Angela L Jefferson

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Atlas-derived perfusion correlates of white matter hyperintensities in patients with reduced cardiac output
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Robinson Complex, Suite 7800 72 East Concord Street Boston, MA 02118 2526, USA
    Neurobiol Aging 32:133-9. 2011
  2. pmc Evaluating elements of executive functioning as predictors of instrumental activities of daily living (IADLs)
    Angela L Jefferson
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    Arch Clin Neuropsychol 21:311-20. 2006
  3. pmc Object perception impairments predict instrumental activities of daily living dependence in Alzheimer's disease
    Angela L Jefferson
    Department of Neurology, University of Pennsylvania Medical Center, Philadellphia, PA, USA
    J Clin Exp Neuropsychol 28:884-97. 2006
  4. pmc Cognitive correlates of HVOT performance differ between individuals with mild cognitive impairment and normal controls
    Angela L Jefferson
    Alzheimer s Disease Center and Department of Neurology, Boston University School of Medicine, Robinson Complex, Suite 7800, 715 Albany Street, Boston, MA 02118 2526, USA
    Arch Clin Neuropsychol 21:405-12. 2006
  5. pmc Cognitive predictors of functional decline in vascular dementia
    Angela L Jefferson
    Alzheimer s Disease Center, Department of Neurology, Boston University Medical Center, Boston, MA 02118, USA
    Int J Geriatr Psychiatry 21:752-4. 2006
  6. pmc Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study
    A L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 68:1032-8. 2007
  7. pmc Lower cardiac output is associated with greater white matter hyperintensities in older adults with cardiovascular disease
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 55:1044-8. 2007
  8. pmc Geriatric performance on an abbreviated version of the Boston naming test
    Angela L Jefferson
    Alzheimer s Disease Center and Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Appl Neuropsychol 14:215-23. 2007
  9. pmc Characterization of activities of daily living in individuals with mild cognitive impairment
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Am J Geriatr Psychiatry 16:375-83. 2008
  10. pmc Decisional capacity for research participation in individuals with mild cognitive impairment
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, School of Medicine, University of Massachusetts at Boston, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 56:1236-43. 2008

Research Grants

  1. Cardiovascular disease and neurocognition in the elderly
    Angela Jefferson; Fiscal Year: 2004
  2. MCI & decisional capacity to provide informed consent
    Angela Jefferson; Fiscal Year: 2007
  3. Neurogenetics & Mild Cognitive Impairment
    Angela Jefferson; Fiscal Year: 2007
  4. Cardiac integrity and the aging brain
    Angela Jefferson; Fiscal Year: 2007

Detail Information

Publications48

  1. pmc Atlas-derived perfusion correlates of white matter hyperintensities in patients with reduced cardiac output
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Robinson Complex, Suite 7800 72 East Concord Street Boston, MA 02118 2526, USA
    Neurobiol Aging 32:133-9. 2011
    ..This spatial perfusion distribution difference for areas of WMH may occur in the context of reduced systemic perfusion, which subsequently impacts cerebral perfusion and contributes to subclinical or clinical microvascular damage...
  2. pmc Evaluating elements of executive functioning as predictors of instrumental activities of daily living (IADLs)
    Angela L Jefferson
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    Arch Clin Neuropsychol 21:311-20. 2006
    ..e., working memory, generation, inhibition, planning, and sequencing) to IADLs among an older adult cohort at risk for future cognitive and functional decline...
  3. pmc Object perception impairments predict instrumental activities of daily living dependence in Alzheimer's disease
    Angela L Jefferson
    Department of Neurology, University of Pennsylvania Medical Center, Philadellphia, PA, USA
    J Clin Exp Neuropsychol 28:884-97. 2006
    ..When considering multiple cognitive components simultaneously, object perception and the integrity of the inferotemporal cortex is important in the completion of functional abilities in general and IADLs in particular among AD patients...
  4. pmc Cognitive correlates of HVOT performance differ between individuals with mild cognitive impairment and normal controls
    Angela L Jefferson
    Alzheimer s Disease Center and Department of Neurology, Boston University School of Medicine, Robinson Complex, Suite 7800, 715 Albany Street, Boston, MA 02118 2526, USA
    Arch Clin Neuropsychol 21:405-12. 2006
    ....
  5. pmc Cognitive predictors of functional decline in vascular dementia
    Angela L Jefferson
    Alzheimer s Disease Center, Department of Neurology, Boston University Medical Center, Boston, MA 02118, USA
    Int J Geriatr Psychiatry 21:752-4. 2006
    ..This study examined changes in cognitive-functional relationships in vascular dementia (VaD) over the course of one year...
  6. pmc Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study
    A L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 68:1032-8. 2007
    ..We hypothesized that inflammatory biomarkers would be associated with neuroimaging markers of ischemia (i.e., white matter hyperintensities [WMH]) and AD (i.e., total brain volume [TCB])...
  7. pmc Lower cardiac output is associated with greater white matter hyperintensities in older adults with cardiovascular disease
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 55:1044-8. 2007
    ..To preliminarily examine the association between cardiac output, a measure of systemic blood flow, and structural brain magnetic resonance imaging indices of white matter hyperintensities (WMHs)...
  8. pmc Geriatric performance on an abbreviated version of the Boston naming test
    Angela L Jefferson
    Alzheimer s Disease Center and Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Appl Neuropsychol 14:215-23. 2007
    ..001). Geriatric normative data therefore suggest that sex, race, and education are all associated with naming performance, and these variables should be taken into consideration when interpreting geriatric BNT-30 performance...
  9. pmc Characterization of activities of daily living in individuals with mild cognitive impairment
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Am J Geriatr Psychiatry 16:375-83. 2008
    ....
  10. pmc Decisional capacity for research participation in individuals with mild cognitive impairment
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, School of Medicine, University of Massachusetts at Boston, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 56:1236-43. 2008
    ..To assess decisional capacity performance and the neuropsychological correlates of such performance to better understand higher-level instrumental activities of daily living in individuals with mild cognitive impairment (MCI)...
  11. pmc Systemic hypoperfusion is associated with executive dysfunction in geriatric cardiac patients
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Robinson Complex, Suite 7800, 715 Albany Street, Boston, MA 02118 2526, USA
    Neurobiol Aging 28:477-83. 2007
    ..The executive dysfunction profile may be secondary to reduced blood flow to vulnerable subcortical structures implicated in frontal-subcortical circuitry...
  12. pmc Factors associated with African American and White elders' participation in a brain donation program
    Angela L Jefferson
    Alzheimer s Disease Center and Department of Neurology, Boston University School of Medicine, Robinson Complex, Boston, MA 02118 2526, USA
    Alzheimer Dis Assoc Disord 25:11-6. 2011
    ..8±8.4, P=0.02). Results suggest that increased religiousness is related to White elders' decisions not to donate, whereas lower reading ability might be related to African American participants' decisions not to donate...
  13. pmc Clinical research participation among aging adults enrolled in an Alzheimer's Disease Center research registry
    Angela L Jefferson
    Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Alzheimers Dis 23:443-52. 2011
    ..Furthermore, favorable attitudes toward medical research are strongly associated with interest in enrolling in additional studies and may serve as a beneficial outreach triage technique...
  14. pmc Inflammatory markers and neuropsychological functioning: the Framingham Heart Study
    Angela L Jefferson
    Boston University School of Medicine, Boston, MA 02118, USA
    Neuroepidemiology 37:21-30. 2011
    ..We hypothesized that inflammatory markers are cross-sectionally and longitudinally associated with neuropsychological indicators of early ischemia and Alzheimer's disease...
  15. pmc Cardiac index is associated with brain aging: the Framingham Heart Study
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, 72 E Concord St, B 7800, Boston, MA 02118, USA
    Circulation 122:690-7. 2010
    ..We hypothesized that cardiac function, as measured by cardiac index, would be associated with preclinical brain magnetic resonance imaging (MRI) and neuropsychological markers of ischemia and Alzheimer disease in the community...
  16. pmc A life course model of cognitive activities, socioeconomic status, education, reading ability, and cognition
    Angela L Jefferson
    Alzheimer s Disease Center, School of Medicine, Boston University, Boston, Massachusetts, USA
    J Am Geriatr Soc 59:1403-11. 2011
    ..To cross-sectionally quantify the contribution of proxy measures of cognitive reserve reflective of the lifespan, such as education, socioeconomic status (SES), reading ability, and cognitive activities, in explaining late-life cognition...
  17. pmc Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study)
    Angela L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 108:1346-51. 2011
    ..In conclusion, although these observational cross-sectional data cannot establish causality, they suggest a nonlinear association between LVEF and measures of accelerated cognitive aging...
  18. pmc Cardiac output as a potential risk factor for abnormal brain aging
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Alzheimers Dis 20:813-21. 2010
    ..e., reduced systemic blood flow disrupts cerebral blood flow homeostasis), contributing to clinical brain injury, independent of shared risk factors for both cardiac dysfunction and abnormal brain aging...
  19. pmc Vascular and cognitive functions associated with cardiovascular disease in the elderly
    Ronald A Cohen
    Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, USA
    J Clin Exp Neuropsychol 31:96-110. 2009
    ....
  20. pmc Predicting cognitive decline and conversion to Alzheimer's disease in older adults using the NAB List Learning test
    Brandon E Gavett
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    J Int Neuropsychol Soc 16:651-60. 2010
    ..The predictive validity of the NAB List Learning algorithm makes it a clinically useful tool for the assessment of older adults...
  21. pmc Neuroimaging and cardiac correlates of cognitive function among patients with cardiac disease
    Robert H Paul
    Center for Behavioral Medicine, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, R I 02903, USA
    Cerebrovasc Dis 20:129-33. 2005
    ....
  22. pmc Sustained attention is associated with left ventricular ejection fraction in older adults with heart disease
    Beth A Jerskey
    Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Int Neuropsychol Soc 15:137-41. 2009
    ..Overall, the results provide support for the hypothesis that a change in cardiac pumping leads to decrements in some aspects of attention; however, inhibitory processes are relatively spared. (JINS, 2009, 15, 137-141.)...
  23. pmc Endothelial function and white matter hyperintensities in older adults with cardiovascular disease
    Karin F Hoth
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA
    Stroke 38:308-12. 2007
    ..The aim of the present study was to examine the association between endothelial-dependent and endothelial-independent vasodilatation and white matter hyperintensity volume...
  24. pmc Blood pressure and cognition among older adults: a meta-analysis
    Katherine A Gifford
    Department of Neurology, Vanderbilt Memory and Alzheimer s Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA
    Arch Clin Neuropsychol 28:649-64. 2013
    ..20, p < .001) with a trend for language (r = -.22, p = .07). Findings underscore the need to manage blood pressure as a key prevention method in minimizing abnormal cognitive aging prior to the onset of clinical dementia. ..
  25. pmc Category and letter verbal fluency across the adult lifespan: relationship to EEG theta power
    Adam M Brickman
    Brown Medical School, Department of Psychiatry, Centers for Behavioral and Preventive Medicine, USA
    Arch Clin Neuropsychol 20:561-73. 2005
    ..The differential age-associated decline between category and letter fluency suggests separate neurobiological substrates underlying the two domains of performance, which is not related to theta activity...
  26. pmc C-reactive protein, but not homocysteine, is related to cognitive dysfunction in older adults with cardiovascular disease
    John Gunstad
    Brown Medical School, Providence, Rhode Island, USA
    J Clin Neurosci 13:540-6. 2006
    ..Further study is needed to identify mechanisms by which inflammatory processes impact on cognitive function and to determine whether reducing circulating levels of inflammatory markers results in improved cognition...
  27. pmc Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease
    Laura H Eggermont
    Alzheimer s Disease Clinical and Research Program, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Arch Phys Med Rehabil 91:584-8. 2010
    ..To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD)...
  28. pmc Clock drawing performance in cognitively normal elderly
    Emily J Hubbard
    Alzheimer s Disease Clinical and Research Program, Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Arch Clin Neuropsychol 23:295-327. 2008
    ..Our results may serve as useful comparisons for clinicians wishing to know whether their patients perform in the general range of cognitively normal elderly...
  29. pmc Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly
    Robert H Paul
    Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, USA
    Arch Clin Neuropsychol 20:697-704. 2005
    ..Further, the findings suggest that cognitive aging is largely determined by factors other than SH for most older adults...
  30. pmc Carotid artery intima-media thickness and cognition in cardiovascular disease
    Andreana P Haley
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, United States
    Int J Cardiol 121:148-54. 2007
    ....
  31. pmc Test-retest stability on the WRAT-3 reading subtest in geriatric cognitive evaluations
    Lee Ashendorf
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118 2526, USA
    J Clin Exp Neuropsychol 31:605-10. 2009
    ..Results indicated that WRAT-3 Reading scores are appropriate for use with older adults, though the use of categorical descriptors to describe premorbid ability based on these scores is not supported...
  32. pmc Diagnostic utility of the NAB List Learning test in Alzheimer's disease and amnestic mild cognitive impairment
    Brandon E Gavett
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    J Int Neuropsychol Soc 15:121-9. 2009
    ..58 to .92 and univariate specificity values ranged from .52 to .97. Multivariate ordinal regression produced a model that classified individuals with 80% accuracy and good predictive power. (JINS, 2009, 15, 121-129.)...
  33. ncbi request reprint The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults
    Katherine A Gifford
    Vanderbilt Memory and Alzheimer s Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
    Alzheimers Dement 10:319-27. 2014
    ..The objective of this study was to compare whether different sources of cognitive complaint (i.e., subjective and informant) predict diagnostic conversion in nondemented older adults...
  34. pmc Clinical research risk assessment among individuals with mild cognitive impairment
    Angela L Jefferson
    Memory and Alzheimer s Center, Department of Neurology, Vanderbilt University, Medical Center North, Nashville, TN 37232, USA
    Am J Geriatr Psychiatry 20:878-86. 2012
    ..To determine whether individuals with mild cognitive impairment (MCI) differ from cognitively normal (NC) elders on a risk assessment task and whether participants and their study partners evaluate risk and benefit similarly...
  35. pmc Cardiac rehabilitation improves cognitive performance in older adults with cardiovascular disease
    John Gunstad
    Brown Medical School, Brown University, Box G MH, Providence, RI 02912 G, USA
    J Cardiopulm Rehabil 25:173-6. 2005
  36. ncbi request reprint An intervention to enhance Alzheimer's disease clinical research participation among older African Americans
    Angela L Jefferson
    Vanderbilt Memory and Alzheimer s Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37203, USA
    J Alzheimers Dis 36:597-606. 2013
    ..Alzheimer's disease (AD) rates are higher among African Americans than in other racial or ethnic groups. However, Black elders participate in research at lower rates than Whites...
  37. pmc Perceptions, knowledge, incentives, and barriers of brain donation among African American elders enrolled in an Alzheimer's research program
    Susan Lambe
    Alzheimer s Disease Center and Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Gerontologist 51:28-38. 2011
    ....
  38. pmc Conceptual and measurement challenges in research on cognitive reserve
    Richard N Jones
    Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USA
    J Int Neuropsychol Soc 17:593-601. 2011
    ..We review the theoretical and ontological status of latent variable modeling approaches to cognitive reserve, and suggest research strategies for advancing the field...
  39. pmc Apathy is associated with volume of the nucleus accumbens in patients infected with HIV
    Robert H Paul
    Brown Medical School Department of Psychiatry and Human Behavior, Providence, RI 02903, USA
    J Neuropsychiatry Clin Neurosci 17:167-71. 2005
    ..By contrast, ratings of depression were unrelated to either apathy or nucleus accumbens volume. These findings provide preliminary evidence that apathy reflects direct involvement of the central nervous system in patients with HIV...
  40. ncbi request reprint The global deterioration scale: relationships to neuropsychological performance and activities of daily living in patients with vascular dementia
    Robert H Paul
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Miriam Hospital, Providence, Rhode Island, USA
    J Geriatr Psychiatry Neurol 15:50-4. 2002
    ..Further, the GDS score accurately classified 87% of the patients with VaD. These findings provide support for the validity of the GDS in general staging of dementia severity of VaD...
  41. pmc Medical student education program in Alzheimer's disease: the PAIRS Program
    Angela L Jefferson
    Vanderbilt Memory and Alzheimer s Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Med Educ 12:80. 2012
    ..The purpose of this study is to evaluate the PAIRS Program and its effectiveness in enhancing medical education as a service-learning activity and replication model for the Buddy ProgramTM...
  42. ncbi request reprint Sensitivity of the dementia rating scale in vascular dementia: comparison between two sets of criteria to define cognitive impairment
    Robert H Paul
    Brown Medical School, Providence, RI 20903, USA
    Cerebrovasc Dis 15:116-20. 2003
    ..The Dementia Rating Scale (DRS) is a common measure of cognitive function, but its sensitivity to identify deficits across cognitive domains in vascular dementia (VaD) remains unclear...
  43. ncbi request reprint Cognitive and motor impairments predict functional declines in patients with vascular dementia
    Patricia A Boyle
    Department of Psychiatry, Brown Medical School, Providence, RI 02912, USA
    Int J Geriatr Psychiatry 17:164-9. 2002
    ..Patients with VaD display diverse cognitive and motor deficits, however, and relationships between these impairments and independent living abilities remain unclear...
  44. ncbi request reprint Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia
    Lawrence H Sweet
    Brown University Medical School, Miriam Hospital, Providence, RI 20903, USA
    J Geriatr Psychiatry Neurol 16:240-4. 2003
    ..These findings indicate that although SH volume increases with disease progression, the relative impact of SH volume on cognitive status decreases among patients with advanced VaD...
  45. ncbi request reprint Long-term citicoline (cytidine diphosphate choline) use in patients with vascular dementia: neuroimaging and neuropsychological outcomes
    Ronald A Cohen
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, R I, USA
    Cerebrovasc Dis 16:199-204. 2003
    ..This randomized, double-blind clinical trial was conducted to determine whether daily citicoline treatment improves neurocognitive and neuroimaging outcome over 12 months among patients diagnosed with vascular dementia (VaD)...
  46. ncbi request reprint The serial position effect in mild and moderately severe vascular dementia
    Robert H Paul
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island 20906, USA
    J Int Neuropsychol Soc 8:584-7. 2002
    ....
  47. ncbi request reprint Progressive morphometric and cognitive changes in vascular dementia
    John Gunstad
    Department of Psychiatry and Human Behavior, Brown Medical School, Miriam Hospital, Coro West Third Floor, 1 Hoppin St, Providence RI 02903, USA
    Arch Clin Neuropsychol 20:229-41. 2005
    ..Further research is needed to determine whether this observed decline is attributable to differential lesion distribution or statistical artifact...
  48. ncbi request reprint The relationship of subcortical MRI hyperintensities and brain volume to cognitive function in vascular dementia
    Ronald A Cohen
    Department of Psychiatry, Brown Medical School, Providence, Rhode Island, USA
    J Int Neuropsychol Soc 8:743-52. 2002
    ..That WBV emerged as a stronger correlate of dementia raises further questions regarding the cerebral mechanisms that contribute to the development of VaD...

Research Grants5

  1. Cardiovascular disease and neurocognition in the elderly
    Angela Jefferson; Fiscal Year: 2004
    ..abstract_text> ..
  2. MCI & decisional capacity to provide informed consent
    Angela Jefferson; Fiscal Year: 2007
    ..Second, information regarding the cognitive domains most important for capacity will assist future investigators in implementing targeted interventions for remediation of compromised decisional capacity. ..
  3. Neurogenetics & Mild Cognitive Impairment
    Angela Jefferson; Fiscal Year: 2007
    ..Furthermore, findings from the proposed pilot study will generate feasibility data for developing a future, large-scale neurogenetics research study. ..
  4. Cardiac integrity and the aging brain
    Angela Jefferson; Fiscal Year: 2007
    ..Jefferson's research career and provide the skill set necessary for an independent program of patient-oriented research focused on cardiovascular risk factors for accelerating cognitive aging. ..