has been of particular concern...
Nonsteroidal antiinflammatory drugs and acute myocardial infarction in patients with no major risk factorsHershel Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Pharmacotherapy 26:1379-87. 2006..To assess the risk of long-term use of five nonsteroidal antiinflammatory drugs (NSAIDs)--rofecoxib, celecoxib, ibuprofen, naproxen, and diclofenac--in relation to acute myocardial infarction...
Incidence of risk factors for myocardial infarction and other vascular diseases in patients with psoriasisJ A Kaye
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA
Br J Dermatol 159:895-902. 2008..Recent cross-sectional studies reported a higher prevalence of diabetes and other risk factors for cardiovascular disease in patients with psoriasis than in the general population...
Recent use of oral contraceptives and the risk of multiple sclerosisAlvaro Alonso
Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital, Boston, MA 02115, USA
Arch Neurol 62:1362-5. 2005..Exogenous estrogens affect the onset and clinical course of experimental allergic encephalomyelitis. Oral contraceptives, a frequent source of exogenous estrogens in humans, could have a role in the development of multiple sclerosis (MS)...
Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective studyMiguel A Hernán
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Neurology 63:838-42. 2004..A potential link between the recombinant hepatitis B vaccine and an increased risk of multiple sclerosis (MS) has been evaluated in several studies, but some of them have substantial methodologic limitations...
Glucocorticoid use, other associated factors, and the risk of tuberculosisSusan S Jick
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA, USA
Arthritis Rheum 55:19-26. 2006..Low adiposity, diabetes, current smoking, and obstructive pulmonary disorders are also important independent risk factors for tuberculosis...
Live attenuated polio vaccine and the risk of intussusceptionH Jick
The Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA
Br J Clin Pharmacol 52:451-3. 2001..CONCLUSIONS: There is no suggestion that oral polio vaccine increases the risk for intussusception...
Cigarette smoking and the progression of multiple sclerosisMiguel A Hernán
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Brain 128:1461-5. 2005....
Itraconazole and fluconazole and certain rare, serious adverse eventsBrian D Bradbury
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Pharmacotherapy 22:697-700. 2002..4/100,000 prescriptions (95% CI 0.25-8.2) for serious, adverse liver events. CONCLUSION: Itraconazole and fluconazole do not commonly cause rare, serious adverse events affecting the liver, kidneys, skin, or blood...
Allergy, histamine 1 receptor blockers, and the risk of multiple sclerosisAlvaro Alonso
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Neurology 66:572-5. 2006....
Hepatitis B vaccination and multiple sclerosis: the jury is still outMiguel A Hernán
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Pharmacoepidemiol Drug Saf 15:653-5. 2006
Use of thiazolidinediones and fracture riskChristian Meier
Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Basel, Hebelstrasse 2, CH 4031 Basel, Switzerland
Arch Intern Med 168:820-5. 2008..Thiazolidinediones may adversely affect the skeleton owing to decreased bone formation and accelerated bone loss...
Who receives lipid-lowering drugs: the effects of comorbidities and patient characteristics on treatment initiationChen-Chang Yang
Department of Medicine, School of Medicine, National Yang-Ming University, 155 Li-Nong, Street, Section 2, Taipei, Taiwan 11217
Br J Clin Pharmacol 55:288-98. 2003....
Statins and the risk of idiopathic venous thromboembolismChen-Chang Yang
Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC
Br J Clin Pharmacol 53:101-5. 2002..9 (0.4, 2.0) in the follow-up analysis, and were 1.1 (0.3, 4.3), 3.7 (0.6, 24.1), 2.0 (0.3, 11.6), and 0.4 (0.2, 1.2) in the case-control analysis. CONCLUSIONS: Current statin use was not associated with a reduced risk of idiopathic VTE...
Use of statins and the risk of Parkinson's disease: a retrospective case-control study in the UKClaudia Becker
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Drug Saf 31:399-407. 2008..Paradoxically, however, statins may have potentially beneficial effects on neurodegenerative diseases due to their anti-inflammatory properties...
Lipid-lowering drugs and the risk of depression and suicidal behaviorChen-Chang Yang
Department of Internal Medicine, Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Arch Intern Med 163:1926-32. 2003....
Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case-control studyYolanda B Brauchli
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
J Am Acad Dermatol 58:421-9. 2008..Small clinical trials suggest that thiazolidinediones may exert a beneficial effect on skin lesions of patients with psoriasis. Little is known about other classes of antidiabetic drugs and the psoriasis risk...
Migraine and the risk of stroke, TIA, or death in the UK (CME)Claudia Becker
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Switzerland
Headache 47:1374-84. 2007..Previous observational studies have reported a higher risk of stroke in migraine patients. Objective.- We aimed to estimate the risk of stroke, transient ischemic attack (TIA), or death in migraineurs in the UK...
Statins and the risk of pneumonia: a population-based, nested case-control studyRaymond G Schlienger
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Pharmacotherapy 27:325-32. 2007..To determine if the use of statins affects pneumonia-related outpatient visits, hospitalizations with survival, and deaths...
Inhaled corticosteroids and the risk of fractures in children and adolescentsRaymond G Schlienger
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital, Petersgraben 4, CH-4031 Basel, Switzerland
Pediatrics 114:469-73. 2004..21 (95% confidence interval: 0.99-1.49). CONCLUSIONS: Exposure to inhaled steroids does not materially increase the fracture risk in children or adolescents compared with nonexposed individuals...
Use of antihypertensives and the risk of Parkinson diseaseClaudia Becker
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Hebelstrasse 2, CH 4031 Basel, Switzerland
Neurology 70:1438-44. 2008..Recent studies related angiotensin converting enzyme (ACE) inhibitors and calcium channel blockers to possible neuroprotective effects. Little is known about neuroprotection of angiotensin II (AT II) antagonists or beta-blockers...
Use of beta-blockers and risk of fracturesRaymond G Schlienger
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital, Basel, Switzerland
JAMA 292:1326-32. 2004..Many elderly patients with hypertension who are at risk of developing osteoporosis may potentially benefit from combined therapy with beta-blockers and thiazides...
Cardiovascular safety of cyclo-oxygenase-2 inhibitorsSusan S Jick
Lancet 369:555-6; author reply 556. 2007
Using prescription claims data for drugs available over-the-counter (OTC)Marianne Ulcickas Yood
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Pharmacoepidemiol Drug Saf 16:961-8. 2007..The purpose of this study is to quantify the effect of misclassification of OTC use in research that uses prescription claims data as the sole source of exposure information...
Discontinuation and switching of therapy after initiation of lipid-lowering drugs: the effects of comorbidities and patient characteristicsChen-Chang Yang
Department of Internal Medicine, Faculty of Medicine, School of Medicine, National Yang-Ming University, 155 Li-Nong Street, Section 2, Taipei, Taiwan 11217
Br J Clin Pharmacol 56:84-91. 2003....
Diabetes in patients with idiopathic Parkinson's diseaseClaudia Becker
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital, Basel, Switzerland
Diabetes Care 31:1808-12. 2008..We aimed at comparing the diabetes prevalence between patients with or without Parkinson's disease and at exploring the risk of developing incident diabetes associated with Parkinson's disease...
The risk of severe depression, psychosis or panic attacks with prophylactic antimalarialsChristoph R Meier
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Drug Saf 27:203-13. 2004....
The risk of newly diagnosed asthma in migraineurs with or without previous triptan prescriptionsClaudia Becker
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Headache 48:606-10. 2008..Previous observational studies reported an increased prevalence of asthma in migraine patients. Whether triptans affect the asthma risk has not yet been explored in an epidemiological study...
